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Clinical and lung function outcomes in a cohort of children with severe asthma.

de Gouveia Belinelo P, Nielsen A, Goddard B, Platt L, Da Silva Sena CR, Robinson PD, Whitehead B, Hilton J, Gulliver T, Roddick L, Pearce K, Murphy VE, Gibson PG, Collison A, Mattes J.

BMC Pulm Med. 2020 Mar 18;20(1):66. doi: 10.1186/s12890-020-1101-6.


A phase IB study of durvalumab with or without tremelimumab and platinum-doublet chemotherapy in advanced solid tumours: Canadian Cancer Trials Group Study IND226.

Juergens RA, Hao D, Ellis PM, Tu D, Mates M, Kollmannsberger C, Bradbury PA, Tehfe M, Wheatley-Price P, Robinson A, Bebb G, Laskin J, Goffin J, Hilton J, Tomiak A, Hotte S, Goss GD, Brown-Walker P, Sun X, Tsao MS, Cabanero M, Gauthier I, Song X, Dennis PA, Seymour LK, Smoragiewicz M, Laurie SA.

Lung Cancer. 2020 Feb 28;143:1-11. doi: 10.1016/j.lungcan.2020.02.016. [Epub ahead of print] Review.


Superoxide dismutase 1 in health and disease: How a front-line antioxidant becomes neurotoxic.

Trist B, Hilton JB, Crouch PJ, Hare DJ, Double KL.

Angew Chem Int Ed Engl. 2020 Mar 6. doi: 10.1002/anie.202000451. [Epub ahead of print]


A novel, more reliable approach to use of progression-free survival as a predictor of gain in overall survival: The Ottawa PFS Predictive Model.

Stewart DJ, Bossé D, Goss G, Hilton JF, Jonker D, Fung-Kee-Fung M.

Crit Rev Oncol Hematol. 2020 Apr;148:102896. doi: 10.1016/j.critrevonc.2020.102896. Epub 2020 Feb 8. Review.


Characterising a Weight Loss Intervention in Obese Asthmatic Children.

Eslick S, Jensen ME, Collins CE, Gibson PG, Hilton J, Wood LG.

Nutrients. 2020 Feb 17;12(2). pii: E507. doi: 10.3390/nu12020507.


Antenatal blood transfusion in South Africa: indications and practice in a high-HIV-prevalence setting.

Bloch EM, Hull J, Green-Thompson R, Ingram C, Crookes RL, Fawcus S, Anthony J, Courtney L, Roubinian N, Jauregui A, Hilton JF, Murphy EL; NHLBI REDS-III South Africa Program.

Transfusion. 2020 Mar;60(3):479-487. doi: 10.1111/trf.15661. Epub 2020 Jan 7.


Structure-Based Design of Novel Biphenyl Amide Antagonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 8 Channels with Potential Implications in the Treatment of Sensory Neuropathies.

Journigan VB, Feng Z, Rahman S, Wang Y, Amin ARMR, Heffner CE, Bachtel N, Wang S, Gonzalez-Rodriguez S, Fernández-Carvajal A, Fernández-Ballester G, Hilton JK, Van Horn WD, Ferrer-Montiel A, Xie XQ, Rahman T.

ACS Chem Neurosci. 2020 Feb 5;11(3):268-290. doi: 10.1021/acschemneuro.9b00404. Epub 2020 Jan 9.


The ENCODE Portal as an Epigenomics Resource.

Jou J, Gabdank I, Luo Y, Lin K, Sud P, Myers Z, Hilton JA, Kagda MS, Lam B, O'Neill E, Adenekan P, Graham K, Baymuradov UK, R Miyasato S, Strattan JS, Jolanki O, Lee JW, Litton C, Y Tanaka F, Hitz BC, Cherry JM.

Curr Protoc Bioinformatics. 2019 Dec;68(1):e89. doi: 10.1002/cpbi.89.


New developments on the Encyclopedia of DNA Elements (ENCODE) data portal.

Luo Y, Hitz BC, Gabdank I, Hilton JA, Kagda MS, Lam B, Myers Z, Sud P, Jou J, Lin K, Baymuradov UK, Graham K, Litton C, Miyasato SR, Strattan JS, Jolanki O, Lee JW, Tanaka FY, Adenekan P, O'Neill E, Cherry JM.

Nucleic Acids Res. 2020 Jan 8;48(D1):D882-D889. doi: 10.1093/nar/gkz1062.


OCTANE (Ontario-wide Cancer Targeted Nucleic Acid Evaluation): a platform for intraprovincial, national, and international clinical data-sharing.

