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Items: 28


Substrate Distortion and the Catalytic Reaction Mechanism of 5-Carboxyvanillate Decarboxylase.

Vladimirova A, Patskovsky Y, Fedorov AA, Bonanno JB, Fedorov EV, Toro R, Hillerich B, Seidel RD, Richards NG, Almo SC, Raushel FM.

J Am Chem Soc. 2016 Jan 27;138(3):826-36. doi: 10.1021/jacs.5b08251. Epub 2016 Jan 12.


Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes.

Pan JJ, Solbiati JO, Ramamoorthy G, Hillerich BS, Seidel RD, Cronan JE, Almo SC, Poulter CD.

ACS Cent Sci. 2015;1(2):77-82.


Structural genomics for drug design against the pathogen Coxiella burnetii.

Franklin MC, Cheung J, Rudolph MJ, Burshteyn F, Cassidy M, Gary E, Hillerich B, Yao ZK, Carlier PR, Totrov M, Love JD.

Proteins. 2015 Dec;83(12):2124-36. doi: 10.1002/prot.24841. Epub 2015 Oct 6.


Computational-guided discovery and characterization of a sesquiterpene synthase from Streptomyces clavuligerus.

Chow JY, Tian BX, Ramamoorthy G, Hillerich BS, Seidel RD, Almo SC, Jacobson MP, Poulter CD.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5661-6. doi: 10.1073/pnas.1505127112. Epub 2015 Apr 21.


Panoramic view of a superfamily of phosphatases through substrate profiling.

Huang H, Pandya C, Liu C, Al-Obaidi NF, Wang M, Zheng L, Toews Keating S, Aono M, Love JD, Evans B, Seidel RD, Hillerich BS, Garforth SJ, Almo SC, Mariano PS, Dunaway-Mariano D, Allen KN, Farelli JD.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E1974-83. doi: 10.1073/pnas.1423570112. Epub 2015 Apr 6.


Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes.

Vetting MW, Al-Obaidi N, Zhao S, San Francisco B, Kim J, Wichelecki DJ, Bouvier JT, Solbiati JO, Vu H, Zhang X, Rodionov DA, Love JD, Hillerich BS, Seidel RD, Quinn RJ, Osterman AL, Cronan JE, Jacobson MP, Gerlt JA, Almo SC.

Biochemistry. 2015 Jan 27;54(3):909-31. doi: 10.1021/bi501388y. Epub 2015 Jan 16.


Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks.

Zhao S, Sakai A, Zhang X, Vetting MW, Kumar R, Hillerich B, San Francisco B, Solbiati J, Steves A, Brown S, Akiva E, Barber A, Seidel RD, Babbitt PC, Almo SC, Gerlt JA, Jacobson MP.

Elife. 2014 Jun 30;3. doi: 10.7554/eLife.03275.


l-Galactose metabolism in Bacteroides vulgatus from the human gut microbiota.

Hobbs ME, Williams HJ, Hillerich B, Almo SC, Raushel FM.

Biochemistry. 2014 Jul 22;53(28):4661-70. doi: 10.1021/bi500656m. Epub 2014 Jul 7.


Functional annotation and structural characterization of a novel lactonase hydrolyzing D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate.

Korczynska M, Xiang DF, Zhang Z, Xu C, Narindoshvili T, Kamat SS, Williams HJ, Chang SS, Kolb P, Hillerich B, Sauder JM, Burley SK, Almo SC, Swaminathan S, Shoichet BK, Raushel FM.

Biochemistry. 2014 Jul 22;53(28):4727-38. doi: 10.1021/bi500595c. Epub 2014 Jul 9.


Discovery of a novel L-lyxonate degradation pathway in Pseudomonas aeruginosa PAO1.

Ghasempur S, Eswaramoorthy S, Hillerich BS, Seidel RD, Swaminathan S, Almo SC, Gerlt JA.

Biochemistry. 2014 May 27;53(20):3357-66. doi: 10.1021/bi5004298. Epub 2014 May 15.


Large-scale determination of sequence, structure, and function relationships in cytosolic glutathione transferases across the biosphere.

Mashiyama ST, Malabanan MM, Akiva E, Bhosle R, Branch MC, Hillerich B, Jagessar K, Kim J, Patskovsky Y, Seidel RD, Stead M, Toro R, Vetting MW, Almo SC, Armstrong RN, Babbitt PC.

PLoS Biol. 2014 Apr 22;12(4):e1001843. doi: 10.1371/journal.pbio.1001843. eCollection 2014 Apr.


Discovery of function in the enolase superfamily: D-mannonate and d-gluconate dehydratases in the D-mannonate dehydratase subgroup.

Wichelecki DJ, Balthazor BM, Chau AC, Vetting MW, Fedorov AA, Fedorov EV, Lukk T, Patskovsky YV, Stead MB, Hillerich BS, Seidel RD, Almo SC, Gerlt JA.

Biochemistry. 2014 Apr 29;53(16):2722-31. doi: 10.1021/bi500264p. Epub 2014 Apr 15.


Prospecting for unannotated enzymes: discovery of a 3',5'-nucleotide bisphosphate phosphatase within the amidohydrolase superfamily.

Cummings JA, Vetting M, Ghodge SV, Xu C, Hillerich B, Seidel RD, Almo SC, Raushel FM.

