Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 34

1.

Erratum: Structural and conformational determinants of macrocycle cell permeability.

Over B, Matsson P, Tyrchan C, Artursson P, Doak BC, Foley MA, Hilgendorf C, Johnston SE, Lee MD 4th, Lewis RJ, McCarren P, Muncipinto G, Norinder U, Perry MWD, Duvall JR, Kihlberg J.

Nat Chem Biol. 2017 Jul 18;13(8):922. doi: 10.1038/nchembio0817-922a. No abstract available.

PMID:
28853740
2.

Mass Spectrometry Imaging proves differential absorption profiles of well-characterised permeability markers along the crypt-villus axis.

Nilsson A, Peric A, Strimfors M, Goodwin RJA, Hayes MA, Andrén PE, Hilgendorf C.

Sci Rep. 2017 Jul 25;7(1):6352. doi: 10.1038/s41598-017-06583-4.

3.

Tenapanor administration and the activity of the H+ -coupled transporter PepT1 in healthy volunteers.

Johansson S, Rosenbaum DP, Palm J, Stefansson B, Knutsson M, Lisbon EA, Hilgendorf C.

Br J Clin Pharmacol. 2017 Sep;83(9):2008-2014. doi: 10.1111/bcp.13313. Epub 2017 May 31.

4.

In Vitro Intrinsic Permeability: A Transporter-Independent Measure of Caco-2 Cell Permeability in Drug Design and Development.

Fredlund L, Winiwarter S, Hilgendorf C.

Mol Pharm. 2017 May 1;14(5):1601-1609. doi: 10.1021/acs.molpharmaceut.6b01059. Epub 2017 Apr 4.

PMID:
28329446
5.

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results.

Margolskee A, Darwich AS, Pepin X, Aarons L, Galetin A, Rostami-Hodjegan A, Carlert S, Hammarberg M, Hilgendorf C, Johansson P, Karlsson E, Murphy D, Tannergren C, Thörn H, Yasin M, Mazuir F, Nicolas O, Ramusovic S, Xu C, Pathak SM, Korjamo T, Laru J, Malkki J, Pappinen S, Tuunainen J, Dressman J, Hansmann S, Kostewicz E, He H, Heimbach T, Wu F, Hoft C, Laplanche L, Pang Y, Bolger MB, Huehn E, Lukacova V, Mullin JM, Szeto KX, Costales C, Lin J, McAllister M, Modi S, Rotter C, Varma M, Wong M, Mitra A, Bevernage J, Biewenga J, Van Peer A, Lloyd R, Shardlow C, Langguth P, Mishenzon I, Nguyen MA, Brown J, Lennernäs H, Abrahamsson B.

Eur J Pharm Sci. 2017 Jan 1;96:610-625. doi: 10.1016/j.ejps.2016.10.036. Epub 2016 Nov 2.

PMID:
27816631
6.

Structural and conformational determinants of macrocycle cell permeability.

Over B, Matsson P, Tyrchan C, Artursson P, Doak BC, Foley MA, Hilgendorf C, Johnston SE, Lee MD 4th, Lewis RJ, McCarren P, Muncipinto G, Norinder U, Perry MW, Duvall JR, Kihlberg J.

Nat Chem Biol. 2016 Dec;12(12):1065-1074. doi: 10.1038/nchembio.2203. Epub 2016 Oct 17. Erratum in: Nat Chem Biol. 2017 Jul 18;13(8):922.

PMID:
27748751
7.

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes.

Darwich AS, Margolskee A, Pepin X, Aarons L, Galetin A, Rostami-Hodjegan A, Carlert S, Hammarberg M, Hilgendorf C, Johansson P, Karlsson E, Murphy D, Tannergren C, Thörn H, Yasin M, Mazuir F, Nicolas O, Ramusovic S, Xu C, Pathak SM, Korjamo T, Laru J, Malkki J, Pappinen S, Tuunainen J, Dressman J, Hansmann S, Kostewicz E, He H, Heimbach T, Wu F, Hoft C, Pang Y, Bolger MB, Huehn E, Lukacova V, Mullin JM, Szeto KX, Costales C, Lin J, McAllister M, Modi S, Rotter C, Varma M, Wong M, Mitra A, Bevernage J, Biewenga J, Van Peer A, Lloyd R, Shardlow C, Langguth P, Mishenzon I, Nguyen MA, Brown J, Lennernäs H, Abrahamsson B.

Eur J Pharm Sci. 2017 Jan 1;96:626-642. doi: 10.1016/j.ejps.2016.09.037. Epub 2016 Sep 28.

PMID:
27693299
8.

Excised segments of rat small intestine in Ussing chamber studies: A comparison of native and stripped tissue viability and permeability to drugs.

Sjögren E, Eriksson J, Vedin C, Breitholtz K, Hilgendorf C.

Int J Pharm. 2016 May 30;505(1-2):361-8. doi: 10.1016/j.ijpharm.2016.03.063. Epub 2016 Apr 9.

PMID:
27073083
9.

Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination.

Jones CR, Hatley OJ, Ungell AL, Hilgendorf C, Peters SA, Rostami-Hodjegan A.

AAPS J. 2016 May;18(3):589-604. doi: 10.1208/s12248-016-9889-y. Epub 2016 Mar 10. Review.

10.

A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity.

Nieskens TT, Peters JG, Schreurs MJ, Smits N, Woestenenk R, Jansen K, van der Made TK, Röring M, Hilgendorf C, Wilmer MJ, Masereeuw R.

AAPS J. 2016 Mar;18(2):465-75. doi: 10.1208/s12248-016-9871-8. Epub 2016 Jan 28.

11.

Montelukast Disposition: No Indication of Transporter-Mediated Uptake in OATP2B1 and OATP1B1 Expressing HEK293 Cells.

Brännström M, Nordell P, Bonn B, Davis AM, Palmgren AP, Hilgendorf C, Rubin K, Grime K.

Pharmaceutics. 2015 Dec 15;7(4):554-64. doi: 10.3390/pharmaceutics7040554.

12.

Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein-Protein Interaction.

Cheng L, Pettersen D, Ohlsson B, Schell P, Karle M, Evertsson E, Pahlén S, Jonforsen M, Plowright AT, Boström J, Fex T, Thelin A, Hilgendorf C, Xue Y, Wahlund G, Lindberg W, Larsson LO, Gustafsson D.

ACS Med Chem Lett. 2014 Feb 18;5(5):538-43. doi: 10.1021/ml400526d. eCollection 2014 May 8.

13.

Impact of stereospecific intramolecular hydrogen bonding on cell permeability and physicochemical properties.

Over B, McCarren P, Artursson P, Foley M, Giordanetto F, Grönberg G, Hilgendorf C, Lee MD 4th, Matsson P, Muncipinto G, Pellisson M, Perry MW, Svensson R, Duvall JR, Kihlberg J.

J Med Chem. 2014 Mar 27;57(6):2746-54. doi: 10.1021/jm500059t. Epub 2014 Feb 26.

14.

Resolving the distribution-metabolism interplay of eight OATP substrates in the standard clearance assay with suspended human cryopreserved hepatocytes.

Nordell P, Winiwarter S, Hilgendorf C.

Mol Pharm. 2013 Dec 2;10(12):4443-51. doi: 10.1021/mp400253f. Epub 2013 Oct 30.

PMID:
24102095
15.

Utility of in vitro systems and preclinical data for the prediction of human intestinal first-pass metabolism during drug discovery and preclinical development.

Karlsson FH, Bouchene S, Hilgendorf C, Dolgos H, Peters SA.

Drug Metab Dispos. 2013 Dec;41(12):2033-46. doi: 10.1124/dmd.113.051664. Epub 2013 Aug 5.

PMID:
23918667
16.

Prediction of fraction metabolized via CYP3A in humans utilizing cryopreserved human hepatocytes from a set of 12 single donors.

Desbans C, Hilgendorf C, Lutz M, Bachellier P, Zacharias T, Weber JC, Dolgos H, Richert L, Ungell AL.

Xenobiotica. 2014 Jan;44(1):17-27. doi: 10.3109/00498254.2013.809617. Epub 2013 Jul 24.

PMID:
23883428
17.

Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1.

Hutter V, Chau DY, Hilgendorf C, Brown A, Cooper A, Zann V, Pritchard DI, Bosquillon C.

Eur J Pharm Biopharm. 2014 Jan;86(1):74-82. doi: 10.1016/j.ejpb.2013.06.010. Epub 2013 Jun 28.

18.

Cationic uremic toxins affect human renal proximal tubule cell functioning through interaction with the organic cation transporter.

Schophuizen CM, Wilmer MJ, Jansen J, Gustavsson L, Hilgendorf C, Hoenderop JG, van den Heuvel LP, Masereeuw R.

Pflugers Arch. 2013 Dec;465(12):1701-14. doi: 10.1007/s00424-013-1307-z. Epub 2013 Jun 29.

PMID:
23812163
19.

Understanding the critical disposition pathways of statins to assess drug-drug interaction risk during drug development: it's not just about OATP1B1.

Elsby R, Hilgendorf C, Fenner K.

Clin Pharmacol Ther. 2012 Nov;92(5):584-98. doi: 10.1038/clpt.2012.163. Epub 2012 Oct 10. Review.

PMID:
23047648
20.

Characterization of THLE-cytochrome P450 (P450) cell lines: gene expression background and relationship to P450-enzyme activity.

Soltanpour Y, Hilgendorf C, Ahlström MM, Foster AJ, Kenna JG, Petersen A, Ungell AL.

Drug Metab Dispos. 2012 Nov;40(11):2054-8. doi: 10.1124/dmd.112.045815. Epub 2012 Jul 30.

PMID:
22851615
21.

Evaluation of layers of the rat airway epithelial cell line RL-65 for permeability screening of inhaled drug candidates.

