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Items: 1 to 50 of 76

1.

Chondrocyte-Specific RUNX2 Overexpression Accelerates Post-traumatic Osteoarthritis Progression in Adult Mice.

Catheline SE, Hoak D, Chang M, Ketz JP, Hilton MJ, Zuscik MJ, Jonason JH.

J Bone Miner Res. 2019 Jun 12. doi: 10.1002/jbmr.3737. [Epub ahead of print]

PMID:
31189030
2.

The CaV1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear.

Cao C, Oswald AB, Fabella BA, Ren Y, Rodriguiz R, Trainor G, Greenblatt MB, Hilton MJ, Pitt GS.

Bone. 2019 Aug;125:160-168. doi: 10.1016/j.bone.2019.05.024. Epub 2019 May 20.

PMID:
31121355
3.

Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells.

Yu Y, Newman H, Shen L, Sharma D, Hu G, Mirando AJ, Zhang H, Knudsen E, Zhang GF, Hilton MJ, Karner CM.

Cell Metab. 2019 Apr 2;29(4):966-978.e4. doi: 10.1016/j.cmet.2019.01.016. Epub 2019 Feb 14.

PMID:
30773468
4.

Diffusion tractography of the rat knee at microscopic resolution.

Wang N, Mirando AJ, Cofer G, Qi Y, Hilton MJ, Johnson GA.

Magn Reson Med. 2019 Jun;81(6):3775-3786. doi: 10.1002/mrm.27652. Epub 2019 Jan 22.

PMID:
30671998
5.

Enantioselective fluorination of homoallylic alcohols enabled by the tuning of non-covalent interactions.

Coelho JAS, Matsumoto A, Orlandi M, Hilton MJ, Sigman MS, Toste FD.

Chem Sci. 2018 Aug 3;9(35):7153-7158. doi: 10.1039/c8sc02223b. eCollection 2018 Sep 21.

6.

The route and rate of thiamethoxam soil degradation in laboratory and outdoor incubated tests, and field studies following seed treatments or spray application.

Hilton MJ, Emburey SN, Edwards PA, Dougan C, Ricketts DC.

Pest Manag Sci. 2019 Jan;75(1):63-78. doi: 10.1002/ps.5168. Epub 2018 Oct 3.

7.

Cell type-specific effects of Notch signaling activation on intervertebral discs: Implications for intervertebral disc degeneration.

Zheng Y, Liu C, Ni L, Liu Z, Mirando AJ, Lin J, Saijilafu, Chen D, Hilton MJ, Li B, Chen J.

J Cell Physiol. 2018 Jul;233(7):5431-5440. doi: 10.1002/jcp.26385. Epub 2018 Jan 19.

8.

Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.

Tsushima H, Tang YJ, Puviindran V, Hsu SC, Nadesan P, Yu C, Zhang H, Mirando AJ, Hilton MJ, Alman BA.

Development. 2018 Jul 9;145(13). pii: dev162396. doi: 10.1242/dev.162396.

9.

Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss.

Cao C, Ren Y, Barnett AS, Mirando AJ, Rouse D, Mun SH, Park-Min KH, McNulty AL, Guilak F, Karner CM, Hilton MJ, Pitt GS.

JCI Insight. 2017 Nov 16;2(22). pii: 95512. doi: 10.1172/jci.insight.95512. eCollection 2017 Nov 16.

10.

Mechanistic Investigations of the Pd(0)-Catalyzed Enantioselective 1,1-Diarylation of Benzyl Acrylates.

Orlandi M, Hilton MJ, Yamamoto E, Toste FD, Sigman MS.

J Am Chem Soc. 2017 Sep 13;139(36):12688-12695. doi: 10.1021/jacs.7b06917. Epub 2017 Aug 30.

11.

Parametrization of Non-covalent Interactions for Transition State Interrogation Applied to Asymmetric Catalysis.

Orlandi M, Coelho JAS, Hilton MJ, Toste FD, Sigman MS.

J Am Chem Soc. 2017 May 24;139(20):6803-6806. doi: 10.1021/jacs.7b02311. Epub 2017 May 11.

12.

Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis.

Dar QA, Schott EM, Catheline SE, Maynard RD, Liu Z, Kamal F, Farnsworth CW, Ketz JP, Mooney RA, Hilton MJ, Jonason JH, Prawitt J, Zuscik MJ.

