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Items: 1 to 50 of 206

1.

Cytoplasmic glycoengineering enables biosynthesis of nanoscale glycoprotein assemblies.

Tytgat HLP, Lin CW, Levasseur MD, Tomek MB, Rutschmann C, Mock J, Liebscher N, Terasaka N, Azuma Y, Wetter M, Bachmann MF, Hilvert D, Aebi M, Keys TG.

Nat Commun. 2019 Nov 27;10(1):5403. doi: 10.1038/s41467-019-13283-2.

2.

A computational method for design of connected catalytic networks in proteins.

Weitzner BD, Kipnis Y, Daniel AG, Hilvert D, Baker D.

Protein Sci. 2019 Dec;28(12):2036-2041. doi: 10.1002/pro.3757.

3.

Expanding the mass range for UVPD-based native top-down mass spectrometry.

Greisch JF, Tamara S, Scheltema RA, Maxwell HWR, Fagerlund RD, Fineran PC, Tetter S, Hilvert D, Heck AJR.

Chem Sci. 2019 Jul 1;10(30):7163-7171. doi: 10.1039/c9sc01857c. eCollection 2019 Aug 14.

4.

Self-Assembly of Proteinaceous Shells around Positively Charged Gold Nanomaterials Enhances Colloidal Stability in High-Ionic-Strength Buffers.

Sasaki E, Dragoman RM, Mantri S, Dirin DN, Kovalenko MV, Hilvert D.

Chembiochem. 2020 Jan 15;21(1-2):74-79. doi: 10.1002/cbic.201900469. Epub 2019 Nov 18.

PMID:
31523885
5.

Non-uniform HYSCORE: Measurement, processing and analysis with Hyscorean.

Fábregas Ibáñez L, Soetbeer J, Klose D, Tinzl M, Hilvert D, Jeschke G.

J Magn Reson. 2019 Oct;307:106576. doi: 10.1016/j.jmr.2019.106576. Epub 2019 Aug 19.

6.

Emergence of a Negative Activation Heat Capacity during Evolution of a Designed Enzyme.

Bunzel HA, Kries H, Marchetti L, Zeymer C, Mittl PRE, Mulholland AJ, Hilvert D.

J Am Chem Soc. 2019 Jul 31;141(30):11745-11748. doi: 10.1021/jacs.9b02731. Epub 2019 Jul 19.

PMID:
31282667
7.

Virus-Inspired Function in Engineered Protein Cages.

Edwardson TGW, Hilvert D.

J Am Chem Soc. 2019 Jun 19;141(24):9432-9443. doi: 10.1021/jacs.9b03705. Epub 2019 Jun 10.

PMID:
31117660
8.

Cell Penetration, Herbicidal Activity, and in-vivo-Toxicity of Oligo-Arginine Derivatives and of Novel Guanidinium-Rich Compounds Derived from the Biopolymer Cyanophycin.

Grogg M, Hilvert D, Ebert MO, Beck AK, Seebach D, Kurth F, Dittrich PS, Sparr C, Wittlin S, Rottmann M, Mäser P.

Helv Chim Acta. 2018 Oct;101(10). pii: e1800112. doi: 10.1002/hlca.201800112.

9.

[Structure and Self-assembly of Negatively Supercharged Protein Cages].

Sasaki E, Hilvert D.

Yakugaku Zasshi. 2019;139(2):199-208. doi: 10.1248/yakushi.18-00169-2. Review. Japanese.

10.

Evolution of a highly active and enantiospecific metalloenzyme from short peptides.

Studer S, Hansen DA, Pianowski ZL, Mittl PRE, Debon A, Guffy SL, Der BS, Kuhlman B, Hilvert D.

Science. 2018 Dec 14;362(6420):1285-1288. doi: 10.1126/science.aau3744.

PMID:
30545884
11.

Rational Engineering of a Designed Protein Cage for siRNA Delivery.

Edwardson TGW, Mori T, Hilvert D.

J Am Chem Soc. 2018 Aug 22;140(33):10439-10442. doi: 10.1021/jacs.8b06442. Epub 2018 Aug 9.

PMID:
30091604
12.

Enzyme Encapsulation in an Engineered Lumazine Synthase Protein Cage.

Azuma Y, Hilvert D.

