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Items: 1 to 50 of 197

1.

Evolution of a highly active and enantiospecific metalloenzyme from short peptides.

Studer S, Hansen DA, Pianowski ZL, Mittl PRE, Debon A, Guffy SL, Der BS, Kuhlman B, Hilvert D.

Science. 2018 Dec 14;362(6420):1285-1288. doi: 10.1126/science.aau3744.

PMID:
30545884
2.

Rational Engineering of a Designed Protein Cage for siRNA Delivery.

Edwardson TGW, Mori T, Hilvert D.

J Am Chem Soc. 2018 Aug 22;140(33):10439-10442. doi: 10.1021/jacs.8b06442. Epub 2018 Aug 9.

PMID:
30091604
3.

Enzyme Encapsulation in an Engineered Lumazine Synthase Protein Cage.

Azuma Y, Hilvert D.

Methods Mol Biol. 2018;1798:39-55. doi: 10.1007/978-1-4939-7893-9_4.

PMID:
29868950
4.

Engineered Metalloenzymes with Non-Canonical Coordination Environments.

Hayashi T, Hilvert D, Green AP.

Chemistry. 2018 Aug 14;24(46):11821-11830. doi: 10.1002/chem.201800975. Epub 2018 Jul 15.

PMID:
29786902
5.

Laboratory evolution of virus-like nucleocapsids from nonviral protein cages.

Terasaka N, Azuma Y, Hilvert D.

Proc Natl Acad Sci U S A. 2018 May 22;115(21):5432-5437. doi: 10.1073/pnas.1800527115. Epub 2018 May 7.

6.

Tailoring lumazine synthase assemblies for bionanotechnology.

Azuma Y, Edwardson TGW, Hilvert D.

Chem Soc Rev. 2018 May 21;47(10):3543-3557. doi: 10.1039/c8cs00154e. Review.

PMID:
29714396
7.

Surface-Engineered Cationic Nanocrystals Stable in Biological Buffers and High Ionic Strength Solutions.

Dragoman RM, Grogg M, Bodnarchuk MI, Tiefenboeck P, Hilvert D, Dirin DN, Kovalenko MV.

Chem Mater. 2017 Nov 14;29(21):9416-9428. doi: 10.1021/acs.chemmater.7b03504. Epub 2017 Oct 16.

8.

Directed Evolution of Protein Catalysts.

Zeymer C, Hilvert D.

Annu Rev Biochem. 2018 Jun 20;87:131-157. doi: 10.1146/annurev-biochem-062917-012034. Epub 2018 Mar 1.

PMID:
29494241
9.

Nonribosomal biosynthesis of backbone-modified peptides.

Niquille DL, Hansen DA, Mori T, Fercher D, Kries H, Hilvert D.

Nat Chem. 2018 Mar;10(3):282-287. doi: 10.1038/nchem.2891. Epub 2017 Nov 20.

PMID:
29461527
10.

Stereodivergent Evolution of Artificial Enzymes for the Michael Reaction.

Garrabou X, Macdonald DS, Wicky BIM, Hilvert D.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5288-5291. doi: 10.1002/anie.201712554. Epub 2018 Apr 3.

PMID:
29446221
11.

Speeding up enzyme discovery and engineering with ultrahigh-throughput methods.

Bunzel HA, Garrabou X, Pott M, Hilvert D.

Curr Opin Struct Biol. 2018 Feb;48:149-156. doi: 10.1016/j.sbi.2017.12.010. Epub 2018 Feb 3. Review.

PMID:
29413955
12.

A Noncanonical Proximal Heme Ligand Affords an Efficient Peroxidase in a Globin Fold.

Pott M, Hayashi T, Mori T, Mittl PRE, Green AP, Hilvert D.

J Am Chem Soc. 2018 Jan 31;140(4):1535-1543. doi: 10.1021/jacs.7b12621. Epub 2018 Jan 19.

PMID:
29309143
13.

Modular Protein Cages for Size-Selective RNA Packaging in Vivo.

Azuma Y, Edwardson TGW, Terasaka N, Hilvert D.