Malone ER, Saleh RR, Yu C, Ahmed L, Pugh T, Torchia J, Bartlett J, Virtanen C, Hotte SJ, Hilton J, Welch S, Robinson A, McCready E, Lo B, Sadikovic B, Feilotter H, Hanna TP, Kamel-Reid S, Stockley TL, Siu LL, Bedard PL.

Curr Oncol. 2019 Oct;26(5):e618-e623. doi: 10.3747/co.26.5235. Epub 2019 Oct 1.


Careless costs related to inefficient technology used within NHS England.

Hilton J.

Clin Med (Lond). 2020 Jan;20(1):115. doi: 10.7861/clinmed.2019-0340. Epub 2019 Nov 8. No abstract available.


Proficiency Testing of Viral Marker Screening in African Blood Centers - Seven African Countries, 2017.

Drammeh B, Laperche S, Hilton JF, Kaidarova Z, Ozeryansky L, De A, Kalou M, Benech I, Parekh B, Murphy EL; CDC Proficiency Testing Study Group.

MMWR Morb Mortal Wkly Rep. 2019 Oct 25;68(42):947-952. doi: 10.15585/mmwr.mm6842a3.


Selecting Patients for Oncotype DX Testing Using Standard Clinicopathologic Information.

Robertson SJ, Pond GR, Hilton J, Petkiewicz SL, Ayroud Y, Kos Z, Gravel DH, Stober C, Vandermeer L, Arnaout A, Clemons M.

Clin Breast Cancer. 2020 Feb;20(1):61-67. doi: 10.1016/j.clbc.2019.07.006. Epub 2019 Aug 22.


Behavioral Treatment of Self-Injury: 2001 to 2016.

Shawler LA, Russo SR, Hilton JL, Kahng S, Davis CJ, Dorsey MF.

Am J Intellect Dev Disabil. 2019 Sep;124(5):450-469. doi: 10.1352/1944-7558-124.5.450.


Effects of the levonorgestrel-containing intrauterine device, copper intrauterine device, and levonorgestrel-containing oral contraceptive on susceptibility of immune cells from cervix, endometrium and blood to HIV-1 fusion measured ex vivo.

Cavrois M, Hilton JF, Roan NR, Takeda M, Seidman D, Averbach S, Chang E, Raman N, Greenblatt R, Shacklett BL, Smith-McCune K.

PLoS One. 2019 Aug 22;14(8):e0221181. doi: 10.1371/journal.pone.0221181. eCollection 2019.


A Phase Ib Trial of Durvalumab in Combination with Trastuzumab in HER2-Positive Metastatic Breast Cancer (CCTG IND.229).

Chia S, Bedard PL, Hilton J, Amir E, Gelmon K, Goodwin R, Villa D, Cabanero M, Tu D, Tsao M, Seymour L.

Oncologist. 2019 Nov;24(11):1439-1445. doi: 10.1634/theoncologist.2019-0321. Epub 2019 Aug 16.


Randomized window of opportunity trial evaluating high-dose vitamin D in breast cancer patients.

Arnaout A, Robertson S, Pond GR, Vieth R, Jeong A, Hilton J, Ramsey T, Clemons M.

Breast Cancer Res Treat. 2019 Nov;178(2):347-356. doi: 10.1007/s10549-019-05392-9. Epub 2019 Aug 9.


A randomized, double-blind, window of opportunity trial evaluating the effects of chloroquine in breast cancer patients.

Arnaout A, Robertson SJ, Pond GR, Lee H, Jeong A, Ianni L, Kroeger L, Hilton J, Coupland S, Gottlieb C, Hurley B, McCarthy A, Clemons M.

Breast Cancer Res Treat. 2019 Nov;178(2):327-335. doi: 10.1007/s10549-019-05381-y. Epub 2019 Aug 7.


Incorporating household structure and demography into models of endemic disease.

Hilton J, Keeling MJ.

J R Soc Interface. 2019 Aug 30;16(157):20190317. doi: 10.1098/rsif.2019.0317. Epub 2019 Aug 7.


The impact of recipient factors on the lower-than-expected hemoglobin increment in transfused outpatients with hematologic diseases.

Karafin MS, Bruhn R, Roubinian NH, Chowdhury D, Qu L, Snyder EL, Murphy EL, Brambilla D, Cable RG, Hilton JF, St Lezin E; NHLBI Recipient Epidemiology and Donor Evaluation (REDS)-III Study.

Transfusion. 2019 Aug;59(8):2544-2550. doi: 10.1111/trf.15439. Epub 2019 Jul 4.


Angioleiomyoma of the inferior turbinate: a rare cause of isolated facial pain.

