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Multicenter study of lumbar discectomy with Barricaid annular closure device for prevention of lumbar disc reherniation in US patients: A historically controlled post-market study protocol.

Strenge KB, DiPaola CP, Miller LE, Hill CP, Whitmore RG.

Medicine (Baltimore). 2019 Aug;98(35):e16953. doi: 10.1097/MD.0000000000016953.


Structure of the Cdc48 segregase in the act of unfolding an authentic substrate.

Cooney I, Han H, Stewart MG, Carson RH, Hansen DT, Iwasa JH, Price JC, Hill CP, Shen PS.

Science. 2019 Aug 2;365(6452):502-505. doi: 10.1126/science.aax0486. Epub 2019 Jun 27.


Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases.

Han H, Fulcher JM, Dandey VP, Iwasa JH, Sundquist WI, Kay MS, Shen PS, Hill CP.

Elife. 2019 Jun 11;8. pii: e44071. doi: 10.7554/eLife.44071.


Selective Kinase Inhibition Shows That Bur1 (Cdk9) Phosphorylates the Rpb1 Linker In Vivo.

Chun Y, Joo YJ, Suh H, Batot G, Hill CP, Formosa T, Buratowski S.

Mol Cell Biol. 2019 Jul 16;39(15). pii: e00602-18. doi: 10.1128/MCB.00602-18. Print 2019 Aug 1.


Phosphorylation of Tyr-950 in the proteasome scaffolding protein RPN2 modulates its interaction with the ubiquitin receptor RPN13.

Hemmis CW, Heard SC, Hill CP.

J Biol Chem. 2019 Jun 21;294(25):9659-9665. doi: 10.1074/jbc.AC119.008881. Epub 2019 May 7.


Structure and mechanism of the ESCRT pathway AAA+ ATPase Vps4.

Han H, Hill CP.

Biochem Soc Trans. 2019 Feb 28;47(1):37-45. doi: 10.1042/BST20180260. Epub 2019 Jan 15. Review.


Vms1p is a release factor for the ribosome-associated quality control complex.

Zurita Rendón O, Fredrickson EK, Howard CJ, Van Vranken J, Fogarty S, Tolley ND, Kalia R, Osuna BA, Shen PS, Hill CP, Frost A, Rutter J.

Nat Commun. 2018 Jun 6;9(1):2197. doi: 10.1038/s41467-018-04564-3.


The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets.

Han H, Monroe N, Sundquist WI, Shen PS, Hill CP.

Elife. 2017 Nov 22;6. pii: e31324. doi: 10.7554/eLife.31324.


Sterol Oxidation Mediates Stress-Responsive Vms1 Translocation to Mitochondria.

Nielson JR, Fredrickson EK, Waller TC, Rendón OZ, Schubert HL, Lin Z, Hill CP, Rutter J.

Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.


A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription.

Sdano MA, Fulcher JM, Palani S, Chandrasekharan MB, Parnell TJ, Whitby FG, Formosa T, Hill CP.

Elife. 2017 Aug 16;6. pii: e28723. doi: 10.7554/eLife.28723.


Structure and energetics of pairwise interactions between proteasome subunits RPN2, RPN13, and ubiquitin clarify a substrate recruitment mechanism.

VanderLinden RT, Hemmis CW, Yao T, Robinson H, Hill CP.

J Biol Chem. 2017 Jun 9;292(23):9493-9504. doi: 10.1074/jbc.M117.785287. Epub 2017 Apr 25.


Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase.

Monroe N, Han H, Shen PS, Sundquist WI, Hill CP.

Elife. 2017 Apr 5;6. pii: e24487. doi: 10.7554/eLife.24487.


Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase.

VanderLinden RT, Hemmis CW, Schmitt B, Ndoja A, Whitby FG, Robinson H, Cohen RE, Yao T, Hill CP.

