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Items: 1 to 50 of 115

1.

Quorum sensing modulates the formation of virulent Legionella persisters within infected cells.

Personnic N, Striednig B, Lezan E, Manske C, Welin A, Schmidt A, Hilbi H.

Nat Commun. 2019 Nov 18;10(1):5216. doi: 10.1038/s41467-019-13021-8.

2.

PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection.

Buckley CM, Heath VL, Guého A, Bosmani C, Knobloch P, Sikakana P, Personnic N, Dove SK, Michell RH, Meier R, Hilbi H, Soldati T, Insall RH, King JS.

PLoS Pathog. 2019 Feb 7;15(2):e1007551. doi: 10.1371/journal.ppat.1007551. eCollection 2019 Feb.

3.

Perturbation of Legionella Cell Infection by RNA Interference.

Steiner B, Swart AL, Hilbi H.

Methods Mol Biol. 2019;1921:221-238. doi: 10.1007/978-1-4939-9048-1_14.

PMID:
30694495
4.

Single Cell Analysis of Legionella and Legionella-Infected Acanthamoeba by Agarose Embedment.

Personnic N, Striednig B, Hilbi H.

Methods Mol Biol. 2019;1921:191-204. doi: 10.1007/978-1-4939-9048-1_12.

PMID:
30694493
5.

Quantitative Imaging Flow Cytometry of Legionella-Containing Vacuoles in Dually Fluorescence-Labeled Dictyostelium.

Welin A, Weber S, Hilbi H.

Methods Mol Biol. 2019;1921:161-177. doi: 10.1007/978-1-4939-9048-1_10.

PMID:
30694491
6.

Migration of Acanthamoeba castellanii Through Legionella Biofilms.

Hochstrasser R, Hilbi H.

Methods Mol Biol. 2019;1921:79-89. doi: 10.1007/978-1-4939-9048-1_5.

PMID:
30694486
7.

Distinct Mycobacterium marinum phosphatases determine pathogen vacuole phosphoinositide pattern, phagosome maturation, and escape to the cytosol.

Koliwer-Brandl H, Knobloch P, Barisch C, Welin A, Hanna N, Soldati T, Hilbi H.

Cell Microbiol. 2019 Jun;21(6):e13008. doi: 10.1111/cmi.13008. Epub 2019 Feb 7.

PMID:
30656819
8.

The pleiotropic Legionella transcription factor LvbR links the Lqs and c-di-GMP regulatory networks to control biofilm architecture and virulence.

Hochstrasser R, Kessler A, Sahr T, Simon S, Schell U, Gomez-Valero L, Buchrieser C, Hilbi H.

Environ Microbiol. 2019 Mar;21(3):1035-1053. doi: 10.1111/1462-2920.14523. Epub 2019 Feb 22.

PMID:
30623561
9.

Legionella-Containing Vacuoles Capture PtdIns(4)P-Rich Vesicles Derived from the Golgi Apparatus.

Weber S, Steiner B, Welin A, Hilbi H.

MBio. 2018 Dec 11;9(6). pii: e02420-18. doi: 10.1128/mBio.02420-18.

10.

Analysis of Legionella Metabolism by Pathogen Vacuole Proteomics.

Manske C, Finsel I, Hoffmann C, Hilbi H.

Methods Mol Biol. 2018;1841:59-76. doi: 10.1007/978-1-4939-8695-8_6.

PMID:
30259480
11.

The large GTPase atlastin controls ER remodeling around a pathogen vacuole.

Steiner B, Weber S, Kaech A, Ziegler U, Hilbi H.

Commun Integr Biol. 2018 Mar 6;11(2):1-5. doi: 10.1080/19420889.2018.1440880. eCollection 2018.

12.

A uniform cloning platform for mycobacterial genetics and protein production.

Arnold FM, Hohl M, Remm S, Koliwer-Brandl H, Adenau S, Chusri S, Sander P, Hilbi H, Seeger MA.

Sci Rep. 2018 Jun 22;8(1):9539. doi: 10.1038/s41598-018-27687-5.

13.

Quantitative Imaging Flow Cytometry of Legionella-Infected Dictyostelium Amoebae Reveals the Impact of Retrograde Trafficking on Pathogen Vacuole Composition.

Welin A, Weber S, Hilbi H.

Appl Environ Microbiol. 2018 May 17;84(11). pii: e00158-18. doi: 10.1128/AEM.00158-18. Print 2018 Jun 1.

14.

Acanthamoeba and Dictyostelium as Cellular Models for Legionella Infection.

Swart AL, Harrison CF, Eichinger L, Steinert M, Hilbi H.

Front Cell Infect Microbiol. 2018 Mar 2;8:61. doi: 10.3389/fcimb.2018.00061. eCollection 2018. Review.

15.

Formation of the Legionella Replicative Compartment at the Crossroads of Retrograde Trafficking.

Bärlocher K, Welin A, Hilbi H.

Front Cell Infect Microbiol. 2017 Nov 24;7:482. doi: 10.3389/fcimb.2017.00482. eCollection 2017. Review.

16.

Legionella quorum sensing and its role in pathogen-host interactions.

Personnic N, Striednig B, Hilbi H.

