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Items: 1 to 50 of 56

1.

Profiling interactions of vaborbactam with metallo-β-lactamases.

Langley GW, Cain R, Tyrrell JM, Hinchliffe P, Calvopiña K, Tooke CL, Widlake E, Dowson CG, Spencer J, Walsh TR, Schofield CJ, Brem J.

Bioorg Med Chem Lett. 2019 Aug 1;29(15):1981-1984. doi: 10.1016/j.bmcl.2019.05.031. Epub 2019 May 17.

2.

β-Lactamases and β-Lactamase Inhibitors in the 21st Century.

Tooke CL, Hinchliffe P, Bragginton EC, Colenso CK, Hirvonen VHA, Takebayashi Y, Spencer J.

J Mol Biol. 2019 Apr 5. pii: S0022-2836(19)30182-2. doi: 10.1016/j.jmb.2019.04.002. [Epub ahead of print] Review.

3.

Neither male age nor semen parameters influence clinical pregnancy or live birth outcomes from IVF.

Mariappen U, Keane KN, Hinchliffe PM, Dhaliwal SS, Yovich JL.

Reprod Biol. 2018 Dec;18(4):324-329. doi: 10.1016/j.repbio.2018.11.003. Epub 2018 Nov 30.

PMID:
30503182
4.

Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-β-lactamases.

Salimraj R, Hinchliffe P, Kosmopoulou M, Tyrrell JM, Brem J, van Berkel SS, Verma A, Owens RJ, McDonough MA, Walsh TR, Schofield CJ, Spencer J.

FEBS J. 2019 Jan;286(1):169-183. doi: 10.1111/febs.14695. Epub 2018 Nov 23.

5.

An ICSI rate of 90% minimizes complete failed fertilization and provides satisfactory implantation rates without elevating fetal abnormalities.

Yovich JL, Conceicao JL, Marjanovich N, Ye Y, Hinchliffe PM, Dhaliwal SS, Keane KN.

Reprod Biol. 2018 Sep;18(3):301-311. doi: 10.1016/j.repbio.2018.05.002. Epub 2018 May 23.

PMID:
29801776
6.

Structural and Kinetic Studies of the Potent Inhibition of Metallo-β-lactamases by 6-Phosphonomethylpyridine-2-carboxylates.

Hinchliffe P, Tanner CA, Krismanich AP, Labbé G, Goodfellow VJ, Marrone L, Desoky AY, Calvopiña K, Whittle EE, Zeng F, Avison MB, Bols NC, Siemann S, Spencer J, Dmitrienko GI.

Biochemistry. 2018 Mar 27;57(12):1880-1892. doi: 10.1021/acs.biochem.7b01299. Epub 2018 Mar 9.

7.

DHEA Supplementation Confers No Additional Benefit to that of Growth Hormone on Pregnancy and Live Birth Rates in IVF Patients Categorized as Poor Prognosis.

Keane KN, Hinchliffe PM, Rowlands PK, Borude G, Srinivasan S, Dhaliwal SS, Yovich JL.

Front Endocrinol (Lausanne). 2018 Jan 31;9:14. doi: 10.3389/fendo.2018.00014. eCollection 2018.

8.

Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis.

Abboud MI, Kosmopoulou M, Krismanich AP, Johnson JW, Hinchliffe P, Brem J, Claridge TDW, Spencer J, Schofield CJ, Dmitrienko GI.

Chemistry. 2018 Apr 17;24(22):5734-5737. doi: 10.1002/chem.201705886. Epub 2018 Jan 17.

9.

Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms.

Yang Q, Li M, Spiller OB, Andrey DO, Hinchliffe P, Li H, MacLean C, Niumsup P, Powell L, Pritchard M, Papkou A, Shen Y, Portal E, Sands K, Spencer J, Tansawai U, Thomas D, Wang S, Wang Y, Shen J, Walsh T.

Nat Commun. 2017 Dec 12;8(1):2054. doi: 10.1038/s41467-017-02149-0.

10.

Finding a place for corifollitropin within the PIVET FSH dosing algorithms.

