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Candida albicans Augments Staphylococcus aureus Virulence by Engaging the Staphylococcal agr Quorum Sensing System.

Todd OA, Fidel PL Jr, Harro JM, Hilliard JJ, Tkaczyk C, Sellman BR, Noverr MC, Peters BM.

MBio. 2019 Jun 4;10(3). pii: e00910-19. doi: 10.1128/mBio.00910-19.


Genistein Has Antiviral Activity against Herpes B Virus and Acts Synergistically with Antiviral Treatments to Reduce Effective Dose.

LeCher JC, Diep N, Krug PW, Hilliard JK.

Viruses. 2019 May 31;11(6). pii: E499. doi: 10.3390/v11060499.


Radiation Therapy Workflow and Dosimetric Analysis from a Phase 1/2 Trial of Noninvasive Cardiac Radioablation for Ventricular Tachycardia.

Knutson NC, Samson PP, Hugo GD, Goddu SM, Reynoso FJ, Kavanaugh JA, Mutic S, Moore K, Hilliard J, Cuculich PS, Robinson CG.

Int J Radiat Oncol Biol Phys. 2019 Apr 16. pii: S0360-3016(19)30623-6. doi: 10.1016/j.ijrobp.2019.04.005. [Epub ahead of print]


Ventral Intermediate Nucleus Versus Zona Incerta Region Deep Brain Stimulation in Essential Tremor.

Eisinger RS, Wong J, Almeida L, Ramirez-Zamora A, Cagle JN, Giugni JC, Ahmed B, Bona AR, Monari E, Wagle Shukla A, Hess CW, Hilliard JD, Foote KD, Gunduz A, Okun MS, Martinez-Ramirez D.

Mov Disord Clin Pract. 2017 Nov 27;5(1):75-82. doi: 10.1002/mdc3.12565. eCollection 2018 Jan-Feb.


A novel antiviral inhibits Zika virus infection while increasing intracellular glutathione biosynthesis in distinct cell culture models.

Vasireddi M, Crum A, May H, Katz D, Hilliard J.

Antiviral Res. 2019 Jan;161:46-52. doi: 10.1016/j.antiviral.2018.09.004. Epub 2018 Sep 11.


The Neutrophilic Response to Pseudomonas Damages the Airway Barrier, Promoting Infection by Klebsiella pneumoniae.

Jones-Nelson O, Hilliard JJ, DiGiandomenico A, Warrener P, Alfaro A, Cheng L, Stover CK, Cohen TS, Sellman BR.

Am J Respir Cell Mol Biol. 2018 Dec;59(6):745-756. doi: 10.1165/rcmb.2018-0107OC.


Editorial. Deep brain stimulation for refractory posttraumatic stress disorder.

Hilliard JD, Foote KD.

Neurosurg Focus. 2018 Aug;45(2):E17. doi: 10.3171/2018.5.FOCUS18266. No abstract available.


In Silico Trial of MR-Guided Midtreatment Adaptive Planning for Hypofractionated Stereotactic Radiation Therapy in Centrally Located Thoracic Tumors.

Henke LE, Kashani R, Hilliard J, DeWees TA, Curcuru A, Przybysz D, Green O, Robinson CG, Bradley JD.

Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):987-995. doi: 10.1016/j.ijrobp.2018.06.022. Epub 2018 Jun 25.



Gustavsen KA, Raphael BL, Wildes MJ, McAloose D, McCann CM, Hilliard JK, Calle PP.

J Zoo Wildl Med. 2018 Jun;49(2):345-354. doi: 10.1638/2017-0241.1.


An irritable newborn with tender red bumps.

Swaney L, Cummings EA, Hilliard J.

Paediatr Child Health. 2017 May;22(2):57-58. doi: 10.1093/pch/pxx032. Epub 2017 Apr 18. No abstract available.


Herpes Simplex Virus 1 Mutant with Point Mutations in UL39 Is Impaired for Acute Viral Replication in Mice, Establishment of Latency, and Explant-Induced Reactivation.

Mostafa HH, Thompson TW, Konen AJ, Haenchen SD, Hilliard JG, Macdonald SJ, Morrison LA, Davido DJ.

J Virol. 2018 Mar 14;92(7). pii: e01654-17. doi: 10.1128/JVI.01654-17. Print 2018 Apr 1.


Postoperative lead migration in deep brain stimulation surgery: Incidence, risk factors, and clinical impact.

Morishita T, Hilliard JD, Okun MS, Neal D, Nestor KA, Peace D, Hozouri AA, Davidson MR, Bova FJ, Sporrer JM, Oyama G, Foote KD.

PLoS One. 2017 Sep 13;12(9):e0183711. doi: 10.1371/journal.pone.0183711. eCollection 2017.


