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Site specific discrete PEGylation of (124)I-labeled mCC49 Fab' fragments improves tumor MicroPET/CT imaging in mice.

Ding H, Carlton MM, Povoski SP, Milum K, Kumar K, Kothandaraman S, Hinkle GH, Colcher D, Brody R, Davis PD, Pokora A, Phelps M, Martin EW Jr, Tweedle MF.

Bioconjug Chem. 2013 Nov 20;24(11):1945-54. doi: 10.1021/bc400375f. Epub 2013 Oct 31.


Anatomic and pharmacokinetic properties of intravitreal bevacizumab and ranibizumab after vitrectomy and lensectomy.

Christoforidis JB, Williams MM, Wang J, Jiang A, Pratt C, Abdel-Rasoul M, Hinkle GH, Knopp MV.

Retina. 2013 May;33(5):946-52. doi: 10.1097/IAE.0b013e3182753b12.


First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement.

Tabernero J, Shapiro GI, LoRusso PM, Cervantes A, Schwartz GK, Weiss GJ, Paz-Ares L, Cho DC, Infante JR, Alsina M, Gounder MM, Falzone R, Harrop J, White AC, Toudjarska I, Bumcrot D, Meyers RE, Hinkle G, Svrzikapa N, Hutabarat RM, Clausen VA, Cehelsky J, Nochur SV, Gamba-Vitalo C, Vaishnaw AK, Sah DW, Gollob JA, Burris HA 3rd.

Cancer Discov. 2013 Apr;3(4):406-17. doi: 10.1158/2159-8290.CD-12-0429. Epub 2013 Jan 28.


Evaluation of exogenous siRNA addition as a metabolic engineering tool for modifying biopharmaceuticals.

Tummala S, Titus M, Wilson L, Wang C, Ciatto C, Thill G, Foster D, Li C, Szabo Z, Guttman A, Bettencourt B, Jayaraman M, Deroot J, Kocisko D, Pollard S, Charisse K, Kuchimanchi S, Hinkle G, Milstein S, Meyers R, Wu SL, Karger BL, Rossomando A.

Biotechnol Prog. 2013 Mar-Apr;29(2):415-24. doi: 10.1002/btpr.1667. Epub 2013 Feb 13.


Comprehensive evaluation of canonical versus Dicer-substrate siRNA in vitro and in vivo.

Foster DJ, Barros S, Duncan R, Shaikh S, Cantley W, Dell A, Bulgakova E, O'Shea J, Taneja N, Kuchimanchi S, Sherrill CB, Akinc A, Hinkle G, Seila White AC, Pang B, Charisse K, Meyers R, Manoharan M, Elbashir SM.

RNA. 2012 Mar;18(3):557-68. doi: 10.1261/rna.031120.111. Epub 2012 Jan 31.


Antigen-directed cancer surgery for primary colorectal cancer: 15-year survival analysis.

Povoski SP, Hatzaras IS, Mojzisik CM, Arnold MW, Hinkle GH, Hitchcock CL, Young DC, Martin EW Jr.

Ann Surg Oncol. 2012 Jan;19(1):131-8. doi: 10.1245/s10434-011-1880-3. Epub 2011 Jul 6.


PET/CT imaging of I-124-radiolabeled bevacizumab and ranibizumab after intravitreal injection in a rabbit model.

Christoforidis JB, Carlton MM, Knopp MV, Hinkle GH.

Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5899-903. doi: 10.1167/iovs.10-6862.


Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models.

Vicent S, Chen R, Sayles LC, Lin C, Walker RG, Gillespie AK, Subramanian A, Hinkle G, Yang X, Saif S, Root DE, Huff V, Hahn WC, Sweet-Cordero EA.

J Clin Invest. 2010 Nov;120(11):3940-52. doi: 10.1172/JCI44165. Epub 2010 Oct 25.


124I-HuCC49deltaCH2 for TAG-72 antigen-directed positron emission tomography (PET) imaging of LS174T colon adenocarcinoma tumor implants in xenograft mice: preliminary results.

Zou P, Povoski SP, Hall NC, Carlton MM, Hinkle GH, Xu RX, Mojzisik CM, Johnson MA, Knopp MV, Martin EW Jr, Sun D.

World J Surg Oncol. 2010 Aug 6;8:65. doi: 10.1186/1477-7819-8-65.


Synthesizing and binding dual-mode poly (lactic-co-glycolic acid) (PLGA) nanobubbles for cancer targeting and imaging.

