Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 88

1.

Genome-Wide Meta-Analysis of Blood Pressure Response to β1-Blockers: Results From ICAPS (International Consortium of Antihypertensive Pharmacogenomics Studies).

Singh S, Warren HR, Hiltunen TP, McDonough CW, El Rouby N, Salvi E, Wang Z, Garofalidou T, Fyhrquist F, Kontula KK, Glorioso V, Zaninello R, Glorioso N, Pepine CJ, Munroe PB, Turner ST, Chapman AB, Boerwinkle E, Johnson JA, Gong Y, Cooper-DeHoff RM.

J Am Heart Assoc. 2019 Aug 20;8(16):e013115. doi: 10.1161/JAHA.119.013115. Epub 2019 Aug 19.

2.

Predator coevolution and prey trait variability determine species coexistence.

Scheuerl T, Cairns J, Becks L, Hiltunen T.

Proc Biol Sci. 2019 May 15;286(1902):20190245. doi: 10.1098/rspb.2019.0245.

PMID:
31088272
3.

Genome-wide association study of white-coat effect in hypertensive patients.

Rimpelä JM, Niiranen T, Jula A, Pörsti IH, Tikkakoski A, Havulinna A, Lehtimäki T, Salomaa V, Kontula KK, Hiltunen TP.

Blood Press. 2019 Aug;28(4):239-249. doi: 10.1080/08037051.2019.1604066. Epub 2019 May 2.

PMID:
31044621
4.

A high-throughput approach to the culture-based estimation of plasmid transfer rates.

Kneis D, Hiltunen T, Heß S.

Plasmid. 2019 Jan;101:28-34. doi: 10.1016/j.plasmid.2018.12.003. Epub 2018 Dec 29.

PMID:
30599142
5.

Dual-stressor selection alters eco-evolutionary dynamics in experimental communities.

Hiltunen T, Cairns J, Frickel J, Jalasvuori M, Laakso J, Kaitala V, Künzel S, Karakoc E, Becks L.

Nat Ecol Evol. 2018 Dec;2(12):1974-1981. doi: 10.1038/s41559-018-0701-5. Epub 2018 Nov 19.

PMID:
30455439
6.

Frequency of virus-resistant hosts determines experimental community dynamics.

Coloma S, Gaedke U, Sivonen K, Hiltunen T.

Ecology. 2019 Jan;100(1):e02554. doi: 10.1002/ecy.2554. Epub 2018 Nov 28.

PMID:
30411791
7.

Black Queen Evolution and Trophic Interactions Determine Plasmid Survival after the Disruption of the Conjugation Network.

Cairns J, Koskinen K, Penttinen R, Patinen T, Hartikainen A, Jokela R, Ruusulehto L, Viitamäki S, Mattila S, Hiltunen T, Jalasvuori M.

mSystems. 2018 Oct 2;3(5). pii: e00104-18. doi: 10.1128/mSystems.00104-18. eCollection 2018 Sep-Oct.

8.

Ecology determines how low antibiotic concentration impacts community composition and horizontal transfer of resistance genes.

Cairns J, Ruokolainen L, Hultman J, Tamminen M, Virta M, Hiltunen T.

Commun Biol. 2018 Apr 19;1:35. doi: 10.1038/s42003-018-0041-7. eCollection 2018.

9.

Construction and Characterization of Synthetic Bacterial Community for Experimental Ecology and Evolution.

Cairns J, Jokela R, Hultman J, Tamminen M, Virta M, Hiltunen T.

Front Genet. 2018 Aug 14;9:312. doi: 10.3389/fgene.2018.00312. eCollection 2018.

10.

Genome-wide association study of nocturnal blood pressure dipping in hypertensive patients.

Rimpelä JM, Pörsti IH, Jula A, Lehtimäki T, Niiranen TJ, Oikarinen L, Porthan K, Tikkakoski A, Virolainen J, Kontula KK, Hiltunen TP.

BMC Med Genet. 2018 Jul 4;19(1):110. doi: 10.1186/s12881-018-0624-7.