Yovich JL, Keane KN, Borude G, Dhaliwal SS, Hinchliffe PM.

Reprod Biomed Online. 2018 Jan;36(1):47-58. doi: 10.1016/j.rbmo.2017.09.017. Epub 2017 Oct 31.

PMID:
29129407
11.

Single-centre retrospective analysis of growth hormone supplementation in IVF patients classified as poor-prognosis.

Keane KN, Yovich JL, Hamidi A, Hinchliffe PM, Dhaliwal SS.

BMJ Open. 2017 Oct 8;7(10):e018107. doi: 10.1136/bmjopen-2017-018107.

12.

Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates.

Calvopiña K, Hinchliffe P, Brem J, Heesom KJ, Johnson S, Cain R, Lohans CT, Fishwick CWG, Schofield CJ, Spencer J, Avison MB.

Mol Microbiol. 2017 Nov;106(3):492-504. doi: 10.1111/mmi.13831. Epub 2017 Sep 21.

13.

1.12 Å resolution crystal structure of the catalytic domain of the plasmid-mediated colistin resistance determinant MCR-2.

Coates K, Walsh TR, Spencer J, Hinchliffe P.

Acta Crystallogr F Struct Biol Commun. 2017 Aug 1;73(Pt 8):443-449. doi: 10.1107/S2053230X17009669. Epub 2017 Jul 26.

14.

19 F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo-β-Lactamase.

Abboud MI, Hinchliffe P, Brem J, Macsics R, Pfeffer I, Makena A, Umland KD, Rydzik AM, Li GB, Spencer J, Claridge TD, Schofield CJ.

Angew Chem Int Ed Engl. 2017 Mar 27;56(14):3862-3866. doi: 10.1002/anie.201612185. Epub 2017 Mar 2.

15.

Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1.

Hinchliffe P, Yang QE, Portal E, Young T, Li H, Tooke CL, Carvalho MJ, Paterson NG, Brem J, Niumsup PR, Tansawai U, Lei L, Li M, Shen Z, Wang Y, Schofield CJ, Mulholland AJ, Shen J, Fey N, Walsh TR, Spencer J.

Sci Rep. 2017 Jan 6;7:39392. doi: 10.1038/srep39392.

16.

Live birth rates are satisfactory following multiple IVF treatment cycles in poor prognosis patients.

Mustafa KB, Keane KN, Walz NL, Mitrovic KI, Hinchliffe PM, Yovich JL.

Reprod Biol. 2017 Mar;17(1):34-41. doi: 10.1016/j.repbio.2016.11.004. Epub 2016 Dec 7.

PMID:
27964842
17.

Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase.

González MM, Kosmopoulou M, Mojica MF, Castillo V, Hinchliffe P, Pettinati I, Brem J, Schofield CJ, Mahler G, Bonomo RA, Llarrull LI, Spencer J, Vila AJ.

ACS Infect Dis. 2015 Nov 13;1(11):544-54. doi: 10.1021/acsinfecdis.5b00046. Epub 2015 Jul 20.

18.

PIVET rFSH dosing algorithms for individualized controlled ovarian stimulation enables optimized pregnancy productivity rates and avoidance of ovarian hyperstimulation syndrome.

Yovich JL, Alsbjerg B, Conceicao JL, Hinchliffe PM, Keane KN.

Drug Des Devel Ther. 2016 Aug 10;10:2561-73. doi: 10.2147/DDDT.S104104. eCollection 2016.

19.

Structural and Biochemical Characterization of Rm3, a Subclass B3 Metallo-β-Lactamase Identified from a Functional Metagenomic Study.

Salimraj R, Zhang L, Hinchliffe P, Wellington EM, Brem J, Schofield CJ, Gaze WH, Spencer J.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5828-40. doi: 10.1128/AAC.00750-16. Print 2016 Oct.

20.

Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes.

Hinchliffe P, González MM, Mojica MF, González JM, Castillo V, Saiz C, Kosmopoulou M, Tooke CL, Llarrull LI, Mahler G, Bonomo RA, Vila AJ, Spencer J.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3745-54. doi: 10.1073/pnas.1601368113. Epub 2016 Jun 14.