Mol Cell. 2016 Feb 4;61(3):487. doi: 10.1016/j.molcel.2016.01.014. Epub 2016 Feb 4. No abstract available.


Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines.

Monroe N, Hill CP.

J Mol Biol. 2016 May 8;428(9 Pt B):1897-911. doi: 10.1016/j.jmb.2015.11.004. Epub 2015 Nov 10. Review.


FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs.

Kemble DJ, McCullough LL, Whitby FG, Formosa T, Hill CP.

Mol Cell. 2015 Oct 15;60(2):294-306. doi: 10.1016/j.molcel.2015.09.008. Epub 2015 Oct 8.


Editorial overview: Macromolecular machines and assemblies: Rise and fall at the molecular level.

Forest KT, Hill CP.

Curr Opin Struct Biol. 2015 Apr;31:vii-viii. doi: 10.1016/ Epub 2015 May 29. No abstract available.


Binding of Substrates to the Central Pore of the Vps4 ATPase Is Autoinhibited by the Microtubule Interacting and Trafficking (MIT) Domain and Activated by MIT Interacting Motifs (MIMs).

Han H, Monroe N, Votteler J, Shakya B, Sundquist WI, Hill CP.

J Biol Chem. 2015 May 22;290(21):13490-9. doi: 10.1074/jbc.M115.642355. Epub 2015 Apr 1.


Structural basis for the activation and inhibition of the UCH37 deubiquitylase.

Vander Linden RT, Hemmis CW, Schmitt B, Ndoja A, Whitby FG, Robinson H, Cohen RE, Yao T, Hill CP.

Mol Cell. 2015 Mar 5;57(5):901-911. doi: 10.1016/j.molcel.2015.01.016. Epub 2015 Feb 19.


Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets.

Clinton TR, Weinstock MT, Jacobsen MT, Szabo-Fresnais N, Pandya MJ, Whitby FG, Herbert AS, Prugar LI, McKinnon R, Hill CP, Welch BD, Dye JM, Eckert DM, Kay MS.

Protein Sci. 2015 Apr;24(4):446-63. doi: 10.1002/pro.2578. Epub 2014 Oct 31.


The oligomeric state of the active Vps4 AAA ATPase.

Monroe N, Han H, Gonciarz MD, Eckert DM, Karren MA, Whitby FG, Sundquist WI, Hill CP.

J Mol Biol. 2014 Feb 6;426(3):510-25. doi: 10.1016/j.jmb.2013.09.043. Epub 2013 Oct 23.


Building a super elongation complex for HIV.

Hill CP, Sundquist WI.

Elife. 2013 Mar 8;2:e00577. doi: 10.7554/eLife.00577.


Structure of the Spt16 middle domain reveals functional features of the histone chaperone FACT.

Kemble DJ, Whitby FG, Robinson H, McCullough LL, Formosa T, Hill CP.

J Biol Chem. 2013 Apr 12;288(15):10188-94. doi: 10.1074/jbc.C113.451369. Epub 2013 Feb 15.


Structural biology of the proteasome.

Kish-Trier E, Hill CP.

Annu Rev Biophys. 2013;42:29-49. doi: 10.1146/annurev-biophys-083012-130417. Epub 2013 Feb 13. Review.


Structure of an actin-related subcomplex of the SWI/SNF chromatin remodeler.

Schubert HL, Wittmeyer J, Kasten MM, Hinata K, Rawling DC, Héroux A, Cairns BR, Hill CP.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3345-50. doi: 10.1073/pnas.1215379110. Epub 2013 Feb 11.


Structure of a proteasome Pba1-Pba2 complex: implications for proteasome assembly, activation, and biological function.

Stadtmueller BM, Kish-Trier E, Ferrell K, Petersen CN, Robinson H, Myszka DG, Eckert DM, Formosa T, Hill CP.

J Biol Chem. 2012 Oct 26;287(44):37371-82. doi: 10.1074/jbc.M112.367003. Epub 2012 Aug 28.


