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Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B6.

Yang J, Minkler P, Grove D, Wang R, Willard B, Dweik R, Hine C.

Commun Biol. 2019 May 21;2(1):194. doi: 10.1038/s42003-019-0431-5.


Intra-urban patterns of neighborhood-level social capital: a pilot study.

King J, Hine CA, Washburn T, Montgomery H, Chaney RA.

Health Promot Perspect. 2019 May 25;9(2):150-155. doi: 10.15171/hpp.2019.21. eCollection 2019.


Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B6.

Yang J, Minkler P, Grove D, Wang R, Willard B, Dweik R, Hine C.

Commun Biol. 2019 May 21;2:194. doi: 10.1038/s42003-019-0431-5. eCollection 2019.


Long-term Dietary Macronutrients and Hepatic Gene Expression in Aging Mice.

Gokarn R, Solon-Biet SM, Cogger VC, Cooney GJ, Wahl D, McMahon AC, Mitchell JR, Mitchell SJ, Hine C, de Cabo R, Raubenheimer D, Simpson SJ, Le Couteur DG.

J Gerontol A Biol Sci Med Sci. 2018 Nov 10;73(12):1618-1625. doi: 10.1093/gerona/gly065.


Dietary and Endocrine Regulation of Endogenous Hydrogen Sulfide Production: Implications for Longevity.

Hine C, Zhu Y, Hollenberg AN, Mitchell JR.

Antioxid Redox Signal. 2018 Jun 1;28(16):1483-1502. doi: 10.1089/ars.2017.7434.


Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production.

Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Treviño-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, Reynolds J, Mejia P, Tao M, Sharma G, Wang R, Corpataux JM, Haefliger JA, Ahn KH, Lee CH, Manning BD, Sinclair DA, Chen CS, Ozaki CK, Mitchell JR.

Cell. 2018 Mar 22;173(1):117-129.e14. doi: 10.1016/j.cell.2018.03.001.


Health benefits of late-onset metformin treatment every other week in mice.

Alfaras I, Mitchell SJ, Mora H, Lugo DR, Warren A, Navas-Enamorado I, Hoffmann V, Hine C, Mitchell JR, Le Couteur DG, Cogger VC, Bernier M, de Cabo R.

NPJ Aging Mech Dis. 2017 Nov 20;3:16. doi: 10.1038/s41514-017-0018-7. eCollection 2017.


Endpoint or Kinetic Measurement of Hydrogen Sulfide Production Capacity in Tissue Extracts.

Hine C, Mitchell JR.

Bio Protoc. 2017 Jul 5;7(13). pii: e2382. doi: 10.21769/BioProtoc.2382.


Conjugation does not conquer all in cancer nanotherapy.

Hine C.

Sci Transl Med. 2017 Jul 12;9(398). pii: eaan8204. doi: 10.1126/scitranslmed.aan8204.


Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.

Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR.

Cell Metab. 2017 Jun 6;25(6):1320-1333.e5. doi: 10.1016/j.cmet.2017.05.003.


Rapamycin keeps the reproductive clock ticking.

Hine C.

Sci Transl Med. 2017 May 31;9(392). pii: eaan4296. doi: 10.1126/scitranslmed.aan4296.


A paternal diet for offspring success?

Hine C.

Sci Transl Med. 2017 Apr 19;9(386). pii: eaan2780. doi: 10.1126/scitranslmed.aan2780.


The importance of staying small.

Hine C.

Sci Transl Med. 2017 Mar 8;9(380). pii: eaam9860. doi: 10.1126/scitranslmed.aam9860.


Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice.

Nikonorova IA, Al-Baghdadi RJT, Mirek ET, Wang Y, Goudie MP, Wetstein BB, Dixon JL, Hine C, Mitchell JR, Adams CM, Wek RC, Anthony TG.

J Biol Chem. 2017 Apr 21;292(16):6786-6798. doi: 10.1074/jbc.M116.768408. Epub 2017 Feb 27.


Surgical injury induces local and distant adipose tissue browning.

Longchamp A, Tao M, Bartelt A, Ding K, Lynch L, Hine C, Corpataux JM, Kristal BS, Mitchell JR, Ozaki CK.

Adipocyte. 2015 Nov 20;5(2):163-74. doi: 10.1080/21623945.2015.1111971. eCollection 2016 Apr-Jun.


Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R.

Cell Metab. 2016 Jun 14;23(6):1093-1112. doi: 10.1016/j.cmet.2016.05.027.


Retrospective cohort study of an enhanced recovery programme in oesophageal and gastric cancer surgery.

Gatenby PA, Shaw C, Hine C, Scholtes S, Koutra M, Andrew H, Hacking M, Allum WH.