J Am Chem Soc. 2018 Jan 17;140(2):566-569. doi: 10.1021/jacs.7b10798. Epub 2018 Jan 3.

PMID:
29278497
14.

Substrate Sorting by a Supercharged Nanoreactor.

Azuma Y, Bader DLV, Hilvert D.

J Am Chem Soc. 2018 Jan 24;140(3):860-863. doi: 10.1021/jacs.7b11210. Epub 2018 Jan 2.

15.

Diversification of Protein Cage Structure Using Circularly Permuted Subunits.

Azuma Y, Herger M, Hilvert D.

J Am Chem Soc. 2018 Jan 17;140(2):558-561. doi: 10.1021/jacs.7b10513. Epub 2018 Jan 2.

PMID:
29257675
16.

Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes.

Fort KL, van de Waterbeemd M, Boll D, Reinhardt-Szyba M, Belov ME, Sasaki E, Zschoche R, Hilvert D, Makarov AA, Heck AJR.

Analyst. 2017 Dec 18;143(1):100-105. doi: 10.1039/c7an01629h.

PMID:
29138777
17.

Enzyme Encapsulation by a Ferritin Cage.

Tetter S, Hilvert D.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14933-14936. doi: 10.1002/anie.201708530. Epub 2017 Oct 12.

PMID:
28902449
18.

Efficient laboratory evolution of computationally designed enzymes with low starting activities using fluorescence-activated droplet sorting.

Obexer R, Pott M, Zeymer C, Griffiths AD, Hilvert D.

Protein Eng Des Sel. 2017 Jul 1;30(7):531. doi: 10.1093/protein/gzx032. No abstract available.

PMID:
28873983
19.

Optimization of Enzyme Mechanism along the Evolutionary Trajectory of a Computationally Designed (Retro-)Aldolase.

Zeymer C, Zschoche R, Hilvert D.

J Am Chem Soc. 2017 Sep 13;139(36):12541-12549. doi: 10.1021/jacs.7b05796. Epub 2017 Aug 28.

PMID:
28783336
20.

Synthesis and characterization of catalytically active thiazolium gold(i)-carbenes.

Dince CC, Meoded RA, Hilvert D.

Chem Commun (Camb). 2017 Jul 4;53(54):7585-7587. doi: 10.1039/c7cc03791k.

PMID:
28638911
21.

The C-terminal peptide of Aquifex aeolicus riboflavin synthase directs encapsulation of native and foreign guests by a cage-forming lumazine synthase.

Azuma Y, Zschoche R, Hilvert D.

J Biol Chem. 2017 Jun 23;292(25):10321-10327. doi: 10.1074/jbc.C117.790311. Epub 2017 May 17.

22.

Structure and assembly of scalable porous protein cages.

Sasaki E, Böhringer D, van de Waterbeemd M, Leibundgut M, Zschoche R, Heck AJ, Ban N, Hilvert D.

Nat Commun. 2017 Mar 10;8:14663. doi: 10.1038/ncomms14663.

23.

Irreversible Cysteine-Selective Protein Labeling Employing Modular Electrophilic Tetrafluoroethylation Reagents.

Václavík J, Zschoche R, Klimánková I, Matoušek V, Beier P, Hilvert D, Togni A.

Chemistry. 2017 May 11;23(27):6490-6494. doi: 10.1002/chem.201700607. Epub 2017 Mar 2.

PMID:
28195376
24.

Chemoselective Henry Condensations Catalyzed by Artificial Carboligases.

Garrabou X, Macdonald DS, Hilvert D.

Chemistry. 2017 May 2;23(25):6001-6003. doi: 10.1002/chem.201605757. Epub 2017 Jan 30.

PMID:
28070900
25.

Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase.

Obexer R, Godina A, Garrabou X, Mittl PR, Baker D, Griffiths AD, Hilvert D.

Nat Chem. 2017 Jan;9(1):50-56. doi: 10.1038/nchem.2596. Epub 2016 Aug 29.

PMID:
27995916
26.

Enantiocomplementary Synthesis of γ-Nitroketones Using Designed and Evolved Carboligases.

