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Items: 1 to 50 of 192

1.

Combination of mTORC1/2 inhibitor vistusertib plus fulvestrant in vitro and in vivo targets oestrogen receptor-positive endocrine-resistant breast cancer.

Pancholi S, Leal MF, Ribas R, Simigdala N, Schuster E, Chateau-Joubert S, Zabaglo L, Hills M, Dodson A, Gao Q, Johnston SR, Dowsett M, Cosulich SC, Maragoni E, Martin LA.

Breast Cancer Res. 2019 Dec 4;21(1):135. doi: 10.1186/s13058-019-1222-0.

2.
3.

Accuracy and Usability of a Novel Algorithm for Detection of Irregular Pulse Using a Smartwatch Among Older Adults: Observational Study.

Ding EY, Han D, Whitcomb C, Bashar SK, Adaramola O, Soni A, Saczynski J, Fitzgibbons TP, Moonis M, Lubitz SA, Lessard D, Hills MT, Barton B, Chon K, McManus DD.

JMIR Cardio. 2019 May 15;3(1):e13850. doi: 10.2196/13850.

4.

Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation.

Perez MV, Mahaffey KW, Hedlin H, Rumsfeld JS, Garcia A, Ferris T, Balasubramanian V, Russo AM, Rajmane A, Cheung L, Hung G, Lee J, Kowey P, Talati N, Nag D, Gummidipundi SE, Beatty A, Hills MT, Desai S, Granger CB, Desai M, Turakhia MP; Apple Heart Study Investigators.

N Engl J Med. 2019 Nov 14;381(20):1909-1917. doi: 10.1056/NEJMoa1901183.

PMID:
31722151
5.

Identifying new lead structures to enhance tolerance towards drought stress via high-throughput screening giving crops a quantum of solace.

Frackenpohl J, Schneider L, Decker LJB, Dittgen J, Fenkl F, Fischer C, Franke J, Freigang J, Getachew R, Gonzalez Fernandez-Nino SM, Helmke H, Hills MJ, Hohmann S, Kleemann J, Kurowski K, Lange G, Luemmen P, Meyering N, Poree F, Schmutzler D, Wrede S.

Bioorg Med Chem. 2019 Dec 15;27(24):115142. doi: 10.1016/j.bmc.2019.115142. Epub 2019 Oct 19.

PMID:
31685332
6.

The Heart Rhythm Society/American College of Physicians Atrial Fibrillation Screening and Education Initiative.

Rosenfeld LE, Amin AN, Hsu JC, Oxner A, Hills MT, Frankel DS.

Heart Rhythm. 2019 Aug;16(8):e59-e65. doi: 10.1016/j.hrthm.2019.04.007. Epub 2019 Apr 5.

PMID:
30954599
7.

Patient-reported triggers of paroxysmal atrial fibrillation.

Groh CA, Faulkner M, Getabecha S, Taffe V, Nah G, Sigona K, McCall D, Hills MT, Sciarappa K, Pletcher MJ, Olgin JE, Marcus GM.

Heart Rhythm. 2019 Jul;16(7):996-1002. doi: 10.1016/j.hrthm.2019.01.027. Epub 2019 Feb 14.

PMID:
30772533
8.
9.

Rationale and design of a large-scale, app-based study to identify cardiac arrhythmias using a smartwatch: The Apple Heart Study.

Turakhia MP, Desai M, Hedlin H, Rajmane A, Talati N, Ferris T, Desai S, Nag D, Patel M, Kowey P, Rumsfeld JS, Russo AM, Hills MT, Granger CB, Mahaffey KW, Perez MV.

Am Heart J. 2019 Jan;207:66-75. doi: 10.1016/j.ahj.2018.09.002. Epub 2018 Sep 8.

10.

Association of p27 and Cyclin D1 Expression and Benefit from Adjuvant Trastuzumab Treatment in HER2-Positive Early Breast Cancer: A TransHERA Study.

Filipits M, Dafni U, Gnant M, Polydoropoulou V, Hills M, Kiermaier A, de Azambuja E, Larsimont D, Rojo F, Viale G, Toi M, Harbeck N, Prichard KI, Gelber RD, Dinh P, Zardavas D, Leyland-Jones B, Piccart-Gebhart MJ, Dowsett M; TransHERA investigators.