Ann R Coll Surg Engl. 2015 Oct;97(7):502-7. doi: 10.1308/003588415X14181254789880.


Protein and Calorie Restriction Contribute Additively to Protection from Renal Ischemia Reperfusion Injury Partly via Leptin Reduction in Male Mice.

Robertson LT, Treviño-Villarreal JH, Mejia P, Grondin Y, Harputlugil E, Hine C, Vargas D, Zheng H, Ozaki CK, Kristal BS, Simpson SJ, Mitchell JR.

J Nutr. 2015 Aug;145(8):1717-27. doi: 10.3945/jn.114.199380. Epub 2015 Jun 3.


Using clinical practice variations as a method for commissioners and clinicians to identify and prioritise opportunities for disinvestment in health care: a cross-sectional study, systematic reviews and qualitative study.

Hollingworth W, Rooshenas L, Busby J, Hine CE, Badrinath P, Whiting PF, Moore THM, Owen-Smith A, Sterne JAC, Jones HE, Beynon C, Donovan JL.

Southampton (UK): NIHR Journals Library; 2015 Apr.


Dietary restriction protects against experimental cerebral malaria via leptin modulation and T-cell mTORC1 suppression.

Mejia P, Treviño-Villarreal JH, Hine C, Harputlugil E, Lang S, Calay E, Rogers R, Wirth D, Duraisingh MT, Mitchell JR.

Nat Commun. 2015 Jan 30;6:6050. doi: 10.1038/ncomms7050.


Endogenous hydrogen sulfide production is essential for dietary restriction benefits.

Hine C, Harputlugil E, Zhang Y, Ruckenstuhl C, Lee BC, Brace L, Longchamp A, Treviño-Villarreal JH, Mejia P, Ozaki CK, Wang R, Gladyshev VN, Madeo F, Mair WB, Mitchell JR.

Cell. 2015 Jan 15;160(1-2):132-44. doi: 10.1016/j.cell.2014.11.048. Epub 2014 Dec 23.


Calorie restriction and methionine restriction in control of endogenous hydrogen sulfide production by the transsulfuration pathway.

Hine C, Mitchell JR.

Exp Gerontol. 2015 Aug;68:26-32. doi: 10.1016/j.exger.2014.12.010. Epub 2014 Dec 16. Review.


Improving the quality of documentation of paediatric post-take ward rounds: the impact of an acrostic.

Newnham AL, Hine C, Rogers C, Agwu JC.

Postgrad Med J. 2015 Jan;91(1071):22-5. doi: 10.1136/postgradmedj-2013-132534. Epub 2014 Dec 4.


Progesterone Reduces Cocaine Use in Postpartum Women with a Cocaine Use Disorder: A Randomized,Double-Blind Study.

Yonkers KA, Forray A, Nich C, Carroll KM, Hine C, Merry BC, Shaw H, Shaw J, Sofuoglu M.

Lancet Psychiatry. 2014 Oct 1;1(5):360-367.


The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo.

Harputlugil E, Hine C, Vargas D, Robertson L, Manning BD, Mitchell JR.

Cell Rep. 2014 Aug 21;8(4):1160-70. doi: 10.1016/j.celrep.2014.07.018. Epub 2014 Aug 14.


Keplerate cluster (Mo-132) mediated electrostatic assembly of nanoparticles.

Gooch J, Jalan AA, Jones S, Hine CR, Alam R, Garai S, Maye MM, Müller A, Zubieta J.

J Colloid Interface Sci. 2014 Oct 15;432:144-50. doi: 10.1016/j.jcis.2014.06.059. Epub 2014 Jul 9.


Student-led oral health education for the homeless community of East London.

Pritchett RM, Hine CE, Franks MA, Fisher-Brown L.

Br Dent J. 2014 Jul;217(2):85-8. doi: 10.1038/sj.bdj.2014.595.


Saying no to drugs: fasting protects hematopoietic stem cells from chemotherapy and aging.

Hine C, Mitchell JR.

Cell Stem Cell. 2014 Jun 5;14(6):704-5. doi: 10.1016/j.stem.2014.05.016.


Regulation of Rad51 promoter.

Hine CM, Li H, Xie L, Mao Z, Seluanov A, Gorbunova V.

Cell Cycle. 2014;13(13):2038-45. doi: 10.4161/cc.29016. Epub 2014 Apr 29.


High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat.

Tian X, Azpurua J, Hine C, Vaidya A, Myakishev-Rempel M, Ablaeva J, Mao Z, Nevo E, Gorbunova V, Seluanov A.

Nature. 2013 Jul 18;499(7458):346-9. doi: 10.1038/nature12234. Epub 2013 Jun 19.


A NICE example? Variation in provision of bariatric surgery in England.