Heyman J, Jones LM, Hilton JM, Cooke JS, Viswanathan H, Hayes SM.

Ann R Coll Surg Engl. 2020 Feb;102(2):e20-e22. doi: 10.1308/rcsann.2019.0086. Epub 2019 Jun 20.


Why "Reply All" Can Push All the Wrong Buttons.

McGee S, Clemons M, Joy AA, Hilton J, Jeong A, Robinson A.

Oncologist. 2019 Aug;24(8):e643-e645. doi: 10.1634/theoncologist.2019-0304. Epub 2019 Jun 4.


Structural and Evolutionary Insights Point to Allosteric Regulation of TRP Ion Channels.

Hilton JK, Kim M, Van Horn WD.

Acc Chem Res. 2019 Jun 18;52(6):1643-1652. doi: 10.1021/acs.accounts.9b00075. Epub 2019 May 31.


Creating a pragmatic trials program for breast cancer patients: Rethinking Clinical Trials (REaCT).

Basulaiman B, Awan AA, Fergusson D, Vandermeer L, Arnaout A, Hilton J, Hutton B, Joy AA, Robinson A, Califaretti N, Stober C, Sienkiewicz M, Thavorn K, Clemons M.

Breast Cancer Res Treat. 2019 Aug;177(1):93-101. doi: 10.1007/s10549-019-05274-0. Epub 2019 May 24. Review.


De-escalation of bone-modifying agents in patients with bone metastases from breast cancer: a systematic review and meta-analysis.

Awan AA, Hutton B, Hilton J, Mazzarello S, Van Poznak C, Vandermeer L, Bota B, Stober C, Sienkiewicz M, Fergusson D, Shorr R, Clemons M.

Breast Cancer Res Treat. 2019 Aug;176(3):507-517. doi: 10.1007/s10549-019-05265-1. Epub 2019 May 11.


A phase 2, open-label study of brentuximab vedotin in patients with CD30-expressing solid tumors.

Sharman JP, Wheler JJ, Einhorn L, Dowlati A, Shapiro GI, Hilton J, Burke JM, Siddiqi T, Whiting N, Jalal SI.

Invest New Drugs. 2019 Aug;37(4):738-747. doi: 10.1007/s10637-019-00768-6. Epub 2019 Apr 16.


Promoting Shared Decision-Making Behaviors During Inpatient Rounds: A Multimodal Educational Intervention.

Harman SM, Blankenburg R, Satterfield JM, Monash B, Rennke S, Yuan P, Sakai DS, Huynh E, Chua I, Hilton JF; Patient Engagement Project.

Acad Med. 2019 Jul;94(7):1010-1018. doi: 10.1097/ACM.0000000000002715.


Therapeutic impact of red blood cell transfusion on anemic outpatients: the RETRO study.

St Lezin E, Karafin MS, Bruhn R, Chowdhury D, Qu L, Bialkowski W, Merenda S, D'Andrea P, McCalla AL, Anderson L, Keating SM, Stone M, Snyder EL, Brambilla D, Murphy EL, Norris PJ, Hilton JF, Spencer BR, Kleinman S, Carson JL; NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS)-III Program.

Transfusion. 2019 Jun;59(6):1934-1943. doi: 10.1111/trf.15249. Epub 2019 Mar 18.


Effect of Prenatal Docosahexaenoic Acid Supplementation on Blood Pressure in Children With Overweight Condition or Obesity: A Secondary Analysis of a Randomized Clinical Trial.

Kerling EH, Hilton JM, Thodosoff JM, Wick J, Colombo J, Carlson SE.

JAMA Netw Open. 2019 Feb 1;2(2):e190088. doi: 10.1001/jamanetworkopen.2019.0088.


How deep is the conflict between molecular and fossil evidence on the age of angiosperms?

Coiro M, Doyle JA, Hilton J.

New Phytol. 2019 Jul;223(1):83-99. doi: 10.1111/nph.15708. Epub 2019 Feb 26. Review.


Does integration of Magee equations into routine clinical practice affect whether oncologists order the Oncotype DX test? A prospective randomized trial.

Robertson SJ, Ibrahim MFK, Stober C, Hilton J, Kos Z, Mazzarello S, Ramsay T, Fergusson D, Vandermeer L, Mallick R, Arnaout A, Dent SF, Segal R, Sehdev S, Gertler S, Hutton B, Clemons M.

J Eval Clin Pract. 2019 Apr;25(2):196-204. doi: 10.1111/jep.13094. Epub 2019 Jan 23.


Effect of endometrial injury on in vitro fertilization pregnancy rates: a randomized, multicentre study.

Hilton J, Liu KE, Laskin CA, Havelock J.