PLoS One. 2017 Apr 6;12(4):e0174705. doi: 10.1371/journal.pone.0174705. eCollection 2017.

13.

Exploiting non-covalent π interactions for catalyst design.

Neel AJ, Hilton MJ, Sigman MS, Toste FD.

Nature. 2017 Mar 29;543(7647):637-646. doi: 10.1038/nature21701. Review.

14.

The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool.

Lawal RA, Zhou X, Batey K, Hoffman CM, Georger MA, Radtke F, Hilton MJ, Xing L, Frisch BJ, Calvi LM.

J Bone Miner Res. 2017 Jun;32(6):1320-1331. doi: 10.1002/jbmr.3106. Epub 2017 Mar 9.

15.

Development and Analysis of a Pd(0)-Catalyzed Enantioselective 1,1-Diarylation of Acrylates Enabled by Chiral Anion Phase Transfer.

Yamamoto E, Hilton MJ, Orlandi M, Saini V, Toste FD, Sigman MS.

J Am Chem Soc. 2016 Dec 14;138(49):15877-15880. Epub 2016 Nov 30.

16.

Palladium-Catalyzed Enantioselective Redox-Relay Heck Arylation of 1,1-Disubstituted Homoallylic Alcohols.

Chen ZM, Hilton MJ, Sigman MS.

J Am Chem Soc. 2016 Sep 14;138(36):11461-4. doi: 10.1021/jacs.6b06994. Epub 2016 Sep 1.

17.

Use of Hes1-GFP reporter mice to assess activity of the Hes1 promoter in bone cells under chronic inflammation.

Zhang H, Sun W, Li X, Wang M, Boyce BF, Hilton MJ, Xing L.

Bone. 2016 Sep;90:80-9. doi: 10.1016/j.bone.2016.06.003. Epub 2016 Jun 4.

18.

HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development.

Rutkowski TP, Kohn A, Sharma D, Ren Y, Mirando AJ, Hilton MJ.

J Cell Sci. 2016 Jun 1;129(11):2145-55. doi: 10.1242/jcs.181271. Epub 2016 May 9.

19.

Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest.

Shang X, Wang J, Luo Z, Wang Y, Morandi MM, Marymont JV, Hilton MJ, Dong Y.

Sci Rep. 2016 May 5;6:25594. doi: 10.1038/srep25594.

20.

NOTCH signaling in skeletal progenitors is critical for fracture repair.

Wang C, Inzana JA, Mirando AJ, Ren Y, Liu Z, Shen J, O'Keefe RJ, Awad HA, Hilton MJ.

J Clin Invest. 2016 Apr 1;126(4):1471-81. doi: 10.1172/JCI80672. Epub 2016 Mar 7.

21.

Suppressive Effects of Insulin on Tumor Necrosis Factor-Dependent Early Osteoarthritic Changes Associated With Obesity and Type 2 Diabetes Mellitus.

Hamada D, Maynard R, Schott E, Drinkwater CJ, Ketz JP, Kates SL, Jonason JH, Hilton MJ, Zuscik MJ, Mooney RA.

Arthritis Rheumatol. 2016 Jun;68(6):1392-402. doi: 10.1002/art.39561.

22.

Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9.

Kohn A, Rutkowski TP, Liu Z, Mirando AJ, Zuscik MJ, O'Keefe RJ, Hilton MJ.

Bone Res. 2015 Aug 11;3:15021. doi: 10.1038/boneres.2015.21. eCollection 2015.

23.

Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance.

Liu Z, Ren Y, Mirando AJ, Wang C, Zuscik MJ, O'Keefe RJ, Hilton MJ.

Osteoarthritis Cartilage. 2016 Apr;24(4):740-51. doi: 10.1016/j.joca.2015.10.015. Epub 2015 Oct 30.

24.

Relative reactivity of alkenyl alcohols in the palladium-catalyzed redox-relay Heck reaction.

Hilton MJ, Cheng B, Buckley BR, Xu L, Wiest O, Sigman MS.

Tetrahedron. 2015 Sep 16;71(37):6513-6518.

25.

CCN1 Regulates Chondrocyte Maturation and Cartilage Development.