Owen-Smith A, Kipping R, Donovan J, Hine C, Maslen C, Coast J.

BMJ. 2013 May 1;346:f2453. doi: 10.1136/bmj.f2453. No abstract available.


NRF2 and the Phase II Response in Acute Stress Resistance Induced by Dietary Restriction.

Hine CM, Mitchell JR.

J Clin Exp Pathol. 2012 Jun 19;S4(4). pii: 7329.


Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism.

Gorbunova V, Hine C, Tian X, Ablaeva J, Gudkov AV, Nevo E, Seluanov A.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19392-6. doi: 10.1073/pnas.1217211109. Epub 2012 Nov 5.


Foraging ecology of fall-migrating shorebirds in the Illinois River valley.

Smith RV, Stafford JD, Yetter AP, Horath MM, Hine CS, Hoover JP.

PLoS One. 2012;7(9):e45121. doi: 10.1371/journal.pone.0045121. Epub 2012 Sep 18.


Shell thickness dependent photoinduced hole transfer in hybrid conjugated polymer/quantum dot nanocomposites: from ensemble to single hybrid level.

Xu Z, Hine CR, Maye MM, Meng Q, Cotlet M.

ACS Nano. 2012 Jun 26;6(6):4984-92. doi: 10.1021/nn300525b. Epub 2012 Jun 11.


Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells.

Fong V, Osterbur M, Capella C, Kim YE, Hine C, Gorbunova V, Seluanov A, Dewhurst S.

PLoS One. 2011;6(12):e28714. doi: 10.1371/journal.pone.0028714. Epub 2011 Dec 9.


Rad51 promoter-targeted gene therapy is effective for in vivo visualization and treatment of cancer.

Hine CM, Seluanov A, Gorbunova V.

Mol Ther. 2012 Feb;20(2):347-55. doi: 10.1038/mt.2011.215. Epub 2011 Oct 18.


SIRT6 promotes DNA repair under stress by activating PARP1.

Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, Seluanov A, Gorbunova V.

Science. 2011 Jun 17;332(6036):1443-6. doi: 10.1126/science.1202723.


A modular phase transfer and ligand exchange protocol for quantum dots.

Zylstra J, Amey J, Miska NJ, Pang L, Hine CR, Langer J, Doyle RP, Maye MM.

Langmuir. 2011 Apr 19;27(8):4371-9. doi: 10.1021/la104542n. Epub 2011 Mar 16.


Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat.

Seluanov A, Hine C, Azpurua J, Feigenson M, Bozzella M, Mao Z, Catania KC, Gorbunova V.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19352-7. doi: 10.1073/pnas.0905252106. Epub 2009 Oct 26.


Use of the Rad51 promoter for targeted anti-cancer therapy.

Hine CM, Seluanov A, Gorbunova V.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20810-5. doi: 10.1073/pnas.0807990106. Epub 2008 Dec 23.


Integration of medical and psychological treatment within the primary health care setting.

Hine CE, Howell HB, Yonkers KA.

Soc Work Health Care. 2008;47(2):122-34. doi: 10.1080/00981380801970244. Review.


Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan.

Seluanov A, Hine C, Bozzella M, Hall A, Sasahara TH, Ribeiro AA, Catania KC, Presgraves DC, Gorbunova V.

Aging Cell. 2008 Dec;7(6):813-23. doi: 10.1111/j.1474-9726.2008.00431.x. Epub 2008 Sep 5.


Hine sight: a glimpse into the life of Maynard K. Hine.

Hine CF.

J Indiana Dent Assoc. 2008 Spring;87(1):51-3. No abstract available.


Changes in DNA repair during aging.

Gorbunova V, Seluanov A, Mao Z, Hine C.

Nucleic Acids Res. 2007;35(22):7466-74. Epub 2007 Oct 2. Review.


Telomerase activity coevolves with body mass not lifespan.

Seluanov A, Chen Z, Hine C, Sasahara TH, Ribeiro AA, Catania KC, Presgraves DC, Gorbunova V.

Aging Cell. 2007 Feb;6(1):45-52. Epub 2006 Dec 14.


Cochlear implants: informing commissioning decisions, based on need.

Taylor F, Hine C.

J Laryngol Otol. 2006 Dec;120(12):1008-13. Epub 2006 Oct 24.


Hypocoagulable state of human preovulatory ovarian follicular fluid: role of sulfated proteoglycan and tissue factor pathway inhibitor in the fluid.

Shimada H, Kasakura S, Shiotani M, Nakamura K, Ikeuchi M, Hoshino T, Komatsu T, Ihara Y, Sohma M, Maeda Y, Matsuura R, Nakamura S, Hine C, Ohkura N, Kato H.

Biol Reprod. 2001 Jun;64(6):1739-45.


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