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SNiPER: a novel hypermethylation biomarker panel for liquid biopsy based early breast cancer detection.

Mijnes J, Tiedemann J, Eschenbruch J, Gasthaus J, Bringezu S, Bauerschlag D, Maass N, Arnold N, Weimer J, Anzeneder T, Fasching PA, Rübner M, Bruno B, Heindrichs U, Freres J, Schulz H, Hilgers RD, Ortiz-Brüchle N, von Serenyi S, Knüchel R, Kloten V, Dahl E.

Oncotarget. 2019 Nov 5;10(60):6494-6508. doi: 10.18632/oncotarget.27303. eCollection 2019 Nov 5.


First Investigation of Dual-Wavelength Lasers (2780 nm Er,Cr:YSGG and 940 nm Diode) on Implants in a Simulating Peri-Implantitis Situation Regarding Temperature Changes in an In Vitro Pocket Model.

Alhaidary D, Franzen R, Hilgers RD, Gutknecht N.

Photobiomodul Photomed Laser Surg. 2019 Aug;37(8):508-514. doi: 10.1089/photob.2019.4650.


Randomization in survival studies: An evaluation method that takes into account selection and chronological bias.

Rückbeil MV, Hilgers RD, Heussen N.

PLoS One. 2019 Jun 3;14(6):e0217946. doi: 10.1371/journal.pone.0217946. eCollection 2019.


Design and analysis of stratified clinical trials in the presence of bias.

Hilgers RD, Manolov M, Heussen N, Rosenberger WF.

Stat Methods Med Res. 2019 May 10:962280219846146. doi: 10.1177/0962280219846146. [Epub ahead of print]


ROCK-ALS: Protocol for a Randomized, Placebo-Controlled, Double-Blind Phase IIa Trial of Safety, Tolerability and Efficacy of the Rho Kinase (ROCK) Inhibitor Fasudil in Amyotrophic Lateral Sclerosis.

Lingor P, Weber M, Camu W, Friede T, Hilgers R, Leha A, Neuwirth C, Günther R, Benatar M, Kuzma-Kozakiewicz M, Bidner H, Blankenstein C, Frontini R, Ludolph A, Koch JC; ROCK-ALS Investigators.

Front Neurol. 2019 Mar 27;10:293. doi: 10.3389/fneur.2019.00293. eCollection 2019.


Interdisciplinary pharmaceutical sciences activity within a pharmacy practice skills course.

Brown KP, Raccor BS, Hilgers RH, Breivogel CS.

Curr Pharm Teach Learn. 2019 Mar;11(3):270-276. doi: 10.1016/j.cptl.2018.12.009. Epub 2018 Dec 27.


Renal outcomes of STOP-IgAN trial patients in relation to baseline histology (MEST-C scores).

Schimpf JI, Klein T, Fitzner C, Eitner F, Porubsky S, Hilgers RD, Floege J, Groene HJ, Rauen T.

BMC Nephrol. 2018 Nov 19;19(1):328. doi: 10.1186/s12882-018-1128-6.


Recommendations for the design of small population clinical trials.

Day S, Jonker AH, Lau LPL, Hilgers RD, Irony I, Larsson K, Roes KC, Stallard N.

Orphanet J Rare Dis. 2018 Nov 6;13(1):195. doi: 10.1186/s13023-018-0931-2.


Urinary Biomarkers in the Prediction of Prognosis and Treatment Response in IgA Nephropathy.

Neuhaus J, Bauer F, Fitzner C, Hilgers RD, Seibert F, Babel N, Doevelaar A, Eitner F, Floege J, Rauen T, Westhoff TH.

Kidney Blood Press Res. 2018;43(5):1563-1572. doi: 10.1159/000494442. Epub 2018 Oct 22.


Improve hip fracture outcome in the elderly patient (iHOPE): a study protocol for a pragmatic, multicentre randomised controlled trial to test the efficacy of spinal versus general anaesthesia.

Kowark A, Adam C, Ahrens J, Bajbouj M, Bollheimer C, Borowski M, Dodel R, Dolch M, Hachenberg T, Henzler D, Hildebrand F, Hilgers RD, Hoeft A, Isfort S, Kienbaum P, Knobe M, Knuefermann P, Kranke P, Laufenberg-Feldmann R, Nau C, Neuman MD, Olotu C, Rex C, Rossaint R, Sanders RD, Schmidt R, Schneider F, Siebert H, Skorning M, Spies C, Vicent O, Wappler F, Wirtz DC, Wittmann M, Zacharowski K, Zarbock A, Coburn M; iHOPE study group.