Methods Mol Biol. 2018;1798:39-55. doi: 10.1007/978-1-4939-7893-9_4.

PMID:
29868950
13.

Engineered Metalloenzymes with Non-Canonical Coordination Environments.

Hayashi T, Hilvert D, Green AP.

Chemistry. 2018 Aug 14;24(46):11821-11830. doi: 10.1002/chem.201800975. Epub 2018 Jul 15.

PMID:
29786902
14.

Laboratory evolution of virus-like nucleocapsids from nonviral protein cages.

Terasaka N, Azuma Y, Hilvert D.

Proc Natl Acad Sci U S A. 2018 May 22;115(21):5432-5437. doi: 10.1073/pnas.1800527115. Epub 2018 May 7.

15.

Tailoring lumazine synthase assemblies for bionanotechnology.

Azuma Y, Edwardson TGW, Hilvert D.

Chem Soc Rev. 2018 May 21;47(10):3543-3557. doi: 10.1039/c8cs00154e. Review.

PMID:
29714396
16.

Surface-Engineered Cationic Nanocrystals Stable in Biological Buffers and High Ionic Strength Solutions.

Dragoman RM, Grogg M, Bodnarchuk MI, Tiefenboeck P, Hilvert D, Dirin DN, Kovalenko MV.

Chem Mater. 2017 Nov 14;29(21):9416-9428. doi: 10.1021/acs.chemmater.7b03504. Epub 2017 Oct 16.

17.

Directed Evolution of Protein Catalysts.

Zeymer C, Hilvert D.

Annu Rev Biochem. 2018 Jun 20;87:131-157. doi: 10.1146/annurev-biochem-062917-012034. Epub 2018 Mar 1. Review.

PMID:
29494241
18.

Nonribosomal biosynthesis of backbone-modified peptides.

Niquille DL, Hansen DA, Mori T, Fercher D, Kries H, Hilvert D.

Nat Chem. 2018 Mar;10(3):282-287. doi: 10.1038/nchem.2891. Epub 2017 Nov 20.

PMID:
29461527
19.

Stereodivergent Evolution of Artificial Enzymes for the Michael Reaction.

Garrabou X, Macdonald DS, Wicky BIM, Hilvert D.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5288-5291. doi: 10.1002/anie.201712554. Epub 2018 Apr 3.

PMID:
29446221
20.

Speeding up enzyme discovery and engineering with ultrahigh-throughput methods.

Bunzel HA, Garrabou X, Pott M, Hilvert D.

Curr Opin Struct Biol. 2018 Feb;48:149-156. doi: 10.1016/j.sbi.2017.12.010. Epub 2018 Feb 3. Review.

PMID:
29413955
21.

A Noncanonical Proximal Heme Ligand Affords an Efficient Peroxidase in a Globin Fold.

Pott M, Hayashi T, Mori T, Mittl PRE, Green AP, Hilvert D.

J Am Chem Soc. 2018 Jan 31;140(4):1535-1543. doi: 10.1021/jacs.7b12621. Epub 2018 Jan 19.

PMID:
29309143
22.

Modular Protein Cages for Size-Selective RNA Packaging in Vivo.

Azuma Y, Edwardson TGW, Terasaka N, Hilvert D.

J Am Chem Soc. 2018 Jan 17;140(2):566-569. doi: 10.1021/jacs.7b10798. Epub 2018 Jan 3.

PMID:
29278497
23.

Substrate Sorting by a Supercharged Nanoreactor.

Azuma Y, Bader DLV, Hilvert D.

J Am Chem Soc. 2018 Jan 24;140(3):860-863. doi: 10.1021/jacs.7b11210. Epub 2018 Jan 2.

24.

Diversification of Protein Cage Structure Using Circularly Permuted Subunits.

Azuma Y, Herger M, Hilvert D.

J Am Chem Soc. 2018 Jan 17;140(2):558-561. doi: 10.1021/jacs.7b10513. Epub 2018 Jan 2.

PMID:
29257675
25.

Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes.

Fort KL, van de Waterbeemd M, Boll D, Reinhardt-Szyba M, Belov ME, Sasaki E, Zschoche R, Hilvert D, Makarov AA, Heck AJR.

Analyst. 2017 Dec 18;143(1):100-105. doi: 10.1039/c7an01629h.