Structure of the Bro1 domain protein BROX and functional analyses of the ALIX Bro1 domain in HIV-1 budding.

Zhai Q, Landesman MB, Robinson H, Sundquist WI, Hill CP.

PLoS One. 2011;6(12):e27466. doi: 10.1371/journal.pone.0027466. Epub 2011 Dec 5.


An asymmetric interface between the regulatory and core particles of the proteasome.

Tian G, Park S, Lee MJ, Huck B, McAllister F, Hill CP, Gygi SP, Finley D.

Nat Struct Mol Biol. 2011 Oct 30;18(11):1259-67. doi: 10.1038/nsmb.2147.


Structure and function of the membrane deformation AAA ATPase Vps4.

Hill CP, Babst M.

Biochim Biophys Acta. 2012 Jan;1823(1):172-81. doi: 10.1016/j.bbamcr.2011.08.017. Epub 2011 Sep 8. Review.


Balamuthia amebic meningoencephalitis and mycotic aneurysms in an infant.

Hill CP, Damodaran O, Walsh P, Jevon GP, Blyth CC.

Pediatr Neurol. 2011 Jul;45(1):45-8. doi: 10.1016/j.pediatrneurol.2011.05.003.


Activation of the retroviral budding factor ALIX.

Zhai Q, Landesman MB, Chung HY, Dierkers A, Jeffries CM, Trewhella J, Hill CP, Sundquist WI.

J Virol. 2011 Sep;85(17):9222-6. doi: 10.1128/JVI.02653-10. Epub 2011 Jun 29.


UNC119 is required for G protein trafficking in sensory neurons.

Zhang H, Constantine R, Vorobiev S, Chen Y, Seetharaman J, Huang YJ, Xiao R, Montelione GT, Gerstner CD, Davis MW, Inana G, Whitby FG, Jorgensen EM, Hill CP, Tong L, Baehr W.

Nat Neurosci. 2011 Jun 5;14(7):874-80. doi: 10.1038/nn.2835.


Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain.

Close D, Johnson SJ, Sdano MA, McDonald SM, Robinson H, Formosa T, Hill CP.

J Mol Biol. 2011 May 13;408(4):697-713. doi: 10.1016/j.jmb.2011.03.002. Epub 2011 Mar 17.


Proteasome activators.

Stadtmueller BM, Hill CP.

Mol Cell. 2011 Jan 7;41(1):8-19. doi: 10.1016/j.molcel.2010.12.020. Review.


Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes.

Koirala S, Bui HT, Schubert HL, Eckert DM, Hill CP, Kay MS, Shaw JM.

J Cell Biol. 2010 Dec 13;191(6):1127-39. doi: 10.1083/jcb.201005046.


Structure and biological importance of the Spn1-Spt6 interaction, and its regulatory role in nucleosome binding.

McDonald SM, Close D, Xin H, Formosa T, Hill CP.

Mol Cell. 2010 Dec 10;40(5):725-35. doi: 10.1016/j.molcel.2010.11.014. Epub 2010 Nov 25.


Identification and structural characterization of the ALIX-binding late domains of simian immunodeficiency virus SIVmac239 and SIVagmTan-1.

Zhai Q, Landesman MB, Robinson H, Sundquist WI, Hill CP.

J Virol. 2011 Jan;85(1):632-7. doi: 10.1128/JVI.01683-10. Epub 2010 Oct 20.


Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations.

Schubert HL, Zhai Q, Sandrin V, Eckert DM, Garcia-Maya M, Saul L, Sundquist WI, Steiner RA, Hill CP.

Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17951-6. doi: 10.1073/pnas.1008206107. Epub 2010 Sep 29.


Emergent Properties of EWS/FLI Regulation via GGAA Microsatellites in Ewing's Sarcoma.

Gangwal K, Close D, Enriquez CA, Hill CP, Lessnick SL.

Genes Cancer. 2010 Feb 1;1(2):177-187.


