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Items: 15

1.

Aggregation and Its Influence on the Immunomodulatory Activity of Synthetic Innate Defense Regulator Peptides.

Haney EF, Wu BC, Lee K, Hilchie AL, Hancock REW.

Cell Chem Biol. 2017 Aug 17;24(8):969-980.e4. doi: 10.1016/j.chembiol.2017.07.010. Epub 2017 Aug 10.

2.

Anticancer activities of bovine and human lactoferricin-derived peptides.

Arias M, Hilchie AL, Haney EF, Bolscher JG, Hyndman ME, Hancock RE, Vogel HJ.

Biochem Cell Biol. 2017 Feb;95(1):91-98. doi: 10.1139/bcb-2016-0175. Epub 2016 Nov 3.

PMID:
28165293
3.

Mastoparan is a membranolytic anti-cancer peptide that works synergistically with gemcitabine in a mouse model of mammary carcinoma.

Hilchie AL, Sharon AJ, Haney EF, Hoskin DW, Bally MB, Franco OL, Corcoran JA, Hancock REW.

Biochim Biophys Acta. 2016 Dec;1858(12):3195-3204. doi: 10.1016/j.bbamem.2016.09.021. Epub 2016 Oct 18.

4.

Enhanced killing of breast cancer cells by a d-amino acid analog of the winter flounder-derived pleurocidin NRC-03.

Hilchie AL, Haney EF, Pinto DM, Hancock RE, Hoskin DW.

Exp Mol Pathol. 2015 Dec;99(3):426-34. doi: 10.1016/j.yexmp.2015.08.021. Epub 2015 Sep 3.

PMID:
26344617
5.

High throughput screening methods for assessing antibiofilm and immunomodulatory activities of synthetic peptides.

Haney EF, Mansour SC, Hilchie AL, de la Fuente-Núñez C, Hancock RE.

Peptides. 2015 Sep;71:276-85. doi: 10.1016/j.peptides.2015.03.015. Epub 2015 Mar 31.

6.

Requirement of the Pseudomonas aeruginosa CbrA sensor kinase for full virulence in a murine acute lung infection model.

Yeung AT, Janot L, Pena OM, Neidig A, Kukavica-Ibrulj I, Hilchie A, Levesque RC, Overhage J, Hancock RE.

Infect Immun. 2014 Mar;82(3):1256-67. doi: 10.1128/IAI.01527-13. Epub 2013 Dec 30.

7.

Immune modulation by multifaceted cationic host defense (antimicrobial) peptides.

Hilchie AL, Wuerth K, Hancock RE.

Nat Chem Biol. 2013 Dec;9(12):761-8. doi: 10.1038/nchembio.1393. Review.

PMID:
24231617
8.

Assessment of antimicrobial (host defense) peptides as anti-cancer agents.

Douglas S, Hoskin DW, Hilchie AL.

Methods Mol Biol. 2014;1088:159-70. doi: 10.1007/978-1-62703-673-3_11.

PMID:
24146403
9.

Generation of a hematologic malignancy-selective membranolytic peptide from the antimicrobial core (RRWQWR) of bovine lactoferricin.

Hilchie AL, Vale R, Zemlak TS, Hoskin DW.

Exp Mol Pathol. 2013 Oct;95(2):192-8. doi: 10.1016/j.yexmp.2013.07.006. Epub 2013 Jul 26.

PMID:
23892223
10.

Pleurocidin-family cationic antimicrobial peptides mediate lysis of multiple myeloma cells and impair the growth of multiple myeloma xenografts.

Hilchie AL, Conrad DM, Coombs MR, Zemlak T, Doucette CD, Liwski RS, Hoskin DW.

Leuk Lymphoma. 2013 Oct;54(10):2255-62. doi: 10.3109/10428194.2013.770847. Epub 2013 Mar 4.

PMID:
23350892
11.

Piperine, a dietary phytochemical, inhibits angiogenesis.

Doucette CD, Hilchie AL, Liwski R, Hoskin DW.

J Nutr Biochem. 2013 Jan;24(1):231-9. doi: 10.1016/j.jnutbio.2012.05.009. Epub 2012 Aug 16.

12.

Pleurocidin-family cationic antimicrobial peptides are cytolytic for breast carcinoma cells and prevent growth of tumor xenografts.

Hilchie AL, Doucette CD, Pinto DM, Patrzykat A, Douglas S, Hoskin DW.

Breast Cancer Res. 2011 Oct 24;13(5):R102. doi: 10.1186/bcr3043.

13.

Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria.

Hilchie AL, Furlong SJ, Sutton K, Richardson A, Robichaud MR, Giacomantonio CA, Ridgway ND, Hoskin DW.

Nutr Cancer. 2010;62(3):379-89. doi: 10.1080/01635580903441238.

PMID:
20358476
14.

Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling.

Watson JL, Greenshields A, Hill R, Hilchie A, Lee PW, Giacomantonio CA, Hoskin DW.

Mol Carcinog. 2010 Jan;49(1):13-24. doi: 10.1002/mc.20571.

PMID:
19676105
15.

Apoptosis induced by intracellular ceramide accumulation in MDA-MB-435 breast carcinoma cells is dependent on the generation of reactive oxygen species.

Chan SY, Hilchie AL, Brown MG, Anderson R, Hoskin DW.

Exp Mol Pathol. 2007 Feb;82(1):1-11. Epub 2006 Apr 19.

PMID:
16624283

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