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Items: 17

1.

Non-isotopic dual parameter competition assay suitable for high-throughput screening of histone deacetylases.

Riester D, Hildmann C, Haus P, Galetovic A, Schober A, Schwienhorst A, Meyer-Almes FJ.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3651-6. doi: 10.1016/j.bmcl.2009.04.102. Epub 2009 May 3.

PMID:
19457659
2.

HKI 46F08, a novel potent histone deacetylase inhibitor, exhibits antitumoral activity against embryonic childhood cancer cells.

Wegener D, Deubzer HE, Oehme I, Milde T, Hildmann C, Schwienhorst A, Witt O.

Anticancer Drugs. 2008 Oct;19(9):849-57. doi: 10.1097/CAD.0b013e32830efbeb.

PMID:
18765999
3.

Identification of novel small-molecule histone deacetylase inhibitors by medium-throughput screening using a fluorigenic assay.

Wegener D, Hildmann C, Riester D, Schober A, Meyer-Almes FJ, Deubzer HE, Oehme I, Witt O, Lang S, Jaensch M, Makarov V, Lange C, Busse B, Schwienhorst A.

Biochem J. 2008 Jul 1;413(1):143-50. doi: 10.1042/BJ20080536.

PMID:
18384290
4.

Inhibitor-mediated stabilization of the conformational structure of a histone deacetylase-like amidohydrolase.

Kern S, Riester D, Hildmann C, Schwienhorst A, Meyer-Almes FJ.

FEBS J. 2007 Jul;274(14):3578-3588. doi: 10.1111/j.1742-4658.2007.05887.x.

5.

Factors affecting the substrate specificity of histone deacetylases.

Riester D, Hildmann C, Grünewald S, Beckers T, Schwienhorst A.

Biochem Biophys Res Commun. 2007 Jun 1;357(2):439-45. Epub 2007 Apr 3.

PMID:
17428445
6.

Complex structure of a bacterial class 2 histone deacetylase homologue with a trifluoromethylketone inhibitor.

Nielsen TK, Hildmann C, Riester D, Wegener D, Schwienhorst A, Ficner R.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Apr 1;63(Pt 4):270-3. Epub 2007 Mar 23.

7.

Histone deacetylases--an important class of cellular regulators with a variety of functions.

Hildmann C, Riester D, Schwienhorst A.

Appl Microbiol Biotechnol. 2007 Jun;75(3):487-97. Epub 2007 Mar 22. Review.

PMID:
17377789
8.

Histone deacetylase inhibitors--turning epigenic mechanisms of gene regulation into tools of therapeutic intervention in malignant and other diseases.

Riester D, Hildmann C, Schwienhorst A.

Appl Microbiol Biotechnol. 2007 Jun;75(3):499-514. Epub 2007 Mar 22. Review.

PMID:
17377788
9.

Histone deacetylase inhibitor assay based on fluorescence resonance energy transfer.

Riester D, Hildmann C, Schwienhorst A, Meyer-Almes FJ.

Anal Biochem. 2007 Mar 1;362(1):136-41. Epub 2007 Jan 4.

PMID:
17250798
10.

An active site tyrosine residue is essential for amidohydrolase but not for esterase activity of a class 2 histone deacetylase-like bacterial enzyme.

Moreth K, Riester D, Hildmann C, Hempel R, Wegener D, Schober A, Schwienhorst A.

Biochem J. 2007 Feb 1;401(3):659-65.

11.

Substrate and inhibitor specificity of class 1 and class 2 histone deacetylases.

Hildmann C, Wegener D, Riester D, Hempel R, Schober A, Merana J, Giurato L, Guccione S, Nielsen TK, Ficner R, Schwienhorst A.

J Biotechnol. 2006 Jun 25;124(1):258-70. Epub 2006 Mar 29.

PMID:
16567013
12.

Crystal structure of a bacterial class 2 histone deacetylase homologue.

Nielsen TK, Hildmann C, Dickmanns A, Schwienhorst A, Ficner R.

J Mol Biol. 2005 Nov 18;354(1):107-20. Epub 2005 Oct 7.

PMID:
16242151
13.

Members of the histone deacetylase superfamily differ in substrate specificity towards small synthetic substrates.

Riester D, Wegener D, Hildmann C, Schwienhorst A.

Biochem Biophys Res Commun. 2004 Nov 19;324(3):1116-23.

PMID:
15485670
14.

A new amidohydrolase from Bordetella or Alcaligenes strain FB188 with similarities to histone deacetylases.

Hildmann C, Ninkovic M, Dietrich R, Wegener D, Riester D, Zimmermann T, Birch OM, Bernegger C, Loidl P, Schwienhorst A.

J Bacteriol. 2004 Apr;186(8):2328-39.

15.

Directed evolution towards protease-resistant hirudin variants.

Wirsching F, Keller M, Hildmann C, Riester D, Schwienhorst A.

Mol Genet Metab. 2003 Dec;80(4):451-62.

PMID:
14654359
16.

Recent progress in the development of assays suited for histone deacetylase inhibitor screening.

Wegener D, Hildmann C, Schwienhorst A.

Mol Genet Metab. 2003 Sep-Oct;80(1-2):138-47. Review.

PMID:
14567963
17.

Improved fluorogenic histone deacetylase assay for high-throughput-screening applications.

Wegener D, Hildmann C, Riester D, Schwienhorst A.

Anal Biochem. 2003 Oct 15;321(2):202-8.

PMID:
14511685

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