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Items: 1 to 50 of 68

1.

Physicochemical Characterization, Glycosylation Pattern and Biosimilarity Assessment of the Fusion Protein Etanercept.

Montacir O, Montacir H, Springer A, Hinderlich S, Mahboudi F, Saadati A, Parr MK.

Protein J. 2018 Apr;37(2):164-179. doi: 10.1007/s10930-018-9757-y.

PMID:
29411222
2.

Bioengineering of rFVIIa Biopharmaceutical and Structure Characterization for Biosimilarity Assessment.

Montacir O, Montacir H, Eravci M, Springer A, Hinderlich S, Mahboudi F, Saadati A, Parr MK.

Bioengineering (Basel). 2018 Jan 19;5(1). pii: E7. doi: 10.3390/bioengineering5010007.

3.

In Vitro Evaluation of Glycoengineered RSV-F in the Human Artificial Lymph Node Reactor.

Radke L, Sandig G, Lubitz A, Schließer U, von Horsten HH, Blanchard V, Keil K, Sandig V, Giese C, Hummel M, Hinderlich S, Frohme M.

Bioengineering (Basel). 2017 Aug 15;4(3). pii: E70. doi: 10.3390/bioengineering4030070.

4.

Engineering of CHO Cells for the Production of Recombinant Glycoprotein Vaccines with Xylosylated N-glycans.

Sandig G, von Horsten HH, Radke L, Blanchard V, Frohme M, Giese C, Sandig V, Hinderlich S.

Bioengineering (Basel). 2017 Apr 28;4(2). pii: E38. doi: 10.3390/bioengineering4020038.

5.

Werner Reutter: A Visionary Pioneer in Molecular Glycobiology.

Hinderlich S, Tauber R, Bertozzi CR, Hackenberger CPR.

Chembiochem. 2017 Jul 4;18(13):1141-1145. doi: 10.1002/cbic.201700277. Epub 2017 Jun 16.

PMID:
28621497
6.

Comparability study of Rituximab originator and follow-on biopharmaceutical.

Montacir O, Montacir H, Eravci M, Springer A, Hinderlich S, Saadati A, Parr MK.

J Pharm Biomed Anal. 2017 Jun 5;140:239-251. doi: 10.1016/j.jpba.2017.03.029. Epub 2017 Mar 19.

PMID:
28371718
7.

Small Molecules Targeting Human N-Acetylmannosamine Kinase.

Hinderlich S, Neuenschwander M, Wratil PR, Oder A, Lisurek M, Nguyen LD, von Kries JP, Hackenberger CPR.

Chembiochem. 2017 Jul 4;18(13):1279-1285. doi: 10.1002/cbic.201700066. Epub 2017 Apr 27.

PMID:
28346741
8.

Inhibition of the key enzyme of sialic acid biosynthesis by C6-Se modified N-acetylmannosamine analogs.

Nieto-Garcia O, Wratil PR, Nguyen LD, Böhrsch V, Hinderlich S, Reutter W, Hackenberger CPR.

Chem Sci. 2016 Jun 1;7(6):3928-3933. doi: 10.1039/c5sc04082e. Epub 2016 Feb 19.

9.

The Interaction of UDP-N-Acetylglucosamine 2-Epimerase/N-Acetylmannosamine Kinase (GNE) and Alpha-Actinin 2 Is Altered in GNE Myopathy M743T Mutant.

Harazi A, Becker-Cohen M, Zer H, Moshel O, Hinderlich S, Mitrani-Rosenbaum S.

Mol Neurobiol. 2017 May;54(4):2928-2938. doi: 10.1007/s12035-016-9862-x. Epub 2016 Mar 29.

PMID:
27023225
10.

Applying Acylated Fucose Analogues to Metabolic Glycoengineering.

Rosenlöcher J, Böhrsch V, Sacharjat M, Blanchard V, Giese C, Sandig V, Hackenberger CPR, Hinderlich S.

Bioengineering (Basel). 2015 Nov 30;2(4):213-234. doi: 10.3390/bioengineering2040213.

11.

Recombinant glycoproteins: The impact of cell lines and culture conditions on the generation of protein species.

Rosenlöcher J, Sandig G, Kannicht C, Blanchard V, Reinke SO, Hinderlich S.