Zhang Y, Sheu TJ, Hoak D, Shen J, Hilton MJ, Zuscik MJ, Jonason JH, O'Keefe RJ.

J Bone Miner Res. 2016 Mar;31(3):549-59. doi: 10.1002/jbmr.2712.

26.

A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.

Liu Z, Chen J, Mirando AJ, Wang C, Zuscik MJ, O'Keefe RJ, Hilton MJ.

Sci Signal. 2015 Jul 21;8(386):ra71. doi: 10.1126/scisignal.aaa3792.

27.

The degradation rate of thiamethoxam in European field studies.

Hilton MJ, Jarvis TD, Ricketts DC.

Pest Manag Sci. 2016 Feb;72(2):388-97. doi: 10.1002/ps.4024. Epub 2015 May 19.

PMID:
25884469
28.

Transient gamma-secretase inhibition accelerates and enhances fracture repair likely via Notch signaling modulation.

Wang C, Shen J, Yukata K, Inzana JA, O'Keefe RJ, Awad HA, Hilton MJ.

Bone. 2015 Apr;73:77-89. doi: 10.1016/j.bone.2014.12.007. Epub 2014 Dec 16.

29.

NOTCH-Mediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A Technology Designed for Orthopedic Regenerative Medicine.

Dong Y, Long T, Wang C, Mirando AJ, Chen J, O'Keefe RJ, Hilton MJ.

Stem Cells Transl Med. 2014 Dec;3(12):1456-66. doi: 10.5966/sctm.2014-0034. Epub 2014 Nov 3.

30.

Investigating the nature of palladium chain-walking in the enantioselective redox-relay Heck reaction of alkenyl alcohols.

Hilton MJ, Xu LP, Norrby PO, Wu YD, Wiest O, Sigman MS.

J Org Chem. 2014 Dec 19;79(24):11841-50. doi: 10.1021/jo501813d. Epub 2014 Sep 10.

31.

Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus.

Brown ML, Yukata K, Farnsworth CW, Chen DG, Awad H, Hilton MJ, O'Keefe RJ, Xing L, Mooney RA, Zuscik MJ.

PLoS One. 2014 Jun 9;9(6):e99656. doi: 10.1371/journal.pone.0099656. eCollection 2014.

32.

NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB.

Zhang H, Hilton MJ, Anolik JH, Welle SL, Zhao C, Yao Z, Li X, Wang Z, Boyce BF, Xing L.

J Clin Invest. 2014 Jul;124(7):3200-14. doi: 10.1172/JCI68901. Epub 2014 Jun 2.

33.

Isolation and culture of murine primary chondrocytes.

Mirando AJ, Dong Y, Kim J, Hilton MJ.

Methods Mol Biol. 2014;1130:267-277. doi: 10.1007/978-1-62703-989-5_20.

PMID:
24482180
34.

Whole-mount in situ hybridization on murine skeletogenic tissues.

Rutkowsky T, Sharma D, Hilton MJ.

Methods Mol Biol. 2014;1130:193-201. doi: 10.1007/978-1-62703-989-5_14. Erratum in: Methods Mol Biol. 2014;1130:E1. Rutkowsky, Timothy [corrected to Rutkowski, Timothy].

PMID:
24482174
35.

Demineralized murine skeletal histology.

Mack SA, Maltby KM, Hilton MJ.

Methods Mol Biol. 2014;1130:165-183. doi: 10.1007/978-1-62703-989-5_12.

PMID:
24482172
36.

Mechanism, reactivity, and selectivity in palladium-catalyzed redox-relay Heck arylations of alkenyl alcohols.

Xu L, Hilton MJ, Zhang X, Norrby PO, Wu YD, Sigman MS, Wiest O.

J Am Chem Soc. 2014 Feb 5;136(5):1960-7. doi: 10.1021/ja4109616. Epub 2014 Jan 22.

37.

Multiple hereditary exostoses (MHE): elucidating the pathogenesis of a rare skeletal disorder through interdisciplinary research.

Jones KB, Pacifici M, Hilton MJ.

Connect Tissue Res. 2014 Apr;55(2):80-8. doi: 10.3109/03008207.2013.867957. Epub 2014 Feb 12.

PMID:
24409815
38.

The effect of mesenchymal stem cell sheets on structural allograft healing of critical sized femoral defects in mice.