11.

Effect of resource availability on evolution of virulence and competition in an environmentally transmitted pathogen.

Pulkkinen K, Pekkala N, Ashrafi R, Hämäläinen DM, Nkembeng AN, Lipponen A, Hiltunen T, Valkonen JK, Taskinen J.

FEMS Microbiol Ecol. 2018 May 1;94(5). doi: 10.1093/femsec/fiy060.

PMID:
29659817
12.

Effect of hydrochlorothiazide on serum uric acid concentration: a genome-wide association study.

Ala-Mutka EM, Rimpelä JM, Fyhrquist F, Kontula KK, Hiltunen TP.

Pharmacogenomics. 2018 Apr;19(6):517-527. doi: 10.2217/pgs-2017-0184. Epub 2018 Mar 27.

PMID:
29580174
13.

Dynamical trade-offs arise from antagonistic coevolution and decrease intraspecific diversity.

Huang W, Traulsen A, Werner B, Hiltunen T, Becks L.

Nat Commun. 2017 Dec 12;8(1):2059. doi: 10.1038/s41467-017-01957-8.

14.

Effects of four different antihypertensive drugs on plasma metabolomic profiles in patients with essential hypertension.

Hiltunen TP, Rimpelä JM, Mohney RP, Stirdivant SM, Kontula KK.

PLoS One. 2017 Nov 9;12(11):e0187729. doi: 10.1371/journal.pone.0187729. eCollection 2017.

15.

Evolutionary contribution to coexistence of competitors in microbial food webs.

Hiltunen T, Kaitala V, Laakso J, Becks L.

Proc Biol Sci. 2017 Oct 11;284(1864). pii: 20170415. doi: 10.1098/rspb.2017.0415.

16.

Replicated evidence for aminoacylase 3 and nephrin gene variations to predict antihypertensive drug responses.

Rimpelä JM, Kontula KK, Fyhrquist F, Donner KM, Tuiskula AM, Sarin AP, Mohney RP, Stirdivant SM, Hiltunen TP.

Pharmacogenomics. 2017 Apr;18(5):445-458. doi: 10.2217/pgs-2016-0204. Epub 2017 Mar 29.

17.

Conjugative ESBL plasmids differ in their potential to rescue susceptible bacteria via horizontal gene transfer in lethal antibiotic concentrations.

Mattila S, Ruotsalainen P, Ojala V, Tuononen T, Hiltunen T, Jalasvuori M.

J Antibiot (Tokyo). 2017 Jun;70(6):805-808. doi: 10.1038/ja.2017.41. Epub 2017 Mar 29. No abstract available.

PMID:
28352105
18.

Evolving interactions between diazotrophic cyanobacterium and phage mediate nitrogen release and host competitive ability.

Cairns J, Coloma S, Sivonen K, Hiltunen T.

R Soc Open Sci. 2016 Dec 14;3(12):160839. doi: 10.1098/rsos.160839. eCollection 2016 Dec.

19.

Genomic evolution of bacterial populations under coselection by antibiotics and phage.

Cairns J, Frickel J, Jalasvuori M, Hiltunen T, Becks L.

Mol Ecol. 2017 Apr;26(7):1848-1859. doi: 10.1111/mec.13950. Epub 2017 Jan 6.

PMID:
27977892
20.

Sublethal streptomycin concentrations and lytic bacteriophage together promote resistance evolution.

Cairns J, Becks L, Jalasvuori M, Hiltunen T.

Philos Trans R Soc Lond B Biol Sci. 2017 Jan 19;372(1712). pii: 20160040.

21.

Antibiotic resistance in the wild: an eco-evolutionary perspective.

Hiltunen T, Virta M, Laine AL.

Philos Trans R Soc Lond B Biol Sci. 2017 Jan 19;372(1712). pii: 20160039. Review.

22.

Newly isolated Nodularia phage influences cyanobacterial community dynamics.

Coloma SE, Dienstbier A, Bamford DH, Sivonen K, Roine E, Hiltunen T.

