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Items: 1 to 50 of 70

1.

High Dimensional Renal Profiling: Towards a Better Understanding or Renal Transplant Immune Suppression.

Castro-Rojas CM, Alloway RR, Woodle ES, Hildeman DA.

Curr Transplant Rep. 2019 Mar;6(1):60-68. doi: 10.1007/s40472-019-0225-1. Epub 2019 Jan 14.

PMID:
31595214
2.

T-cell receptor signal strength and epigenetic control of Bim predict memory CD8+ T-cell fate.

Li KP, Ladle BH, Kurtulus S, Sholl A, Shanmuganad S, Hildeman DA.

Cell Death Differ. 2019 Sep 26. doi: 10.1038/s41418-019-0410-x. [Epub ahead of print]

PMID:
31558776
3.

A prospective, iterative, adaptive trial of carfilzomib-based desensitization.

Tremblay S, Driscoll JJ, Rike-Shields A, Hildeman DA, Alloway RR, Girnita AL, Brailey PA, Woodle ES.

Am J Transplant. 2019 Sep 24. doi: 10.1111/ajt.15613. [Epub ahead of print]

PMID:
31550069
4.

mTOR Inhibitor Therapy Diminishes Circulating CD8+ CD28- Effector Memory T Cells and Improves Allograft Inflammation in Belatacept-Refractory Renal Allograft Rejection.

Castro-Rojas CM, Godarova A, Shi T, Hummel SA, Shields A, Tremblay S, Alloway RR, Jordan MB, Woodle ES, Hildeman DA.

Transplantation. 2019 Aug 12. doi: 10.1097/TP.0000000000002917. [Epub ahead of print]

PMID:
31415033
5.

Publisher Correction: The immune cell landscape in kidneys of patients with lupus nephritis.

Arazi A, Rao DA, Berthier CC, Davidson A, Liu Y, Hoover PJ, Chicoine A, Eisenhaure TM, Jonsson AH, Li S, Lieb DJ, Zhang F, Slowikowski K, Browne EP, Noma A, Sutherby D, Steelman S, Smilek DE, Tosta P, Apruzzese W, Massarotti E, Dall'Era M, Park M, Kamen DL, Furie RA, Payan-Schober F, Pendergraft WF 3rd, McInnis EA, Buyon JP, Petri MA, Putterman C, Kalunian KC, Woodle ES, Lederer JA, Hildeman DA, Nusbaum C, Raychaudhuri S, Kretzler M, Anolik JH, Brenner MB, Wofsy D, Hacohen N, Diamond B; Accelerating Medicines Partnership in SLE network.

Nat Immunol. 2019 Oct;20(10):1404. doi: 10.1038/s41590-019-0473-3.

PMID:
31409923
6.

The immune cell landscape in kidneys of patients with lupus nephritis.

Arazi A, Rao DA, Berthier CC, Davidson A, Liu Y, Hoover PJ, Chicoine A, Eisenhaure TM, Jonsson AH, Li S, Lieb DJ, Zhang F, Slowikowski K, Browne EP, Noma A, Sutherby D, Steelman S, Smilek DE, Tosta P, Apruzzese W, Massarotti E, Dall'Era M, Park M, Kamen DL, Furie RA, Payan-Schober F, Pendergraft WF 3rd, McInnis EA, Buyon JP, Petri MA, Putterman C, Kalunian KC, Woodle ES, Lederer JA, Hildeman DA, Nusbaum C, Raychaudhuri S, Kretzler M, Anolik JH, Brenner MB, Wofsy D, Hacohen N, Diamond B; Accelerating Medicines Partnership in SLE network.

Nat Immunol. 2019 Jul;20(7):902-914. doi: 10.1038/s41590-019-0398-x. Epub 2019 Jun 17. Erratum in: Nat Immunol. 2019 Aug 13;:.

PMID:
31209404
7.

Olfactomedin 4 marks a subset of neutrophils in mice.

Alder MN, Mallela J, Opoka AM, Lahni P, Hildeman DA, Wong HR.

Innate Immun. 2019 Jan;25(1):22-33. doi: 10.1177/1753425918817611. Epub 2018 Dec 11.

8.

Extending Remission and Reversing New-Onset Type 1 Diabetes by Targeted Ablation of Autoreactive T Cells.

Carroll KR, Elfers EE, Stevens JJ, McNally JP, Hildeman DA, Jordan MB, Katz JD.

Diabetes. 2018 Nov;67(11):2319-2328. doi: 10.2337/db18-0204. Epub 2018 Aug 13.

9.

IL-1 signaling mediates intrauterine inflammation and chorio-decidua neutrophil recruitment and activation.

