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Items: 14


Neoantigen-directed immune escape in lung cancer evolution.

Rosenthal R, Cadieux EL, Salgado R, Bakir MA, Moore DA, Hiley CT, Lund T, Tanić M, Reading JL, Joshi K, Henry JY, Ghorani E, Wilson GA, Birkbak NJ, Jamal-Hanjani M, Veeriah S, Szallasi Z, Loi S, Hellmann MD, Feber A, Chain B, Herrero J, Quezada SA, Demeulemeester J, Van Loo P, Beck S, McGranahan N, Swanton C; TRACERx consortium.

Nature. 2019 Mar;567(7749):479-485. doi: 10.1038/s41586-019-1032-7. Epub 2019 Mar 20.


Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution.

McGranahan N, Rosenthal R, Hiley CT, Rowan AJ, Watkins TBK, Wilson GA, Birkbak NJ, Veeriah S, Van Loo P, Herrero J, Swanton C; TRACERx Consortium.

Cell. 2017 Nov 30;171(6):1259-1271.e11. doi: 10.1016/j.cell.2017.10.001. Epub 2017 Oct 26.


Tracking the Evolution of Non-Small-Cell Lung Cancer.

Jamal-Hanjani M, Wilson GA, McGranahan N, Birkbak NJ, Watkins TBK, Veeriah S, Shafi S, Johnson DH, Mitter R, Rosenthal R, Salm M, Horswell S, Escudero M, Matthews N, Rowan A, Chambers T, Moore DA, Turajlic S, Xu H, Lee SM, Forster MD, Ahmad T, Hiley CT, Abbosh C, Falzon M, Borg E, Marafioti T, Lawrence D, Hayward M, Kolvekar S, Panagiotopoulos N, Janes SM, Thakrar R, Ahmed A, Blackhall F, Summers Y, Shah R, Joseph L, Quinn AM, Crosbie PA, Naidu B, Middleton G, Langman G, Trotter S, Nicolson M, Remmen H, Kerr K, Chetty M, Gomersall L, Fennell DA, Nakas A, Rathinam S, Anand G, Khan S, Russell P, Ezhil V, Ismail B, Irvin-Sellers M, Prakash V, Lester JF, Kornaszewska M, Attanoos R, Adams H, Davies H, Dentro S, Taniere P, O'Sullivan B, Lowe HL, Hartley JA, Iles N, Bell H, Ngai Y, Shaw JA, Herrero J, Szallasi Z, Schwarz RF, Stewart A, Quezada SA, Le Quesne J, Van Loo P, Dive C, Hackshaw A, Swanton C; TRACERx Consortium.

N Engl J Med. 2017 Jun 1;376(22):2109-2121. doi: 10.1056/NEJMoa1616288. Epub 2017 Apr 26.


Challenges in molecular testing in non-small-cell lung cancer patients with advanced disease.

Hiley CT, Le Quesne J, Santis G, Sharpe R, de Castro DG, Middleton G, Swanton C.

Lancet. 2016 Sep 3;388(10048):1002-11. doi: 10.1016/S0140-6736(16)31340-X. Epub 2016 Sep 1. Review.


Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade.

McGranahan N, Furness AJ, Rosenthal R, Ramskov S, Lyngaa R, Saini SK, Jamal-Hanjani M, Wilson GA, Birkbak NJ, Hiley CT, Watkins TB, Shafi S, Murugaesu N, Mitter R, Akarca AU, Linares J, Marafioti T, Henry JY, Van Allen EM, Miao D, Schilling B, Schadendorf D, Garraway LA, Makarov V, Rizvi NA, Snyder A, Hellmann MD, Merghoub T, Wolchok JD, Shukla SA, Wu CJ, Peggs KS, Chan TA, Hadrup SR, Quezada SA, Swanton C.

Science. 2016 Mar 25;351(6280):1463-9. doi: 10.1126/science.aaf1490. Epub 2016 Mar 3.


Pruning Cancer's Evolutionary Tree with Lesion-Directed Therapy.

Hiley CT, Swanton C.

Cancer Discov. 2016 Feb;6(2):122-4. doi: 10.1158/2159-8290.CD-15-1493.


Evolutionary Precision Medicine: A Role for Repeat Epidermal Growth Factor Receptor Analysis in ALK-Rearranged Lung Adenocarcinoma?

Birkbak NJ, Hiley CT, Swanton C.

J Clin Oncol. 2015 Nov 10;33(32):3681-3. doi: 10.1200/JCO.2015.63.2976. Epub 2015 Sep 28. No abstract available.


Cognitive Impairment in Survivors of Irradiated Brain Tumors Is Multifactorial: Implications of Polypharmacy With Antiepileptics?

Hiley CT.

J Clin Oncol. 2015 Dec 1;33(34):4122. doi: 10.1200/JCO.2015.62.5350. Epub 2015 Sep 14. No abstract available.


Can oncology recapitulate paleontology? Lessons from species extinctions.

Walther V, Hiley CT, Shibata D, Swanton C, Turner PE, Maley CC.

Nat Rev Clin Oncol. 2015 May;12(5):273-85. doi: 10.1038/nrclinonc.2015.12. Epub 2015 Feb 17. Review.


Spatial and temporal cancer evolution: causes and consequences of tumour diversity.

Hiley CT, Swanton C.

Clin Med (Lond). 2014 Dec;14 Suppl 6:s33-7. doi: 10.7861/clinmedicine.14-6-s33. Review.


Vascular endothelial growth factor A promotes vaccinia virus entry into host cells via activation of the Akt pathway.

Hiley CT, Chard LS, Gangeswaran R, Tysome JR, Briat A, Lemoine NR, Wang Y.

J Virol. 2013 Mar;87(5):2781-90. doi: 10.1128/JVI.00854-12. Epub 2012 Dec 26.


Methylseleninic acid inhibits HDAC activity in diffuse large B-cell lymphoma cell lines.

Kassam S, Goenaga-Infante H, Maharaj L, Hiley CT, Juliger S, Joel SP.

Cancer Chemother Pharmacol. 2011 Sep;68(3):815-21. doi: 10.1007/s00280-011-1649-1. Epub 2011 Apr 26.


Lister strain vaccinia virus, a potential therapeutic vector targeting hypoxic tumours.

Hiley CT, Yuan M, Lemoine NR, Wang Y.

Gene Ther. 2010 Feb;17(2):281-7. doi: 10.1038/gt.2009.132. Epub 2009 Nov 5.


Expression of vascular endothelial growth factor (VEGF) in locally invasive prostate cancer is prognostic for radiotherapy outcome.

Green MM, Hiley CT, Shanks JH, Bottomley IC, West CM, Cowan RA, Stratford IJ.

Int J Radiat Oncol Biol Phys. 2007 Jan 1;67(1):84-90.


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