Environ Microbiol. 2017 Jan;19(1):273-286. doi: 10.1111/1462-2920.13601. Epub 2017 Jan 23.

PMID:
27878952
23.

Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide.

Salvi E, Wang Z, Rizzi F, Gong Y, McDonough CW, Padmanabhan S, Hiltunen TP, Lanzani C, Zaninello R, Chittani M, Bailey KR, Sarin AP, Barcella M, Melander O, Chapman AB, Manunta P, Kontula KK, Glorioso N, Cusi D, Dominiczak AF, Johnson JA, Barlassina C, Boerwinkle E, Cooper-DeHoff RM, Turner ST.

Hypertension. 2017 Jan;69(1):51-59. Epub 2016 Oct 31. Review.

24.

Scoping the effectiveness and evolutionary obstacles in using plasmid-dependent phages to fight antibiotic resistance.

Ojala V, Mattila S, Hoikkala V, Bamford JKh, Hiltunen T, Jalasvuori M.

Future Microbiol. 2016 Aug;11:999-1009. doi: 10.2217/fmb-2016-0038. Epub 2016 Aug 9.

PMID:
27503765
25.

Conjugation is necessary for a bacterial plasmid to survive under protozoan predation.

Cairns J, Jalasvuori M, Ojala V, Brockhurst M, Hiltunen T.

Biol Lett. 2016 Feb;12(2):20150953. doi: 10.1098/rsbl.2015.0953.

26.

PTPRD gene associated with blood pressure response to atenolol and resistant hypertension.

Gong Y, McDonough CW, Beitelshees AL, El Rouby N, Hiltunen TP, O'Connell JR, Padmanabhan S, Langaee TY, Hall K, Schmidt SO, Curry RW Jr, Gums JG, Donner KM, Kontula KK, Bailey KR, Boerwinkle E, Takahashi A, Tanaka T, Kubo M, Chapman AB, Turner ST, Pepine CJ, Cooper-DeHoff RM, Johnson JA.

J Hypertens. 2015 Nov;33(11):2278-85. doi: 10.1097/HJH.0000000000000714.

27.

Environmental fluctuations restrict eco-evolutionary dynamics in predator-prey system.

Hiltunen T, Ayan GB, Becks L.

Proc Biol Sci. 2015 Jun 7;282(1808):20150013. doi: 10.1098/rspb.2015.0013.

28.

Protist predation can select for bacteria with lowered susceptibility to infection by lytic phages.

Örmälä-Odegrip AM, Ojala V, Hiltunen T, Zhang J, Bamford JK, Laakso J.

BMC Evol Biol. 2015 May 7;15:81. doi: 10.1186/s12862-015-0341-1.

29.

TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives.

Chittani M, Zaninello R, Lanzani C, Frau F, Ortu MF, Salvi E, Fresu G, Citterio L, Braga D, Piras DA, Carpini SD, Velayutham D, Simonini M, Argiolas G, Pozzoli S, Troffa C, Glorioso V, Kontula KK, Hiltunen TP, Donner KM, Turner ST, Boerwinkle E, Chapman AB, Padmanabhan S, Dominiczak AF, Melander O, Johnson JA, Cooper-Dehoff RM, Gong Y, Rivera NV, Condorelli G, Trimarco B, Manunta P, Cusi D, Glorioso N, Barlassina C.

J Hypertens. 2015 Jun;33(6):1301-9. doi: 10.1097/HJH.0000000000000541.

30.

Pharmacogenomics of hypertension: a genome‐wide, placebo‐controlled cross‐over study, using four classes of antihypertensive drugs.

Hiltunen TP, Donner KM, Sarin AP, Saarela J, Ripatti S, Chapman AB, Gums JG, Gong Y, Cooper-DeHoff RM, Frau F, Glorioso V, Zaninello R, Salvi E, Glorioso N, Boerwinkle E, Turner ST, Johnson JA, Kontula KK.