Design of a potent D-peptide HIV-1 entry inhibitor with a strong barrier to resistance.

Welch BD, Francis JN, Redman JS, Paul S, Weinstock MT, Reeves JD, Lie YS, Whitby FG, Eckert DM, Hill CP, Root MJ, Kay MS.

J Virol. 2010 Nov;84(21):11235-44. doi: 10.1128/JVI.01339-10. Epub 2010 Aug 18.


Dynamic anterior cervical plating for multi-level spondylosis: Does it help?

Ragab AA, Hodges FS, Hill CP, McGuire RA, Tucci M.

Evid Based Spine Care J. 2010 May;1(1):41-6. doi: 10.1055/s-0028-1100892.


X-ray structures of isopentenyl phosphate kinase.

Mabanglo MF, Schubert HL, Chen M, Hill CP, Poulter CD.

ACS Chem Biol. 2010 May 21;5(5):517-27. doi: 10.1021/cb100032g.


Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening.

Sadre-Bazzaz K, Whitby FG, Robinson H, Formosa T, Hill CP.

Mol Cell. 2010 Mar 12;37(5):728-35. doi: 10.1016/j.molcel.2010.02.002.


Structural models for interactions between the 20S proteasome and its PAN/19S activators.

Stadtmueller BM, Ferrell K, Whitby FG, Heroux A, Robinson H, Myszka DG, Hill CP.

J Biol Chem. 2010 Jan 1;285(1):13-7. doi: 10.1074/jbc.C109.070425. Epub 2009 Nov 4.


Structural and kinetic characterization of mutant human uroporphyrinogen decarboxylases.

Warby CA, Phillips JD, Bergonia HA, Whitby FG, Hill CP, Kushner JP.

Cell Mol Biol (Noisy-le-grand). 2009 Jul 1;55(2):40-5.


Structural basis for ESCRT-III protein autoinhibition.

Bajorek M, Schubert HL, McCullough J, Langelier C, Eckert DM, Stubblefield WM, Uter NT, Myszka DG, Hill CP, Sundquist WI.

Nat Struct Mol Biol. 2009 Jul;16(7):754-62. doi: 10.1038/nsmb.1621. Epub 2009 Jun 14.


X-ray structures of the hexameric building block of the HIV capsid.

Pornillos O, Ganser-Pornillos BK, Kelly BN, Hua Y, Whitby FG, Stout CD, Sundquist WI, Hill CP, Yeager M.

Cell. 2009 Jun 26;137(7):1282-92. doi: 10.1016/j.cell.2009.04.063. Epub 2009 Jun 11.


Substrate shuttling between active sites of uroporphyrinogen decarboxylase is not required to generate coproporphyrinogen.

Phillips JD, Warby CA, Whitby FG, Kushner JP, Hill CP.

J Mol Biol. 2009 Jun 5;389(2):306-14. doi: 10.1016/j.jmb.2009.04.013. Epub 2009 Apr 10.


Biochemical and structural studies of yeast Vps4 oligomerization.

Gonciarz MD, Whitby FG, Eckert DM, Kieffer C, Heroux A, Sundquist WI, Hill CP.

J Mol Biol. 2008 Dec 26;384(4):878-95. doi: 10.1016/j.jmb.2008.09.066. Epub 2008 Oct 4.


Structure and mechanistic implications of a uroporphyrinogen III synthase-product complex.

Schubert HL, Phillips JD, Heroux A, Hill CP.

Biochemistry. 2008 Aug 19;47(33):8648-55. doi: 10.1021/bi800635y. Epub 2008 Jul 24.


Structure and function of SirC from Bacillus megaterium: a metal-binding precorrin-2 dehydrogenase.

Schubert HL, Rose RS, Leech HK, Brindley AA, Hill CP, Rigby SE, Warren MJ.

Biochem J. 2008 Oct 15;415(2):257-63. doi: 10.1042/BJ20080785.

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