Biochemistry. 2014 Jan 28;53(3):591-600. doi: 10.1021/bi401640r. Epub 2014 Jan 13.


Discovery of new enzymes and metabolic pathways by using structure and genome context.

Zhao S, Kumar R, Sakai A, Vetting MW, Wood BM, Brown S, Bonanno JB, Hillerich BS, Seidel RD, Babbitt PC, Almo SC, Sweedler JV, Gerlt JA, Cronan JE, Jacobson MP.

Nature. 2013 Oct 31;502(7473):698-702. doi: 10.1038/nature12576. Epub 2013 Sep 22.


Deamination of 6-aminodeoxyfutalosine in menaquinone biosynthesis by distantly related enzymes.

Goble AM, Toro R, Li X, Ornelas A, Fan H, Eswaramoorthy S, Patskovsky Y, Hillerich B, Seidel R, Sali A, Shoichet BK, Almo SC, Swaminathan S, Tanner ME, Raushel FM.

Biochemistry. 2013 Sep 17;52(37):6525-36. doi: 10.1021/bi400750a. Epub 2013 Sep 4.


Structure-guided discovery of new deaminase enzymes.

Hitchcock DS, Fan H, Kim J, Vetting M, Hillerich B, Seidel RD, Almo SC, Shoichet BK, Sali A, Raushel FM.

J Am Chem Soc. 2013 Sep 18;135(37):13927-33. doi: 10.1021/ja4066078. Epub 2013 Sep 4.


Protein production from the structural genomics perspective: achievements and future needs.

Almo SC, Garforth SJ, Hillerich BS, Love JD, Seidel RD, Burley SK.

Curr Opin Struct Biol. 2013 Jun;23(3):335-44. doi: 10.1016/ Epub 2013 May 1. Review.


Crystal structure of human Karyopherin β2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2.

Soniat M, Sampathkumar P, Collett G, Gizzi AS, Banu RN, Bhosle RC, Chamala S, Chowdhury S, Fiser A, Glenn AS, Hammonds J, Hillerich B, Khafizov K, Love JD, Matikainen B, Seidel RD, Toro R, Rajesh Kumar P, Bonanno JB, Chook YM, Almo SC.

J Struct Funct Genomics. 2013 Jun;14(2):31-5. doi: 10.1007/s10969-013-9150-1. Epub 2013 Mar 28.


Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily.

Wallrapp FH, Pan JJ, Ramamoorthy G, Almonacid DE, Hillerich BS, Seidel R, Patskovsky Y, Babbitt PC, Almo SC, Jacobson MP, Poulter CD.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):E1196-202. doi: 10.1073/pnas.1300632110. Epub 2013 Mar 14.


Structural and mechanistic characterization of L-histidinol phosphate phosphatase from the polymerase and histidinol phosphatase family of proteins.

Ghodge SV, Fedorov AA, Fedorov EV, Hillerich B, Seidel R, Almo SC, Raushel FM.

Biochemistry. 2013 Feb 12;52(6):1101-12. doi: 10.1021/bi301496p. Epub 2013 Jan 30.


Assignment of pterin deaminase activity to an enzyme of unknown function guided by homology modeling and docking.

Fan H, Hitchcock DS, Seidel RD 2nd, Hillerich B, Lin H, Almo SC, Sali A, Shoichet BK, Raushel FM.

J Am Chem Soc. 2013 Jan 16;135(2):795-803. doi: 10.1021/ja309680b. Epub 2013 Jan 2.


Discovery of an L-fucono-1,5-lactonase from cog3618 of the amidohydrolase superfamily.

Hobbs ME, Vetting M, Williams HJ, Narindoshvili T, Kebodeaux DM, Hillerich B, Seidel RD, Almo SC, Raushel FM.

Biochemistry. 2013 Jan 8;52(1):239-53. doi: 10.1021/bi3015554. Epub 2012 Dec 20.


Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily.

Lukk T, Sakai A, Kalyanaraman C, Brown SD, Imker HJ, Song L, Fedorov AA, Fedorov EV, Toro R, Hillerich B, Seidel R, Patskovsky Y, Vetting MW, Nair SK, Babbitt PC, Almo SC, Gerlt JA, Jacobson MP.

Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4122-7. doi: 10.1073/pnas.1112081109. Epub 2012 Mar 5.


Homologue structure of the SLAC1 anion channel for closing stomata in leaves.

Chen YH, Hu L, Punta M, Bruni R, Hillerich B, Kloss B, Rost B, Love J, Siegelbaum SA, Hendrickson WA.

Nature. 2010 Oct 28;467(7319):1074-80. doi: 10.1038/nature09487.


A new TetR family transcriptional regulator required for morphogenesis in Streptomyces coelicolor.

Hillerich B, Westpheling J.

J Bacteriol. 2008 Jan;190(1):61-7. Epub 2007 Oct 26.


Application of finite element method and SPICE simulation for design optimization of oven-controlled crystal oscillators.

Hillerich B, Nagler O.

IEEE Trans Ultrason Ferroelectr Freq Control. 2001 Nov;48(6):1662-8.


Shape analysis and coupling loss of microlenses on single-mode fiber tips.

Hillerich B.

Appl Opt. 1988 Aug 1;27(15):3102-6. doi: 10.1364/AO.27.003102.


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