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Items: 1 to 50 of 67

1.

Pro-Angiogenic Macrophage Phenotype to Promote Myocardial Repair.

Ferraro B, Leoni G, Hinkel R, Ormanns S, Paulin N, Ortega-Gomez A, Viola JR, de Jong R, Bongiovanni D, Bozoglu T, Maas SL, D'Amico M, Kessler T, Zeller T, Hristov M, Reutelingsperger C, Sager HB, Döring Y, Nahrendorf M, Kupatt C, Soehnlein O.

J Am Coll Cardiol. 2019 Jun 18;73(23):2990-3002. doi: 10.1016/j.jacc.2019.03.503.

2.

Author Correction: Consistent success in life-supporting porcine cardiac xenotransplantation.

Längin M, Mayr T, Reichart B, Michel S, Buchholz S, Guethoff S, Dashkevich A, Baehr A, Egerer S, Bauer A, Mihalj M, Panelli A, Issl L, Ying J, Fresch AK, Buttgereit I, Mokelke M, Radan J, Werner F, Lutzmann I, Steen S, Sjöberg T, Paskevicius A, Qiuming L, Sfriso R, Rieben R, Dahlhoff M, Kessler B, Kemter E, Kurome M, Zakhartchenko V, Klett K, Hinkel R, Kupatt C, Falkenau A, Reu S, Ellgass R, Herzog R, Binder U, Wich G, Skerra A, Ayares D, Kind A, Schönmann U, Kaup FJ, Hagl C, Wolf E, Klymiuk N, Brenner P, Abicht JM.

Nature. 2019 Apr;568(7752):E7. doi: 10.1038/s41586-019-1108-4.

PMID:
30944481
3.

Consistent success in life-supporting porcine cardiac xenotransplantation.

Längin M, Mayr T, Reichart B, Michel S, Buchholz S, Guethoff S, Dashkevich A, Baehr A, Egerer S, Bauer A, Mihalj M, Panelli A, Issl L, Ying J, Fresch AK, Buttgereit I, Mokelke M, Radan J, Werner F, Lutzmann I, Steen S, Sjöberg T, Paskevicius A, Qiuming L, Sfriso R, Rieben R, Dahlhoff M, Kessler B, Kemter E, Kurome M, Zakhartchenko V, Klett K, Hinkel R, Kupatt C, Falkenau A, Reu S, Ellgass R, Herzog R, Binder U, Wich G, Skerra A, Ayares D, Kind A, Schönmann U, Kaup FJ, Hagl C, Wolf E, Klymiuk N, Brenner P, Abicht JM.

Nature. 2018 Dec;564(7736):430-433. doi: 10.1038/s41586-018-0765-z. Epub 2018 Dec 5. Erratum in: Nature. 2019 Apr;568(7752):E7.

PMID:
30518863
4.

Thymosin β4-mediated protective effects in the heart.

Hinkel R, Klett K, Bähr A, Kupatt C.

Expert Opin Biol Ther. 2018 Jul;18(sup1):121-129. doi: 10.1080/14712598.2018.1490409. Review.

PMID:
30063857
5.

Induced pluripotent stem cell derived cardiac models: effects of Thymosin β4.

Ziegler T, Hinkel R, Kupatt C.

Expert Opin Biol Ther. 2018 Jul;18(sup1):111-120. doi: 10.1080/14712598.2018.1473370. Review.

PMID:
30063852
6.

Tβ4 Increases Neovascularization and Cardiac Function in Chronic Myocardial Ischemia of Normo- and Hypercholesterolemic Pigs.

Ziegler T, Bähr A, Howe A, Klett K, Husada W, Weber C, Laugwitz KL, Kupatt C, Hinkel R.

Mol Ther. 2018 Jul 5;26(7):1706-1714. doi: 10.1016/j.ymthe.2018.06.004. Epub 2018 Jun 19.

7.

Translational Aspects of Adeno-Associated Virus-Mediated Cardiac Gene Therapy.