Clin Cancer Res. 2018 Jul 1;24(13):3079-3086. doi: 10.1158/1078-0432.CCR-17-3473. Epub 2018 Mar 12.

11.

The transformative power of understanding and trust in AF care: How doctors can provide better treatment by understanding the hearts - and minds - of AF patients.

Hills MT.

J Cardiovasc Electrophysiol. 2018 Apr;29(4):641-642. doi: 10.1111/jce.13443. Epub 2018 Feb 23. No abstract available.

PMID:
29399919
12.

Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance.

Martin LA, Ribas R, Simigdala N, Schuster E, Pancholi S, Tenev T, Gellert P, Buluwela L, Harrod A, Thornhill A, Nikitorowicz-Buniak J, Bhamra A, Turgeon MO, Poulogiannis G, Gao Q, Martins V, Hills M, Garcia-Murillas I, Fribbens C, Patani N, Li Z, Sikora MJ, Turner N, Zwart W, Oesterreich S, Carroll J, Ali S, Dowsett M.

Nat Commun. 2017 Nov 30;8(1):1865. doi: 10.1038/s41467-017-01864-y.

13.

NHS is not all that bad.

Hills M.

Br J Gen Pract. 2017 Nov;67(664):504. doi: 10.3399/bjgp17X693269. No abstract available.

14.

Single-cell template strand sequencing by Strand-seq enables the characterization of individual homologs.

Sanders AD, Falconer E, Hills M, Spierings DCJ, Lansdorp PM.

Nat Protoc. 2017 Jun;12(6):1151-1176. doi: 10.1038/nprot.2017.029. Epub 2017 May 11.

PMID:
28492527
15.

Screening for Atrial Fibrillation: A Report of the AF-SCREEN International Collaboration.

Freedman B, Camm J, Calkins H, Healey JS, Rosenqvist M, Wang J, Albert CM, Anderson CS, Antoniou S, Benjamin EJ, Boriani G, Brachmann J, Brandes A, Chao TF, Conen D, Engdahl J, Fauchier L, Fitzmaurice DA, Friberg L, Gersh BJ, Gladstone DJ, Glotzer TV, Gwynne K, Hankey GJ, Harbison J, Hillis GS, Hills MT, Kamel H, Kirchhof P, Kowey PR, Krieger D, Lee VWY, Levin LÅ, Lip GYH, Lobban T, Lowres N, Mairesse GH, Martinez C, Neubeck L, Orchard J, Piccini JP, Poppe K, Potpara TS, Puererfellner H, Rienstra M, Sandhu RK, Schnabel RB, Siu CW, Steinhubl S, Svendsen JH, Svennberg E, Themistoclakis S, Tieleman RG, Turakhia MP, Tveit A, Uittenbogaart SB, Van Gelder IC, Verma A, Wachter R, Yan BP; AF-Screen Collaborators.

Circulation. 2017 May 9;135(19):1851-1867. doi: 10.1161/CIRCULATIONAHA.116.026693. Review.

PMID:
28483832
16.

Assembling draft genomes using contiBAIT.

O'Neill K, Hills M, Gottlieb M, Borkowski M, Karsan A, Lansdorp PM.

Bioinformatics. 2017 Sep 1;33(17):2737-2739. doi: 10.1093/bioinformatics/btx281.

17.

Relationship between IHC4 score and response to neo-adjuvant chemotherapy in estrogen receptor-positive breast cancer.

Sheri A, Smith IE, Hills M, Jones RL, Johnston SR, Dowsett M.

Breast Cancer Res Treat. 2017 Jul;164(2):395-400. doi: 10.1007/s10549-017-4266-9. Epub 2017 Apr 26.

18.

Failure and success in severe gastrointestinal disease complicating neurodisability: who is at the end of the line?

Puntis JWL, Hills M.

Arch Dis Child. 2017 May;102(5):391-392. doi: 10.1136/archdischild-2016-312237. Epub 2017 Jan 17. No abstract available.

