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Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.

Sigoillot M, Overtus M, Grodecka M, Scholl D, Garcia-Pino A, Laeremans T, He L, Pardon E, Hildebrandt E, Urbatsch I, Steyaert J, Riordan JR, Govaerts C.

Nat Commun. 2019 Jun 14;10(1):2636. doi: 10.1038/s41467-019-10714-y.


Protein Isoprenylation in Yeast Targets COOH-Terminal Sequences Not Adhering to the CaaX Consensus.

Berger BM, Kim JH, Hildebrandt ER, Davis IC, Morgan MC, Hougland JL, Schmidt WK.

Genetics. 2018 Dec;210(4):1301-1316. doi: 10.1534/genetics.118.301454. Epub 2018 Sep 26.


Adsorption of phospholipids at oil/water interfaces during emulsification is controlled by stress relaxation and diffusion.

Hildebrandt E, Nirschl H, Kok RJ, Leneweit G.

Soft Matter. 2018 May 16;14(19):3730-3737. doi: 10.1039/c8sm00005k.


Quantitative analysis of receptor-mediated uptake and pro-apoptotic activity of mistletoe lectin-1 by high content imaging.

Beztsinna N, de Matos MBC, Walther J, Heyder C, Hildebrandt E, Leneweit G, Mastrobattista E, Kok RJ.

Sci Rep. 2018 Feb 9;8(1):2768. doi: 10.1038/s41598-018-20915-y.


Structural stability of purified human CFTR is systematically improved by mutations in nucleotide binding domain 1.

Yang Z, Hildebrandt E, Jiang F, Aleksandrov AA, Khazanov N, Zhou Q, An J, Mezzell AT, Xavier BM, Ding H, Riordan JR, Senderowitz H, Kappes JC, Brouillette CG, Urbatsch IL.

Biochim Biophys Acta Biomembr. 2018 May;1860(5):1193-1204. doi: 10.1016/j.bbamem.2018.02.006. Epub 2018 Feb 7.


Efficient farnesylation of an extended C-terminal C(x)3X sequence motif expands the scope of the prenylated proteome.

Blanden MJ, Suazo KF, Hildebrandt ER, Hardgrove DS, Patel M, Saunders WP, Distefano MD, Schmidt WK, Hougland JL.

J Biol Chem. 2018 Feb 23;293(8):2770-2785. doi: 10.1074/jbc.M117.805770. Epub 2017 Dec 27.


Instability Mechanisms of Water-in-Oil Nanoemulsions with Phospholipids: Temporal and Morphological Structures.

Sommerling JH, de Matos MBC, Hildebrandt E, Dessy A, Kok RJ, Nirschl H, Leneweit G.

Langmuir. 2018 Jan 16;34(2):572-584. doi: 10.1021/acs.langmuir.7b02852. Epub 2018 Jan 3.


Substitution of Yor1p NBD1 residues improves the thermal stability of Human Cystic Fibrosis Transmembrane Conductance Regulator.

Xavier BM, Hildebrandt E, Jiang F, Ding H, Kappes JC, Urbatsch IL.

Protein Eng Des Sel. 2017 Oct 1;30(10):729-741. doi: 10.1093/protein/gzx054.


Low temperature growth of fully covered single-layer graphene using a CoCu catalyst.

Sugime H, D'Arsié L, Esconjauregui S, Zhong G, Wu X, Hildebrandt E, Sezen H, Amati M, Gregoratti L, Weatherup RS, Robertson J.

Nanoscale. 2017 Oct 5;9(38):14467-14475. doi: 10.1039/c7nr02553j.


FIB based fabrication of an operative Pt/HfO2/TiN device for resistive switching inside a transmission electron microscope.

Zintler A, Kunz U, Pivak Y, Sharath SU, Vogel S, Hildebrandt E, Kleebe HJ, Alff L, Molina-Luna L.

Ultramicroscopy. 2017 Oct;181:144-149. doi: 10.1016/j.ultramic.2017.04.008. Epub 2017 Apr 21.