Ziegler T, Ishikawa K, Hinkel R, Kupatt C.

Hum Gene Ther. 2018 Dec;29(12):1341-1351. doi: 10.1089/hum.2017.229. Epub 2018 Jul 24.

PMID:
29848073
8.

Interplay of cell-cell contacts and RhoA/MRTF-A signaling regulates cardiomyocyte identity.

Dorn T, Kornherr J, Parrotta EI, Zawada D, Ayetey H, Santamaria G, Iop L, Mastantuono E, Sinnecker D, Goedel A, Dirschinger RJ, My I, Laue S, Bozoglu T, Baarlink C, Ziegler T, Graf E, Hinkel R, Cuda G, Kääb S, Grace AA, Grosse R, Kupatt C, Meitinger T, Smith AG, Laugwitz KL, Moretti A.

EMBO J. 2018 Jun 15;37(12). pii: e98133. doi: 10.15252/embj.201798133. Epub 2018 May 15.

9.

Individualized Biventricular Epicardial Augmentation Technology in a Drug-Induced Porcine Failing Heart Model.

Jagschies L, Hirschvogel M, Matallo J, Maier A, Mild K, Brunner H, Hinkel R, Gee MW, Radermacher P, Wildhirt SM, Hafner S.

ASAIO J. 2018 Jul/Aug;64(4):480-488. doi: 10.1097/MAT.0000000000000686.

PMID:
29028694
10.

Steerable Induction of the Thymosin β4/MRTF-A Pathway via AAV-Based Overexpression Induces Therapeutic Neovascularization.

Ziegler T, Kraus M, Husada W, Gesenhues F, Jiang Q, Pinkenburg O, Trenkwalder T, Laugwitz KL, le Noble F, Weber C, Kupatt C, Hinkel R.

Hum Gene Ther. 2017 Oct 3. doi: 10.1089/hum.2017.013. [Epub ahead of print]

PMID:
28726522
11.

Corrigendum: Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.

Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseño CG, Ramasamy SK, Krishnasamy K, Limbourg A, Häger C, Kapanadze T, Ishifune C, Hinkel R, Radtke F, Strobl LJ, Zimber-Strobl U, Napp LC, Bauersachs J, Haller H, Yasutomo K, Kupatt C, Murphy KM, Adams RH, Weber C, Limbourg FP.

Nat Commun. 2017 May 3;8:15486. doi: 10.1038/ncomms15486. No abstract available.

12.

Thymosin β4 Improves Differentiation and Vascularization of EHTs.

Ziegler T, Hinkel R, Stöhr A, Eschenhagen T, Laugwitz KL, le Noble F, David R, Hansen A, Kupatt C.

Stem Cells Int. 2017;2017:6848271. doi: 10.1155/2017/6848271. Epub 2017 Jan 16.

13.

Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes.

Chen Z, Xian W, Bellin M, Dorn T, Tian Q, Goedel A, Dreizehnter L, Schneider CM, Ward-van Oostwaard D, Ng JK, Hinkel R, Pane LS, Mummery CL, Lipp P, Moretti A, Laugwitz KL, Sinnecker D.

Eur Heart J. 2017 Jan 21;38(4):292-301. doi: 10.1093/eurheartj/ehw189. No abstract available.

14.

Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium.

Hinkel R, Howe A, Renner S, Ng J, Lee S, Klett K, Kaczmarek V, Moretti A, Laugwitz KL, Skroblin P, Mayr M, Milting H, Dendorfer A, Reichart B, Wolf E, Kupatt C.

J Am Coll Cardiol. 2017 Jan 17;69(2):131-143. doi: 10.1016/j.jacc.2016.10.058.

15.
16.

Pim1 Overexpressing ckit+ Cardiac Stem Cells in Cardiac Regeneration: Preconditioning as Next-Generation Stem Cell Therapy?

Hinkel R.

J Am Coll Cardiol. 2016 Dec 6;68(22):2465-2466. doi: 10.1016/j.jacc.2016.09.924. No abstract available.

