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Items: 1 to 50 of 288

1.

Systematic Parameterization, Storage, and Representation of Volumetric DICOM Data.

Fischer F, Selver MA, Gezer S, Dicle O, Hillen W.

J Med Biol Eng. 2015;35(6):709-723. Epub 2015 Nov 18.

2.

Performance comparison of compression algorithms for archiving segmented volumetric binary medical data.

Fischer F, Selver MA, Dicle O, Hillen W.

Stud Health Technol Inform. 2014;205:1138-42.

PMID:
25160367
3.

Semi-automatic segmentation methods for 3-D visualization and analysis of the liver.

Selver MA, Fischer F, Gezer S, Hillen W, Dicle O.

Stud Health Technol Inform. 2014;205:1133-7.

PMID:
25160366
4.

Complex formation between malate dehydrogenase and isocitrate dehydrogenase from Bacillus subtilis is regulated by tricarboxylic acid cycle metabolites.

Bartholomae M, Meyer FM, Commichau FM, Burkovski A, Hillen W, Seidel G.

FEBS J. 2014 Feb;281(4):1132-43. doi: 10.1111/febs.12679. Epub 2014 Jan 9.

5.

A novel method to analyze nucleocytoplasmic transport in vivo by using short peptide tags.

Wimmer C, Platzer S, Hillen W, Klotzsche M.

J Mol Biol. 2013 May 27;425(10):1839-45. doi: 10.1016/j.jmb.2013.02.007. Epub 2013 Feb 13.

PMID:
23416199
6.

High- and low-affinity cre boxes for CcpA binding in Bacillus subtilis revealed by genome-wide analysis.

Marciniak BC, Pabijaniak M, de Jong A, Dűhring R, Seidel G, Hillen W, Kuipers OP.

BMC Genomics. 2012 Aug 17;13:401. doi: 10.1186/1471-2164-13-401.

7.

Promoter strength driving TetR determines the regulatory properties of Tet-controlled expression systems.

Georgi C, Buerger J, Hillen W, Berens C.

PLoS One. 2012;7(7):e41620. doi: 10.1371/journal.pone.0041620. Epub 2012 Jul 27.

8.

Protein expression can be monitored in yeast by peptide-mediated induction of TetR-controlled gene expression.

Stoeckle C, Klotzsche M, Hillen W.

J Biotechnol. 2012 Oct 31;161(3):265-8. doi: 10.1016/j.jbiotec.2012.05.012. Epub 2012 Jun 20.

PMID:
22728389
9.

CcpA forms complexes with CodY and RpoA in Bacillus subtilis.

Wünsche A, Hammer E, Bartholomae M, Völker U, Burkovski A, Seidel G, Hillen W.

FEBS J. 2012 Jun;279(12):2201-14. doi: 10.1111/j.1742-4658.2012.08604.x. Epub 2012 May 21.

10.

Short peptides act as inducers, anti-inducers and corepressors of Tet repressor.

Goeke D, Kaspar D, Stoeckle C, Grubmüller S, Berens C, Klotzsche M, Hillen W.

J Mol Biol. 2012 Feb 10;416(1):33-45. doi: 10.1016/j.jmb.2011.12.009. Epub 2011 Dec 9.

PMID:
22178480
11.

An exclusive α/β code directs allostery in TetR-peptide complexes.

Sevvana M, Goetz C, Goeke D, Wimmer C, Berens C, Hillen W, Muller YA.

J Mol Biol. 2012 Feb 10;416(1):46-56. doi: 10.1016/j.jmb.2011.12.008. Epub 2011 Dec 9.

PMID:
22178479
12.

Carbon source control of the phosphorylation state of the Bacillus subtilis carbon-flux regulator Crh in vivo.

Landmann JJ, Werner S, Hillen W, Stülke J, Görke B.

FEMS Microbiol Lett. 2012 Feb;327(1):47-53. doi: 10.1111/j.1574-6968.2011.02456.x. Epub 2011 Nov 28.

13.

Role of CcpA in polyhydroxybutyrate biosynthesis in a newly isolated Bacillus sp. MA3.3.

Lopes MS, Steinert N, Rojas JD, Hillen W, Gomez JG, Silva LF.

J Mol Microbiol Biotechnol. 2011 Apr;20(2):63-9. doi: 10.1159/000324502. Epub 2011 Mar 9.

PMID:
21389734
14.

Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators.

Schumacher MA, Sprehe M, Bartholomae M, Hillen W, Brennan RG.

Nucleic Acids Res. 2011 Apr;39(7):2931-42. doi: 10.1093/nar/gkq1177. Epub 2010 Nov 23.

15.

Tetracycline sensing using novel doxycycline derivatives immobilized on different surface plasmon resonance biosensor surfaces.

Andree U, Mueller-Seitz E, Usai I, Loeber S, Gmeiner P, Wimmer C, Hillen W, Petz M.