In vitro affinity of Deinococcus radiodurans MutS towards mismatched DNA exceeds that of its orthologues from Escherichia coli and Thermus thermophilus.

Banasik M, Stanisławska-Sachadyn A, Hildebrandt E, Sachadyn P.

J Biotechnol. 2017 Jun 20;252:55-64. doi: 10.1016/j.jbiotec.2017.05.010. Epub 2017 May 12.


Electron holography on HfO2/HfO2-x bilayer structures with multilevel resistive switching properties.

Niu G, Schubert MA, Sharath SU, Zaumseil P, Vogel S, Wenger C, Hildebrandt E, Bhupathi S, Perez E, Alff L, Lehmann M, Schroeder T, Niermann T.

Nanotechnology. 2017 May 26;28(21):215702. doi: 10.1088/1361-6528/aa6cd9. Epub 2017 May 2.


Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease.

Ghosh A, Tyson T, George S, Hildebrandt EN, Steiner JA, Madaj Z, Schulz E, Machiela E, McDonald WG, Escobar Galvis ML, Kordower JH, Van Raamsdonk JM, Colca JR, Brundin P.

Sci Transl Med. 2016 Dec 7;8(368):368ra174.


Specific stabilization of CFTR by phosphatidylserine.

Hildebrandt E, Khazanov N, Kappes JC, Dai Q, Senderowitz H, Urbatsch IL.

Biochim Biophys Acta Biomembr. 2017 Feb;1859(2):289-293. doi: 10.1016/j.bbamem.2016.11.013. Epub 2016 Nov 30.


Understanding the Lives and Challenges of Women in Poverty after TANF.

Hildebrandt E.

Policy Polit Nurs Pract. 2016 Aug;17(3):156-169. Epub 2016 Oct 16.


A shunt pathway limits the CaaX processing of Hsp40 Ydj1p and regulates Ydj1p-dependent phenotypes.

Hildebrandt ER, Cheng M, Zhao P, Kim JH, Wells L, Schmidt WK.

Elife. 2016 Aug 15;5. pii: e15899. doi: 10.7554/eLife.15899.


Interactions between Phospholipids and Organic Phases: Insights into Lipoproteins and Nanoemulsions.

Hildebrandt E, Dessy A, Sommerling JH, Guthausen G, Nirschl H, Leneweit G.

Langmuir. 2016 Jun 14;32(23):5821-9. doi: 10.1021/acs.langmuir.6b00978. Epub 2016 May 31.


Ste24p Mediates Proteolysis of Both Isoprenylated and Non-prenylated Oligopeptides.

Hildebrandt ER, Arachea BT, Wiener MC, Schmidt WK.

J Biol Chem. 2016 Jul 1;291(27):14185-98. doi: 10.1074/jbc.M116.718197. Epub 2016 Apr 29.


8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells.

Mohammed I, Hampton SE, Ashall L, Hildebrandt ER, Kutlik RA, Manandhar SP, Floyd BJ, Smith HE, Dozier JK, Distefano MD, Schmidt WK, Dore TM.

Bioorg Med Chem. 2016 Jan 15;24(2):160-78. doi: 10.1016/j.bmc.2015.11.043. Epub 2015 Nov 30.


Bilateral Asymmetry of Radius and Tibia Bone Macroarchitecture and Microarchitecture: A High-Resolution Peripheral Quantitative Computed Tomography Study.

Hildebrandt EM, Manske SL, Hanley DA, Boyd SK.

J Clin Densitom. 2016 Apr-Jun;19(2):250-4. doi: 10.1016/j.jocd.2015.02.005. Epub 2015 Apr 8.


Characterizing in vivo stability and potential interactions of a UL5 helicase-primase mutation previously shown to reduce virulence and in vivo replication of Marek's disease virus.

Hildebrandt E, Dunn JR, Cheng HH.

Virus Res. 2015 May 4;203:1-3. doi: 10.1016/j.virusres.2015.03.011. Epub 2015 Mar 28.