17.

Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.

Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseño CG, Ramasamy SK, Krishnasamy K, Limbourg A, Kapanadze T, Ishifune C, Hinkel R, Radtke F, Strobl LJ, Zimber-Strobl U, Napp LC, Bauersachs J, Haller H, Yasutomo K, Kupatt C, Murphy KM, Adams RH, Weber C, Limbourg FP.

Nat Commun. 2016 Aug 31;7:12597. doi: 10.1038/ncomms12597.

18.

Endothelial RAGE exacerbates acute postischaemic cardiac inflammation.

Ziegler T, Horstkotte M, Lange P, Ng J, Bongiovanni D, Hinkel R, Laugwitz KL, Sperandio M, Horstkotte J, Kupatt C.

Thromb Haemost. 2016 Aug 1;116(2):300-8. doi: 10.1160/TH15-11-0898. Epub 2016 Jun 2.

PMID:
27412300
19.

Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5.

Alard JE, Ortega-Gomez A, Wichapong K, Bongiovanni D, Horckmans M, Megens RT, Leoni G, Ferraro B, Rossaint J, Paulin N, Ng J, Ippel H, Suylen D, Hinkel R, Blanchet X, Gaillard F, D'Amico M, von Hundelshausen P, Zarbock A, Scheiermann C, Hackeng TM, Steffens S, Kupatt C, Nicolaes GA, Weber C, Soehnlein O.

Sci Transl Med. 2015 Dec 9;7(317):317ra196. doi: 10.1126/scitranslmed.aad5330.

PMID:
26659570
20.

C-terminal variable AGES domain of Thymosin β4: the molecule's primary contribution in support of post-ischemic cardiac function and repair.

Hinkel R, Ball HL, DiMaio JM, Shrivastava S, Thatcher JE, Singh AN, Sun X, Faskerti G, Olson EN, Kupatt C, Bock-Marquette I.

J Mol Cell Cardiol. 2015 Oct;87:113-25. doi: 10.1016/j.yjmcc.2015.07.004. Epub 2015 Aug 5.

PMID:
26255251
21.

Heme Oxygenase-1 Gene Therapy Provides Cardioprotection Via Control of Post-Ischemic Inflammation: An Experimental Study in a Pre-Clinical Pig Model.

Hinkel R, Lange P, Petersen B, Gottlieb E, Ng JK, Finger S, Horstkotte J, Lee S, Thormann M, Knorr M, El-Aouni C, Boekstegers P, Reichart B, Wenzel P, Niemann H, Kupatt C.

J Am Coll Cardiol. 2015 Jul 14;66(2):154-65. doi: 10.1016/j.jacc.2015.04.064.

22.

Thymosin-β4-mediated therapeutic neovascularization: role of the PI3K/AKT pathway.

Trenkwalder T, Deindl E, Bongiovanni D, Lee S, Schunkert H, Kupatt C, Hinkel R.

Expert Opin Biol Ther. 2015;15 Suppl 1:S175-85. doi: 10.1517/14712598.2015.1011122. Epub 2015 Feb 4.

PMID:
25652683
23.

Thymosin β4 attenuates microcirculatory and hemodynamic destabilization in sepsis.

Bongiovanni D, Ziegler T, D'Almeida S, Zhang T, Ng JK, Dietzel S, Hinkel R, Kupatt C.

Expert Opin Biol Ther. 2015;15 Suppl 1:S203-10. doi: 10.1517/14712598.2015.1006193. Epub 2015 Jan 21.

PMID:
25604254
24.

Annexin A1 counteracts chemokine-induced arterial myeloid cell recruitment.

Drechsler M, de Jong R, Rossaint J, Viola JR, Leoni G, Wang JM, Grommes J, Hinkel R, Kupatt C, Weber C, Döring Y, Zarbock A, Soehnlein O.

Circ Res. 2015 Feb 27;116(5):827-35. doi: 10.1161/CIRCRESAHA.116.305825. Epub 2014 Dec 17.