J Am Heart Assoc. 2015 Jan 26;4(1):e001521. doi: 10.1161/JAHA.115.001778.

31.

Rapid evolutionary adaptation to elevated salt concentrations in pathogenic freshwater bacteria Serratia marcescens.

Ketola T, Hiltunen T.

Ecol Evol. 2014 Oct;4(20):3901-8. doi: 10.1002/ece3.1253. Epub 2014 Sep 23.

32.

Genome-wide association study identifies CAMKID variants involved in blood pressure response to losartan: the SOPHIA study.

Frau F, Zaninello R, Salvi E, Ortu MF, Braga D, Velayutham D, Argiolas G, Fresu G, Troffa C, Bulla E, Bulla P, Pitzoi S, Piras DA, Glorioso V, Chittani M, Bernini G, Bardini M, Fallo F, Malatino L, Stancanelli B, Regolisti G, Ferri C, Desideri G, Scioli GA, Galletti F, Sciacqua A, Perticone F, Degli Esposti E, Sturani A, Semplicini A, Veglio F, Mulatero P, Williams TA, Lanzani C, Hiltunen TP, Kontula K, Boerwinkle E, Turner ST, Manunta P, Barlassina C, Cusi D, Glorioso N.

Pharmacogenomics. 2014 Sep;15(13):1643-52. doi: 10.2217/pgs.14.119.

PMID:
25410890
33.

Consumer co-evolution as an important component of the eco-evolutionary feedback.

Hiltunen T, Becks L.

Nat Commun. 2014 Oct 22;5:5226. doi: 10.1038/ncomms6226.

PMID:
25335515
34.

Elevated serum squalene and cholesterol synthesis markers in pregnant obese women with gestational diabetes mellitus.

Miettinen HE, Rönö K, Koivusalo S, Stach-Lempinen B, Pöyhönen-Alho M, Eriksson JG, Hiltunen TP, Gylling H.

J Lipid Res. 2014 Dec;55(12):2644-54. doi: 10.1194/jlr.P049510. Epub 2014 Oct 9.

35.

Synchronous multiscale neuroimaging environment for critically sampled physiological analysis of brain function: hepta-scan concept.

Korhonen V, Hiltunen T, Myllylä T, Wang X, Kantola J, Nikkinen J, Zang YF, LeVan P, Kiviniemi V.

Brain Connect. 2014 Nov;4(9):677-89. doi: 10.1089/brain.2014.0258. Epub 2014 Sep 26.

36.

A newly discovered role of evolution in previously published consumer-resource dynamics.

Hiltunen T, Hairston NG Jr, Hooker G, Jones LE, Ellner SP.

Ecol Lett. 2014 Aug;17(8):915-23. doi: 10.1111/ele.12291. Epub 2014 May 12.

PMID:
24813182
37.

Infra-slow EEG fluctuations are correlated with resting-state network dynamics in fMRI.

Hiltunen T, Kantola J, Abou Elseoud A, Lepola P, Suominen K, Starck T, Nikkinen J, Remes J, Tervonen O, Palva S, Kiviniemi V, Palva JM.

J Neurosci. 2014 Jan 8;34(2):356-62. doi: 10.1523/JNEUROSCI.0276-13.2014.

39.

Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide.

Turner ST, Boerwinkle E, O'Connell JR, Bailey KR, Gong Y, Chapman AB, McDonough CW, Beitelshees AL, Schwartz GL, Gums JG, Padmanabhan S, Hiltunen TP, Citterio L, Donner KM, Hedner T, Lanzani C, Melander O, Saarela J, Ripatti S, Wahlstrand B, Manunta P, Kontula K, Dominiczak AF, Cooper-DeHoff RM, Johnson JA.

Hypertension. 2013 Aug;62(2):391-7. doi: 10.1161/HYPERTENSIONAHA.111.00436. Epub 2013 Jun 10.

40.

Generalized glucocorticoid resistance caused by a novel two-nucleotide deletion in the hormone-binding domain of the glucocorticoid receptor gene NR3C1.

