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BK Virus Replication in the Glomerular Vascular Unit: Implications for BK Virus Associated Nephropathy.

Popik W, Khatua AK, Fabre NF, Hildreth JEK, Alcendor DJ.

Viruses. 2019 Jun 27;11(7). pii: E583. doi: 10.3390/v11070583.


Hydroxypropyl-Beta-Cyclodextrin Reduces Inflammatory Signaling from Monocytes: Possible Implications for Suppression of HIV Chronic Immune Activation.

Matassoli FL, Leão IC, Bezerra BB, Pollard RB, Lütjohann D, Hildreth JEK, Arruda LB.

mSphere. 2018 Nov 7;3(6). pii: e00497-18. doi: 10.1128/mSphere.00497-18.


Hydroxypropyl-beta and -gamma cyclodextrins rescue cholesterol accumulation in Niemann-Pick C1 mutant cell via lysosome-associated membrane protein 1.

Singhal A, Szente L, Hildreth JEK, Song B.

Cell Death Dis. 2018 Oct 3;9(10):1019. doi: 10.1038/s41419-018-1056-1.


Phosphorodiamidate morpholino targeting the 5' untranslated region of the ZIKV RNA inhibits virus replication.

Popik W, Khatua A, Hildreth JEK, Lee B, Alcendor DJ.

Virology. 2018 Jun;519:77-85. doi: 10.1016/j.virol.2018.04.001. Epub 2018 Apr 19.


Pseudotyping of HIV-1 with Human T-Lymphotropic Virus 1 (HTLV-1) Envelope Glycoprotein during HIV-1-HTLV-1 Coinfection Facilitates Direct HIV-1 Infection of Female Genital Epithelial Cells: Implications for Sexual Transmission of HIV-1.

Tang Y, George AM, Petrechko O, Nouvet FJ, Sweet SD, Tanaka Y, Imbiakha BS, Jiang G, Gao W, Anastos K, Hildreth JEK.

mSphere. 2018 Apr 4;3(2). pii: e00038-18. doi: 10.1128/mSphere.00038-18. Print 2018 Apr 25.


HIV As Trojan Exosome: Immunological Paradox Explained?

Hildreth JEK.

Front Immunol. 2017 Dec 1;8:1715. doi: 10.3389/fimmu.2017.01715. eCollection 2017.


Erratum for Saha et al., A trans-Dominant Form of Gag Restricts Ty1 Retrotransposition and Mediates Copy Number Control.

Saha A, Mitchell JA, Nishida Y, Hildreth JE, Arribere JA, Gilbert WV, Garfinkel DJ.

J Virol. 2016 Apr 29;90(10):5210. doi: 10.1128/JVI.00418-16. Print 2016 May 15. No abstract available.


Hyaluronic Acid-Based Biocompatible Supramolecular Assembly for Sustained Release of Antiretroviral Drug.

Song B, Puskás I, Szente L, Hildreth JEK.

J Pharm Sci. 2016 Sep;105(9):2760-2769. doi: 10.1016/j.xphs.2016.01.023. Epub 2016 Mar 12.


Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation.

Jiang G, Mendes EA, Kaiser P, Wong DP, Tang Y, Cai I, Fenton A, Melcher GP, Hildreth JE, Thompson GR, Wong JK, Dandekar S.

PLoS Pathog. 2015 Jul 30;11(7):e1005066. doi: 10.1371/journal.ppat.1005066. eCollection 2015 Jul.


A trans-dominant form of Gag restricts Ty1 retrotransposition and mediates copy number control.

Saha A, Mitchell JA, Nishida Y, Hildreth JE, Ariberre JA, Gilbert WV, Garfinkel DJ.

J Virol. 2015 Apr;89(7):3922-38. doi: 10.1128/JVI.03060-14. Epub 2015 Jan 21. Erratum in: J Virol. 2016 Apr 29;90(10 ):5210.


Heat-stable molecule derived from Streptococcus cristatus induces APOBEC3 expression and inhibits HIV-1 replication.

Wang Z, Luo Y, Shao Q, Kinlock BL, Wang C, Hildreth JE, Xie H, Liu B.

PLoS One. 2014 Aug 28;9(8):e106078. doi: 10.1371/journal.pone.0106078. eCollection 2014.


Infection of female primary lower genital tract epithelial cells after natural pseudotyping of HIV-1: possible implications for sexual transmission of HIV-1.

Tang Y, George A, Nouvet F, Sweet S, Emeagwali N, Taylor HE, Simmons G, Hildreth JE.

PLoS One. 2014 Jul 10;9(7):e101367. doi: 10.1371/journal.pone.0101367. eCollection 2014.


Greater ethnic diversity correlates with lower HIV prevalence in Africa: justification for an alloimmunity vaccine.

Zamani C, Elzey JD, Hildreth JE.

HIV AIDS (Auckl). 2013 Apr 12;5:75-80. doi: 10.2147/HIV.S38922. Print 2013.