Identification of unique B virus (Macacine Herpesvirus 1) epitopes of zoonotic and macaque isolates using monoclonal antibodies.

Katz D, Shi W, Gowda MS, Vasireddi M, Patrusheva I, Seoh HK, Filfili CN, Wildes MJ, Oh J, Hilliard JK.

PLoS One. 2017 Aug 4;12(8):e0182355. doi: 10.1371/journal.pone.0182355. eCollection 2017.


Safety and efficacy of dual-lead thalamic deep brain stimulation for patients with treatment-refractory multiple sclerosis tremor: a single-centre, randomised, single-blind, pilot trial.

Oliveria SF, Rodriguez RL, Bowers D, Kantor D, Hilliard JD, Monari EH, Scott BM, Okun MS, Foote KD.

Lancet Neurol. 2017 Sep;16(9):691-700. doi: 10.1016/S1474-4422(17)30166-7. Epub 2017 Jun 20.


Regulation of PI3K/Akt dependent apoptotic markers during b virus infection of human and macaque fibroblasts.

Vasireddi M, Hilliard JK.

PLoS One. 2017 May 30;12(5):e0178314. doi: 10.1371/journal.pone.0178314. eCollection 2017.


Targeting Alpha Toxin To Mitigate Its Lethal Toxicity in Ferret and Rabbit Models of Staphylococcus aureus Necrotizing Pneumonia.

Diep BA, Hilliard JJ, Le VT, Tkaczyk C, Le HN, Tran VG, Rao RL, Dip EC, Pereira-Franchi EP, Cha P, Jacobson S, Broome R, Cheng LI, Weiss W, Prokai L, Nguyen V, Stover CK, Sellman BR.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02456-16. doi: 10.1128/AAC.02456-16. Print 2017 Apr.


B Virus (Macacine Herpesvirus 1) Divergence: Variations in Glycoprotein D from Clinical and Laboratory Isolates Diversify Virus Entry Strategies.

Patrusheva I, Perelygina L, Torshin I, LeCher J, Hilliard J.

J Virol. 2016 Sep 29;90(20):9420-32. doi: 10.1128/JVI.00799-16. Print 2016 Oct 15.


Critical Role of Alpha-Toxin and Protective Effects of Its Neutralization by a Human Antibody in Acute Bacterial Skin and Skin Structure Infections.

Le VT, Tkaczyk C, Chau S, Rao RL, Dip EC, Pereira-Franchi EP, Cheng L, Lee S, Koelkebeck H, Hilliard JJ, Yu XQ, Datta V, Nguyen V, Weiss W, Prokai L, O'Day T, Stover CK, Sellman BR, Diep BA.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5640-8. doi: 10.1128/AAC.00710-16. Print 2016 Oct.


Post-mortem Findings in Huntington's Deep Brain Stimulation: A Moving Target Due to Atrophy.

Vedam-Mai V, Martinez-Ramirez D, Hilliard JD, Carbunaru S, Yachnis AT, Bloom J, Keeling P, Awe L, Foote KD, Okun MS.

Tremor Other Hyperkinet Mov (N Y). 2016 Apr 27;6:372. doi: 10.7916/D8ZP462H. eCollection 2016.


Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections.

Cohen TS, Hilliard JJ, Jones-Nelson O, Keller AE, O'Day T, Tkaczyk C, DiGiandomenico A, Hamilton M, Pelletier M, Wang Q, Diep BA, Le VT, Cheng L, Suzich J, Stover CK, Sellman BR.

Sci Transl Med. 2016 Mar 9;8(329):329ra31. doi: 10.1126/scitranslmed.aad9922.


Evaluation of a rapid hydration protocol: Safety and effectiveness.

Meredith S, Hilliard J, Vaillancourt R.

J Oncol Pharm Pract. 2017 Jun;23(4):249-254. doi: 10.1177/1078155216631406. Epub 2016 Feb 23.


Polytrauma Increases Susceptibility to Pseudomonas Pneumonia in Mature Mice.

Turnbull IR, Ghosh S, Fuchs A, Hilliard J, Davis CG, Bochicchio GV, Southard RE.

Shock. 2016 May;45(5):555-63. doi: 10.1097/SHK.0000000000000538.


Klebsiella pneumoniae FimK Promotes Virulence in Murine Pneumonia.

Rosen DA, Hilliard JK, Tiemann KM, Todd EM, Morley SC, Hunstad DA.

J Infect Dis. 2016 Feb 15;213(4):649-58. doi: 10.1093/infdis/jiv440. Epub 2015 Sep 7.


Short pauses in thalamic deep brain stimulation promote tremor and neuronal bursting.

Swan BD, Brocker DT, Hilliard JD, Tatter SB, Gross RE, Turner DA, Grill WM.

Clin Neurophysiol. 2016 Feb;127(2):1551-1559. doi: 10.1016/j.clinph.2015.07.034. Epub 2015 Aug 20.