Arch Gynecol Obstet. 2019 Apr;299(4):1159-1164. doi: 10.1007/s00404-019-05044-9. Epub 2019 Jan 19.


Conflict of interest: "Be rigorous in judging ourselves and gracious in judging others".

Basulaiman B, Awan A, Hilton JF, Clemons M.

Curr Oncol. 2018 Dec;25(6):355-357. doi: 10.3747/co.25.4587. Epub 2018 Dec 1. No abstract available.


Complete Genome Sequences of 18 Paenibacillus larvae Phages from the Western United States.

Merrill BD, Fajardo CP, Hilton JA, Payne AM, Ward AT, Walker JK, Dhalai A, Imahara C, Mangohig J, Monk J, Pascacio C, Rai P, Salisbury A, Velez K, Bloomfield TJ, Buhler B, Duncan SG, Fuhriman DA, George J, Graves K, Heaton K, Hill HL, Kim M, Knabe BK, Ririe DB, Rogers SL, Stamereilers C, Stephenson MB, Usher BK, Ward CS, Withers JM, Wright CK, Breakwell DP, Grose JH, Hope S, Tsourkas PK.

Microbiol Resour Announc. 2018 Oct 4;7(13). pii: e00966-18. doi: 10.1128/MRA.00966-18. eCollection 2018 Oct.


Bystander Phage Therapy: Inducing Host-Associated Bacteria to Produce Antimicrobial Toxins against the Pathogen Using Phages.

Brady TS, Fajardo CP, Merrill BD, Hilton JA, Graves KA, Eggett DL, Hope S.

Antibiotics (Basel). 2018 Dec 4;7(4). pii: E105. doi: 10.3390/antibiotics7040105.


A prospective intervention to improve happiness and reduce burnout in oncologists.

Clemons M, Mazzarello S, Pond G, Amir E, Asmis T, Berry S, Brackstone M, Brule S, Goodwin R, Hilton JF, Julião M, Nicholas G, Stewart DJ, Wheatley-Price P, Cholmsky L, Krentel A, Hutton B, Joy AA.

Support Care Cancer. 2019 Apr;27(4):1563-1572. doi: 10.1007/s00520-018-4567-5. Epub 2018 Nov 30.


Physician Survey of Timing of Adjuvant Endocrine Therapy Relative to Radiotherapy in Early Stage Breast Cancer Patients.

McGee SF, Vandermeer L, Mazzarello S, Sienkiewicz M, Stober C, Hutton B, Fergusson D, Hilton J, Caudrelier JM, Blanchette P, Clemons M.

Clin Breast Cancer. 2019 Feb;19(1):e40-e47. doi: 10.1016/j.clbc.2018.08.012. Epub 2018 Sep 4.


Nasal obstruction secondary to an inverted midline supernumerary tooth.

Jones L, Hilton JM, Heyman J, Viswanathan H, Wreesmann VB, Hayes SM.

Ann R Coll Surg Engl. 2019 Jan;101(1):e14-e16. doi: 10.1308/rcsann.2018.0163. Epub 2018 Oct 5.


Anatomical redistribution of endogenous copper in embryonic mice overexpressing SOD1.

Kysenius K, Hilton JB, Paul B, Hare DJ, Crouch PJ.

Metallomics. 2019 Jan 23;11(1):141-150. doi: 10.1039/c8mt00242h.


A versatile quantitative microdroplet elemental imaging method optimised for integration in biochemical workflows for low-volume samples.

Kysenius K, Paul B, Hilton JB, Liddell JR, Hare DJ, Crouch PJ.

Anal Bioanal Chem. 2019 Jan;411(3):603-616. doi: 10.1007/s00216-018-1362-6. Epub 2018 Sep 15.


Observation of topological phenomena in a programmable lattice of 1,800 qubits.

King AD, Carrasquilla J, Raymond J, Ozfidan I, Andriyash E, Berkley A, Reis M, Lanting T, Harris R, Altomare F, Boothby K, Bunyk PI, Enderud C, Fréchette A, Hoskinson E, Ladizinsky N, Oh T, Poulin-Lamarre G, Rich C, Sato Y, Smirnov AY, Swenson LJ, Volkmann MH, Whittaker J, Yao J, Ladizinsky E, Johnson MW, Hilton J, Amin MH.

Nature. 2018 Aug;560(7719):456-460. doi: 10.1038/s41586-018-0410-x. Epub 2018 Aug 22.


Perceptions of vascular access for intravenous systemic therapy and risk factors for lymphedema in early-stage breast cancer-a patient survey.