PMID:
25520364
25.

Adeno-associated viral vector 2.9 thymosin ß4 application attenuates rejection after heart transplantation: results of a preclinical study in the pig.

Postrach J, Schmidt M, Thormann M, Thein E, Burdorf L, Reichart B, Sotlar K, Walz C, Faber C, Bauer A, Schmoeckel M, Kupatt C, Hinkel R.

Transplantation. 2014 Oct 27;98(8):835-43. doi: 10.1097/TP.0000000000000327.

PMID:
25321165
26.

Targeting microRNAs for cardiovascular therapeutics in coronary artery disease.

Hinkel R, Ng JK, Kupatt C.

Curr Opin Cardiol. 2014 Nov;29(6):586-94. doi: 10.1097/HCO.0000000000000107. Review.

PMID:
25159281
27.

MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2.

Hinkel R, Trenkwalder T, Petersen B, Husada W, Gesenhues F, Lee S, Hannappel E, Bock-Marquette I, Theisen D, Leitner L, Boekstegers P, Cierniewski C, Müller OJ, le Noble F, Adams RH, Weinl C, Nordheim A, Reichart B, Weber C, Olson E, Posern G, Deindl E, Niemann H, Kupatt C.

Nat Commun. 2014 Jun 9;5:3970. doi: 10.1038/ncomms4970.

PMID:
24910328
28.

Feasibility of dynamic CT-based adenosine stress myocardial perfusion imaging to detect and differentiate ischemic and infarcted myocardium in an large experimental porcine animal model.

Bamberg F, Hinkel R, Marcus RP, Baloch E, Hildebrandt K, Schwarz F, Hetterich H, Sandner TA, Schlett CL, Ebersberger U, Kupatt C, Hoffmann U, Reiser MF, Theisen D, Nikolaou K.

Int J Cardiovasc Imaging. 2014 Apr;30(4):803-12. doi: 10.1007/s10554-014-0390-3. Epub 2014 Feb 26.

PMID:
24570085
29.

VEGF-B: a more balanced approach toward cardiac neovascularization?

Kupatt C, Hinkel R.

EMBO Mol Med. 2014 Mar;6(3):297-8. doi: 10.1002/emmm.201303730. Epub 2014 Feb 12.

30.

In vivo monitoring of sorafenib therapy effects on experimental prostate carcinomas using dynamic contrast-enhanced MRI and macromolecular contrast media.

Cyran CC, Schwarz B, Paprottka PM, Sourbron S, von Einem JC, Dietrich O, Hinkel R, Clevert DA, Bruns CJ, Reiser MF, Nikolaou K, Wintersperger BJ.

Cancer Imaging. 2013 Dec 16;13(4):557-66. doi: 10.1102/1470-7330.2013.0049.

31.

Myocardial CT perfusion imaging in a large animal model: comparison of dynamic versus single-phase acquisitions.

Schwarz F, Hinkel R, Baloch E, Marcus RP, Hildebrandt K, Sandner TA, Kupatt C, Hoffmann V, Wintersperger BJ, Reiser MF, Theisen D, Nikolaou K, Bamberg F.

JACC Cardiovasc Imaging. 2013 Dec;6(12):1229-38. doi: 10.1016/j.jcmg.2013.05.018. Epub 2013 Oct 23.

32.

Inhibition of microRNA-92a protects against ischemia/reperfusion injury in a large-animal model.

Hinkel R, Penzkofer D, Zühlke S, Fischer A, Husada W, Xu QF, Baloch E, van Rooij E, Zeiher AM, Kupatt C, Dimmeler S.

Circulation. 2013 Sep 3;128(10):1066-75. doi: 10.1161/CIRCULATIONAHA.113.001904. Epub 2013 Jul 29.

PMID:
23897866
33.

Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis.