J Proteomics. 2016 Feb 16;134:85-92. doi: 10.1016/j.jprot.2015.08.011. Epub 2015 Aug 24.

PMID:
26316330
12.

The human rhabdomyosarcoma cell line TE671--Towards an innovative production platform for glycosylated biopharmaceuticals.

Rosenlöcher J, Weilandt C, Sandig G, Reinke SO, Blanchard V, Hinderlich S.

Protein Expr Purif. 2015 Nov;115:83-94. doi: 10.1016/j.pep.2015.08.008. Epub 2015 Aug 10.

PMID:
26272370
13.

UDP-GlcNAc 2-Epimerase/ManNAc Kinase (GNE): A Master Regulator of Sialic Acid Synthesis.

Hinderlich S, Weidemann W, Yardeni T, Horstkorte R, Huizing M.

Top Curr Chem. 2015;366:97-137. doi: 10.1007/128_2013_464. Review.

14.

The analysis of N-glycans of cell membrane proteins from human hematopoietic cell lines reveals distinctions in their pattern.

Reinke SO, Bayer M, Berger M, Hinderlich S, Blanchard V.

Biol Chem. 2012 Aug;393(8):731-47. doi: 10.1515/hsz-2012-0195.

PMID:
22944676
15.

Glycan-specific metabolic oligosaccharide engineering of C7-substituted sialic acids.

Möller H, Böhrsch V, Bentrop J, Bender J, Hinderlich S, Hackenberger CP.

Angew Chem Int Ed Engl. 2012 Jun 11;51(24):5986-90. doi: 10.1002/anie.201108809. No abstract available.

PMID:
22674889
16.

Crystal structures of N-acetylmannosamine kinase provide insights into enzyme activity and inhibition.

Martinez J, Nguyen LD, Hinderlich S, Zimmer R, Tauberger E, Reutter W, Saenger W, Fan H, Moniot S.

J Biol Chem. 2012 Apr 20;287(17):13656-65. doi: 10.1074/jbc.M111.318170. Epub 2012 Feb 16.

17.

Loss of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) induces apoptotic processes in pancreatic carcinoma cells.

Kemmner W, Kessel P, Sanchez-Ruderisch H, Möller H, Hinderlich S, Schlag PM, Detjen K.

FASEB J. 2012 Feb;26(2):938-46. doi: 10.1096/fj.11-186700. Epub 2011 Nov 2.

PMID:
22049060
18.

Efficient metabolic oligosaccharide engineering of glycoproteins by UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) knock-down.

Möller H, Böhrsch V, Lucka L, Hackenberger CP, Hinderlich S.

Mol Biosyst. 2011 Jul;7(7):2245-51. doi: 10.1039/c1mb05059a. Epub 2011 May 16.

PMID:
21584309
19.

Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy.

Cirak S, von Deimling F, Sachdev S, Errington WJ, Herrmann R, Bönnemann C, Brockmann K, Hinderlich S, Lindner TH, Steinbrecher A, Hoffmann K, Privé GG, Hannink M, Nürnberg P, Voit T.

Brain. 2010 Jul;133(Pt 7):2123-35. doi: 10.1093/brain/awq108. Epub 2010 Jun 16.

20.

Regulation and pathophysiological implications of UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) as the key enzyme of sialic acid biosynthesis.

Reinke SO, Lehmer G, Hinderlich S, Reutter W.

Biol Chem. 2009 Jul;390(7):591-9. doi: 10.1515/BC.2009.073. Review.

PMID:
19426133
21.

Characterization of ligand binding to N-acetylglucosamine kinase studied by STD NMR.

Blume A, Berger M, Benie AJ, Peters T, Hinderlich S.

Biochemistry. 2008 Dec 9;47(49):13138-46. doi: 10.1021/bi8016894.

PMID:
19006331
22.

Biochemical characterization of human and murine isoforms of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE).

Reinke SO, Eidenschink C, Jay CM, Hinderlich S.

Glycoconj J. 2009 May;26(4):415-22. doi: 10.1007/s10719-008-9189-6. Epub 2008 Sep 23.

PMID:
18815882
23.

UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) binds to alpha-actinin 1: novel pathways in skeletal muscle?

Amsili S, Zer H, Hinderlich S, Krause S, Becker-Cohen M, MacArthur DG, North KN, Mitrani-Rosenbaum S.