Presicce P, Park CW, Senthamaraikannan P, Bhattacharyya S, Jackson C, Kong F, Rueda CM, DeFranco E, Miller LA, Hildeman DA, Salomonis N, Chougnet CA, Jobe AH, Kallapur SG.

JCI Insight. 2018 Mar 22;3(6). pii: 98306. doi: 10.1172/jci.insight.98306.

10.

NKT cells contribute to basal IL-4 production but are not required to induce experimental asthma.

McKnight CG, Morris SC, Perkins C, Zhu Z, Hildeman DA, Bendelac A, Finkelman FD.

PLoS One. 2017 Nov 28;12(11):e0188221. doi: 10.1371/journal.pone.0188221. eCollection 2017.

11.

Tissue-specific control of latent CMV reactivation by regulatory T cells.

Almanan M, Raynor J, Sholl A, Wang M, Chougnet C, Cardin RD, Hildeman DA.

PLoS Pathog. 2017 Aug 10;13(8):e1006507. doi: 10.1371/journal.ppat.1006507. eCollection 2017 Aug.

12.

Manipulating DNA damage-response signaling for the treatment of immune-mediated diseases.

McNally JP, Millen SH, Chaturvedi V, Lakes N, Terrell CE, Elfers EE, Carroll KR, Hogan SP, Andreassen PR, Kanter J, Allen CE, Henry MM, Greenberg JN, Ladisch S, Hermiston ML, Joyce M, Hildeman DA, Katz JD, Jordan MB.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4782-E4791. doi: 10.1073/pnas.1703683114. Epub 2017 May 22.

13.

Dying to protect: cell death and the control of T-cell homeostasis.

Li KP, Shanmuganad S, Carroll K, Katz JD, Jordan MB, Hildeman DA.

Immunol Rev. 2017 May;277(1):21-43. doi: 10.1111/imr.12538. Review.

14.

The Bcl2a1 gene cluster finally knocked out: first clues to understanding the enigmatic role of the Bcl-2 protein A1.

Berberich I, Hildeman DA.

Cell Death Differ. 2017 Apr;24(4):572-574. doi: 10.1038/cdd.2017.25. Epub 2017 Mar 24. No abstract available.

15.

Type I interferons regulate susceptibility to inflammation-induced preterm birth.

Cappelletti M, Presicce P, Lawson MJ, Chaturvedi V, Stankiewicz TE, Vanoni S, Harley IT, McAlees JW, Giles DA, Moreno-Fernandez ME, Rueda CM, Senthamaraikannan P, Sun X, Karns R, Hoebe K, Janssen EM, Karp CL, Hildeman DA, Hogan SP, Kallapur SG, Chougnet CA, Way SS, Divanovic S.

JCI Insight. 2017 Mar 9;2(5):e91288. doi: 10.1172/jci.insight.91288.

16.

Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner.

Rice TC, Armocida SM, Kuethe JW, Midura EF, Jain A, Hildeman DA, Healy DP, Gulbins E, Caldwell CC.

Cell Immunol. 2017 Mar;313:25-31. doi: 10.1016/j.cellimm.2016.12.004. Epub 2016 Dec 26.

17.

Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire.

Li KP, Fähnrich A, Roy E, Cuda CM, Grimes HL, Perlman HR, Kalies K, Hildeman DA.

J Immunol. 2017 Jan 1;198(1):257-269. Epub 2016 Nov 16.

18.

Olfactomedin-4 Is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock.

Alder MN, Opoka AM, Lahni P, Hildeman DA, Wong HR.

Crit Care Med. 2017 Apr;45(4):e426-e432. doi: 10.1097/CCM.0000000000002102.

19.

De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation.

Ladle BH, Li KP, Phillips MJ, Pucsek AB, Haile A, Powell JD, Jaffee EM, Hildeman DA, Gamper CJ.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10631-6. doi: 10.1073/pnas.1524490113. Epub 2016 Aug 31.

20.

IL-4 and IL-15 promotion of virtual memory CD8+ T cells is determined by genetic background.

Tripathi P, Morris SC, Perkins C, Sholl A, Finkelman FD, Hildeman DA.

Eur J Immunol. 2016 Oct;46(10):2333-2339. doi: 10.1002/eji.201646404. Epub 2016 Aug 16.

21.

Fecal Microbiota Transplant Restores Mucosal Integrity in a Murine Model of Burn Injury.

Kuethe JW, Armocida SM, Midura EF, Rice TC, Hildeman DA, Healy DP, Caldwell CC.

Shock. 2016 Jun;45(6):647-52. doi: 10.1097/SHK.0000000000000551.

22.

IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age.

Raynor J, Karns R, Almanan M, Li KP, Divanovic S, Chougnet CA, Hildeman DA.

J Immunol. 2015 Aug 1;195(3):944-52. doi: 10.4049/jimmunol.1500443. Epub 2015 Jun 24.