Xu JS, Huang J, Qin R, Hinkle GH, Povoski SP, Martin EW, Xu RX.

Biomaterials. 2010 Mar;31(7):1716-22. doi: 10.1016/j.biomaterials.2009.11.052. Epub 2009 Dec 16.


Fabrication of indocyanine green encapsulated biodegradable microbubbles for structural and functional imaging of cancer.

Xu RX, Huang J, Xu JS, Sun D, Hinkle GH, Martin EW, Povoski SP.

J Biomed Opt. 2009 May-Jun;14(3):034020. doi: 10.1117/1.3147424.


A comprehensive overview of radioguided surgery using gamma detection probe technology.

Povoski SP, Neff RL, Mojzisik CM, O'Malley DM, Hinkle GH, Hall NC, Murrey DA Jr, Knopp MV, Martin EW Jr.

World J Surg Oncol. 2009 Jan 27;7:11. doi: 10.1186/1477-7819-7-11. Review.


Highly parallel identification of essential genes in cancer cells.

Luo B, Cheung HW, Subramanian A, Sharifnia T, Okamoto M, Yang X, Hinkle G, Boehm JS, Beroukhim R, Weir BA, Mermel C, Barbie DA, Awad T, Zhou X, Nguyen T, Piqani B, Li C, Golub TR, Meyerson M, Hacohen N, Hahn WC, Lander ES, Sabatini DM, Root DE.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20380-5. doi: 10.1073/pnas.0810485105. Epub 2008 Dec 17.


Comprehensive evaluation of occupational radiation exposure to intraoperative and perioperative personnel from 18F-FDG radioguided surgical procedures.

Povoski SP, Sarikaya I, White WC, Marsh SG, Hall NC, Hinkle GH, Martin EW Jr, Knopp MV.

Eur J Nucl Med Mol Imaging. 2008 Nov;35(11):2026-34. doi: 10.1007/s00259-008-0880-4. Epub 2008 Jul 10.


Extended stability of iobenguane under simulated clinical conditions.

Hinkle GH, Dura JV, Morosco RS, Nahata MC.

Am J Health Syst Pharm. 2008 Jan 15;65(2):142-4. doi: 10.2146/ajhp070247.


Stability of a mixture of technetium Tc 99m sulfur colloid and lidocaine hydrochloride.

Dura JV, Hinkle GH.

Am J Health Syst Pharm. 2007 Dec 1;64(23):2477-9.


A performance evaluation of 90Y dose-calibrator measurements in nuclear pharmacies and clinics in the United States.

Schultz MK, Cessna JT, Anderson TL, Ponto JA, Petry N, Kowalsky RJ, Palmer MR, Beinlich UF, Baker W, Hinkle GH, Hung JC, Quinton T, Rice PA, Divgi C, Norenberg JP.

Appl Radiat Isot. 2008 Feb;66(2):252-60. Epub 2007 Sep 18.


Radioimmunoguided surgery (RIGS), PET/CT image-guided surgery, and fluorescence image-guided surgery: past, present, and future.

Sun D, Bloomston M, Hinkle G, Al-Saif OH, Hall NC, Povoski SP, Arnold MW, Martin EW Jr.

J Surg Oncol. 2007 Sep 15;96(4):297-308.


Integrative genomic approaches identify IKBKE as a breast cancer oncogene.

Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, Hirozane-Kishikawa T, Hill DE, Vidal M, Meyerson M, Grenier JK, Hinkle G, Root DE, Roberts TM, Lander ES, Polyak K, Hahn WC.

Cell. 2007 Jun 15;129(6):1065-79.


Population pharmacokinetics of humanized monoclonal antibody HuCC49deltaCH2 and murine antibody CC49 in colorectal cancer patients.

Fang L, Holford NH, Hinkle G, Cao X, Xiao JJ, Bloomston M, Gibbs S, Saif OH, Dalton JT, Chan KK, Schlom J, Martin EW Jr, Sun D.

J Clin Pharmacol. 2007 Feb;47(2):227-37.


Evolution of sensory complexity recorded in a myxobacterial genome.

Goldman BS, Nierman WC, Kaiser D, Slater SC, Durkin AS, Eisen JA, Ronning CM, Barbazuk WB, Blanchard M, Field C, Halling C, Hinkle G, Iartchuk O, Kim HS, Mackenzie C, Madupu R, Miller N, Shvartsbeyn A, Sullivan SA, Vaudin M, Wiegand R, Kaplan HB.

Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15200-5. Epub 2006 Oct 2. Erratum in: Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19605. Eisen, J [corrected to Eisen, J A].


A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.

Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, Hahn WC, Lander ES, Sabatini DM, Root DE.

Cell. 2006 Mar 24;124(6):1283-98.


Pharmacokinetics and clinical evaluation of 125I-radiolabeled humanized CC49 monoclonal antibody (HuCC49deltaC(H)2) in recurrent and metastatic colorectal cancer patients.

Xiao J, Horst S, Hinkle G, Cao X, Kocak E, Fang J, Young D, Khazaeli M, Agnese D, Sun D, Martin E Jr.

Cancer Biother Radiopharm. 2005 Feb;20(1):16-26.


Low variation in ribosomal DNA and internal transcribed spacers of the symbiotic fungi of leaf-cutting ants (Attini: Formicidae).

Silva-Pinhati AC, Bacci M Jr, Hinkle G, Sogin ML, Pagnocca FC, Martins VG, Bueno OC, Hebling MJ.

Braz J Med Biol Res. 2004 Oct;37(10):1463-72. Epub 2004 Sep 22.


Pilot study using a humanized CC49 monoclonal antibody (HuCC49DeltaCH2) to localize recurrent colorectal carcinoma.

Agnese DM, Abdessalam SF, Burak WE Jr, Arnold MW, Soble D, Hinkle GH, Young D, Khazaeli MB, Martin EW Jr.

Ann Surg Oncol. 2004 Feb;11(2):197-202.


Imaging of metastatic pulmonary tumors following NIS gene transfer using single photon emission computed tomography.

Marsee DK, Shen DH, MacDonald LR, Vadysirisack DD, Lin X, Hinkle G, Kloos RT, Jhiang SM.

Cancer Gene Ther. 2004 Feb;11(2):121-7.


Effects of dose, intervention time, and radionuclide on sodium iodide symporter (NIS)-targeted radionuclide therapy.

Shen DH, Marsee DK, Schaap J, Yang W, Cho JY, Hinkle G, Nagaraja HN, Kloos RT, Barth RF, Jhiang SM.

Gene Ther. 2004 Jan;11(2):161-9.


Intraoperative Gamma Detection of FDG Distribution in Colorectal Cancer.

Desai D, Arnold M, Saha S, Hinkle G, Soble D, Frye J, DePalatis L, Mantil J, Satter M, Martin E.

Clin Positron Imaging. 1999 Nov;2(6):325. No abstract available.


In vivo imaging and radioiodine therapy following sodium iodide symporter gene transfer in animal model of intracerebral gliomas.

Cho JY, Shen DH, Yang W, Williams B, Buckwalter TL, La Perle KM, Hinkle G, Pozderac R, Kloos R, Nagaraja HN, Barth RF, Jhiang SM.

Gene Ther. 2002 Sep;9(17):1139-45.


Kit formulation for the preparation of radioactive blue liposomes for sentinel node lymphoscintigraphy.

Plut EM, Hinkle GH, Guo W, Lee RJ.

J Pharm Sci. 2002 Jul;91(7):1717-32.


In vivo expression and function of the sodium iodide symporter following gene transfer in the MATLyLu rat model of metastatic prostate cancer.

La Perle KM, Shen D, Buckwalter TL, Williams B, Haynam A, Hinkle G, Pozderac R, Capen CC, Jhiang SM.

Prostate. 2002 Feb 15;50(3):170-8.


Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58.

Goodner B, Hinkle G, Gattung S, Miller N, Blanchard M, Qurollo B, Goldman BS, Cao Y, Askenazi M, Halling C, Mullin L, Houmiel K, Gordon J, Vaudin M, Iartchouk O, Epp A, Liu F, Wollam C, Allinger M, Doughty D, Scott C, Lappas C, Markelz B, Flanagan C, Crowell C, Gurson J, Lomo C, Sear C, Strub G, Cielo C, Slater S.

Science. 2001 Dec 14;294(5550):2323-8.


Radioimmunoguided breast surgery using radiolabeled antibody NR-LU-10 FAB: a pilot study.

Burak WE Jr, DePalatis L, Mosic JL, Soble D, Hinkle G, Hitchcock CL.

Tumori. 2001 May-Jun;87(3):142-6.


Correlative Whole-Body FDG-PET and Intraoperative Gamma Detection of FDG Distribution in Colorectal Cancer.