BMJ Open. 2018 Oct 18;8(10):e023609. doi: 10.1136/bmjopen-2018-023609.


Observations below multiple lower limits of quantification: How to estimate the mean and variance.

Berger T, Hilgers RD, Heussen N.

Biom J. 2019 Sep;61(5):1258-1269. doi: 10.1002/bimj.201700293. Epub 2018 Sep 16.


Lessons learned from IDeAl - 33 recommendations from the IDeAl-net about design and analysis of small population clinical trials.

Hilgers RD, Bogdan M, Burman CF, Dette H, Karlsson M, König F, Male C, Mentré F, Molenberghs G, Senn S.

Orphanet J Rare Dis. 2018 May 11;13(1):77. doi: 10.1186/s13023-018-0820-8. Review.


Preterm Pulmonary Hemorrhage Is Associated with Multiple Births but Not with Intracytoplasmic Sperm Injection: A Cohort Study on Medical Records.

Stierling S, Hilgers RD, Trepels-Kottek S, Heimann K, Orlikowsky T, Schoberer M.

Am J Perinatol. 2018 Sep;35(11):1087-1092. doi: 10.1055/s-0038-1641589. Epub 2018 Apr 10.


CTLA-4 Polymorphisms in Patients with IgA Nephropathy Correlate with Proteinuria.

Jacob M, Ohl K, Goodarzi T, Harendza S, Eggermann T, Fitzner C, Hilgers RD, Bolte A, Floege J, Rauen T, Tenbrock K.

Kidney Blood Press Res. 2018;43(2):360-366. doi: 10.1159/000488069. Epub 2018 Mar 8.


Laccase/Mediator Systems: Their Reactivity toward Phenolic Lignin Structures.

Hilgers R, Vincken JP, Gruppen H, Kabel MA.

ACS Sustain Chem Eng. 2018 Feb 5;6(2):2037-2046. doi: 10.1021/acssuschemeng.7b03451. Epub 2018 Jan 4.


The impact of selection bias in randomized multi-arm parallel group clinical trials.

Uschner D, Hilgers RD, Heussen N.

PLoS One. 2018 Jan 31;13(1):e0192065. doi: 10.1371/journal.pone.0192065. eCollection 2018.


ERDO - a framework to select an appropriate randomization procedure for clinical trials.

Hilgers RD, Uschner D, Rosenberger WF, Heussen N.

BMC Med Res Methodol. 2017 Dec 4;17(1):159. doi: 10.1186/s12874-017-0428-z.


Quantification of the catalytic performance of C1-cellulose-specific lytic polysaccharide monooxygenases.

Frommhagen M, Westphal AH, Hilgers R, Koetsier MJ, Hinz SWA, Visser J, Gruppen H, van Berkel WJH, Kabel MA.

Appl Microbiol Biotechnol. 2018 Feb;102(3):1281-1295. doi: 10.1007/s00253-017-8541-9. Epub 2017 Dec 2.


Effects of Two Immunosuppressive Treatment Protocols for IgA Nephropathy.

Rauen T, Fitzner C, Eitner F, Sommerer C, Zeier M, Otte B, Panzer U, Peters H, Benck U, Mertens PR, Kuhlmann U, Witzke O, Gross O, Vielhauer V, Mann JFE, Hilgers RD, Floege J.

J Am Soc Nephrol. 2018 Jan;29(1):317-325. doi: 10.1681/ASN.2017060713. Epub 2017 Oct 17.


Incidence of adult respiratory distress syndrome in trauma patients: A systematic review and meta-analysis over a period of three decades.

Pfeifer R, Heussen N, Michalewicz E, Hilgers RD, Pape HC.

J Trauma Acute Care Surg. 2017 Sep;83(3):496-506. doi: 10.1097/TA.0000000000001571. Review.


Enzymatic Browning in Sugar Beet Leaves (Beta vulgaris L.): Influence of Caffeic Acid Derivatives, Oxidative Coupling, and Coupled Oxidation.

Vissers A, Kiskini A, Hilgers R, Marinea M, Wierenga PA, Gruppen H, Vincken JP.