23.

Oncolytic HSV virotherapy in murine sarcomas differentially triggers an antitumor T-cell response in the absence of virus permissivity.

Leddon JL, Chen CY, Currier MA, Wang PY, Jung FA, Denton NL, Cripe KM, Haworth KB, Arnold MA, Gross AC, Eubank TD, Goins WF, Glorioso JC, Cohen JB, Grandi P, Hildeman DA, Cripe TP.

Mol Ther Oncolytics. 2015 Jan 21;1:14010. doi: 10.1038/mto.2014.10. eCollection 2015.

24.

IL-10/Janus kinase/signal transducer and activator of transcription 3 signaling dysregulates Bim expression in autoimmune lymphoproliferative syndrome.

Niss O, Sholl A, Bleesing JJ, Hildeman DA.

J Allergy Clin Immunol. 2015 Mar;135(3):762-70. doi: 10.1016/j.jaci.2014.07.020. Epub 2014 Aug 28.

25.

Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins.

Kurtulus S, Sholl A, Toe J, Tripathi P, Raynor J, Li KP, Pellegrini M, Hildeman DA.

Cell Death Differ. 2015 Jan;22(1):174-84. doi: 10.1038/cdd.2014.118. Epub 2014 Aug 15.

26.

Eliminating encephalitogenic T cells without undermining protective immunity.

McNally JP, Elfers EE, Terrell CE, Grunblatt E, Hildeman DA, Jordan MB, Katz JD.

J Immunol. 2014 Jan 1;192(1):73-83. doi: 10.4049/jimmunol.1301891. Epub 2013 Nov 25. Erratum in: J Immunol. 2014 Mar 1;192(5):2522.

27.

Etoposide selectively ablates activated T cells to control the immunoregulatory disorder hemophagocytic lymphohistiocytosis.

Johnson TS, Terrell CE, Millen SH, Katz JD, Hildeman DA, Jordan MB.

J Immunol. 2014 Jan 1;192(1):84-91. doi: 10.4049/jimmunol.1302282. Epub 2013 Nov 20.

28.

Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors.

Phelan JD, Saba I, Zeng H, Kosan C, Messer MS, Olsson HA, Fraszczak J, Hildeman DA, Aronow BJ, Möröy T, Grimes HL.

PLoS Genet. 2013;9(9):e1003713. doi: 10.1371/journal.pgen.1003713. Epub 2013 Sep 12.

29.

IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels.

Raynor J, Sholl A, Plas DR, Bouillet P, Chougnet CA, Hildeman DA.

Front Immunol. 2013 Jun 24;4:161. doi: 10.3389/fimmu.2013.00161. eCollection 2013.

30.

Mcl-1 antagonizes Bax/Bak to promote effector CD4(+) and CD8(+) T-cell responses.

Tripathi P, Koss B, Opferman JT, Hildeman DA.

Cell Death Differ. 2013 Aug;20(8):998-1007. doi: 10.1038/cdd.2013.25. Epub 2013 Apr 5.

31.

Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling.

Sena LA, Li S, Jairaman A, Prakriya M, Ezponda T, Hildeman DA, Wang CR, Schumacker PT, Licht JD, Perlman H, Bryce PJ, Chandel NS.

Immunity. 2013 Feb 21;38(2):225-36. doi: 10.1016/j.immuni.2012.10.020. Epub 2013 Feb 15.

32.

Protecting and rescuing the effectors: roles of differentiation and survival in the control of memory T cell development.

Kurtulus S, Tripathi P, Hildeman DA.

Front Immunol. 2013 Jan 23;3:404. doi: 10.3389/fimmu.2012.00404. eCollection 2012.

33.

Homeostasis and function of regulatory T cells in aging.

Raynor J, Lages CS, Shehata H, Hildeman DA, Chougnet CA.

Curr Opin Immunol. 2012 Aug;24(4):482-7. doi: 10.1016/j.coi.2012.04.005. Epub 2012 May 5. Review.

34.

Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim.

Kurtulus S, Tripathi P, Moreno-Fernandez ME, Sholl A, Katz JD, Grimes HL, Hildeman DA.

J Immunol. 2011 May 15;186(10):5729-37. doi: 10.4049/jimmunol.1100102. Epub 2011 Mar 30.

35.

Divergent effects of calcineurin Aβ on regulatory and conventional T-cell homeostasis.

Doetschman T, Sholl A, Chen Hd, Gard C, Hildeman DA, Bommireddy R.

Clin Immunol. 2011 Mar;138(3):321-30. doi: 10.1016/j.clim.2010.12.020. Epub 2011 Jan 20.

36.

RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling.

Chae HD, Siefring JE, Hildeman DA, Gu Y, Williams DA.