Structural and thermodynamic insights into the recognition of native proteins by anti-peptide antibodies.

Armstrong A, Hildreth JEK, Amzel LM.

J Mol Biol. 2013 Jun 12;425(11):2027-2038. doi: 10.1016/j.jmb.2013.02.031. Epub 2013 Mar 6.


The conserved set of host proteins incorporated into HIV-1 virions suggests a common egress pathway in multiple cell types.

Linde ME, Colquhoun DR, Ubaida Mohien C, Kole T, Aquino V, Cotter R, Edwards N, Hildreth JE, Graham DR.

J Proteome Res. 2013 May 3;12(5):2045-54. doi: 10.1021/pr300918r. Epub 2013 Mar 29.


Cholesterol depletion inactivates XMRV and leads to viral envelope protein release from virions: evidence for role of cholesterol in XMRV infection.

Tang Y, George A, Taylor T, Hildreth JE.

PLoS One. 2012;7(10):e48013. doi: 10.1371/journal.pone.0048013. Epub 2012 Oct 26.


Caveolin-1 suppresses human immunodeficiency virus-1 replication by inhibiting acetylation of NF-κB.

Simmons GE Jr, Taylor HE, Hildreth JE.

Virology. 2012 Oct 10;432(1):110-9. doi: 10.1016/j.virol.2012.05.016. Epub 2012 Jun 28.


Antibody against integrin lymphocyte function-associated antigen 1 inhibits HIV type 1 infection in primary cells through caspase-8-mediated apoptosis.

Walker TN, Cimakasky LM, Coleman EM, Madison MN, Hildreth JE.

AIDS Res Hum Retroviruses. 2013 Feb;29(2):371-83. doi: 10.1089/AID.2011.0395. Epub 2012 Aug 20.


Cultural differences in acceptability of a vaginal microbicide: a comparison between potential users from Nashville, Tennessee, USA, and Kafue and Mumbwa, Zambia.

Rice VM, Maimbolwa MC, Nkandu EM, Hampton JF, Lee JE, Hildreth JE.

HIV AIDS (Auckl). 2012;4:73-80. doi: 10.2147/HIV.S25848. Epub 2012 May 9.


Filamin A protein interacts with human immunodeficiency virus type 1 Gag protein and contributes to productive particle assembly.

Cooper J, Liu L, Woodruff EA, Taylor HE, Goodwin JS, D'Aquila RT, Spearman P, Hildreth JE, Dong X.

J Biol Chem. 2011 Aug 12;286(32):28498-510. doi: 10.1074/jbc.M111.239053. Epub 2011 Jun 24.


Sterol regulatory element-binding protein 2 couples HIV-1 transcription to cholesterol homeostasis and T cell activation.

Taylor HE, Linde ME, Khatua AK, Popik W, Hildreth JE.

J Virol. 2011 Aug;85(15):7699-709. doi: 10.1128/JVI.00337-11. Epub 2011 May 25.


N-terminal hemagglutinin tag renders lysine-deficient APOBEC3G resistant to HIV-1 Vif-induced degradation by reduced polyubiquitination.

Wang Y, Shao Q, Yu X, Kong W, Hildreth JE, Liu B.

J Virol. 2011 May;85(9):4510-9. doi: 10.1128/JVI.01925-10. Epub 2011 Feb 23.


Non-productive HIV-1 infection of human glomerular and urinary podocytes.

Khatua AK, Taylor HE, Hildreth JE, Popik W.

Virology. 2010 Dec 5;408(1):119-27. doi: 10.1016/j.virol.2010.09.005.


Inhibition of LINE-1 and Alu retrotransposition by exosomes encapsidating APOBEC3G and APOBEC3F.

Khatua AK, Taylor HE, Hildreth JE, Popik W.

Virology. 2010 Apr 25;400(1):68-75. doi: 10.1016/j.virol.2010.01.021. Epub 2010 Feb 11.


Polyubiquitination of APOBEC3G is essential for its degradation by HIV-1 Vif.

Shao Q, Wang Y, Hildreth JE, Liu B.

J Virol. 2010 May;84(9):4840-4. doi: 10.1128/JVI.01911-09. Epub 2010 Feb 10.


Deficiency of niemann-pick type C-1 protein impairs release of human immunodeficiency virus type 1 and results in Gag accumulation in late endosomal/lysosomal compartments.

Tang Y, Leao IC, Coleman EM, Broughton RS, Hildreth JE.

J Virol. 2009 Aug;83(16):7982-95. doi: 10.1128/JVI.00259-09. Epub 2009 May 27.


Exosomes packaging APOBEC3G confer human immunodeficiency virus resistance to recipient cells.

Khatua AK, Taylor HE, Hildreth JE, Popik W.

J Virol. 2009 Jan;83(2):512-21. doi: 10.1128/JVI.01658-08. Epub 2008 Nov 5.


Incomplete protection against simian immunodeficiency virus vaginal transmission in rhesus macaques by a topical antiviral agent revealed by repeat challenges.