Garrabou X, Verez R, Hilvert D.

J Am Chem Soc. 2017 Jan 11;139(1):103-106. doi: 10.1021/jacs.6b11928. Epub 2016 Dec 22.

PMID:
27992715
27.

Efficient laboratory evolution of computationally designed enzymes with low starting activities using fluorescence-activated droplet sorting.

Obexer R, Pott M, Zeymer C, Griffiths AD, Hilvert D.

Protein Eng Des Sel. 2016 Sep;29(9):355-66. doi: 10.1093/protein/gzw032. Epub 2016 Aug 19.

PMID:
27542390
28.

Upregulation of an Artificial Zymogen by Proteolysis.

Liu Z, Lebrun V, Kitanosono T, Mallin H, Köhler V, Häussinger D, Hilvert D, Kobayashi S, Ward TR.

Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11587-90. doi: 10.1002/anie.201605010. Epub 2016 Aug 16.

PMID:
27529471
29.

A Chemically Programmed Proximal Ligand Enhances the Catalytic Properties of a Heme Enzyme.

Green AP, Hayashi T, Mittl PR, Hilvert D.

J Am Chem Soc. 2016 Sep 7;138(35):11344-52. doi: 10.1021/jacs.6b07029. Epub 2016 Aug 26.

PMID:
27500802
30.

Enzyme-mediated polymerization inside engineered protein cages.

Frey R, Hayashi T, Hilvert D.

Chem Commun (Camb). 2016 Aug 16;52(68):10423-6. doi: 10.1039/c6cc05301g.

PMID:
27484787
31.

Bottom-up Construction of a Primordial Carboxysome Mimic.

Frey R, Mantri S, Rocca M, Hilvert D.

J Am Chem Soc. 2016 Aug 17;138(32):10072-5. doi: 10.1021/jacs.6b04744. Epub 2016 Aug 8.

PMID:
27479274
32.

Evaluation of the Ser-His Dipeptide, a Putative Catalyst of Amide and Ester Hydrolysis.

MacDonald MJ, Lavis LD, Hilvert D, Gellman SH.

Org Lett. 2016 Aug 5;18(15):3518-21. doi: 10.1021/acs.orglett.6b01279. Epub 2016 Jul 11.

PMID:
27400366
33.

Fast Knoevenagel Condensations Catalyzed by an Artificial Schiff-Base-Forming Enzyme.

Garrabou X, Wicky BI, Hilvert D.

J Am Chem Soc. 2016 Jun 8;138(22):6972-4. doi: 10.1021/jacs.6b00816. Epub 2016 May 31.

PMID:
27196438
34.

Protein Nanocontainers from Nonviral Origin: Testing the Mechanics of Artificial and Natural Protein Cages by AFM.

Heinze K, Sasaki E, King NP, Baker D, Hilvert D, Wuite GJ, Roos WH.

J Phys Chem B. 2016 Jul 7;120(26):5945-52. doi: 10.1021/acs.jpcb.6b01464. Epub 2016 May 17.

PMID:
27187612
35.

Self-Assembly of Proteinaceous Multishell Structures Mediated by a Supercharged Protein.

Sasaki E, Hilvert D.

J Phys Chem B. 2016 Jul 7;120(26):6089-95. doi: 10.1021/acs.jpcb.6b02068. Epub 2016 Apr 22.

PMID:
27064167
36.

Chiral recognition in amyloid fiber growth.

Torbeev V, Grogg M, Ruiz J, Boehringer R, Schirer A, Hellwig P, Jeschke G, Hilvert D.

J Pept Sci. 2016 May;22(5):290-304. doi: 10.1002/psc.2861. Epub 2016 Mar 1.

PMID:
26929241
37.

DNA Nanoparticles for Improved Protein Synthesis In Vitro.

Galinis R, Stonyte G, Kiseliovas V, Zilionis R, Studer S, Hilvert D, Janulaitis A, Mazutis L.

Angew Chem Int Ed Engl. 2016 Feb 24;55(9):3120-3. doi: 10.1002/anie.201511809. Epub 2016 Jan 28.

38.

Quantitative Packaging of Active Enzymes into a Protein Cage.