PMID:
29138777
26.

Enzyme Encapsulation by a Ferritin Cage.

Tetter S, Hilvert D.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14933-14936. doi: 10.1002/anie.201708530. Epub 2017 Oct 12.

PMID:
28902449
27.

Efficient laboratory evolution of computationally designed enzymes with low starting activities using fluorescence-activated droplet sorting.

Obexer R, Pott M, Zeymer C, Griffiths AD, Hilvert D.

Protein Eng Des Sel. 2017 Jul 1;30(7):531. doi: 10.1093/protein/gzx032. No abstract available.

PMID:
28873983
28.

Optimization of Enzyme Mechanism along the Evolutionary Trajectory of a Computationally Designed (Retro-)Aldolase.

Zeymer C, Zschoche R, Hilvert D.

J Am Chem Soc. 2017 Sep 13;139(36):12541-12549. doi: 10.1021/jacs.7b05796. Epub 2017 Aug 28.

PMID:
28783336
29.

Synthesis and characterization of catalytically active thiazolium gold(i)-carbenes.

Dince CC, Meoded RA, Hilvert D.

Chem Commun (Camb). 2017 Jul 4;53(54):7585-7587. doi: 10.1039/c7cc03791k.

PMID:
28638911
30.

The C-terminal peptide of Aquifex aeolicus riboflavin synthase directs encapsulation of native and foreign guests by a cage-forming lumazine synthase.

Azuma Y, Zschoche R, Hilvert D.

J Biol Chem. 2017 Jun 23;292(25):10321-10327. doi: 10.1074/jbc.C117.790311. Epub 2017 May 17.

31.

Structure and assembly of scalable porous protein cages.

Sasaki E, Böhringer D, van de Waterbeemd M, Leibundgut M, Zschoche R, Heck AJ, Ban N, Hilvert D.

Nat Commun. 2017 Mar 10;8:14663. doi: 10.1038/ncomms14663.

32.

Irreversible Cysteine-Selective Protein Labeling Employing Modular Electrophilic Tetrafluoroethylation Reagents.

Václavík J, Zschoche R, Klimánková I, Matoušek V, Beier P, Hilvert D, Togni A.

Chemistry. 2017 May 11;23(27):6490-6494. doi: 10.1002/chem.201700607. Epub 2017 Mar 2.

PMID:
28195376
33.

Chemoselective Henry Condensations Catalyzed by Artificial Carboligases.

Garrabou X, Macdonald DS, Hilvert D.

Chemistry. 2017 May 2;23(25):6001-6003. doi: 10.1002/chem.201605757. Epub 2017 Jan 30.

PMID:
28070900
34.

Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase.

Obexer R, Godina A, Garrabou X, Mittl PR, Baker D, Griffiths AD, Hilvert D.

Nat Chem. 2017 Jan;9(1):50-56. doi: 10.1038/nchem.2596. Epub 2016 Aug 29.

PMID:
27995916
35.

Enantiocomplementary Synthesis of γ-Nitroketones Using Designed and Evolved Carboligases.

Garrabou X, Verez R, Hilvert D.

J Am Chem Soc. 2017 Jan 11;139(1):103-106. doi: 10.1021/jacs.6b11928. Epub 2016 Dec 22.

PMID:
27992715
36.

Efficient laboratory evolution of computationally designed enzymes with low starting activities using fluorescence-activated droplet sorting.

Obexer R, Pott M, Zeymer C, Griffiths AD, Hilvert D.

Protein Eng Des Sel. 2016 Sep;29(9):355-66. doi: 10.1093/protein/gzw032. Epub 2016 Aug 19.

PMID:
27542390
37.

Upregulation of an Artificial Zymogen by Proteolysis.

Liu Z, Lebrun V, Kitanosono T, Mallin H, Köhler V, Häussinger D, Hilvert D, Kobayashi S, Ward TR.

Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11587-90. doi: 10.1002/anie.201605010. Epub 2016 Aug 16.

PMID:
27529471
38.

A Chemically Programmed Proximal Ligand Enhances the Catalytic Properties of a Heme Enzyme.

Green AP, Hayashi T, Mittl PR, Hilvert D.

J Am Chem Soc. 2016 Sep 7;138(35):11344-52. doi: 10.1021/jacs.6b07029. Epub 2016 Aug 26.