PLoS One. 2008 Jun 18;3(6):e2477. doi: 10.1371/journal.pone.0002477.

24.

Preclinical assessment of wt GNE gene plasmid for management of hereditary inclusion body myopathy 2 (HIBM2).

Jay C, Nemunaitis G, Nemunaitis J, Senzer N, Hinderlich S, Darvish D, Ogden J, Eager J, Tong A, Maples PB.

Gene Regul Syst Bio. 2008 Jun 20;2:243-52.

25.

Chemoselective labeling of engineered fucosylated glycoproteins.

Hackenberger CP, Hinderlich S.

Chembiochem. 2007 Oct 15;8(15):1763-5. No abstract available.

PMID:
17768729
26.

GNE protein expression and subcellular distribution are unaltered in HIBM.

Krause S, Aleo A, Hinderlich S, Merlini L, Tournev I, Walter MC, Argov Z, Mitrani-Rosenbaum S, Lochmüller H.

Neurology. 2007 Aug 14;69(7):655-9.

PMID:
17698786
27.

Prediction of three different isoforms of the human UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase.

Reinke SO, Hinderlich S.

FEBS Lett. 2007 Jul 10;581(17):3327-31. Epub 2007 Jun 21.

28.

Evidence for dynamic interplay of different oligomeric states of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase by biophysical methods.

Ghaderi D, Strauss HM, Reinke S, Cirak S, Reutter W, Lucka L, Hinderlich S.

J Mol Biol. 2007 Jun 8;369(3):746-58. Epub 2007 Mar 21.

PMID:
17448495
29.
30.

Structures of human N-Acetylglucosamine kinase in two complexes with N-Acetylglucosamine and with ADP/glucose: insights into substrate specificity and regulation.

Weihofen WA, Berger M, Chen H, Saenger W, Hinderlich S.

J Mol Biol. 2006 Dec 1;364(3):388-99. Epub 2006 Sep 3.

PMID:
17010375
31.

Does potentized HgCl2 (Mercurius corrosivus) affect the activity of diastase and alpha-amylase?

Witt CM, Bluth M, Hinderlich S, Albrecht H, Lüdtke R, Weisshuhn TE, Willich SN.

J Altern Complement Med. 2006 May;12(4):359-65.

PMID:
16722785
33.

Influence of UDP-GlcNAc 2-epimerase/ManNAc kinase mutant proteins on hereditary inclusion body myopathy.

Penner J, Mantey LR, Elgavish S, Ghaderi D, Cirak S, Berger M, Krause S, Lucka L, Voit T, Mitrani-Rosenbaum S, Hinderlich S.

Biochemistry. 2006 Mar 7;45(9):2968-77.

PMID:
16503651
34.

Engineering intracellular CMP-sialic acid metabolism into insect cells and methods to enhance its generation.

Viswanathan K, Narang S, Hinderlich S, Lee YC, Betenbaugh MJ.

Biochemistry. 2005 May 24;44(20):7526-34.

PMID:
15895995
35.

Localization of UDP-GlcNAc 2-epimerase/ManAc kinase (GNE) in the Golgi complex and the nucleus of mammalian cells.

Krause S, Hinderlich S, Amsili S, Horstkorte R, Wiendl H, Argov Z, Mitrani-Rosenbaum S, Lochmüller H.

Exp Cell Res. 2005 Apr 1;304(2):365-79. Epub 2004 Dec 19.

PMID:
15748884
36.

No overall hyposialylation in hereditary inclusion body myopathy myoblasts carrying the homozygous M712T GNE mutation.

Salama I, Hinderlich S, Shlomai Z, Eisenberg I, Krause S, Yarema K, Argov Z, Lochmuller H, Reutter W, Dabby R, Sadeh M, Ben-Bassat H, Mitrani-Rosenbaum S.

Biochem Biophys Res Commun. 2005 Mar 4;328(1):221-6.

PMID:
15670773
37.

Characterization of ligand binding to the bifunctional key enzyme in the sialic acid biosynthesis by NMR: I. Investigation of the UDP-GlcNAc 2-epimerase functionality.

Blume A, Benie AJ, Stolz F, Schmidt RR, Reutter W, Hinderlich S, Peters T.

J Biol Chem. 2004 Dec 31;279(53):55715-21. Epub 2004 Oct 21.

38.