Erratum to: A Stable Human-Cell System Overexpressing Cystic Fibrosis Transmembrane Conductance Regulator Recombinant Protein at the Cell Surface.

Hildebrandt E, Ding H, Mulky A, Dai Q, Aleksandrov AA, Bajrami B, Diego PA, Wu X, Ray M, Naren AP, Riordan JR, Yao X, DeLucas LJ, Urbatsch IL, Kappes JC.

Mol Biotechnol. 2015 May;57(5):406. doi: 10.1007/s12033-015-9857-2. No abstract available.


A stable human-cell system overexpressing cystic fibrosis transmembrane conductance regulator recombinant protein at the cell surface.

Hildebrandt E, Mulky A, Ding H, Dai Q, Aleksandrov AA, Bajrami B, Diego PA, Wu X, Ray M, Naren AP, Riordan JR, Yao X, DeLucas LJ, Urbatsch IL, Kappes JC.

Mol Biotechnol. 2015 May;57(5):391-405. doi: 10.1007/s12033-014-9830-5. Erratum in: Mol Biotechnol. 2015 May;57(5):406.


Oxygen vacancy induced room temperature ferromagnetism in Pr-doped CeO2 thin films on silicon.

Niu G, Hildebrandt E, Schubert MA, Boscherini F, Zoellner MH, Alff L, Walczyk D, Zaumseil P, Costina I, Wilkens H, Schroeder T.

ACS Appl Mater Interfaces. 2014 Oct 22;6(20):17496-505. doi: 10.1021/am502238w. Epub 2014 Oct 7.


A survey of detergents for the purification of stable, active human cystic fibrosis transmembrane conductance regulator (CFTR).

Hildebrandt E, Zhang Q, Cant N, Ding H, Dai Q, Peng L, Fu Y, DeLucas LJ, Ford R, Kappes JC, Urbatsch IL.

Biochim Biophys Acta. 2014 Nov;1838(11):2825-37. doi: 10.1016/j.bbamem.2014.07.016. Epub 2014 Jul 24.


Spreading of α-synuclein in the face of axonal transport deficits in Parkinson's disease: a speculative synthesis.

Lamberts JT, Hildebrandt EN, Brundin P.

Neurobiol Dis. 2015 May;77:276-83. doi: 10.1016/j.nbd.2014.07.002. Epub 2014 Jul 15. Review.


Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains.

Yang Z, Wang C, Zhou Q, An J, Hildebrandt E, Aleksandrov LA, Kappes JC, DeLucas LJ, Riordan JR, Urbatsch IL, Hunt JF, Brouillette CG.

Protein Sci. 2014 Jun;23(6):769-89. doi: 10.1002/pro.2460. Epub 2014 May 3.


Topology of the yeast Ras converting enzyme as inferred from cysteine accessibility studies.

Hildebrandt ER, Davis DM, Deaton J, Krishnankutty RK, Lilla E, Schmidt WK.

Biochemistry. 2013 Sep 24;52(38):6601-14. doi: 10.1021/bi400647c. Epub 2013 Sep 10.


The effect of attachment style on sleep in postdeployed service members.

Escolas SM, Hildebrandt EJ, Maiers AJ, Baker MT, Mason ST.

US Army Med Dep J. 2013 Apr-Jun:35-45.


Hematologic toxicity in RTOG 0418: a phase 2 study of postoperative IMRT for gynecologic cancer.

Klopp AH, Moughan J, Portelance L, Miller BE, Salehpour MR, Hildebrandt E, Nuanjing J, D'Souza D, Souhami L, Small W Jr, Gaur R, Jhingran A.

Int J Radiat Oncol Biol Phys. 2013 May 1;86(1):83-90. doi: 10.1016/j.ijrobp.2013.01.017.


TANF over time: the tale of three studies.

Hildebrandt E, Kelber ST.

Policy Polit Nurs Pract. 2012 Aug;13(3):130-41. doi: 10.1177/1527154412456433. Epub 2012 Sep 4.