LeVasseur N, Stober C, Ibrahim M, Gertler S, Hilton J, Robinson A, McDiarmid S, Fergusson D, Mazzarello S, Hutton B, Joy AA, McInnes M, Clemons M.

Curr Oncol. 2018 Aug;25(4):e305-e310. doi: 10.3747/co.25.3911. Epub 2018 Aug 14.


Optimizing vascular access for patients receiving intravenous systemic therapy for early-stage breast cancer-a survey of oncology nurses and physicians.

LeVasseur N, Stober C, Daigle K, Robinson A, McDiarmid S, Mazzarello S, Hutton B, Joy A, Fergusson D, Hilton J, McInnes M, Clemons M.

Curr Oncol. 2018 Aug;25(4):e298-e304. doi: 10.3747/co.25.3903. Epub 2018 Aug 14.


Feasibility of using a pragmatic trials model to compare two primary febrile neutropenia prophylaxis regimens (ciprofloxacin versus G-CSF) in patients receiving docetaxel-cyclophosphamide chemotherapy for breast cancer (REaCT-TC).

Clemons M, Mazzarello S, Hilton J, Joy A, Price-Hiller J, Zhu X, Verma S, Kehoe A, Ibrahim MF, Sienkiewicz M, Stober C, Vandermeer L, Hutton B, Mallick R, Fergusson D.

Support Care Cancer. 2019 Apr;27(4):1345-1354. doi: 10.1007/s00520-018-4408-6. Epub 2018 Aug 11.


Lifetime Measurements of Excited States in ^{172}Pt and the Variation of Quadrupole Transition Strength with Angular Momentum.

Cederwall B, Doncel M, Aktas Ö, Ertoprak A, Liotta R, Qi C, Grahn T, Cullen DM, Hodge D, Giles M, Stolze S, Badran H, Braunroth T, Calverley T, Cox DM, Fang YD, Greenlees PT, Hilton J, Ideguchi E, Julin R, Juutinen S, Raju MK, Li H, Liu H, Matta S, Modamio V, Pakarinen J, Papadakis P, Partanen J, Petrache CM, Rahkila P, Ruotsalainen P, Sandzelius M, Sarén J, Scholey C, Sorri J, Subramaniam P, Taylor MJ, Uusitalo J, Valiente-Dobón JJ.

Phys Rev Lett. 2018 Jul 13;121(2):022502. doi: 10.1103/PhysRevLett.121.022502.


Randomised feasibility trial to compare three standard of care chemotherapy regimens for early stage triple-negative breast cancer (REaCT-TNBC trial).

Hilton J, Stober C, Mazzarello S, Vandermeer L, Fergusson D, Hutton B, Clemons M.

PLoS One. 2018 Jul 24;13(7):e0199297. doi: 10.1371/journal.pone.0199297. eCollection 2018.


Optimal sequence of adjuvant endocrine and radiation therapy in early-stage breast cancer - A systematic review.

McGee SF, Mazzarello S, Caudrelier JM, Lima MAG, Hutton B, Sienkiewicz M, Stober C, Fernandes R, Ibrahim MFK, Vandermeer L, Hilton J, Shorr R, Fergusson D, Clemons M.

Cancer Treat Rev. 2018 Sep;69:132-142. doi: 10.1016/j.ctrv.2018.06.015. Epub 2018 Jun 28. Review.


Optimal vascular access strategies for patients receiving chemotherapy for early-stage breast cancer: a systematic review.

Robinson A, Souied O, Bota AB, Levasseur N, Stober C, Hilton J, Kamel D, Hutton B, Vandermeer L, Mazzarello S, Joy AA, Fergusson D, McDiarmid S, McInnes M, Shorr R, Clemons M.

Breast Cancer Res Treat. 2018 Oct;171(3):607-620. doi: 10.1007/s10549-018-4868-x. Epub 2018 Jul 4. Review.


A cholecystokinin B receptor antagonist and cocaine interaction, phase I study.

Elkashef A, Brašić JR, Cantelina LR Jr, Kahn R, Chiang N, Ye W, Zhou Y, Mojsiak J, Warren KR, Crabb A, Hilton J, Wong DF, Vocci F.

CNS Neurosci Ther. 2019 Jan;25(1):136-146. doi: 10.1111/cns.12994. Epub 2018 Jun 20.


The accumulation of enzymatically inactive cuproenzymes is a CNS-specific phenomenon of the SOD1G37R mouse model of ALS and can be restored by overexpressing the human copper transporter hCTR1.

Hilton JB, Kysenius K, White AR, Crouch PJ.

Exp Neurol. 2018 Sep;307:118-128. doi: 10.1016/j.expneurol.2018.06.006. Epub 2018 Jun 12.

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