PMID:
28096103
19.

Case report: A rare case of eosinophilic cholecystitis presenting after talc pleurodesis for recurrent pneumothorax.

Caesar J, Jordan M, Hills M.

Respir Med Case Rep. 2016 Nov 5;20:16-18. eCollection 2017.

20.

Direct chromosome-length haplotyping by single-cell sequencing.

Porubský D, Sanders AD, van Wietmarschen N, Falconer E, Hills M, Spierings DC, Bevova MR, Guryev V, Lansdorp PM.

Genome Res. 2016 Nov;26(11):1565-1574. Epub 2016 Sep 19.

21.

Characterizing polymorphic inversions in human genomes by single-cell sequencing.

Sanders AD, Hills M, Porubský D, Guryev V, Falconer E, Lansdorp PM.

Genome Res. 2016 Nov;26(11):1575-1587. Epub 2016 Jul 29.

22.

Heterogeneity in global gene expression profiles between biopsy specimens taken peri-surgically from primary ER-positive breast carcinomas.

López-Knowles E, Gao Q, Cheang MC, Morden J, Parker J, Martin LA, Pinhel I, McNeill F, Hills M, Detre S, Afentakis M, Zabaglo L, Dodson A, Skene A, Holcombe C, Robertson J, Smith I, Bliss JM, Dowsett M; POETIC trialists.

Breast Cancer Res. 2016 Apr 1;18(1):39. doi: 10.1186/s13058-016-0696-2.

23.

Crowdsourcing reproducible seizure forecasting in human and canine epilepsy.

Brinkmann BH, Wagenaar J, Abbot D, Adkins P, Bosshard SC, Chen M, Tieng QM, He J, Muñoz-Almaraz FJ, Botella-Rocamora P, Pardo J, Zamora-Martinez F, Hills M, Wu W, Korshunova I, Cukierski W, Vite C, Patterson EE, Litt B, Worrell GA.

Brain. 2016 Jun;139(Pt 6):1713-22. doi: 10.1093/brain/aww045. Epub 2016 Mar 31.

24.

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.