The impact of attachment style on posttraumatic stress disorder symptoms in postdeployed service members.

Escolas SM, Arata-Maiers R, Hildebrandt EJ, Maiers AJ, Mason ST, Baker MT.

US Army Med Dep J. 2012 Jul-Sep:54-61.


Novice to expert: the evolution of an advanced practice evaluation tool.

Dale JC, Drews B, Dimmitt P, Hildebrandt E, Hittle K, Tielsch-Goddard A.

J Pediatr Health Care. 2013 May-Jun;27(3):195-201. doi: 10.1016/j.pedhc.2011.12.004. Epub 2012 Jan 5.


A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris.

Bai J, Swartz DJ, Protasevich II, Brouillette CG, Harrell PM, Hildebrandt E, Gasser B, Mattanovich D, Ward A, Chang G, Urbatsch IL.

PLoS One. 2011;6(8):e22577. doi: 10.1371/journal.pone.0022577. Epub 2011 Aug 3.


Cholesterol enhances Helicobacter pylori resistance to antibiotics and LL-37.

McGee DJ, George AE, Trainor EA, Horton KE, Hildebrandt E, Testerman TL.

Antimicrob Agents Chemother. 2011 Jun;55(6):2897-904. doi: 10.1128/AAC.00016-11. Epub 2011 Apr 4.


Expanding the diversity of mycobacteriophages: insights into genome architecture and evolution.

Pope WH, Jacobs-Sera D, Russell DA, Peebles CL, Al-Atrache Z, Alcoser TA, Alexander LM, Alfano MB, Alford ST, Amy NE, Anderson MD, Anderson AG, Ang AA, Ares M Jr, Barber AJ, Barker LP, Barrett JM, Barshop WD, Bauerle CM, Bayles IM, Belfield KL, Best AA, Borjon A Jr, Bowman CA, Boyer CA, Bradley KW, Bradley VA, Broadway LN, Budwal K, Busby KN, Campbell IW, Campbell AM, Carey A, Caruso SM, Chew RD, Cockburn CL, Cohen LB, Corajod JM, Cresawn SG, Davis KR, Deng L, Denver DR, Dixon BR, Ekram S, Elgin SC, Engelsen AE, English BE, Erb ML, Estrada C, Filliger LZ, Findley AM, Forbes L, Forsyth MH, Fox TM, Fritz MJ, Garcia R, George ZD, Georges AE, Gissendanner CR, Goff S, Goldstein R, Gordon KC, Green RD, Guerra SL, Guiney-Olsen KR, Guiza BG, Haghighat L, Hagopian GV, Harmon CJ, Harmson JS, Hartzog GA, Harvey SE, He S, He KJ, Healy KE, Higinbotham ER, Hildebrandt EN, Ho JH, Hogan GM, Hohenstein VG, Holz NA, Huang VJ, Hufford EL, Hynes PM, Jackson AS, Jansen EC, Jarvik J, Jasinto PG, Jordan TC, Kasza T, Katelyn MA, Kelsey JS, Kerrigan LA, Khaw D, Kim J, Knutter JZ, Ko CC, Larkin GV, Laroche JR, Latif A, Leuba KD, Leuba SI, Lewis LO, Loesser-Casey KE, Long CA, Lopez AJ, Lowery N, Lu TQ, Mac V, Masters IR, McCloud JJ, McDonough MJ, Medenbach AJ, Menon A, Miller R, Morgan BK, Ng PC, Nguyen E, Nguyen KT, Nguyen ET, Nicholson KM, Parnell LA, Peirce CE, Perz AM, Peterson LJ, Pferdehirt RE, Philip SV, Pogliano K, Pogliano J, Polley T, Puopolo EJ, Rabinowitz HS, Resiss MJ, Rhyan CN, Robinson YM, Rodriguez LL, Rose AC, Rubin JD, Ruby JA, Saha MS, Sandoz JW, Savitskaya J, Schipper DJ, Schnitzler CE, Schott AR, Segal JB, Shaffer CD, Sheldon KE, Shepard EM, Shepardson JW, Shroff MK, Simmons JM, Simms EF, Simpson BM, Sinclair KM, Sjoholm RL, Slette IJ, Spaulding BC, Straub CL, Stukey J, Sughrue T, Tang TY, Tatyana LM, Taylor SB, Taylor BJ, Temple LM, Thompson JV, Tokarz MP, Trapani SE, Troum AP, Tsay J, Tubbs AT, Walton JM, Wang DH, Wang H, Warner JR, Weisser EG, Wendler SC, Weston-Hafer KA, Whelan HM, Williamson KE, Willis AN, Wirtshafter HS, Wong TW, Wu P, Yang Yj, Yee BC, Zaidins DA, Zhang B, Zúniga MY, Hendrix RW, Hatfull GF.