Bioanalysis. 2010 Feb;2(2):217-27. doi: 10.4155/bio.09.176.

PMID:
21083305
16.

A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting.

Schubert I, Kellner C, Stein C, Kügler M, Schwenkert M, Saul D, Mentz K, Singer H, Stockmeyer B, Hillen W, Mackensen A, Fey GH.

MAbs. 2011 Jan-Feb;3(1):21-30. Epub 2011 Jan 1.

17.

Anhydrotetracycline-peptide conjugates as representatives for ligand-based transactivating systems.

Lochner S, Einsiedel J, Schaefer G, Berens C, Hillen W, Gmeiner P.

Bioorg Med Chem. 2010 Aug 15;18(16):6127-33. doi: 10.1016/j.bmc.2010.06.061. Epub 2010 Jun 22.

PMID:
20638851
18.

Adjusting transgene expression levels in lymphocytes with a set of inducible promoters.

Danke C, Grünz X, Wittmann J, Schmidt A, Agha-Mohammadi S, Kutsch O, Jäck HM, Hillen W, Berens C.

J Gene Med. 2010 Jun;12(6):501-15. doi: 10.1002/jgm.1461.

PMID:
20527043
19.

Integrating segmentation methods from different tools into a visualization program using an object-based plug-in interface.

Fischer F, Selver MA, Hillen W, Güzeliş C.

IEEE Trans Inf Technol Biomed. 2010 Jul;14(4):923-34. doi: 10.1109/TITB.2010.2044243. Epub 2010 Apr 15.

PMID:
20403791
20.

Click-chemistry-derived tetracycline-amino acid conjugates exhibiting exceptional potency and exclusive recognition of the reverse tet repressor.

Usai I, Krueger M, Einsiedel J, Hillen W, Gmeiner P.

Chembiochem. 2010 Mar 22;11(5):703-12. doi: 10.1002/cbic.200900710.

PMID:
20148427
21.

Diarylpropane-1,3-dione derivatives as TetR-inducing tetracycline mimetics: Synthesis and biological investigations.

Kormann C, Pimenta I, Löber S, Wimmer C, Lanig H, Clark T, Hillen W, Gmeiner P.

Chembiochem. 2009 Dec 14;10(18):2924-33. doi: 10.1002/cbic.200900564.

PMID:
19885899
22.

Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair.

Klieber MA, Scholz O, Lochner S, Gmeiner P, Hillen W, Muller YA.

FEBS J. 2009 Oct;276(19):5610-21. doi: 10.1111/j.1742-4658.2009.07254.x. Epub 2009 Aug 27.

23.

In vivo activation of tetracycline repressor by Cre/lox-mediated gene assembly.

Bertram R, Kolb M, Hillen W.

J Mol Microbiol Biotechnol. 2009;17(3):136-45. doi: 10.1159/000229606. Epub 2009 Jul 21.

24.

An RNA aptamer that induces transcription.

Hunsicker A, Steber M, Mayer G, Meitert J, Klotzsche M, Blind M, Hillen W, Berens C, Suess B.

Chem Biol. 2009 Feb 27;16(2):173-80. doi: 10.1016/j.chembiol.2008.12.008.

25.

Functionally important residues of the Tet repressor inducing peptide TIP determined by a complete mutational analysis.

Daam J, Mehdaoui K, Klotzsche M, Pfleiderer K, Berens C, Hillen W.

Gene. 2008 Nov 1;423(2):201-6. doi: 10.1016/j.gene.2008.07.004. Epub 2008 Jul 12.

PMID:
18672042
26.

A protein functional leap: how a single mutation reverses the function of the transcription regulator TetR.

Resch M, Striegl H, Henssler EM, Sevvana M, Egerer-Sieber C, Schiltz E, Hillen W, Muller YA.

Nucleic Acids Res. 2008 Aug;36(13):4390-401. doi: 10.1093/nar/gkn400. Epub 2008 Jun 28.

27.

Specific binding of divalent metal ions to tetracycline and to the Tet repressor/tetracycline complex.

Palm GJ, Lederer T, Orth P, Saenger W, Takahashi M, Hillen W, Hinrichs W.

J Biol Inorg Chem. 2008 Sep;13(7):1097-110. doi: 10.1007/s00775-008-0395-2. Epub 2008 Jun 12.

PMID:
18548290
28.

The application of Tet repressor in prokaryotic gene regulation and expression.

Bertram R, Hillen W.

Microb Biotechnol. 2008 Jan;1(1):2-16. doi: 10.1111/j.1751-7915.2007.00001.x. Review.

29.

In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice.

Gandotra S, Schnappinger D, Monteleone M, Hillen W, Ehrt S.

Nat Med. 2007 Dec;13(12):1515-20. Epub 2007 Dec 2.