J Agric Food Chem. 2017 Jun 21;65(24):4911-4920. doi: 10.1021/acs.jafc.7b01897. Epub 2017 Jun 9.


Testing the clinical value of multifocal electroretinography and microperimetry and the effects of intravitreal therapy with ranibizumab on macular function in the course of wet age-related macular degeneration: a 1-year prospective study.

Reinsberg M, Hilgers RD, Lüdeke I, Nassar K, Grisanti S, Grisanti S, Lüke J, Lüke M.

Clin Ophthalmol. 2017 Apr 6;11:621-629. doi: 10.2147/OPTH.S123513. eCollection 2017.


Assessing the impact of selection bias on test decisions in trials with a time-to-event outcome.

Rückbeil MV, Hilgers RD, Heussen N.

Stat Med. 2017 Jul 30;36(17):2656-2668. doi: 10.1002/sim.7299. Epub 2017 Apr 17.


Thioredoxin reverses age-related hypertension by chronically improving vascular redox and restoring eNOS function.

Hilgers RH, Kundumani-Sridharan V, Subramani J, Chen LC, Cuello LG, Rusch NJ, Das KC.

Sci Transl Med. 2017 Feb 8;9(376). pii: eaaf6094. doi: 10.1126/scitranslmed.aaf6094.


Telemedical support for prehospital Emergency Medical Service (TEMS trial): study protocol for a randomized controlled trial.

Stevanovic A, Beckers SK, Czaplik M, Bergrath S, Coburn M, Brokmann JC, Hilgers RD, Rossaint R; TEMS Collaboration Group.

Trials. 2017 Jan 26;18(1):43. doi: 10.1186/s13063-017-1781-2.


Efficacy and safety of a fixed bimonthly ranibizumab treatment regimen in eyes with neovascular age-related macular degeneration: results from the RABIMO trial.

Feltgen N, Bertelmann T, Bretag M, Pfeiffer S, Hilgers R, Callizo J, Goldammer L, Bemme S, Hoerauf H.

Graefes Arch Clin Exp Ophthalmol. 2017 May;255(5):923-934. doi: 10.1007/s00417-017-3589-x. Epub 2017 Jan 19.


Maxillary advancement versus mandibular setback in class III dentofacial deformity: are there any differences in aesthetic outcomes?

Ghassemi M, Hilgers RD, Fritz U, Modabber A, Ghassemi A.

Int J Oral Maxillofac Surg. 2017 Apr;46(4):483-489. doi: 10.1016/j.ijom.2016.11.017. Epub 2016 Dec 30.


Secretory products from epicardial adipose tissue from patients with type 2 diabetes impair mitochondrial β-oxidation in cardiomyocytes via activation of the cardiac renin-angiotensin system and induction of miR-208a.

Blumensatt M, Fahlbusch P, Hilgers R, Bekaert M, Herzfeld de Wiza D, Akhyari P, Ruige JB, Ouwens DM.

Basic Res Cardiol. 2017 Jan;112(1):2. Epub 2016 Nov 18.


Progression characteristics of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS): a 2 year cohort study.

Reetz K, Dogan I, Hilgers RD, Giunti P, Mariotti C, Durr A, Boesch S, Klopstock T, de Rivera FJR, Schöls L, Klockgether T, Bürk K, Rai M, Pandolfo M, Schulz JB; EFACTS Study Group.

Lancet Neurol. 2016 Dec;15(13):1346-1354. doi: 10.1016/S1474-4422(16)30287-3. Erratum in: Lancet Neurol. 2017 Dec;16(12 ):954.


Erratum to: Making sense of big data in health research: towards an EU action plan.

Auffray C, Balling R, Barroso I, Bencze L, Benson M, Bergeron J, Bernal-Delgado E, Blomberg N, Bock C, Conesa A, Del Signore S, Delogne C, Devilee P, Di Meglio A, Eijkemans M, Flicek P, Graf N, Grimm V, Guchelaar HJ, Guo YK, Gut IG, Hanbury A, Hanif S, Hilgers RD, Honrado Á, Hose DR, Houwing-Duistermaat J, Hubbard T, Janacek SH, Karanikas H, Kievits T, Kohler M, Kremer A, Lanfear J, Lengauer T, Maes E, Meert T, Müller W, Nickel D, Oledzki P, Pedersen B, Petkovic M, Pliakos K, Rattray M, I Màs JR, Schneider R, Sengstag T, Serra-Picamal X, Spek W, Vaas LA, van Batenburg O, Vandelaer M, Varnai P, Villoslada P, Vizcaíno JA, Wubbe JP, Zanetti G.

