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Items: 32


Combining Wet and Dry Lab Techniques to Guide the Crystallization of Large Coiled-coil Containing Proteins.

Zalewski JK, Heber S, Mo JH, O'Conor K, Hildebrand JD, VanDemark AP.

J Vis Exp. 2017 Jan 6;(119). doi: 10.3791/54886.


Structure of the Shroom-Rho Kinase Complex Reveals a Binding Interface with Monomeric Shroom That Regulates Cell Morphology and Stimulates Kinase Activity.

Zalewski JK, Mo JH, Heber S, Heroux A, Gardner RG, Hildebrand JD, VanDemark AP.

J Biol Chem. 2016 Dec 2;291(49):25364-25374. Epub 2016 Oct 10.


Shroom3 functions downstream of planar cell polarity to regulate myosin II distribution and cellular organization during neural tube closure.

McGreevy EM, Vijayraghavan D, Davidson LA, Hildebrand JD.

Biol Open. 2015 Jan 16;4(2):186-96. doi: 10.1242/bio.20149589.


The interaction between Shroom3 and Rho-kinase is required for neural tube morphogenesis in mice.

Das D, Zalewski JK, Mohan S, Plageman TF, VanDemark AP, Hildebrand JD.

Biol Open. 2014 Aug 29;3(9):850-60. doi: 10.1242/bio.20147450.


p120-catenin-dependent junctional recruitment of Shroom3 is required for apical constriction during lens pit morphogenesis.

Lang RA, Herman K, Reynolds AB, Hildebrand JD, Plageman TF Jr.

Development. 2014 Aug;141(16):3177-87. doi: 10.1242/dev.107433. Epub 2014 Jul 18.


Structure of a highly conserved domain of Rock1 required for Shroom-mediated regulation of cell morphology.

Mohan S, Das D, Bauer RJ, Heroux A, Zalewski JK, Heber S, Dosunmu-Ogunbi AM, Trakselis MA, Hildebrand JD, Vandemark AP.

PLoS One. 2013 Dec 9;8(12):e81075. doi: 10.1371/journal.pone.0081075. eCollection 2013.


Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction.

Mohan S, Rizaldy R, Das D, Bauer RJ, Heroux A, Trakselis MA, Hildebrand JD, VanDemark AP.

Mol Biol Cell. 2012 Jun;23(11):2131-42. doi: 10.1091/mbc.E11-11-0937. Epub 2012 Apr 4.


A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination.

Plageman TF Jr, Chauhan BK, Yang C, Jaudon F, Shang X, Zheng Y, Lou M, Debant A, Hildebrand JD, Lang RA.

Development. 2011 Dec;138(23):5177-88. doi: 10.1242/dev.067868. Epub 2011 Oct 26.


Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis.

Grosse AS, Pressprich MF, Curley LB, Hamilton KL, Margolis B, Hildebrand JD, Gumucio DL.

Development. 2011 Oct;138(20):4423-32. doi: 10.1242/dev.065789. Epub 2011 Aug 31.


Shroom2 regulates contractility to control endothelial morphogenesis.

Farber MJ, Rizaldy R, Hildebrand JD.

Mol Biol Cell. 2011 Mar 15;22(6):795-805. doi: 10.1091/mbc.E10-06-0505. Epub 2011 Jan 19.


Nucleofection disrupts tight junction fence function to alter membrane polarity of renal epithelial cells.

Mo D, Potter BA, Bertrand CA, Hildebrand JD, Bruns JR, Weisz OA.

Am J Physiol Renal Physiol. 2010 Nov;299(5):F1178-84. doi: 10.1152/ajprenal.00152.2010. Epub 2010 Aug 11.


Specific isoforms of drosophila shroom define spatial requirements for the induction of apical constriction.

Bolinger C, Zasadil L, Rizaldy R, Hildebrand JD.

Dev Dyn. 2010 Jul;239(7):2078-93. doi: 10.1002/dvdy.22326.


Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination.

Plageman TF Jr, Chung MI, Lou M, Smith AN, Hildebrand JD, Wallingford JB, Lang RA.

Development. 2010 Feb;137(3):405-15. doi: 10.1242/dev.045369.


Shroom4 (Kiaa1202) is an actin-associated protein implicated in cytoskeletal organization.

Yoder M, Hildebrand JD.

Cell Motil Cytoskeleton. 2007 Jan;64(1):49-63.


Shroom2 (APXL) regulates melanosome biogenesis and localization in the retinal pigment epithelium.

Fairbank PD, Lee C, Ellis A, Hildebrand JD, Gross JM, Wallingford JB.

Development. 2006 Oct;133(20):4109-18. Epub 2006 Sep 20.


Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins.

Dietz ML, Bernaciak TM, Vendetti F, Kielec JM, Hildebrand JD.

J Biol Chem. 2006 Jul 21;281(29):20542-54. Epub 2006 May 8.


Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network.

Hildebrand JD.

J Cell Sci. 2005 Nov 15;118(Pt 22):5191-203. Epub 2005 Oct 25.


Shroom induces apical constriction and is required for hingepoint formation during neural tube closure.

Haigo SL, Hildebrand JD, Harland RM, Wallingford JB.

Curr Biol. 2003 Dec 16;13(24):2125-37.


Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development.

Howell BW, Herrick TM, Hildebrand JD, Zhang Y, Cooper JA.

Curr Biol. 2000 Jul 27-Aug 10;10(15):877-85.


The secretory protein Sec8 is required for paraxial mesoderm formation in the mouse.

Friedrich GA, Hildebrand JD, Soriano P.

Dev Biol. 1997 Dec 15;192(2):364-74.


p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase.

Harte MT, Hildebrand JD, Burnham MR, Bouton AH, Parsons JT.

J Biol Chem. 1996 Jun 7;271(23):13649-55.


Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.

Schaller MD, Otey CA, Hildebrand JD, Parsons JT.

J Cell Biol. 1995 Sep;130(5):1181-7.


Interaction of focal adhesion kinase with cytoskeletal protein talin.

Chen HC, Appeddu PA, Parsons JT, Hildebrand JD, Schaller MD, Guan JL.

J Biol Chem. 1995 Jul 14;270(28):16995-9.


Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.

Schaller MD, Hildebrand JD, Shannon JD, Fox JW, Vines RR, Parsons JT.

Mol Cell Biol. 1994 Mar;14(3):1680-8.


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