30.

Engineered Tet repressors with recognition specificity for the tetO-4C5G operator variant.

Krueger M, Scholz O, Wisshak S, Hillen W.

Gene. 2007 Dec 1;404(1-2):93-100. Epub 2007 Sep 12.

PMID:
17928170
31.

Efficient and exclusive induction of Tet repressor by the oligopeptide Tip results from co-variation of their interaction site.

Klotzsche M, Goeke D, Berens C, Hillen W.

Nucleic Acids Res. 2007;35(12):3945-52. Epub 2007 Jun 1.

32.

Silencing Mycobacterium smegmatis by using tetracycline repressors.

Guo XV, Monteleone M, Klotzsche M, Kamionka A, Hillen W, Braunstein M, Ehrt S, Schnappinger D.

J Bacteriol. 2007 Jul;189(13):4614-23. Epub 2007 May 4.

33.

A software tool for interactive generation, representation, and systematical storage of transfer functions for 3D medical images.

Alper Selver M, Fischer F, Kuntalp M, Hillen W.

Comput Methods Programs Biomed. 2007 Jun;86(3):270-80. Epub 2007 Apr 23.

PMID:
17451839
34.

Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors glucose 6-phosphate and fructose 1,6-bisphosphate.

Schumacher MA, Seidel G, Hillen W, Brennan RG.

J Mol Biol. 2007 May 11;368(4):1042-50. Epub 2007 Feb 27.

PMID:
17376479
35.

How an agonist peptide mimics the antibiotic tetracycline to induce Tet-repressor.

Luckner SR, Klotzsche M, Berens C, Hillen W, Muller YA.

J Mol Biol. 2007 May 4;368(3):780-90. Epub 2007 Feb 22.

PMID:
17374541
36.

Improved single-chain transactivators of the Tet-On gene expression system.

Zhou X, Symons J, Hoppes R, Krueger C, Berens C, Hillen W, Berkhout B, Das AT.

BMC Biotechnol. 2007 Jan 19;7:6.

37.

CcpA mutants with differential activities in Bacillus subtilis.

Sprehe M, Seidel G, Diel M, Hillen W.

J Mol Microbiol Biotechnol. 2007;12(1-2):96-105.

PMID:
17183216
38.

Interference of components of the phosphoenolpyruvate phosphotransferase system with the central virulence gene regulator PrfA of Listeria monocytogenes.

Mertins S, Joseph B, Goetz M, Ecke R, Seidel G, Sprehe M, Hillen W, Goebel W, Müller-Altrock S.

J Bacteriol. 2007 Jan;189(2):473-90. Epub 2006 Nov 3.

39.

Residues His-15 and Arg-17 of HPr participate differently in catabolite signal processing via CcpA.

Horstmann N, Seidel G, Aung-Hilbrich LM, Hillen W.

J Biol Chem. 2007 Jan 12;282(2):1175-82. Epub 2006 Nov 3.

40.

Species-specific differences in the activity of PrfA, the key regulator of listerial virulence genes.

Mauder N, Ecke R, Mertins S, Loeffler DI, Seidel G, Sprehe M, Hillen W, Goebel W, Müller-Altrock S.

J Bacteriol. 2006 Nov;188(22):7941-56. Epub 2006 Sep 15.

41.

Induction of single chain tetracycline repressor requires the binding of two inducers.

Kamionka A, Majewski M, Roth K, Bertram R, Kraft C, Hillen W.

Nucleic Acids Res. 2006;34(14):3834-41. Epub 2006 Aug 9.

42.
43.

Subtype selective tetracycline agonists and their application for a two-stage regulatory system.

Berens C, Lochner S, Löber S, Usai I, Schmidt A, Drueppel L, Hillen W, Gmeiner P.

Chembiochem. 2006 Sep;7(9):1320-4. No abstract available.

PMID:
16871602
45.

A gene regulation system with four distinct expression levels.

Krueger C, Danke C, Pfleiderer K, Schuh W, Jäck HM, Lochner S, Gmeiner P, Hillen W, Berens C.

J Gene Med. 2006 Aug;8(8):1037-47.

PMID:
16779863
46.
47.
48.

Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation.

Schumacher MA, Seidel G, Hillen W, Brennan RG.

J Biol Chem. 2006 Mar 10;281(10):6793-800. Epub 2005 Nov 29.

49.

Integrative elements for Bacillus subtilis yielding tetracycline-dependent growth phenotypes.

Bertram R, Köstner M, Müller J, Vazquez Ramos J, Hillen W.

Nucleic Acids Res. 2005 Oct 12;33(18):e153.

50.

Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange.

Wong ET, Kolman JL, Li YC, Mesner LD, Hillen W, Berens C, Wahl GM.

Nucleic Acids Res. 2005 Oct 4;33(17):e147.

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