Characterization of ligand binding to the bifunctional key enzyme in the sialic acid biosynthesis by NMR: II. Investigation of the ManNAc kinase functionality.

Benie AJ, Blume A, Schmidt RR, Reutter W, Hinderlich S, Peters T.

J Biol Chem. 2004 Dec 31;279(53):55722-7. Epub 2004 Oct 21.

39.

Synthesis and biochemical properties of reversible inhibitors of UDP-N-acetylglucosamine 2-epimerase.

Al-Rawi S, Hinderlich S, Reutter W, Giannis A.

Angew Chem Int Ed Engl. 2004 Aug 20;43(33):4366-70. No abstract available.

PMID:
15368395
40.

Domain-specific characteristics of the bifunctional key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase.

Blume A, Weidemann W, Stelzl U, Wanker EE, Lucka L, Donner P, Reutter W, Horstkorte R, Hinderlich S.

Biochem J. 2004 Dec 15;384(Pt 3):599-607.

41.

The homozygous M712T mutation of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase results in reduced enzyme activities but not in altered overall cellular sialylation in hereditary inclusion body myopathy.

Hinderlich S, Salama I, Eisenberg I, Potikha T, Mantey LR, Yarema KJ, Horstkorte R, Argov Z, Sadeh M, Reutter W, Mitrani-Rosenbaum S.

FEBS Lett. 2004 May 21;566(1-3):105-9.

42.

UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, functionally expressed in and purified from Escherichia coli, yeast, and insect cells.

Blume A, Ghaderi D, Liebich V, Hinderlich S, Donner P, Reutter W, Lucka L.

Protein Expr Purif. 2004 Jun;35(2):387-96.

PMID:
15135418
43.

Engineering sialic acid synthetic ability into insect cells: identifying metabolic bottlenecks and devising strategies to overcome them.

Viswanathan K, Lawrence S, Hinderlich S, Yarema KJ, Lee YC, Betenbaugh MJ.

Biochemistry. 2003 Dec 30;42(51):15215-25.

PMID:
14690432
44.

Epigenetically mediated loss of UDP-GlcNAc 2-epimerase/ManNAc kinase expression in hyposialylated cell lines.

Oetke C, Hinderlich S, Reutter W, Pawlita M.

Biochem Biophys Res Commun. 2003 Sep 5;308(4):892-8.

PMID:
12927803
45.

Distal myopathy with rimmed vacuoles is allelic to hereditary inclusion body myopathy.

Hinderlich S, Salama I, Eisenberg I, Mitrani-Rosenbaum S.

Neurology. 2003 Jul 8;61(1):145; author reply 145. No abstract available.

PMID:
12847185
46.

Identification of rhythmic subsystems in the circadian cycle of crassulacean acid metabolism under thermoperiodic perturbations.

Bohn A, Hinderlich S, Hütt MT, Kaiser F, Lüttge U.

Biol Chem. 2003 May;384(5):721-8.

PMID:
12817468
47.

Identification and characterization of adsorbed serum sialoglycans on Leishmania donovani promastigotes.

Chatterjee M, Chava AK, Kohla G, Pal S, Merling A, Hinderlich S, Unger U, Strasser P, Gerwig GJ, Kamerling JP, Vlasak R, Crocker PR, Schauer R, Schwartz-Albiez R, Mandal C.

Glycobiology. 2003 May;13(5):351-61. Epub 2002 Dec 17.

PMID:
12626423
48.

Sialic acid biosynthesis: stereochemistry and mechanism of the reaction catalyzed by the mammalian UDP-N-acetylglucosamine 2-epimerase.

Chou WK, Hinderlich S, Reutter W, Tanner ME.

J Am Chem Soc. 2003 Mar 5;125(9):2455-61.

PMID:
12603133
49.

Structure and function of N-acetylglucosamine kinase. Identification of two active site cysteines.

Berger M, Chen H, Reutter W, Hinderlich S.

Eur J Biochem. 2002 Sep;269(17):4212-8.

50.

2',3'-Dialdehydo-UDP-N-acetylglucosamine inhibits UDP-N-acetylglucosamine 2-epimerase, the key enzyme of sialic acid biosynthesis.

Blume A, Chen H, Reutter W, Schmidt RR, Hinderlich S.

FEBS Lett. 2002 Jun 19;521(1-3):127-32.

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