Genome Med. 2016 Nov 7;8(1):118. No abstract available.


Subtarsal Versus Transconjunctival Approach-Esthetic and Functional Long-Term Experience.

Strobel L, Hölzle F, Riediger D, Hilgers RD, Modabber A, Gerressen M.

J Oral Maxillofac Surg. 2016 Nov;74(11):2230-2238. doi: 10.1016/j.joms.2016.06.181. Epub 2016 Jul 1.


The randomized shortened dental arch study: influence of two different treatments on interdental spacing over 5 years.

Kern JS, Wolfart S, Hilgers RD, Marré B, Scheller H, Strub J, Böning K, Hannak W, Luthardt RG, Heydecke G, Huppertz J, Pospiech P, Wöstmann B, Stark H, Mundt T, Jahn F, Kern M, Edelhoff D, Walter MH.

Clin Oral Investig. 2017 Jul;21(6):1945-1951. doi: 10.1007/s00784-016-1981-2. Epub 2016 Oct 26.


Estimating the reliability of repeatedly measured endpoints based on linear mixed-effects models. A tutorial.

Van der Elst W, Molenberghs G, Hilgers RD, Verbeke G, Heussen N.

Pharm Stat. 2016 Nov;15(6):486-493. doi: 10.1002/pst.1787. Epub 2016 Sep 29.


Disinfection of gloves: feasible, but pay attention to the disinfectant/glove combination.

Scheithauer S, Häfner H, Seef R, Seef S, Hilgers RD, Lemmen S.

J Hosp Infect. 2016 Nov;94(3):268-272. doi: 10.1016/j.jhin.2016.08.007. Epub 2016 Aug 18.


Thioredoxin Uses a GSH-independent Route to Deglutathionylate Endothelial Nitric-oxide Synthase and Protect against Myocardial Infarction.

Subramani J, Kundumani-Sridharan V, Hilgers RH, Owens C, Das KC.

J Biol Chem. 2016 Nov 4;291(45):23374-23389. Epub 2016 Sep 1.


Data Integration for Integrated Research and Care.

Winter A, Hilgers RD, Hofestädt R, Knaup-Gregori P, Ose C, Timmer A.

Methods Inf Med. 2016 Aug 5;55(4):365-6. doi: 10.3414/ME2016040001. Epub 2016 Jul 13.


Making sense of big data in health research: Towards an EU action plan.

Auffray C, Balling R, Barroso I, Bencze L, Benson M, Bergeron J, Bernal-Delgado E, Blomberg N, Bock C, Conesa A, Del Signore S, Delogne C, Devilee P, Di Meglio A, Eijkemans M, Flicek P, Graf N, Grimm V, Guchelaar HJ, Guo YK, Gut IG, Hanbury A, Hanif S, Hilgers RD, Honrado Á, Hose DR, Houwing-Duistermaat J, Hubbard T, Janacek SH, Karanikas H, Kievits T, Kohler M, Kremer A, Lanfear J, Lengauer T, Maes E, Meert T, Müller W, Nickel D, Oledzki P, Pedersen B, Petkovic M, Pliakos K, Rattray M, I Màs JR, Schneider R, Sengstag T, Serra-Picamal X, Spek W, Vaas LA, van Batenburg O, Vandelaer M, Varnai P, Villoslada P, Vizcaíno JA, Wubbe JP, Zanetti G.

Genome Med. 2016 Jun 23;8(1):71. doi: 10.1186/s13073-016-0323-y. Erratum in: Genome Med. 2016 Nov 7;8(1):118.


Directions for new developments on statistical design and analysis of small population group trials.

Hilgers RD, Roes K, Stallard N; IDeAl, Asterix and InSPiRe project groups.

Orphanet J Rare Dis. 2016 Jun 14;11(1):78. doi: 10.1186/s13023-016-0464-5.


Primary vitrectomy for rhegmatogenous retinal detachment in pseudophakic eyes: 20-gauge versus 25-gauge vitrectomy.

Süsskind D, Neuhann I, Hilgers RD, Hagemann U, Szurman P, Bartz-Schmidt KU, Aisenbrey S.

