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Olfactomedin 4 marks a subset of neutrophils in mice.

Alder MN, Mallela J, Opoka AM, Lahni P, Hildeman DA, Wong HR.

Innate Immun. 2019 Jan;25(1):22-33. doi: 10.1177/1753425918817611. Epub 2018 Dec 11.


Extending Remission and Reversing New-Onset Type 1 Diabetes by Targeted Ablation of Autoreactive T Cells.

Carroll KR, Elfers EE, Stevens JJ, McNally JP, Hildeman DA, Jordan MB, Katz JD.

Diabetes. 2018 Nov;67(11):2319-2328. doi: 10.2337/db18-0204. Epub 2018 Aug 13.


IL-1 signaling mediates intrauterine inflammation and chorio-decidua neutrophil recruitment and activation.

Presicce P, Park CW, Senthamaraikannan P, Bhattacharyya S, Jackson C, Kong F, Rueda CM, DeFranco E, Miller LA, Hildeman DA, Salomonis N, Chougnet CA, Jobe AH, Kallapur SG.

JCI Insight. 2018 Mar 22;3(6). pii: 98306. doi: 10.1172/jci.insight.98306.


A guide to choosing fluorescent protein combinations for flow cytometric analysis based on spectral overlap.

Kleeman B, Olsson A, Newkold T, Kofron M, DeLay M, Hildeman D, Grimes HL.

Cytometry A. 2018 May;93(5):556-562. doi: 10.1002/cyto.a.23360. Epub 2018 Mar 13.


Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology.

Patterson AR, Endale M, Lampe K, Aksoylar HI, Flagg A, Woodgett JR, Hildeman D, Jordan MB, Singh H, Kucuk Z, Bleesing J, Hoebe K.

Nat Commun. 2018 Jan 30;9(1):430. doi: 10.1038/s41467-018-02897-7.


NKT cells contribute to basal IL-4 production but are not required to induce experimental asthma.

McKnight CG, Morris SC, Perkins C, Zhu Z, Hildeman DA, Bendelac A, Finkelman FD.

PLoS One. 2017 Nov 28;12(11):e0188221. doi: 10.1371/journal.pone.0188221. eCollection 2017.


Tissue-specific control of latent CMV reactivation by regulatory T cells.

Almanan M, Raynor J, Sholl A, Wang M, Chougnet C, Cardin RD, Hildeman DA.

PLoS Pathog. 2017 Aug 10;13(8):e1006507. doi: 10.1371/journal.ppat.1006507. eCollection 2017 Aug.


Manipulating DNA damage-response signaling for the treatment of immune-mediated diseases.

McNally JP, Millen SH, Chaturvedi V, Lakes N, Terrell CE, Elfers EE, Carroll KR, Hogan SP, Andreassen PR, Kanter J, Allen CE, Henry MM, Greenberg JN, Ladisch S, Hermiston ML, Joyce M, Hildeman DA, Katz JD, Jordan MB.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4782-E4791. doi: 10.1073/pnas.1703683114. Epub 2017 May 22.


Dying to protect: cell death and the control of T-cell homeostasis.

Li KP, Shanmuganad S, Carroll K, Katz JD, Jordan MB, Hildeman DA.

Immunol Rev. 2017 May;277(1):21-43. doi: 10.1111/imr.12538. Review.


The Bcl2a1 gene cluster finally knocked out: first clues to understanding the enigmatic role of the Bcl-2 protein A1.

Berberich I, Hildeman DA.

Cell Death Differ. 2017 Apr;24(4):572-574. doi: 10.1038/cdd.2017.25. Epub 2017 Mar 24. No abstract available.


Type I interferons regulate susceptibility to inflammation-induced preterm birth.

Cappelletti M, Presicce P, Lawson MJ, Chaturvedi V, Stankiewicz TE, Vanoni S, Harley IT, McAlees JW, Giles DA, Moreno-Fernandez ME, Rueda CM, Senthamaraikannan P, Sun X, Karns R, Hoebe K, Janssen EM, Karp CL, Hildeman DA, Hogan SP, Kallapur SG, Chougnet CA, Way SS, Divanovic S.

JCI Insight. 2017 Mar 9;2(5):e91288. doi: 10.1172/jci.insight.91288.


Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner.