Dunning AM, Michailidou K, Kuchenbaecker KB, Thompson D, French JD, Beesley J, Healey CS, Kar S, Pooley KA, Lopez-Knowles E, Dicks E, Barrowdale D, Sinnott-Armstrong NA, Sallari RC, Hillman KM, Kaufmann S, Sivakumaran H, Moradi Marjaneh M, Lee JS, Hills M, Jarosz M, Drury S, Canisius S, Bolla MK, Dennis J, Wang Q, Hopper JL, Southey MC, Broeks A, Schmidt MK, Lophatananon A, Muir K, Beckmann MW, Fasching PA, Dos-Santos-Silva I, Peto J, Sawyer EJ, Tomlinson I, Burwinkel B, Marme F, Guénel P, Truong T, Bojesen SE, Flyger H, González-Neira A, Perez JI, Anton-Culver H, Eunjung L, Arndt V, Brenner H, Meindl A, Schmutzler RK, Brauch H, Hamann U, Aittomäki K, Blomqvist C, Ito H, Matsuo K, Bogdanova N, Dörk T, Lindblom A, Margolin S, Kosma VM, Mannermaa A, Tseng CC, Wu AH, Lambrechts D, Wildiers H, Chang-Claude J, Rudolph A, Peterlongo P, Radice P, Olson JE, Giles GG, Milne RL, Haiman CA, Henderson BE, Goldberg MS, Teo SH, Yip CH, Nord S, Borresen-Dale AL, Kristensen V, Long J, Zheng W, Pylkäs K, Winqvist R, Andrulis IL, Knight JA, Devilee P, Seynaeve C, Figueroa J, Sherman ME, Czene K, Darabi H, Hollestelle A, van den Ouweland AM, Humphreys K, Gao YT, Shu XO, Cox A, Cross SS, Blot W, Cai Q, Ghoussaini M, Perkins BJ, Shah M, Choi JY, Kang D, Lee SC, Hartman M, Kabisch M, Torres D, Jakubowska A, Lubinski J, Brennan P, Sangrajrang S, Ambrosone CB, Toland AE, Shen CY, Wu PE, Orr N, Swerdlow A, McGuffog L, Healey S, Lee A, Kapuscinski M, John EM, Terry MB, Daly MB, Goldgar DE, Buys SS, Janavicius R, Tihomirova L, Tung N, Dorfling CM, van Rensburg EJ, Neuhausen SL, Ejlertsen B, Hansen TV, Osorio A, Benitez J, Rando R, Weitzel JN, Bonanni B, Peissel B, Manoukian S, Papi L, Ottini L, Konstantopoulou I, Apostolou P, Garber J, Rashid MU, Frost D; EMBRACE, Izatt L, Ellis S, Godwin AK, Arnold N, Niederacher D, Rhiem K, Bogdanova-Markov N, Sagne C, Stoppa-Lyonnet D, Damiola F; GEMO Study Collaborators, Sinilnikova OM, Mazoyer S, Isaacs C, Claes KB, De Leeneer K, de la Hoya M, Caldes T, Nevanlinna H, Khan S, Mensenkamp AR; HEBON, Hooning MJ, Rookus MA, Kwong A, Olah E, Diez O, Brunet J, Pujana MA, Gronwald J, Huzarski T, Barkardottir RB, Laframboise R, Soucy P, Montagna M, Agata S, Teixeira MR; kConFab Investigators, Park SK, Lindor N, Couch FJ, Tischkowitz M, Foretova L, Vijai J, Offit K, Singer CF, Rappaport C, Phelan CM, Greene MH, Mai PL, Rennert G, Imyanitov EN, Hulick PJ, Phillips KA, Piedmonte M, Mulligan AM, Glendon G, Bojesen A, Thomassen M, Caligo MA, Yoon SY, Friedman E, Laitman Y, Borg A, von Wachenfeldt A, Ehrencrona H, Rantala J, Olopade OI, Ganz PA, Nussbaum RL, Gayther SA, Nathanson KL, Domchek SM, Arun BK, Mitchell G, Karlan BY, Lester J, Maskarinec G, Woolcott C, Scott C, Stone J, Apicella C, Tamimi R, Luben R, Khaw KT, Helland Å, Haakensen V, Dowsett M, Pharoah PD, Simard J, Hall P, García-Closas M, Vachon C, Chenevix-Trench G, Antoniou AC, Easton DF, Edwards SL.

Nat Genet. 2016 Apr;48(4):374-86. doi: 10.1038/ng.3521. Epub 2016 Feb 29.

25.

Telomere maintenance through recruitment of internal genomic regions.

Seo B, Kim C, Hills M, Sung S, Kim H, Kim E, Lim DS, Oh HS, Choi RMJ, Chun J, Shim J, Lee J.

Nat Commun. 2015 Sep 18;6:8189. doi: 10.1038/ncomms9189.

26.

Clinical utility of the IHC4+C score in oestrogen receptor-positive early breast cancer: a prospective decision impact study.

Yeo B, Zabaglo L, Hills M, Dodson A, Smith I, Dowsett M.

Br J Cancer. 2015 Jul 28;113(3):390-5. doi: 10.1038/bjc.2015.222. Epub 2015 Jul 16.

27.

Cardiac tachyarrhythmias and patient values and preferences for their management: the European Heart Rhythm Association (EHRA) consensus document endorsed by the Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLEACE).

Lane DA, Aguinaga L, Blomström-Lundqvist C, Boriani G, Dan GA, Hills MT, Hylek EM, LaHaye SA, Lip GY, Lobban T, Mandrola J, McCabe PJ, Pedersen SS, Pisters R, Stewart S, Wood K, Potpara TS, Gorenek B, Conti JB, Keegan R, Power S, Hendriks J, Ritter P, Calkins H, Violi F, Hurwitz J.

Europace. 2015 Dec;17(12):1747-69. doi: 10.1093/europace/euv233. Epub 2015 Jun 24. Review. No abstract available.

PMID:
26108807
28.

Antiproliferative Effect of Lapatinib in HER2-Positive and HER2-Negative/HER3-High Breast Cancer: Results of the Presurgical Randomized MAPLE Trial (CRUK E/06/039).