21.

Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers.

Keane KN, Mustafa KB, Hinchliffe P, Conceicao J, Yovich JL.

Reprod Biomed Online. 2016 Aug;33(2):149-60. doi: 10.1016/j.rbmo.2016.04.014. Epub 2016 May 10.

PMID:
27209497
22.

Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates.

Calvopiña K, Umland KD, Rydzik AM, Hinchliffe P, Brem J, Spencer J, Schofield CJ, Avison MB.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):4170-5. doi: 10.1128/AAC.00371-16. Print 2016 Jul.

23.

Novel dehydroepiandrosterone troche supplementation improves the serum androgen profile of women undergoing in vitro fertilization.

Keane KN, Hinchliffe PM, Namdar N, Conceicao JL, Newsholme P, Yovich JL.

Drug Des Devel Ther. 2015 Oct 9;9:5569-78. doi: 10.2147/DDDT.S92467. eCollection 2015.

24.

Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement.

Yovich JL, Conceicao JL, Stanger JD, Hinchliffe PM, Keane KN.

Reprod Biomed Online. 2015 Aug;31(2):180-91. doi: 10.1016/j.rbmo.2015.05.005. Epub 2015 May 18.

PMID:
26099447
25.

Which blastocysts should be considered for genetic screening?

Yovich JL, Conceicao J, Hinchliffe P, Keane K.

Hum Reprod. 2015 Jul;30(7):1743-4. doi: 10.1093/humrep/dev105. Epub 2015 May 13. No abstract available.

PMID:
25976659
26.

GnRH agonist is not required for frozen embryo transfers conducted under artificial hormone therapy.

Yovich JL, Conceicao JL, Hinchliffe PM.

Reprod Biomed Online. 2015 May;30(5):560. doi: 10.1016/j.rbmo.2015.01.004. Epub 2015 Jan 26. No abstract available.

PMID:
25754225
27.

Structure of the periplasmic adaptor protein from a major facilitator superfamily (MFS) multidrug efflux pump.

Hinchliffe P, Greene NP, Paterson NG, Crow A, Hughes C, Koronakis V.

FEBS Lett. 2014 Aug 25;588(17):3147-53. doi: 10.1016/j.febslet.2014.06.055. Epub 2014 Jul 1.

28.

Structure of an atypical periplasmic adaptor from a multidrug efflux pump of the spirochete Borrelia burgdorferi.

Greene NP, Hinchliffe P, Crow A, Ababou A, Hughes C, Koronakis V.

FEBS Lett. 2013 Sep 17;587(18):2984-8. doi: 10.1016/j.febslet.2013.06.056. Epub 2013 Jul 10.

29.

Structure and operation of bacterial tripartite pumps.

Hinchliffe P, Symmons MF, Hughes C, Koronakis V.

Annu Rev Microbiol. 2013;67:221-42. doi: 10.1146/annurev-micro-092412-155718. Epub 2013 Jun 26. Review.

PMID:
23808339
30.

Genomic evolution and polymorphism: segmental duplications and haplotypes at 108 regions on 21 chromosomes.

McLure CA, Hinchliffe P, Lester S, Williamson JF, Millman JA, Keating PJ, Stewart BJ, Dawkins RL.

Genomics. 2013 Jul;102(1):15-26. doi: 10.1016/j.ygeno.2013.02.011. Epub 2013 Mar 13.

31.

Targeted gonadotrophin stimulation using the PIVET algorithm markedly reduces the risk of OHSS.

Yovich J, Stanger J, Hinchliffe P.

Reprod Biomed Online. 2012 Mar;24(3):281-92. doi: 10.1016/j.rbmo.2011.11.014. Epub 2011 Nov 30.

PMID:
22296972
32.

Structures of sequential open states in a symmetrical opening transition of the TolC exit duct.

Pei XY, Hinchliffe P, Symmons MF, Koronakis E, Benz R, Hughes C, Koronakis V.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2112-7. doi: 10.1073/pnas.1012588108. Epub 2011 Jan 18.

33.

Identification of a novel subunit of respiratory complex I from Thermus thermophilus.