Rice TC, Armocida SM, Kuethe JW, Midura EF, Jain A, Hildeman DA, Healy DP, Gulbins E, Caldwell CC.

Cell Immunol. 2017 Mar;313:25-31. doi: 10.1016/j.cellimm.2016.12.004. Epub 2016 Dec 26.


Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire.

Li KP, Fähnrich A, Roy E, Cuda CM, Grimes HL, Perlman HR, Kalies K, Hildeman DA.

J Immunol. 2017 Jan 1;198(1):257-269. Epub 2016 Nov 16.


Olfactomedin-4 Is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock.

Alder MN, Opoka AM, Lahni P, Hildeman DA, Wong HR.

Crit Care Med. 2017 Apr;45(4):e426-e432. doi: 10.1097/CCM.0000000000002102.


De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation.

Ladle BH, Li KP, Phillips MJ, Pucsek AB, Haile A, Powell JD, Jaffee EM, Hildeman DA, Gamper CJ.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10631-6. doi: 10.1073/pnas.1524490113. Epub 2016 Aug 31.


Helios-controller of Treg stability and function.

Chougnet C, Hildeman D.

Transl Cancer Res. 2016 Aug;5(Suppl 2):S338-S341. doi: 10.21037/tcr.2016.07.37. No abstract available.


IL-4 and IL-15 promotion of virtual memory CD8+ T cells is determined by genetic background.

Tripathi P, Morris SC, Perkins C, Sholl A, Finkelman FD, Hildeman DA.

Eur J Immunol. 2016 Oct;46(10):2333-2339. doi: 10.1002/eji.201646404. Epub 2016 Aug 16.


Fecal Microbiota Transplant Restores Mucosal Integrity in a Murine Model of Burn Injury.

Kuethe JW, Armocida SM, Midura EF, Rice TC, Hildeman DA, Healy DP, Caldwell CC.

Shock. 2016 Jun;45(6):647-52. doi: 10.1097/SHK.0000000000000551.


IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age.

Raynor J, Karns R, Almanan M, Li KP, Divanovic S, Chougnet CA, Hildeman DA.

J Immunol. 2015 Aug 1;195(3):944-52. doi: 10.4049/jimmunol.1500443. Epub 2015 Jun 24.


Slp-76 is a critical determinant of NK-cell mediated recognition of missing-self targets.

Lampe K, Endale M, Cashman S, Fang H, Mattner J, Hildeman D, Hoebe K.

Eur J Immunol. 2015 Jul;45(7):2072-83. doi: 10.1002/eji.201445352. Epub 2015 May 22.


Oncolytic HSV virotherapy in murine sarcomas differentially triggers an antitumor T-cell response in the absence of virus permissivity.

Leddon JL, Chen CY, Currier MA, Wang PY, Jung FA, Denton NL, Cripe KM, Haworth KB, Arnold MA, Gross AC, Eubank TD, Goins WF, Glorioso JC, Cohen JB, Grandi P, Hildeman DA, Cripe TP.

Mol Ther Oncolytics. 2015 Jan 21;1:14010. doi: 10.1038/mto.2014.10. eCollection 2015.


Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice.

Herold MJ, Stuchbery R, Mérino D, Willson T, Strasser A, Hildeman D, Bouillet P.

Cell Death Dis. 2014 Oct 9;5:e1446. doi: 10.1038/cddis.2014.409.


IL-10/Janus kinase/signal transducer and activator of transcription 3 signaling dysregulates Bim expression in autoimmune lymphoproliferative syndrome.

Niss O, Sholl A, Bleesing JJ, Hildeman DA.

J Allergy Clin Immunol. 2015 Mar;135(3):762-70. doi: 10.1016/j.jaci.2014.07.020. Epub 2014 Aug 28.


Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins.

Kurtulus S, Sholl A, Toe J, Tripathi P, Raynor J, Li KP, Pellegrini M, Hildeman DA.

Cell Death Differ. 2015 Jan;22(1):174-84. doi: 10.1038/cdd.2014.118. Epub 2014 Aug 15.


Eliminating encephalitogenic T cells without undermining protective immunity.

McNally JP, Elfers EE, Terrell CE, Grunblatt E, Hildeman DA, Jordan MB, Katz JD.