Leary A, Evans A, Johnston SR, A'Hern R, Bliss JM, Sahoo R, Detre S, Haynes BP, Hills M, Harper-Wynne C, Bundred N, Coombes G, Smith I, Dowsett M.

Clin Cancer Res. 2015 Jul 1;21(13):2932-40. doi: 10.1158/1078-0432.CCR-14-1428. Epub 2014 Nov 14.

29.

Residual proliferative cancer burden to predict long-term outcome following neoadjuvant chemotherapy.

Sheri A, Smith IE, Johnston SR, A'Hern R, Nerurkar A, Jones RL, Hills M, Detre S, Pinder SE, Symmans WF, Dowsett M.

Ann Oncol. 2015 Jan;26(1):75-80. doi: 10.1093/annonc/mdu508. Epub 2014 Oct 30.

30.

The lambda sign: a new radiographic indicator of latent syndesmosis instability.

Ryan LP, Hills MC, Chang J, Wilson CD.

Foot Ankle Int. 2014 Sep;35(9):903-8. doi: 10.1177/1071100714543646. Epub 2014 Jul 18.

PMID:
25037708
31.

Atrial fibrillation-linked germline GJA5/connexin40 mutants showed an increased hemichannel function.

Sun Y, Hills MD, Ye WG, Tong X, Bai D.

PLoS One. 2014 Apr 14;9(4):e95125. doi: 10.1371/journal.pone.0095125. eCollection 2014.

32.

Biomarker changes associated with the development of resistance to aromatase inhibitors (AIs) in estrogen receptor-positive breast cancer.

Arnedos M, Drury S, Afentakis M, A'Hern R, Hills M, Salter J, Smith IE, Reis-Filho JS, Dowsett M.

Ann Oncol. 2014 Mar;25(3):605-10. doi: 10.1093/annonc/mdt575. Epub 2014 Feb 12.

33.

Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes.

Lee M, Hills M, Conomos D, Stutz MD, Dagg RA, Lau LM, Reddel RR, Pickett HA.

Nucleic Acids Res. 2014 Feb;42(3):1733-46. doi: 10.1093/nar/gkt1117. Epub 2013 Nov 12.

34.

BAIT: Organizing genomes and mapping rearrangements in single cells.

Hills M, O'Neill K, Falconer E, Brinkman R, Lansdorp PM.

Genome Med. 2013 Sep 13;5(9):82. doi: 10.1186/gm486. eCollection 2013.

35.

Attitudes toward epilepsy among the primary and secondary school teachers in Malaysia, using the public attitudes toward epilepsy (PATE) scale.

Lim KS, Hills MD, Choo WY, Wong MH, Wu C, Tan CT.

Epilepsy Res. 2013 Oct;106(3):433-9. doi: 10.1016/j.eplepsyres.2013.06.014. Epub 2013 Jul 23.

PMID:
23886655
36.

Molecular markers as a complementary tool in risk assessments: quantifying interspecific gene flow from triticale to spring wheat and durum wheat.

Kavanagh VB, Hills MJ, Goyal A, Randhawa HS, Topinka AK, Eudes F, Hall LM.

Transgenic Res. 2013 Aug;22(4):767-78. doi: 10.1007/s11248-012-9683-2. Epub 2013 Feb 7.

PMID:
23389776
37.

A web-based survey of attitudes toward epilepsy in secondary and tertiary students in Malaysia, using the Public Attitudes Toward Epilepsy (PATE) scale.

Lim KS, Hills MD, Choo WY, Wong MH, Wu C, Tan CT.

Epilepsy Behav. 2013 Feb;26(2):158-61. doi: 10.1016/j.yebeh.2012.12.001. Epub 2013 Jan 9.

PMID:
23314303
38.

Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells.

Conomos D, Stutz MD, Hills M, Neumann AA, Bryan TM, Reddel RR, Pickett HA.

J Cell Biol. 2012 Dec 10;199(6):893-906. doi: 10.1083/jcb.201207189.

39.

Medical image. The vanishing lung.

Hamilton N, Hills MA.