Ambrose Z, Compton L, Piatak M Jr, Lu D, Alvord WG, Lubomirski MS, Hildreth JE, Lifson JD, Miller CJ, KewalRamani VN.

J Virol. 2008 Jul;82(13):6591-9. doi: 10.1128/JVI.02730-07. Epub 2008 Apr 23.


Delipidated retroviruses as potential autologous therapeutic vaccines--a pilot experiment.

Kitabwalla M, Ansari AA, Villinger F, Akeefe H, Conner AP, Mayne AE, Hildreth JE.

Exp Biol Med (Maywood). 2008 Jun;233(6):732-40. doi: 10.3181/0712-RM-349. Epub 2008 Apr 11.


Cervicovaginal evaluation in macaques used as a model for topical microbicide safety studies.

Scorpio DG, Ruben DS, Liao Z, Hildreth JE, Fletcher CA.

J Med Primatol. 2008 Feb;37 Suppl 1:65-73. doi: 10.1111/j.1600-0684.2007.00265.x.


Production and characterization of a monoclonal antibody against Niemann Pick type C protein.

Leao IC, Maciel M, Hildreth JE.

Hybridoma (Larchmt). 2006 Aug;25(4):216-24.


Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane.

Booth AM, Fang Y, Fallon JK, Yang JM, Hildreth JE, Gould SJ.

J Cell Biol. 2006 Mar 13;172(6):923-35.


Characterization of an anti-lymphocyte function-associated antigen-1 antibody in a simian immunodeficiency virus-pig-tailed macaque (Macaca nemestrina) model.

Fletcher CA, Liao Z, Adams RJ, Carter DL, Jones OD, Davis HG, Bryant JL, Hildreth JE.

Comp Med. 2006 Feb;56(1):23-30.


Enhancement of cell mediated immune responses using lipid depleted lentivirus as immunogen: a novel approach for inducing recognition of new viral epitopes.

Kitabwalla M, Villinger F, Akeefe H, Liao Z, Mayne AE, Gargano L, Conner AP, Maltais JA, Kunas G, Hildreth JE, Ansari AA, Bellotti M.

Vaccine. 2005 Sep 7;23(38):4666-77.


The evolution of alloimmunity and the genesis of adaptive immunity.

Gould SJ, Hildreth JE, Booth AM.

Q Rev Biol. 2004 Dec;79(4):359-82. Review.


Barrier-to-autointegration factor BAF binds p55 Gag and matrix and is a host component of human immunodeficiency virus type 1 virions.

Mansharamani M, Graham DR, Monie D, Lee KK, Hildreth JE, Siliciano RF, Wilson KL.

J Virol. 2003 Dec;77(24):13084-92.


Evidence that HIV budding in primary macrophages occurs through the exosome release pathway.

Nguyen DG, Booth A, Gould SJ, Hildreth JE.

J Biol Chem. 2003 Dec 26;278(52):52347-54. Epub 2003 Oct 14.


Lipid rafts and HIV pathogenesis: virion-associated cholesterol is required for fusion and infection of susceptible cells.

Liao Z, Graham DR, Hildreth JE.

AIDS Res Hum Retroviruses. 2003 Aug;19(8):675-87.


The Trojan exosome hypothesis.

Gould SJ, Booth AM, Hildreth JE.

Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10592-7. Epub 2003 Aug 28.


Sustained antibody-dependent cell-mediated cytotoxicity (ADCC) in SIV-infected macaques correlates with delayed progression to AIDS.

Banks ND, Kinsey N, Clements J, Hildreth JE.

AIDS Res Hum Retroviruses. 2002 Nov 1;18(16):1197-205.


Oligomers of glycamino acid.

Suhara Y, Yamaguchi Y, Collins B, Schnaar RL, Yanagishita M, Hildreth JE, Shimada I, Ichikawa Y.

Bioorg Med Chem. 2002 Jun;10(6):1999-2013.


Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent.

Khanna KV, Whaley KJ, Zeitlin L, Moench TR, Mehrazar K, Cone RA, Liao Z, Hildreth JE, Hoen TE, Shultz L, Markham RB.

J Clin Invest. 2002 Jan;109(2):205-11.


Lipid rafts and HIV pathogenesis: host membrane cholesterol is required for infection by HIV type 1.

Liao Z, Cimakasky LM, Hampton R, Nguyen DH, Hildreth JE.

AIDS Res Hum Retroviruses. 2001 Jul 20;17(11):1009-19.


LuSIV cells: a reporter cell line for the detection and quantitation of a single cycle of HIV and SIV replication.

Roos JW, Maughan MF, Liao Z, Hildreth JE, Clements JE.

Virology. 2000 Aug 1;273(2):307-15.


CD4-independent, CCR5-dependent simian immunodeficiency virus infection and chemotaxis of human cells.

Iyengar S, Schwartz DH, Clements JE, Hildreth JE.

J Virol. 2000 Aug;74(15):6720-4.

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