Ziegler T, Horstkotte J, Schwab C, Pfetsch V, Weinmann K, Dietzel S, Rohwedder I, Hinkel R, Gross L, Lee S, Hu J, Soehnlein O, Franz WM, Sperandio M, Pohl U, Thomas M, Weber C, Augustin HG, Fässler R, Deutsch U, Kupatt C.

J Clin Invest. 2013 Jul 1. pii: 66549. doi: 10.1172/JCI66549. [Epub ahead of print]

34.

SDF-1 fused to a fractalkine stalk and a GPI anchor enables functional neovascularization.

Stachel G, Trenkwalder T, Götz F, El Aouni C, Muenchmeier N, Pfosser A, Nussbaum C, Sperandio M, Hatzopoulos AK, Hinkel R, Nelson PJ, Kupatt C.

Stem Cells. 2013 Sep;31(9):1795-805. doi: 10.1002/stem.1439.

35.

Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia.

Qin D, Trenkwalder T, Lee S, Chillo O, Deindl E, Kupatt C, Hinkel R.

PLoS One. 2013 Apr 16;8(4):e61831. doi: 10.1371/journal.pone.0061831. Print 2013.

36.

Angiogenetic potential of Ad2/Hif-1α/VP16 after regional application in a preclinical pig model of chronic ischemia.

Hinkel R, Lebherz C, Fydanaki M, Wuchrer A, El-Aouni C, Thormann M, Thein E, Kupatt C, Boekstegers P.

Curr Vasc Pharmacol. 2013 Jan;11(1):29-37.

PMID:
23391420
37.

Molecular and cellular mechanisms of thymosin β4-mediated cardioprotection.

Hinkel R, Trenkwalder T, Kupatt C.

Ann N Y Acad Sci. 2012 Oct;1269:102-9. doi: 10.1111/j.1749-6632.2012.06693.x.

PMID:
23045977
38.

Adjuvant early and late cardioprotective therapy: access to the heart.

Hinkel R, Boekstegers P, Kupatt C.

Cardiovasc Res. 2012 May 1;94(2):226-36. doi: 10.1093/cvr/cvs075. Epub 2012 Feb 7. Review.

PMID:
22318936
39.

Perfusion MRI for monitoring the effect of sorafenib on experimental prostate carcinoma: a validation study.

Cyran CC, Paprottka PM, Schwarz B, Sourbron S, Ingrisch M, von Einem J, Pietsch H, Dietrich O, Hinkel R, Bruns CJ, Reiser MF, Wintersperger BJ, Nikolaou K.

AJR Am J Roentgenol. 2012 Feb;198(2):384-91. doi: 10.2214/AJR.11.6951.

PMID:
22268182
40.

Accuracy of dynamic computed tomography adenosine stress myocardial perfusion imaging in estimating myocardial blood flow at various degrees of coronary artery stenosis using a porcine animal model.

Bamberg F, Hinkel R, Schwarz F, Sandner TA, Baloch E, Marcus R, Becker A, Kupatt C, Wintersperger BJ, Johnson TR, Theisen D, Klotz E, Reiser MF, Nikolaou K.

Invest Radiol. 2012 Jan;47(1):71-7. doi: 10.1097/RLI.0b013e31823fd42b.

PMID:
22178894
41.

Mitochondrial thioredoxin reductase is essential for early postischemic myocardial protection.

Horstkotte J, Perisic T, Schneider M, Lange P, Schroeder M, Kiermayer C, Hinkel R, Ziegler T, Mandal PK, David R, Schulz S, Schmitt S, Widder J, Sinowatz F, Becker BF, Bauersachs J, Naebauer M, Franz WM, Jeremias I, Brielmeier M, Zischka H, Conrad M, Kupatt C.

Circulation. 2011 Dec 20;124(25):2892-902. doi: 10.1161/CIRCULATIONAHA.111.059253. Epub 2011 Dec 5.

PMID:
22144571
42.

Dynamic contrast-enhanced computed tomography imaging biomarkers correlated with immunohistochemistry for monitoring the effects of sorafenib on experimental prostate carcinomas.