Desai DC, Arnold M, Saha S, Hinkle G, Soble D, Fry J, DePalatis LR, Mantil J, Satter M, Martin EW.

Clin Positron Imaging. 2000 Sep;3(5):189-196.


The Giardia genome project database.

McArthur AG, Morrison HG, Nixon JE, Passamaneck NQ, Kim U, Hinkle G, Crocker MK, Holder ME, Farr R, Reich CI, Olsen GE, Aley SB, Adam RD, Gillin FD, Sogin ML.

FEMS Microbiol Lett. 2000 Aug 15;189(2):271-3.


Lymphoscintigraphy and intraoperative lymphatic mapping of sentinel lymph nodes in melanoma patients.

Williams BS, Hinkle GH, Douthit RA, Fry JP, Pozderac RF, Olsen JO.

J Nucl Med Technol. 1999 Dec;27(4):309-17.


Immunoscintigraphy with indium-111-capromab pendetide: evaluation before definitive therapy in patients with prostate cancer.

Manyak MJ, Hinkle GH, Olsen JO, Chiaccherini RP, Partin AW, Piantadosi S, Burgers JK, Texter JH, Neal CE, Libertino JA, Wright GL Jr, Maguire RT.

Urology. 1999 Dec;54(6):1058-63.


Compounding radiolabeled blood cells for diagnostic imaging.

Hinkle G.

Int J Pharm Compd. 1999 Nov-Dec;3(6):443-6. No abstract available.


Routine preoperative lymphoscintigraphy is not necessary prior to sentinel node biopsy for breast cancer.

Burak WE Jr, Walker MJ, Yee LD, Kim JA, Saha S, Hinkle G, Olsen JO, Pozderac R, Farrar WB.

Am J Surg. 1999 Jun;177(6):445-9.


Biodistribution and localization of radiolabeled NR-LU-10 Fab fragment in human breast cancer xenografts.

Burak WE Jr, DePalatis L, Nines R, Hitchcock C, Hinkle G, Houchens D, Farrar WB.

Nucl Med Biol. 1998 Oct;25(7):633-7.


Multicenter radioimmunoscintigraphic evaluation of patients with prostate carcinoma using indium-111 capromab pendetide.

Hinkle GH, Burgers JK, Neal CE, Texter JH, Kahn D, Williams RD, Maguire R, Rogers B, Olsen JO, Badalament RA.

Cancer. 1998 Aug 15;83(4):739-47.


Psychiatric pharmacy practice specialty certification process.

Crismon ML, Fankhauser MP, Hinkle GH, Jann MW, Juni H, Love RC, Ray MD, Stimmel GL, Wells BG.

Am J Health Syst Pharm. 1998 Aug 1;55(15):1594-8. No abstract available.


Prostate cancer abdominal metastases detected with indium-111 capromab pendetide.

Hinkle GH, Burgers JK, Olsen JO, Williams BS, Lamatrice RA, Barth RF, Rogers B, Maguire RT.

J Nucl Med. 1998 Apr;39(4):650-2.


Genes coding for reverse transcriptase, DNA-directed RNA polymerase, and chitin synthase from the microsporidian Spraguea lophii.

Hinkle G, Morrison HG, Sogin ML.

Biol Bull. 1997 Oct;193(2):250-1. No abstract available.


Phylogenetic analysis of olfactory receptor genes from mudpuppy (Necturus maculosus).

Zhou Q, Hinkle G, Sogin ML, Dionne VE.

Biol Bull. 1997 Oct;193(2):248-50. No abstract available.


Technical considerations for acquiring and processing indium-111 capromab pendetide images.

Williams BS, Hinkle GH, Lamatrice RA, Fry JP, Loesch JA, Olsen JO.

J Nucl Med Technol. 1997 Sep;25(3):205-16.


Localization of Neuroendocrine Tumors Using Somatostatin Receptor Imaging With Indium-111-Pentetreotide (OctreoScan).

Ellison EC, Schirmer WJ, Olsen JO, Pozderac RV, Hinkle G, Hill T, O'Dorisio TM, O'Dorisio MS.

Cancer Control. 1997 Jan;4(1):35-39.


Pharmacokinetics of iodine-125 CC49 monoclonal antibody in patients with colon cancer.

Cook CH, Hinkle GH, Thurston MO, Martin EW Jr.

Cancer Biother Radiopharm. 1996 Dec;11(6):415-22.


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