PMID:
27500802
39.

Enzyme-mediated polymerization inside engineered protein cages.

Frey R, Hayashi T, Hilvert D.

Chem Commun (Camb). 2016 Aug 16;52(68):10423-6. doi: 10.1039/c6cc05301g.

PMID:
27484787
40.

Bottom-up Construction of a Primordial Carboxysome Mimic.

Frey R, Mantri S, Rocca M, Hilvert D.

J Am Chem Soc. 2016 Aug 17;138(32):10072-5. doi: 10.1021/jacs.6b04744. Epub 2016 Aug 8.

PMID:
27479274
41.

Evaluation of the Ser-His Dipeptide, a Putative Catalyst of Amide and Ester Hydrolysis.

MacDonald MJ, Lavis LD, Hilvert D, Gellman SH.

Org Lett. 2016 Aug 5;18(15):3518-21. doi: 10.1021/acs.orglett.6b01279. Epub 2016 Jul 11.

PMID:
27400366
42.

Fast Knoevenagel Condensations Catalyzed by an Artificial Schiff-Base-Forming Enzyme.

Garrabou X, Wicky BI, Hilvert D.

J Am Chem Soc. 2016 Jun 8;138(22):6972-4. doi: 10.1021/jacs.6b00816. Epub 2016 May 31.

PMID:
27196438
43.

Protein Nanocontainers from Nonviral Origin: Testing the Mechanics of Artificial and Natural Protein Cages by AFM.

Heinze K, Sasaki E, King NP, Baker D, Hilvert D, Wuite GJ, Roos WH.

J Phys Chem B. 2016 Jul 7;120(26):5945-52. doi: 10.1021/acs.jpcb.6b01464. Epub 2016 May 17.

PMID:
27187612
44.

Self-Assembly of Proteinaceous Multishell Structures Mediated by a Supercharged Protein.

Sasaki E, Hilvert D.

J Phys Chem B. 2016 Jul 7;120(26):6089-95. doi: 10.1021/acs.jpcb.6b02068. Epub 2016 Apr 22.

PMID:
27064167
45.

Chiral recognition in amyloid fiber growth.

Torbeev V, Grogg M, Ruiz J, Boehringer R, Schirer A, Hellwig P, Jeschke G, Hilvert D.

J Pept Sci. 2016 May;22(5):290-304. doi: 10.1002/psc.2861. Epub 2016 Mar 1.

PMID:
26929241
46.

DNA Nanoparticles for Improved Protein Synthesis In Vitro.

Galinis R, Stonyte G, Kiseliovas V, Zilionis R, Studer S, Hilvert D, Janulaitis A, Mazutis L.

Angew Chem Int Ed Engl. 2016 Feb 24;55(9):3120-3. doi: 10.1002/anie.201511809. Epub 2016 Jan 28.

47.

Quantitative Packaging of Active Enzymes into a Protein Cage.

Azuma Y, Zschoche R, Tinzl M, Hilvert D.

Angew Chem Int Ed Engl. 2016 Jan 22;55(4):1531-4. doi: 10.1002/anie.201508414. Epub 2015 Dec 23.

PMID:
26695342
48.

Site-Specific Polymer Conjugation Stabilizes Therapeutic Enzymes in the Gastrointestinal Tract.

Schulz JD, Patt M, Basler S, Kries H, Hilvert D, Gauthier MA, Leroux JC.

Adv Mater. 2016 Feb 17;28(7):1455-60. doi: 10.1002/adma.201504797. Epub 2015 Dec 7.

PMID:
26640034
49.

Diffusion-Limited Cargo Loading of an Engineered Protein Container.

Zschoche R, Hilvert D.

J Am Chem Soc. 2015 Dec 30;137(51):16121-32. doi: 10.1021/jacs.5b10588. Epub 2015 Dec 17.

PMID:
26637019
50.

Kinetic consequences of introducing a proximal selenocysteine ligand into cytochrome P450cam.

Vandemeulebroucke A, Aldag C, Stiebritz MT, Reiher M, Hilvert D.

Biochemistry. 2015 Nov 10;54(44):6692-703. doi: 10.1021/acs.biochem.5b00939. Epub 2015 Oct 27.

PMID:
26460790

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