J Immunol. 2014 Jan 1;192(1):73-83. doi: 10.4049/jimmunol.1301891. Epub 2013 Nov 25. Erratum in: J Immunol. 2014 Mar 1;192(5):2522.


Etoposide selectively ablates activated T cells to control the immunoregulatory disorder hemophagocytic lymphohistiocytosis.

Johnson TS, Terrell CE, Millen SH, Katz JD, Hildeman DA, Jordan MB.

J Immunol. 2014 Jan 1;192(1):84-91. doi: 10.4049/jimmunol.1302282. Epub 2013 Nov 20.


Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors.

Phelan JD, Saba I, Zeng H, Kosan C, Messer MS, Olsson HA, Fraszczak J, Hildeman DA, Aronow BJ, Möröy T, Grimes HL.

PLoS Genet. 2013;9(9):e1003713. doi: 10.1371/journal.pgen.1003713. Epub 2013 Sep 12.


Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells.

Pierson W, Cauwe B, Policheni A, Schlenner SM, Franckaert D, Berges J, Humblet-Baron S, Schönefeldt S, Herold MJ, Hildeman D, Strasser A, Bouillet P, Lu LF, Matthys P, Freitas AA, Luther RJ, Weaver CT, Dooley J, Gray DH, Liston A.

Nat Immunol. 2013 Sep;14(9):959-65. doi: 10.1038/ni.2649. Epub 2013 Jul 14.


IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels.

Raynor J, Sholl A, Plas DR, Bouillet P, Chougnet CA, Hildeman DA.

Front Immunol. 2013 Jun 24;4:161. doi: 10.3389/fimmu.2013.00161. eCollection 2013.


Mcl-1 antagonizes Bax/Bak to promote effector CD4(+) and CD8(+) T-cell responses.

Tripathi P, Koss B, Opferman JT, Hildeman DA.

Cell Death Differ. 2013 Aug;20(8):998-1007. doi: 10.1038/cdd.2013.25. Epub 2013 Apr 5.


VEGF blockade enables oncolytic cancer virotherapy in part by modulating intratumoral myeloid cells.

Currier MA, Eshun FK, Sholl A, Chernoguz A, Crawford K, Divanovic S, Boon L, Goins WF, Frischer JS, Collins MH, Leddon JL, Baird WH, Haseley A, Streby KA, Wang PY, Hendrickson BW, Brekken RA, Kaur B, Hildeman D, Cripe TP.

Mol Ther. 2013 May;21(5):1014-23. doi: 10.1038/mt.2013.39. Epub 2013 Mar 12.


Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling.

Sena LA, Li S, Jairaman A, Prakriya M, Ezponda T, Hildeman DA, Wang CR, Schumacker PT, Licht JD, Perlman H, Bryce PJ, Chandel NS.

Immunity. 2013 Feb 21;38(2):225-36. doi: 10.1016/j.immuni.2012.10.020. Epub 2013 Feb 15.


Assessment of CD4(+) and CD8 (+) T cell responses using MHC class I and II tetramers.

Kurtulus S, Hildeman D.

Methods Mol Biol. 2013;979:71-9. doi: 10.1007/978-1-62703-290-2_8.


Protecting and rescuing the effectors: roles of differentiation and survival in the control of memory T cell development.

Kurtulus S, Tripathi P, Hildeman DA.

Front Immunol. 2013 Jan 23;3:404. doi: 10.3389/fimmu.2012.00404. eCollection 2012.


Homeostasis and function of regulatory T cells in aging.

Raynor J, Lages CS, Shehata H, Hildeman DA, Chougnet CA.

Curr Opin Immunol. 2012 Aug;24(4):482-7. doi: 10.1016/j.coi.2012.04.005. Epub 2012 May 5. Review.


Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation.

Guo F, Zhang S, Tripathi P, Mattner J, Phelan J, Sproles A, Mo J, Wills-Karp M, Grimes HL, Hildeman D, Zheng Y.

PLoS One. 2011 Mar 24;6(3):e18002. doi: 10.1371/journal.pone.0018002.


Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim.

Kurtulus S, Tripathi P, Moreno-Fernandez ME, Sholl A, Katz JD, Grimes HL, Hildeman DA.

J Immunol. 2011 May 15;186(10):5729-37. doi: 10.4049/jimmunol.1100102. Epub 2011 Mar 30.