Hutter V, Hilgendorf C, Cooper A, Zann V, Pritchard DI, Bosquillon C.

Eur J Pharm Sci. 2012 Sep 29;47(2):481-9. doi: 10.1016/j.ejps.2012.07.007. Epub 2012 Jul 20.

22.

Development of a highly sensitive method using liquid chromatography-multiple reaction monitoring to quantify membrane P-glycoprotein in biological matrices and relationship to transport function.

Miliotis T, Ali L, Palm JE, Lundqvist AJ, Ahnoff M, Andersson TB, Hilgendorf C.

Drug Metab Dispos. 2011 Dec;39(12):2440-9. doi: 10.1124/dmd.111.040774. Epub 2011 Sep 23.

PMID:
21949244
23.

The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat.

Lowes S, Haslam IS, Fihn BM, Hilgendorf C, Karlsson JE, Simmons NL, Ungell AL.

Pharmaceutics. 2010 Mar 15;2(1):61-77.

24.

High-activity p-glycoprotein, multidrug resistance protein 2, and breast cancer resistance protein membrane vesicles prepared from transiently transfected human embryonic kidney 293-epstein-barr virus nuclear antigen cells.

Karlsson JE, Heddle C, Rozkov A, Rotticci-Mulder J, Tuvesson O, Hilgendorf C, Andersson TB.

Drug Metab Dispos. 2010 Apr;38(4):705-14. doi: 10.1124/dmd.109.028886. Epub 2010 Jan 13.

PMID:
20071452
25.

Endogenous gene and protein expression of drug-transporting proteins in cell lines routinely used in drug discovery programs.

Ahlin G, Hilgendorf C, Karlsson J, Szigyarto CA, Uhlén M, Artursson P.

Drug Metab Dispos. 2009 Dec;37(12):2275-83. doi: 10.1124/dmd.109.028654. Epub 2009 Sep 9.

PMID:
19741037
26.

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories.

Hayeshi R, Hilgendorf C, Artursson P, Augustijns P, Brodin B, Dehertogh P, Fisher K, Fossati L, Hovenkamp E, Korjamo T, Masungi C, Maubon N, Mols R, Müllertz A, Mönkkönen J, O'Driscoll C, Oppers-Tiemissen HM, Ragnarsson EG, Rooseboom M, Ungell AL.

Eur J Pharm Sci. 2008 Dec 18;35(5):383-96. doi: 10.1016/j.ejps.2008.08.004. Epub 2008 Aug 19.

PMID:
18782614
27.

Modeling of drug-transporter interactions using structural information.

Winiwarter S, Hilgendorf C.

Curr Opin Drug Discov Devel. 2008 Jan;11(1):95-103. Review.

PMID:
18175272
28.

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.

Hilgendorf C, Ahlin G, Seithel A, Artursson P, Ungell AL, Karlsson J.

Drug Metab Dispos. 2007 Aug;35(8):1333-40. Epub 2007 May 11.

PMID:
17496207
29.

Innovative methods to study human intestinal drug metabolism in vitro: precision-cut slices compared with ussing chamber preparations.

van de Kerkhof EG, Ungell AL, Sjöberg AK, de Jager MH, Hilgendorf C, de Graaf IA, Groothuis GM.

Drug Metab Dispos. 2006 Nov;34(11):1893-902. Epub 2006 Aug 16.

PMID:
16914511
30.

Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: comparison between human segments and Caco-2 cells.

Seithel A, Karlsson J, Hilgendorf C, Björquist A, Ungell AL.

Eur J Pharm Sci. 2006 Jul;28(4):291-9. Epub 2006 Mar 22.

PMID:
16704924
31.

Selective downregulation of the MDR1 gene product in Caco-2 cells by stable transfection to prove its relevance in secretory drug transport.

Hilgendorf C, Spahn-Langguth H, Rhedin M, Regårdh CG, Löwenadler B, Langguth P.

Mol Pharm. 2005 Jan-Feb;2(1):64-73.

PMID:
15804179
32.

Caco-2 versus Caco-2/HT29-MTX co-cultured cell lines: permeabilities via diffusion, inside- and outside-directed carrier-mediated transport.

Hilgendorf C, Spahn-Langguth H, Regårdh CG, Lipka E, Amidon GL, Langguth P.

J Pharm Sci. 2000 Jan;89(1):63-75.

PMID:
10664539
33.

Characterization of binding properties to human P-glycoprotein: development of a [3H]verapamil radioligand-binding assay.

Döppenschmitt S, Langguth P, Regårdh CG, Andersson TB, Hilgendorf C, Spahn-Langguth H.

J Pharmacol Exp Ther. 1999 Jan;288(1):348-57.

PMID:
9862789
34.

P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels.

Anderle P, Niederer E, Rubas W, Hilgendorf C, Spahn-Langguth H, Wunderli-Allenspach H, Merkle HP, Langguth P.

J Pharm Sci. 1998 Jun;87(6):757-62.

PMID:
9607955

Supplemental Content

Loading ...
Support Center