Cyran CC, von Einem JC, Paprottka PM, Schwarz B, Ingrisch M, Dietrich O, Hinkel R, Bruns CJ, Clevert DA, Eschbach R, Reiser MF, Wintersperger BJ, Nikolaou K.

Invest Radiol. 2012 Jan;47(1):49-57. doi: 10.1097/RLI.0b013e3182300fe4.

PMID:
21934514
43.

Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model.

Pleger ST, Shan C, Ksienzyk J, Bekeredjian R, Boekstegers P, Hinkel R, Schinkel S, Leuchs B, Ludwig J, Qiu G, Weber C, Raake P, Koch WJ, Katus HA, Müller OJ, Most P.

Sci Transl Med. 2011 Jul 20;3(92):92ra64. doi: 10.1126/scitranslmed.3002097.

44.

Gene therapy for ischemic heart disease.

Hinkel R, Trenkwalder T, Kupatt C.

Expert Opin Biol Ther. 2011 Jun;11(6):723-37. doi: 10.1517/14712598.2011.570749. Epub 2011 Mar 25. Review.

PMID:
21434842
45.

Cotransfection of vascular endothelial growth factor-A and platelet-derived growth factor-B via recombinant adeno-associated virus resolves chronic ischemic malperfusion role of vessel maturation.

Kupatt C, Hinkel R, Pfosser A, El-Aouni C, Wuchrer A, Fritz A, Globisch F, Thormann M, Horstkotte J, Lebherz C, Thein E, Banfi A, Boekstegers P.

J Am Coll Cardiol. 2010 Jul 27;56(5):414-22. doi: 10.1016/j.jacc.2010.03.050.

46.

Thymosin beta4: a key factor for protective effects of eEPCs in acute and chronic ischemia.

Hinkel R, Bock-Marquette I, Hatzopoulos AK, Kupatt C.

Ann N Y Acad Sci. 2010 Apr;1194:105-11. doi: 10.1111/j.1749-6632.2010.05489.x. Erratum in: Ann N Y Acad Sci. 2010 Sep;1205(1):284. Hazopoulos, Antonis K [corrected to Hatzopoulos, Antonis K].

47.

Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli.

Oropeza M, Petersen B, Carnwath JW, Lucas-Hahn A, Lemme E, Hassel P, Herrmann D, Barg-Kues B, Holler S, Queisser AL, Schwinzer R, Hinkel R, Kupatt C, Niemann H.

Xenotransplantation. 2009 Nov-Dec;16(6):522-34. doi: 10.1111/j.1399-3089.2009.00556.x.

PMID:
20042052
48.

NF kappaB activation in embryonic endothelial progenitor cells enhances neovascularization via PSGL-1 mediated recruitment: novel role for LL37.

Pfosser A, El-Aouni C, Pfisterer I, Dietz M, Globisch F, Stachel G, Trenkwalder T, Pinkenburg O, Horstkotte J, Hinkel R, Sperandio M, Hatzopoulos AK, Boekstegers P, Bals R, Kupatt C.

Stem Cells. 2010 Feb;28(2):376-85. doi: 10.1002/stem.280.

49.

Optimization of delivery of adeno-associated virus mediated gene transfer to a transplanted heart in a rat model.

Xiaofeng J, Burdorf L, Hinkel R, Gheith C, Reichart B, Brandl U, Schmoeckel M.

Exp Clin Transplant. 2009 Sep;7(3):184-7.

50.

Recombinant adeno-associated virus-based gene transfer of cathelicidin induces therapeutic neovascularization preferentially via potent collateral growth.

Pinkenburg O, Pfosser A, Hinkel R, Böttcher M, Dinges C, Lebherz C, Sultana S, Enssle J, El-Aouni C, Büning H, Boekstegers P, Bals R, Kupatt C.

Hum Gene Ther. 2009 Feb;20(2):159-67. doi: 10.1089/hum.2007.178.

PMID:
20377367

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