Divergent effects of calcineurin Aβ on regulatory and conventional T-cell homeostasis.

Doetschman T, Sholl A, Chen Hd, Gard C, Hildeman DA, Bommireddy R.

Clin Immunol. 2011 Mar;138(3):321-30. doi: 10.1016/j.clim.2010.12.020. Epub 2011 Jan 20.


RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling.

Chae HD, Siefring JE, Hildeman DA, Gu Y, Williams DA.

PLoS One. 2010 Nov 12;5(11):e13970. doi: 10.1371/journal.pone.0013970.


A major role for Bim in regulatory T cell homeostasis.

Chougnet CA, Tripathi P, Lages CS, Raynor J, Sholl A, Fink P, Plas DR, Hildeman DA.

J Immunol. 2011 Jan 1;186(1):156-63. doi: 10.4049/jimmunol.1001505. Epub 2010 Nov 22.


Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis.

Guo F, Hildeman D, Tripathi P, Velu CS, Grimes HL, Zheng Y.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18505-10. doi: 10.1073/pnas.1010249107. Epub 2010 Oct 11.


Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis.

Kasten KR, Prakash PS, Unsinger J, Goetzman HS, England LG, Cave CM, Seitz AP, Mazuski CN, Zhou TT, Morre M, Hotchkiss RS, Hildeman DA, Caldwell CC.

Infect Immun. 2010 Nov;78(11):4714-22. doi: 10.1128/IAI.00456-10. Epub 2010 Sep 7.


Immune responses to coiled coil supramolecular biomaterials.

Rudra JS, Tripathi PK, Hildeman DA, Jung JP, Collier JH.

Biomaterials. 2010 Nov;31(32):8475-83. doi: 10.1016/j.biomaterials.2010.07.068. Epub 2010 Aug 12.


STAT5 is critical to maintain effector CD8+ T cell responses.

Tripathi P, Kurtulus S, Wojciechowski S, Sholl A, Hoebe K, Morris SC, Finkelman FD, Grimes HL, Hildeman DA.

J Immunol. 2010 Aug 15;185(4):2116-24. doi: 10.4049/jimmunol.1000842. Epub 2010 Jul 19.


Contracting the 'mus cells'--does down-sizing suit us for diving into the memory pool?

Kurtulus S, Tripathi P, Opferman JT, Hildeman DA.

Immunol Rev. 2010 Jul;236:54-67. doi: 10.1111/j.1600-065X.2010.00920.x. Review.


Androgens suppress antigen-specific T cell responses and IFN-γ production during intracranial LCMV infection.

Lin AA, Wojciechowski SE, Hildeman DA.

J Neuroimmunol. 2010 Sep 14;226(1-2):8-19. doi: 10.1016/j.jneuroim.2010.05.026.


T-cell activation differentially mediates the host response to sepsis.

Kasten KR, Tschöp J, Goetzman HS, England LG, Dattilo JR, Cave CM, Seitz AP, Hildeman DA, Caldwell CC.

Shock. 2010 Oct;34(4):377-83. doi: 10.1097/SHK.0b013e3181dc0845.


T cells are potent early mediators of the host response to sepsis.

Kasten KR, Tschöp J, Adediran SG, Hildeman DA, Caldwell CC.

Shock. 2010 Oct;34(4):327-36. doi: 10.1097/SHK.0b013e3181e14c2e. Review.


IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.

Unsinger J, McGlynn M, Kasten KR, Hoekzema AS, Watanabe E, Muenzer JT, McDonough JS, Tschoep J, Ferguson TA, McDunn JE, Morre M, Hildeman DA, Caldwell CC, Hotchkiss RS.

J Immunol. 2010 Apr 1;184(7):3768-79. doi: 10.4049/jimmunol.0903151. Epub 2010 Mar 3.


Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice.

Barnes MJ, Aksoylar H, Krebs P, Bourdeau T, Arnold CN, Xia Y, Khovananth K, Engel I, Sovath S, Lampe K, Laws E, Saunders A, Butcher GW, Kronenberg M, Steinbrecher K, Hildeman D, Grimes HL, Beutler B, Hoebe K.

J Immunol. 2010 Apr 1;184(7):3743-54. doi: 10.4049/jimmunol.0903164. Epub 2010 Feb 26.

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