PLoS One. 2010 Nov 12;5(11):e13970. doi: 10.1371/journal.pone.0013970.

37.

A major role for Bim in regulatory T cell homeostasis.

Chougnet CA, Tripathi P, Lages CS, Raynor J, Sholl A, Fink P, Plas DR, Hildeman DA.

J Immunol. 2011 Jan 1;186(1):156-63. doi: 10.4049/jimmunol.1001505. Epub 2010 Nov 22.

38.

Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis.

Kasten KR, Prakash PS, Unsinger J, Goetzman HS, England LG, Cave CM, Seitz AP, Mazuski CN, Zhou TT, Morre M, Hotchkiss RS, Hildeman DA, Caldwell CC.

Infect Immun. 2010 Nov;78(11):4714-22. doi: 10.1128/IAI.00456-10. Epub 2010 Sep 7.

39.

Immune responses to coiled coil supramolecular biomaterials.

Rudra JS, Tripathi PK, Hildeman DA, Jung JP, Collier JH.

Biomaterials. 2010 Nov;31(32):8475-83. doi: 10.1016/j.biomaterials.2010.07.068. Epub 2010 Aug 12.

40.

STAT5 is critical to maintain effector CD8+ T cell responses.

Tripathi P, Kurtulus S, Wojciechowski S, Sholl A, Hoebe K, Morris SC, Finkelman FD, Grimes HL, Hildeman DA.

J Immunol. 2010 Aug 15;185(4):2116-24. doi: 10.4049/jimmunol.1000842. Epub 2010 Jul 19.

41.

Contracting the 'mus cells'--does down-sizing suit us for diving into the memory pool?

Kurtulus S, Tripathi P, Opferman JT, Hildeman DA.

Immunol Rev. 2010 Jul;236:54-67. doi: 10.1111/j.1600-065X.2010.00920.x. Review.

42.

Androgens suppress antigen-specific T cell responses and IFN-γ production during intracranial LCMV infection.

Lin AA, Wojciechowski SE, Hildeman DA.

J Neuroimmunol. 2010 Sep 14;226(1-2):8-19. doi: 10.1016/j.jneuroim.2010.05.026.

43.

T-cell activation differentially mediates the host response to sepsis.

Kasten KR, Tschöp J, Goetzman HS, England LG, Dattilo JR, Cave CM, Seitz AP, Hildeman DA, Caldwell CC.

Shock. 2010 Oct;34(4):377-83. doi: 10.1097/SHK.0b013e3181dc0845.

PMID:
20610943
44.

T cells are potent early mediators of the host response to sepsis.

Kasten KR, Tschöp J, Adediran SG, Hildeman DA, Caldwell CC.

Shock. 2010 Oct;34(4):327-36. doi: 10.1097/SHK.0b013e3181e14c2e. Review.

PMID:
20386500
45.

IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.

Unsinger J, McGlynn M, Kasten KR, Hoekzema AS, Watanabe E, Muenzer JT, McDonough JS, Tschoep J, Ferguson TA, McDunn JE, Morre M, Hildeman DA, Caldwell CC, Hotchkiss RS.

J Immunol. 2010 Apr 1;184(7):3768-79. doi: 10.4049/jimmunol.0903151. Epub 2010 Mar 3.

46.

Gamma interferon signaling in macrophage lineage cells regulates central nervous system inflammation and chemokine production.

Lin AA, Tripathi PK, Sholl A, Jordan MB, Hildeman DA.

J Virol. 2009 Sep;83(17):8604-15. doi: 10.1128/JVI.02477-08. Epub 2009 Jun 10.

47.

Endogenously produced IL-4 nonredundantly stimulates CD8+ T cell proliferation.

Morris SC, Heidorn SM, Herbert DR, Perkins C, Hildeman DA, Khodoun MV, Finkelman FD.

J Immunol. 2009 Feb 1;182(3):1429-38.

48.

Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation.

Lages CS, Suffia I, Velilla PA, Huang B, Warshaw G, Hildeman DA, Belkaid Y, Chougnet C.

J Immunol. 2008 Aug 1;181(3):1835-48.

49.

Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1.

Zarebski A, Velu CS, Baktula AM, Bourdeau T, Horman SR, Basu S, Bertolone SJ, Horwitz M, Hildeman DA, Trent JO, Grimes HL.

Immunity. 2008 Mar;28(3):370-80. doi: 10.1016/j.immuni.2007.12.020. Epub 2008 Mar 6.

50.

Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis.

Wojciechowski S, Tripathi P, Bourdeau T, Acero L, Grimes HL, Katz JD, Finkelman FD, Hildeman DA.

J Exp Med. 2007 Jul 9;204(7):1665-75. Epub 2007 Jun 25.

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