Azuma Y, Zschoche R, Tinzl M, Hilvert D.

Angew Chem Int Ed Engl. 2016 Jan 22;55(4):1531-4. doi: 10.1002/anie.201508414. Epub 2015 Dec 23.

PMID:
26695342
39.

Site-Specific Polymer Conjugation Stabilizes Therapeutic Enzymes in the Gastrointestinal Tract.

Schulz JD, Patt M, Basler S, Kries H, Hilvert D, Gauthier MA, Leroux JC.

Adv Mater. 2016 Feb 17;28(7):1455-60. doi: 10.1002/adma.201504797. Epub 2015 Dec 7.

PMID:
26640034
40.

Diffusion-Limited Cargo Loading of an Engineered Protein Container.

Zschoche R, Hilvert D.

J Am Chem Soc. 2015 Dec 30;137(51):16121-32. doi: 10.1021/jacs.5b10588. Epub 2015 Dec 17.

PMID:
26637019
41.

Kinetic consequences of introducing a proximal selenocysteine ligand into cytochrome P450cam.

Vandemeulebroucke A, Aldag C, Stiebritz MT, Reiher M, Hilvert D.

Biochemistry. 2015 Nov 10;54(44):6692-703. doi: 10.1021/acs.biochem.5b00939. Epub 2015 Oct 27.

PMID:
26460790
42.

A subdomain swap strategy for reengineering nonribosomal peptides.

Kries H, Niquille DL, Hilvert D.

Chem Biol. 2015 May 21;22(5):640-8. doi: 10.1016/j.chembiol.2015.04.015.

43.

A Promiscuous De Novo Retro-Aldolase Catalyzes Asymmetric Michael Additions via Schiff Base Intermediates.

Garrabou X, Beck T, Hilvert D.

Angew Chem Int Ed Engl. 2015 May 4;54(19):5609-12. doi: 10.1002/anie.201500217. Epub 2015 Mar 16.

PMID:
25777153
44.

Comparative laboratory evolution of ordered and disordered enzymes.

Schulenburg C, Stark Y, Künzle M, Hilvert D.

J Biol Chem. 2015 Apr 10;290(15):9310-20. doi: 10.1074/jbc.M115.638080. Epub 2015 Feb 19.

45.

Substitution of proline32 by α-methylproline preorganizes β2-microglobulin for oligomerization but not for aggregation into amyloids.

Torbeev V, Ebert MO, Dolenc J, Hilvert D.

J Am Chem Soc. 2015 Feb 25;137(7):2524-35. doi: 10.1021/ja510109p. Epub 2015 Feb 16.

PMID:
25633201
46.

Harnessing selenocysteine reactivity for oxidative protein folding.

Metanis N, Hilvert D.

Chem Sci. 2015 Jan 1;6(1):322-325. doi: 10.1039/c4sc02379j. Epub 2014 Sep 23.

47.

Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis.

Burschowsky D, van Eerde A, Ökvist M, Kienhöfer A, Kast P, Hilvert D, Krengel U.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17516-21. doi: 10.1073/pnas.1408512111. Epub 2014 Nov 24.

48.

Construction of Matryoshka-type structures from supercharged protein nanocages.

Beck T, Tetter S, Künzle M, Hilvert D.

Angew Chem Int Ed Engl. 2015 Jan 12;54(3):937-40. doi: 10.1002/anie.201408677. Epub 2014 Nov 13.

PMID:
25392947
49.

Natural and synthetic selenoproteins.

Metanis N, Hilvert D.

Curr Opin Chem Biol. 2014 Oct;22:27-34. doi: 10.1016/j.cbpa.2014.09.010. Epub 2014 Sep 28. Review.

PMID:
25261915
50.

Reprogramming nonribosomal peptide synthetases for "clickable" amino acids.

Kries H, Wachtel R, Pabst A, Wanner B, Niquille D, Hilvert D.

Angew Chem Int Ed Engl. 2014 Sep 15;53(38):10105-8. doi: 10.1002/anie.201405281. Epub 2014 Jul 31.

PMID:
25081643

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