Hinchliffe P, Carroll J, Sazanov LA.

Biochemistry. 2006 Apr 11;45(14):4413-20.

PMID:
16584177
34.

Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus.

Sazanov LA, Hinchliffe P.

Science. 2006 Mar 10;311(5766):1430-6. Epub 2006 Feb 9.

35.

Different transition-state structures for the reactions of beta-lactams and analogous beta-sultams with serine beta-lactamases.

Tsang WY, Ahmed N, Hinchliffe PS, Wood JM, Harding LP, Laws AP, Page MI.

J Am Chem Soc. 2005 Dec 14;127(49):17556-64.

PMID:
16332108
36.

Organization of iron-sulfur clusters in respiratory complex I.

Hinchliffe P, Sazanov LA.

Science. 2005 Jul 29;309(5735):771-4.

37.

Novel mechanism of inhibiting beta-lactamases by sulfonylation using beta-sultams.

Page MI, Hinchliffe PS, Wood JM, Harding LP, Laws AP.

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4489-92.

PMID:
14643353
38.

Structure-reactivity relationships in the inactivation of elastase by beta-sultams.

Hinchliffe PS, Wood JM, Davis AM, Austin RP, Beckett RP, Page MI.

Org Biomol Chem. 2003 Jan 7;1(1):67-80.

PMID:
12929392
39.

Hydrolysis of a sulfonamide by a novel elimination mechanism generated by carbanion formation in the leaving group.

Wood JM, Hinchliffe PS, Davis AM, Austin RP, Page MI.

Chem Commun (Camb). 2002 Apr 7;(7):772-3.

PMID:
12119716
40.

A novel one-shot anastomotic stapler prototype for coronary bypass grafting on the beating heart: feasibility in the pig.

Heijmen RH, Hinchliffe P, Borst C, Verlaan CW, Mouës CM, van der Helm YJ, Manzo S, Jansen EW, Gründeman PF.

J Thorac Cardiovasc Surg. 1999 Jan;117(1):117-25.

41.

Facilitated vascular anastomoses: the one-shot device.

Nataf P, Hinchliffe P, Manzo S, Simpson J, Kirsch WM, Zhu YH, Anton T.

Ann Thorac Surg. 1998 Sep;66(3):1041-4.

PMID:
9768999
42.

Computing: learning to love bytes.

Hinchliffe P.

Nurs Stand. 1992 Jun 17-23;6(39):44-5. No abstract available.

PMID:
1642988
43.

Communication skills. Keeping hope alive.

Hinchliffe P.

Nurs Times. 1991 Mar 20-26;87(12):28, 30. No abstract available.

PMID:
2008341
44.

Evidence of udder excretion of Campylobacter jejuni as the cause of milk-borne campylobacter outbreak.

Hutchinson DN, Bolton FJ, Hinchliffe PM, Dawkins HC, Horsley SD, Jessop EG, Robertshaw PA, Counter DE.

J Hyg (Lond). 1985 Apr;94(2):205-15.

45.
46.

Comparison of selective media for isolation of Campylobacter jejuni/coli.

Bolton FJ, Coates D, Hinchliffe PM, Robertson L.

J Clin Pathol. 1983 Jan;36(1):78-83.

47.

Detection of complement fixation by enzyme linked immunosorbant assay (COMPELISA).

Hinchliffe PM, Robertson L.

J Clin Pathol. 1983 Jan;36(1):100-3.

48.

A most probable number method for estimating small numbers of campylobacters in water.

Bolton FJ, Hinchliffe PM, Coates D, Robertson L.

J Hyg (Lond). 1982 Oct;89(2):185-90.

49.

A simple method for determining bacterial susceptibility to aminoglycosides.

Hinchliffe PM, Robertson L, Farrell ID, Kirkwood BR.

J Med Microbiol. 1977 Aug;10(3):381-7.

PMID:
408495
50.

The isolation of Brucellae from contaminated sources. A review.

Robertson L, Farrell ID, Hinchliffe PM.

Br Vet J. 1977 Mar-Apr;133(2):193-200. Review. No abstract available.

PMID:
415790

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