MEDI4893* Promotes Survival and Extends the Antibiotic Treatment Window in a Staphylococcus aureus Immunocompromised Pneumonia Model.

Hua L, Cohen TS, Shi Y, Datta V, Hilliard JJ, Tkaczyk C, Suzich J, Stover CK, Sellman BR.

Antimicrob Agents Chemother. 2015 Aug;59(8):4526-32. doi: 10.1128/AAC.00510-15. Epub 2015 May 18.


B Virus (Macacine herpesvirus 1) Glycoprotein D Is Functional but Dispensable for Virus Entry into Macaque and Human Skin Cells.

Perelygina L, Patrusheva I, Vasireddi M, Brock N, Hilliard J.

J Virol. 2015 May;89(10):5515-24. doi: 10.1128/JVI.03568-14. Epub 2015 Mar 4.


7-(4-Alkylidenylpiperidinyl)-quinolone bacterial topoisomerase inhibitors.

Grant EB, Foleno BD, Goldschmidt R, Hilliard JJ, Lin SC, Morrow B, Paget SD, Weidner-Wells MA, Xu X, Xu X, Murray WV, Bush K, Macielag MJ.

Bioorg Med Chem Lett. 2014 Dec 1;24(23):5502-6. doi: 10.1016/j.bmcl.2014.10.014. Epub 2014 Oct 12.


A multifunctional bispecific antibody protects against Pseudomonas aeruginosa.

DiGiandomenico A, Keller AE, Gao C, Rainey GJ, Warrener P, Camara MM, Bonnell J, Fleming R, Bezabeh B, Dimasi N, Sellman BR, Hilliard J, Guenther CM, Datta V, Zhao W, Gao C, Yu XQ, Suzich JA, Stover CK.

Sci Transl Med. 2014 Nov 12;6(262):262ra155. doi: 10.1126/scitranslmed.3009655.


Attitudes and perceptions of parents and staff toward the rapid hydration protocol prior to chemotherapy in children.

Samonis R, Hilliard J, Bains T, Hollis K, O'Shaughnessy E, Vaillancourt R, Johnston D.

J Pediatr Oncol Nurs. 2015 Mar-Apr;32(2):114-9. doi: 10.1177/1043454214553706. Epub 2014 Nov 3.


Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model.

Hilliard JJ, Datta V, Tkaczyk C, Hamilton M, Sadowska A, Jones-Nelson O, O'Day T, Weiss WJ, Szarka S, Nguyen V, Prokai L, Suzich J, Stover CK, Sellman BR.

Antimicrob Agents Chemother. 2015 Jan;59(1):299-309. doi: 10.1128/AAC.03918-14. Epub 2014 Oct 27.


PNI Biomarkers and Health Outcomes in College Women.

Lee SY, Vasireddi M, Chen YP, Wang YT, Hilliard J.

Healthcare (Basel). 2014 Apr 28;2(2):207-19. doi: 10.3390/healthcare2020207.


Assessment of an anti-alpha-toxin monoclonal antibody for prevention and treatment of Staphylococcus aureus-induced pneumonia.

Hua L, Hilliard JJ, Shi Y, Tkaczyk C, Cheng LI, Yu X, Datta V, Ren S, Feng H, Zinsou R, Keller A, O'Day T, Du Q, Cheng L, Damschroder M, Robbie G, Suzich J, Stover CK, Sellman BR.

Antimicrob Agents Chemother. 2014;58(2):1108-17. doi: 10.1128/AAC.02190-13. Epub 2013 Dec 2.


Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model.

Tkaczyk C, Hamilton MM, Datta V, Yang XP, Hilliard JJ, Stephens GL, Sadowska A, Hua L, O'Day T, Suzich J, Stover CK, Sellman BR.

PLoS One. 2013 Oct 2;8(10):e75103. doi: 10.1371/journal.pone.0075103. eCollection 2013.


A magnetic resonance imaging, histological, and dose modeling comparison of focused ultrasound, radiofrequency, and Gamma Knife radiosurgery lesions in swine thalamus.

Elias WJ, Khaled M, Hilliard JD, Aubry JF, Frysinger RC, Sheehan JP, Wintermark M, Lopes MB.

J Neurosurg. 2013 Aug;119(2):307-17. doi: 10.3171/2013.5.JNS122327. Epub 2013 Jun 7.


Barrier protection capacity of flip-top pharmaceutical vials.

Hilliard JG, Cambronne ED, Kirsch JR, Aziz MF.

J Clin Anesth. 2013 May;25(3):177-80. doi: 10.1016/j.jclinane.2012.07.006. Epub 2013 Apr 3.


Effective deep brain stimulation suppresses low-frequency network oscillations in the basal ganglia by regularizing neural firing patterns.