N Z Med J. 2012 Sep 21;125(1362):92-4. No abstract available.

PMID:
23178610
40.

Histone H3K4 demethylation is negatively regulated by histone H3 acetylation in Saccharomyces cerevisiae.

Maltby VE, Martin BJ, Brind'Amour J, Chruscicki AT, McBurney KL, Schulze JM, Johnson IJ, Hills M, Hentrich T, Kobor MS, Lorincz MC, Howe LJ.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18505-10. doi: 10.1073/pnas.1202070109. Epub 2012 Oct 22.

41.

DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution.

Falconer E, Hills M, Naumann U, Poon SS, Chavez EA, Sanders AD, Zhao Y, Hirst M, Lansdorp PM.

Nat Methods. 2012 Nov;9(11):1107-12. doi: 10.1038/nmeth.2206. Epub 2012 Oct 7.

42.

Assessment of the contribution of the IHC4+C score to decision making in clinical practice in early breast cancer.

Barton S, Zabaglo L, A'Hern R, Turner N, Ferguson T, O'Neill S, Hills M, Smith I, Dowsett M.

Br J Cancer. 2012 May 22;106(11):1760-5. doi: 10.1038/bjc.2012.166. Epub 2012 Apr 24.

43.

ER and HER2 expression are positively correlated in HER2 non-overexpressing breast cancer.

Pinhel I, Hills M, Drury S, Salter J, Sumo G, A'Hern R, Bliss JM, Sestak I, Cuzick J, Barrett-Lee P, Harris A, Dowsett M; NCRI Adjuvant Breast Cancer Trial Management Group.

Breast Cancer Res. 2012 Mar 14;14(2):R46.

44.

Telomere length measurement-caveats and a critical assessment of the available technologies and tools.

Aubert G, Hills M, Lansdorp PM.

Mutat Res. 2012 Feb 1;730(1-2):59-67. doi: 10.1016/j.mrfmmm.2011.04.003. Epub 2011 Jun 12. Review.

45.

Relationship between estrogen receptor, progesterone receptor, HER-2 and Ki67 expression and efficacy of aromatase inhibitors in advanced breast cancer.

Anderson H, Hills M, Zabaglo L, A'hern R, Leary AF, Haynes BP, Smith IE, Dowsett M.

Ann Oncol. 2011 Aug;22(8):1770-6. doi: 10.1093/annonc/mdq700. Epub 2011 Feb 1.

PMID:
21285137
46.

Extreme loss of immunoreactive p-Akt and p-Erk1/2 during routine fixation of primary breast cancer.

Pinhel IF, Macneill FA, Hills MJ, Salter J, Detre S, A'hern R, Nerurkar A, Osin P, Smith IE, Dowsett M.

Breast Cancer Res. 2010;12(5):R76. doi: 10.1186/bcr2719. Epub 2010 Sep 28.

47.

A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer.

Graeser M, McCarthy A, Lord CJ, Savage K, Hills M, Salter J, Orr N, Parton M, Smith IE, Reis-Filho JS, Dowsett M, Ashworth A, Turner NC.

Clin Cancer Res. 2010 Dec 15;16(24):6159-68. doi: 10.1158/1078-0432.CCR-10-1027. Epub 2010 Aug 27.

48.

After death 2: Exploring the procedures for laying out and preparing the body for viewing.

Hills M, Albarran JW.

Nurs Times. 2010 Jul 20-26;106(28):22-4.

PMID:
20715650
49.

After death 1: caring for bereaved relatives and being aware of cultural differences.

Hills M, Albarran JW.

Nurs Times. 2010 Jul 13-19;106(27):19-20.

PMID:
20712211
50.

Pre-surgical study of the biological effects of the selective cyclo-oxygenase-2 inhibitor celecoxib in patients with primary breast cancer.

Martin LA, Davies GL, Weigel MT, Betambeau N, Hills MJ, Salter J, Walsh G, A'Hern R, Dowsett M.

Breast Cancer Res Treat. 2010 Oct;123(3):829-36. doi: 10.1007/s10549-010-1100-z. Epub 2010 Aug 10.

PMID:
20697803

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