Long T, Zhu Z, Awad HA, Schwarz EM, Hilton MJ, Dong Y.

Biomaterials. 2014 Mar;35(9):2752-9. doi: 10.1016/j.biomaterials.2013.12.039. Epub 2014 Jan 3.

39.

TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages.

Gao L, Sheu TJ, Dong Y, Hoak DM, Zuscik MJ, Schwarz EM, Hilton MJ, O'Keefe RJ, Jonason JH.

J Cell Sci. 2013 Dec 15;126(Pt 24):5704-13. doi: 10.1242/jcs.135483. Epub 2013 Oct 21.

40.

RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance.

Mirando AJ, Liu Z, Moore T, Lang A, Kohn A, Osinski AM, O'Keefe RJ, Mooney RA, Zuscik MJ, Hilton MJ.

Arthritis Rheum. 2013 Oct;65(10):2623-33. doi: 10.1002/art.38076.

41.

Troponin T3 expression in skeletal and smooth muscle is required for growth and postnatal survival: characterization of Tnnt3(tm2a(KOMP)Wtsi) mice.

Ju Y, Li J, Xie C, Ritchlin CT, Xing L, Hilton MJ, Schwarz EM.

Genesis. 2013 Sep;51(9):667-75. doi: 10.1002/dvg.22407. Epub 2013 Jul 9.

42.

Engineering superficial zone features in tissue engineered cartilage.

Chen T, Hilton MJ, Brown EB, Zuscik MJ, Awad HA.

Biotechnol Bioeng. 2013 May;110(5):1476-86. doi: 10.1002/bit.24799. Epub 2012 Dec 27.

43.

Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development.

Dao DY, Jonason JH, Zhang Y, Hsu W, Chen D, Hilton MJ, O'Keefe RJ.

J Bone Miner Res. 2012 Aug;27(8):1680-94. doi: 10.1002/jbmr.1639.

44.

Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes.

Kim KO, Sampson ER, Maynard RD, O'Keefe RJ, Chen D, Drissi H, Rosier RN, Hilton MJ, Zuscik MJ.

J Cell Biochem. 2012 Jun;113(6):2156-66. doi: 10.1002/jcb.24089.

45.

Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development.

Kohn A, Dong Y, Mirando AJ, Jesse AM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ.

Development. 2012 Mar;139(6):1198-212. doi: 10.1242/dev.070649.

46.

BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development.

Shu B, Zhang M, Xie R, Wang M, Jin H, Hou W, Tang D, Harris SE, Mishina Y, O'Keefe RJ, Hilton MJ, Wang Y, Chen D.

J Cell Sci. 2011 Oct 15;124(Pt 20):3428-40. doi: 10.1242/jcs.083659. Epub 2011 Oct 7.

47.

Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis.

Sampson ER, Hilton MJ, Tian Y, Chen D, Schwarz EM, Mooney RA, Bukata SV, O'Keefe RJ, Awad H, Puzas JE, Rosier RN, Zuscik MJ.

Sci Transl Med. 2011 Sep 21;3(101):101ra93. doi: 10.1126/scitranslmed.3002214.

48.

TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: limitations of anti-TNF therapy for degenerative disc disease.

Papuga MO, Kwok E, You Z, Rubery PT, Dougherty PE, Pryhuber G, Beck CA, Hilton MJ, Awad HA, Schwarz EM.

J Orthop Res. 2011 Sep;29(9):1367-74. doi: 10.1002/jor.21370. Epub 2011 Mar 28.

49.

Establishment of an index with increased sensitivity for assessing murine arthritis.

Sampson ER, Beck CA, Ketz J, Canary KL, Hilton MJ, Awad H, Schwarz EM, Chen D, O'Keefe RJ, Rosier RN, Zuscik MJ.

J Orthop Res. 2011 Aug;29(8):1145-51. doi: 10.1002/jor.21368. Epub 2011 Mar 3.

50.

Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing.

Katzel EB, Wolenski M, Loiselle AE, Basile P, Flick LM, Langstein HN, Hilton MJ, Awad HA, Hammert WC, O'Keefe RJ.

J Orthop Res. 2011 May;29(5):684-93. doi: 10.1002/jor.21235. Epub 2010 Sep 14.

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