McConnell GC, So RQ, Hilliard JD, Lopomo P, Grill WM.

J Neurosci. 2012 Nov 7;32(45):15657-68. doi: 10.1523/JNEUROSCI.2824-12.2012.


Pulmonary contusion is associated with toll-like receptor 4 upregulation and decreased susceptibility to pseudomonas pneumonia in a mouse model.

Southard R, Ghosh S, Hilliard J, Davis C, Mazuski C, Walton A, Hotchkiss R.

Shock. 2012 Jun;37(6):629-33. doi: 10.1097/SHK.0b013e31824ee551.


An automated ELISA using recombinant antigens for serologic diagnosis of B virus infections in macaques.

Katz D, Shi W, Patrusheva I, Perelygina L, Gowda MS, Krug PW, Filfili CN, Ward JA, Hilliard JK.

Comp Med. 2012 Dec;62(6):527-34.


Reassessing the detection of B-virus-specific serum antibodies.

Katz D, Shi W, Wildes MJ, Krug PW, Hilliard JK.

Comp Med. 2012 Dec;62(6):516-26.


Effective subthalamic nucleus deep brain stimulation sites may differ for tremor, bradykinesia and gait disturbances in Parkinson's disease.

Hilliard JD, Frysinger RC, Elias WJ.

Stereotact Funct Neurosurg. 2011;89(6):357-64. doi: 10.1159/000331269. Epub 2011 Nov 19.


Herpes simplex virus 1 ICP0 phosphorylation site mutants are attenuated for viral replication and impaired for explant-induced reactivation.

Mostafa HH, Thompson TW, Kushnir AS, Haenchen SD, Bayless AM, Hilliard JG, Link MA, Pitcher LA, Loveday E, Schaffer PA, Davido DJ.

J Virol. 2011 Dec;85(23):12631-7. doi: 10.1128/JVI.05661-11. Epub 2011 Sep 21.


Efficacy of a new fluoroquinolone, JNJ-Q2, in murine models of Staphylococcus aureus and Streptococcus pneumoniae skin, respiratory, and systemic infections.

Fernandez J, Hilliard JJ, Morrow BJ, Melton JL, Flamm RK, Barron AM, Lynch AS.

Antimicrob Agents Chemother. 2011 Dec;55(12):5522-8. doi: 10.1128/AAC.00471-11. Epub 2011 Sep 12.


Monkey B virus.

Hilliard J.

In: Arvin A, Campadelli-Fiume G, Mocarski E, Moore PS, Roizman B, Whitley R, Yamanishi K, editors. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge: Cambridge University Press; 2007. Chapter 57.


Comparative effects of carbapenems on bacterial load and host immune response in a Klebsiella pneumoniae murine pneumonia model.

Hilliard JJ, Melton JL, Hall L, Abbanat D, Fernandez J, Ward CK, Bunting RA, Barron A, Lynch AS, Flamm RK.

Antimicrob Agents Chemother. 2011 Feb;55(2):836-44. doi: 10.1128/AAC.00670-10. Epub 2010 Dec 6.


On humanizing the expert witness: a proposed narrative approach to expert witness qualification.

Commons ML, Gutheil TG, Hilliard JT.

J Am Acad Psychiatry Law. 2010;38(3):302-4. No abstract available.


Performance of the Aptima HIV-1 RNA qualitative assay with 16- and 32-member specimen pools.

Ethridge SF, Hart C, Hanson DL, Parker MM, Sullivan TJ, Bennett B, Stephens P, Hilliard J, Patel P.

J Clin Microbiol. 2010 Sep;48(9):3343-5. doi: 10.1128/JCM.01030-10. Epub 2010 Jun 30.


Synthesis and in vitro Efficacy Studies of Silver Carbene Complexes on Biosafety Level 3 Bacteria.

Panzner MJ, Deeraksa A, Smith A, Wright BD, Hindi KM, Kascatan-Nebioglu A, Torres AG, Judy BM, Hovis CE, Hilliard JK, Mallett RJ, Cope E, Estes DM, Cannon CL, Leid JG, Youngs WJ.

Eur J Inorg Chem. 2009 May 1;2009(13):1739-1745.


In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa.

Fernandez J, Hilliard JJ, Abbanat D, Zhang W, Melton JL, Santoro CM, Flamm RK, Bush K.

Antimicrob Agents Chemother. 2010 Jan;54(1):116-25. doi: 10.1128/AAC.00642-09. Epub 2009 Nov 2.


Inhibition of B virus (Macacine herpesvirus 1) by conventional and experimental antiviral compounds.

Krug PW, Schinazi RF, Hilliard JK.

Antimicrob Agents Chemother. 2010 Jan;54(1):452-9. doi: 10.1128/AAC.01435-08. Epub 2009 Oct 26.

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