PLoS One. 2011 Jan 27;6(1):e16329. doi: 10.1371/journal.pone.0016329.


Modulation of the inhibitor properties of dipeptidyl (acyloxy)methyl ketones toward the CaaX proteases.

Dechert AM, MacNamara JP, Breevoort SR, Hildebrandt ER, Hembree NW, Rea AC, McLain DE, Porter SB, Schmidt WK, Dore TM.

Bioorg Med Chem. 2010 Sep 1;18(17):6230-7. doi: 10.1016/j.bmc.2010.07.041. Epub 2010 Jul 21.


Chemical inhibition of CaaX protease activity disrupts yeast Ras localization.

Manandhar SP, Hildebrandt ER, Jacobsen WH, Santangelo GM, Schmidt WK.

Yeast. 2010 Jun;27(6):327-43. doi: 10.1002/yea.1756.


Justice and impoverished women: the ethical implications of work-based welfare.

Hildebrandt E, Ford SL.

Policy Polit Nurs Pract. 2009 Nov;10(4):295-302. doi: 10.1177/1527154409359328. Epub 2010 Jan 3. Erratum in: Policy Polit Nurs Pract. 2010 May;11(2):164. Hildebrandt [corrected to Hildebrandt, E].


Large-scale analysis of protein expression changes in human keratinocytes immortalized by human papilloma virus type 16 E6 and E7 oncogenes.

Merkley MA, Hildebrandt E, Podolsky RH, Arnouk H, Ferris DG, Dynan WS, Stöppler H.

Proteome Sci. 2009 Aug 23;7:29. doi: 10.1186/1477-5956-7-29.


The multidimensional burden of hepatitis C and its treatment: a case study.

Taylor-Young P, Hildebrandt E.

Gastroenterol Nurs. 2009 May-Jun;32(3):180-7. doi: 10.1097/SGA.0b013e3181a80655. Review.


Impoverished women with children and no welfare benefits: the urgency of researching failures of the Temporary Assistance for Needy Families program.

Hildebrandt E, Stevens P.

Am J Public Health. 2009 May;99(5):793-801. doi: 10.2105/AJPH.2006.106211. Epub 2009 Mar 19.


Pill taking from the perspective of HIV-Infected women who are vulnerable to antiretroviral treatment failure.

Stevens PE, Hildebrandt E.

Qual Health Res. 2009 May;19(5):593-604. doi: 10.1177/1049732309333272. Epub 2009 Mar 3.


Characterization of Bacillus anthracis arginase: effects of pH, temperature, and cell viability on metal preference.

Viator RJ, Rest RF, Hildebrandt E, McGee DJ.

BMC Biochem. 2008 Jun 3;9:15. doi: 10.1186/1471-2091-9-15.


Small-molecule inhibitors of the Rce1p CaaX protease.

Manandhar SP, Hildebrandt ER, Schmidt WK.

J Biomol Screen. 2007 Oct;12(7):983-93.


Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.

Porter SB, Hildebrandt ER, Breevoort SR, Mokry DZ, Dore TM, Schmidt WK.

Biochim Biophys Acta. 2007 Jun;1773(6):853-62. Epub 2007 Mar 20.

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