Acta Ophthalmol. 2016 Dec;94(8):824-828. doi: 10.1111/aos.13133. Epub 2016 Jun 8.


Hedgehog Blockade for Basal Cell Carcinoma: Coming at a (Secondary Neoplastic) Price.

Rübben A, Hilgers RD, Leverkus M.

JAMA Dermatol. 2016 May 1;152(5):521-3. doi: 10.1001/jamadermatol.2015.5239. No abstract available.


Induction of regulatory T cells in Th1-/Th17-driven experimental autoimmune encephalomyelitis by zinc administration.

Rosenkranz E, Maywald M, Hilgers RD, Brieger A, Clarner T, Kipp M, Plümäkers B, Meyer S, Schwerdtle T, Rink L.

J Nutr Biochem. 2016 Mar;29:116-23. doi: 10.1016/j.jnutbio.2015.11.010. Epub 2015 Dec 1.


Effects of Smoking Cessation on Presynaptic Dopamine Function of Addicted Male Smokers.

Rademacher L, Prinz S, Winz O, Henkel K, Dietrich CA, Schmaljohann J, Mohammadkhani Shali S, Schabram I, Stoppe C, Cumming P, Hilgers RD, Kumakura Y, Coburn M, Mottaghy FM, Gründer G, Vernaleken I.

Biol Psychiatry. 2016 Aug 1;80(3):198-206. doi: 10.1016/j.biopsych.2015.11.009. Epub 2015 Dec 1.


Intensive Supportive Care plus Immunosuppression in IgA Nephropathy.

Rauen T, Eitner F, Fitzner C, Sommerer C, Zeier M, Otte B, Panzer U, Peters H, Benck U, Mertens PR, Kuhlmann U, Witzke O, Gross O, Vielhauer V, Mann JF, Hilgers RD, Floege J; STOP-IgAN Investigators.

N Engl J Med. 2015 Dec 3;373(23):2225-36. doi: 10.1056/NEJMoa1415463.


Zinc supplementation induces regulatory T cells by inhibition of Sirt-1 deacetylase in mixed lymphocyte cultures.

Rosenkranz E, Metz CH, Maywald M, Hilgers RD, Weßels I, Senff T, Haase H, Jäger M, Ott M, Aspinall R, Plümäkers B, Rink L.

Mol Nutr Food Res. 2016 Mar;60(3):661-71. doi: 10.1002/mnfr.201500524. Epub 2015 Dec 28.


Zinc enhances the number of regulatory T cells in allergen-stimulated cells from atopic subjects.

Rosenkranz E, Hilgers RD, Uciechowski P, Petersen A, Plümäkers B, Rink L.

Eur J Nutr. 2017 Mar;56(2):557-567. doi: 10.1007/s00394-015-1100-1. Epub 2015 Nov 20.


Significant Reduction of External Ventricular Drainage-Associated Meningoventriculitis by Chlorhexidine-Containing Dressings: A Before-After Trial.

Scheithauer S, Schulze-Steinen H, Höllig A, Lopez-Gonzalez L, Hilgers RD, Reinges MH, Marx G, Lemmen S.

Clin Infect Dis. 2016 Feb 1;62(3):404-5. doi: 10.1093/cid/civ887. Epub 2015 Oct 20. No abstract available.


Combined Tin-Containing Fluoride Solution and CO2 Laser Treatment Reduces Enamel Erosion in vitro.

Esteves-Oliveira M, Witulski N, Hilgers RD, Apel C, Meyer-Lueckel H, Eduardo Cde P.

Caries Res. 2015;49(6):565-74. doi: 10.1159/000439316. Epub 2015 Sep 30.


Good Medicine and Good Healthcare Demand Good Information (Systems).

Winter A, Hilgers RD, Hofestädt R, Hübner U, Knaup-Gregori P, Ose C, Schmoor C, Timmer A, Wege D.

Methods Inf Med. 2015;54(5):385-7. doi: 10.3414/ME15-05-1001. Epub 2015 Sep 17.


Comparison of two different concepts of mesh and fixation technique in laparoscopic ventral hernia repair: a randomized controlled trial.

Pawlak M, Hilgers RD, Bury K, Lehmann A, Owczuk R, Śmietański M.

Surg Endosc. 2016 Mar;30(3):1188-97. doi: 10.1007/s00464-015-4329-0. Epub 2015 Jul 3.


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