Donner KM, Hiltunen TP, Jänne OA, Sane T, Kontula K.

Eur J Endocrinol. 2012 Dec 10;168(1):K9-K18. doi: 10.1530/EJE-12-0532. Print 2013 Jan.

PMID:
23076843
41.

Clinical and molecular approaches to individualize antihypertensive drug therapy.

Hiltunen TP, Kontula K.

Ann Med. 2012 Jun;44 Suppl 1:S23-9. doi: 10.3109/07853890.2012.679960. Review.

PMID:
22713145
42.

Preface to the proceedings of the XVII Paavo Nurmi Symposium.

Hiltunen TP, Pörsti I.

Ann Med. 2012 Jun;44 Suppl 1:S1. doi: 10.3109/07853890.2012.692501. No abstract available.

PMID:
22713138
43.

Effects of long-term intake of lactotripeptides on cardiovascular risk factors in hypertensive subjects.

Jauhiainen T, Niittynen L, Orešič M, Järvenpää S, Hiltunen TP, Rönnback M, Vapaatalo H, Korpela R.

Eur J Clin Nutr. 2012 Jul;66(7):843-9. doi: 10.1038/ejcn.2012.44. Epub 2012 May 23.

PMID:
22617279
44.

Integrated model for providing tactical emergency medicine support (TEMS): analysis of 120 tactical situations.

Vainionpää T, Peräjoki K, Hiltunen T, Porthan K, Taskinen A, Boyd J, Kuisma M.

Acta Anaesthesiol Scand. 2012 Feb;56(2):158-63. doi: 10.1111/j.1399-6576.2011.02565.x. Epub 2011 Oct 19.

PMID:
22092068
45.

STK39 variation predicts the ambulatory blood pressure response to losartan in hypertensive men.

Donner KM, Hiltunen TP, Hannila-Handelberg T, Suonsyrjä T, Kontula K.

Hypertens Res. 2012 Jan;35(1):107-14. doi: 10.1038/hr.2011.166. Epub 2011 Oct 13.

PMID:
21993215
46.

Pulsed-resource dynamics increase the asymmetry of antagonistic coevolution between a predatory protist and a prey bacterium.

Friman VP, Laakso J, Koivu-Orava M, Hiltunen T.

J Evol Biol. 2011 Dec;24(12):2563-73. doi: 10.1111/j.1420-9101.2011.02379.x. Epub 2011 Sep 8.

47.

High temperature and bacteriophages can indirectly select for bacterial pathogenicity in environmental reservoirs.

Friman VP, Hiltunen T, Jalasvuori M, Lindstedt C, Laanto E, Örmälä AM, Laakso J, Mappes J, Bamford JK.

PLoS One. 2011 Mar 15;6(3):e17651. doi: 10.1371/journal.pone.0017651.

48.

Licorice-induced hypertension and common variants of genes regulating renal sodium reabsorption.

Miettinen HE, Piippo K, Hannila-Handelberg T, Paukku K, Hiltunen TP, Gautschi I, Schild L, Kontula K.

Ann Med. 2010 Sep;42(6):465-74. doi: 10.3109/07853890.2010.499133.

PMID:
20597806
49.

Common genetic variation of beta1- and beta2-adrenergic receptor and response to four classes of antihypertensive treatment.

Suonsyrjä T, Donner K, Hannila-Handelberg T, Fodstad H, Kontula K, Hiltunen TP.

Pharmacogenet Genomics. 2010 May;20(5):342-5. doi: 10.1097/FPC.0b013e328338e1b8.

PMID:
20300048
50.

Common genetic variations of the renin-angiotensin-aldosterone system and response to acute angiotensin I-converting enzyme inhibition in essential hypertension.

Hannila-Handelberg T, Kontula KK, Paukku K, Lehtonen JY, Virtamo J, Tikkanen I, Hiltunen TP.

J Hypertens. 2010 Apr;28(4):771-9. doi: 10.1097/HJH.0b013e328335c368.

PMID:
20027122

Supplemental Content

Loading ...
Support Center