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Items: 12


Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release.

Szot C, Saha S, Zhang XM, Zhu Z, Hilton MB, Morris K, Seaman S, Dunleavey JM, Hsu KS, Yu GJ, Morris H, Swing DA, Haines DC, Wang Y, Hwang J, Feng Y, Welsch D, DeCrescenzo G, Chaudhary A, Zudaire E, Dimitrov DS, St Croix B.

J Clin Invest. 2018 Jul 2;128(7):2927-2943. doi: 10.1172/JCI120481. Epub 2018 Jun 4.


Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature.

Seaman S, Zhu Z, Saha S, Zhang XM, Yang MY, Hilton MB, Morris K, Szot C, Morris H, Swing DA, Tessarollo L, Smith SW, Degrado S, Borkin D, Jain N, Scheiermann J, Feng Y, Wang Y, Li J, Welsch D, DeCrescenzo G, Chaudhary A, Zudaire E, Klarmann KD, Keller JR, Dimitrov DS, St Croix B.

Cancer Cell. 2017 Apr 10;31(4):501-515.e8. doi: 10.1016/j.ccell.2017.03.005.


GPR124 functions as a WNT7-specific coactivator of canonical β-catenin signaling.

Posokhova E, Shukla A, Seaman S, Volate S, Hilton MB, Wu B, Morris H, Swing DA, Zhou M, Zudaire E, Rubin JS, St Croix B.

Cell Rep. 2015 Jan 13;10(2):123-30. doi: 10.1016/j.celrep.2014.12.020. Epub 2014 Dec 31.


COX-2 inhibition potentiates antiangiogenic cancer therapy and prevents metastasis in preclinical models.

Xu L, Stevens J, Hilton MB, Seaman S, Conrads TP, Veenstra TD, Logsdon D, Morris H, Swing DA, Patel NL, Kalen J, Haines DC, Zudaire E, St Croix B.

Sci Transl Med. 2014 Jun 25;6(242):242ra84. doi: 10.1126/scitranslmed.3008455.


Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116.

Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B.

Cell Rep. 2013 May 30;3(5):1457-64. doi: 10.1016/j.celrep.2013.04.019. Epub 2013 May 16.


TEM8/ANTXR1 blockade inhibits pathological angiogenesis and potentiates tumoricidal responses against multiple cancer types.

Chaudhary A, Hilton MB, Seaman S, Haines DC, Stevenson S, Lemotte PK, Tschantz WR, Zhang XM, Saha S, Fleming T, St Croix B.

Cancer Cell. 2012 Feb 14;21(2):212-26. doi: 10.1016/j.ccr.2012.01.004.


GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.

Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5759-64. doi: 10.1073/pnas.1017192108. Epub 2011 Mar 18.


Host-derived tumor endothelial marker 8 promotes the growth of melanoma.

Cullen M, Seaman S, Chaudhary A, Yang MY, Hilton MB, Logsdon D, Haines DC, Tessarollo L, St Croix B.

Cancer Res. 2009 Aug 1;69(15):6021-6. doi: 10.1158/0008-5472.CAN-09-1086. Epub 2009 Jul 21.


Cdk2 and Cdk4 activities are dispensable for tumorigenesis caused by the loss of p53.

Padmakumar VC, Aleem E, Berthet C, Hilton MB, Kaldis P.

Mol Cell Biol. 2009 May;29(10):2582-93. doi: 10.1128/MCB.00952-08. Epub 2009 Mar 23.


Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G1/S transition.

Li W, Kotoshiba S, Berthet C, Hilton MB, Kaldis P.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):486-91. doi: 10.1073/pnas.0804177106. Epub 2009 Jan 7.


p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint.

Satyanarayana A, Hilton MB, Kaldis P.

Mol Biol Cell. 2008 Jan;19(1):65-77. Epub 2007 Oct 17.


Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation.

Berthet C, Klarmann KD, Hilton MB, Suh HC, Keller JR, Kiyokawa H, Kaldis P.

Dev Cell. 2006 May;10(5):563-73.

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