Curr Opin Microbiol. 2018 Feb;41:29-35. doi: 10.1016/j.mib.2017.11.010. Epub 2017 Nov 27. Review.

PMID:
29190490
17.

Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5.

Bärlocher K, Hutter CAJ, Swart AL, Steiner B, Welin A, Hohl M, Letourneur F, Seeger MA, Hilbi H.

Nat Commun. 2017 Nov 16;8(1):1543. doi: 10.1038/s41467-017-01512-5.

18.

Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages.

Escoll P, Song OR, Viana F, Steiner B, Lagache T, Olivo-Marin JC, Impens F, Brodin P, Hilbi H, Buchrieser C.

Cell Host Microbe. 2017 Sep 13;22(3):302-316.e7. doi: 10.1016/j.chom.2017.07.020. Epub 2017 Aug 31.

19.

Formation of the Legionella-containing vacuole: phosphoinositide conversion, GTPase modulation and ER dynamics.

Steiner B, Weber S, Hilbi H.

Int J Med Microbiol. 2018 Jan;308(1):49-57. doi: 10.1016/j.ijmm.2017.08.004. Epub 2017 Aug 16. Review.

PMID:
28865995
20.

ER remodeling by the large GTPase atlastin promotes vacuolar growth of Legionella pneumophila.

Steiner B, Swart AL, Welin A, Weber S, Personnic N, Kaech A, Freyre C, Ziegler U, Klemm RW, Hilbi H.

EMBO Rep. 2017 Oct;18(10):1817-1836. doi: 10.15252/embr.201743903. Epub 2017 Aug 23.

21.

Inhibitors of Mycobacterium marinum virulence identified in a Dictyostelium discoideum host model.

Ouertatani-Sakouhi H, Kicka S, Chiriano G, Harrison CF, Hilbi H, Scapozza L, Soldati T, Cosson P.

PLoS One. 2017 Jul 20;12(7):e0181121. doi: 10.1371/journal.pone.0181121. eCollection 2017.

22.

Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection.

Hilbi H, Kortholt A.

Small GTPases. 2019 Sep;10(5):336-342. doi: 10.1080/21541248.2017.1331721. Epub 2017 Jun 23.

23.

Intra-Species and Inter-Kingdom Signaling of Legionella pneumophila.

Hochstrasser R, Hilbi H.

Front Microbiol. 2017 Feb 3;8:79. doi: 10.3389/fmicb.2017.00079. eCollection 2017. Review.

24.

Comparative Proteomics of Purified Pathogen Vacuoles Correlates Intracellular Replication of Legionella pneumophila with the Small GTPase Ras-related protein 1 (Rap1).

Schmölders J, Manske C, Otto A, Hoffmann C, Steiner B, Welin A, Becher D, Hilbi H.

Mol Cell Proteomics. 2017 Apr;16(4):622-641. doi: 10.1074/mcp.M116.063453. Epub 2017 Feb 9.

25.

Subversion of Host Membrane Dynamics by the Legionella Dot/Icm Type IV Secretion System.

Hilbi H, Nagai H, Kubori T, Roy CR.

Curr Top Microbiol Immunol. 2017;413:221-242. doi: 10.1007/978-3-319-75241-9_9.

PMID:
29536361
26.

Legionella shows a diverse secondary metabolism dependent on a broad spectrum Sfp-type phosphopantetheinyl transferase.

Tobias NJ, Ahrendt T, Schell U, Miltenberger M, Hilbi H, Bode HB.

PeerJ. 2016 Nov 24;4:e2720. eCollection 2016.

27.

Inflammasome Recognition and Regulation of the Legionella Flagellum.

Schell U, Simon S, Hilbi H.

Curr Top Microbiol Immunol. 2016;397:161-81. doi: 10.1007/978-3-319-41171-2_8. Review.

PMID:
27460809
28.

Metabolism of myo-Inositol by Legionella pneumophila Promotes Infection of Amoebae and Macrophages.

Manske C, Schell U, Hilbi H.

Appl Environ Microbiol. 2016 Jul 29;82(16):5000-14. doi: 10.1128/AEM.01018-16. Print 2016 Aug 15.

29.

Subversion of Retrograde Trafficking by Translocated Pathogen Effectors.

Personnic N, Bärlocher K, Finsel I, Hilbi H.

Trends Microbiol. 2016 Jun;24(6):450-462. doi: 10.1016/j.tim.2016.02.003. Epub 2016 Feb 26. Review.

PMID:
26924068
30.

Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy.

Rolando M, Escoll P, Nora T, Botti J, Boitez V, Bedia C, Daniels C, Abraham G, Stogios PJ, Skarina T, Christophe C, Dervins-Ravault D, Cazalet C, Hilbi H, Rupasinghe TW, Tull D, McConville MJ, Ong SY, Hartland EL, Codogno P, Levade T, Naderer T, Savchenko A, Buchrieser C.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1901-6. doi: 10.1073/pnas.1522067113. Epub 2016 Feb 1.

31.

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.

Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B.

PLoS Pathog. 2016 Feb 1;12(2):e1005408. doi: 10.1371/journal.ppat.1005408. eCollection 2016 Feb.

32.

In Silico Driven Design and Synthesis of Rhodanine Derivatives as Novel Antibacterials Targeting the Enoyl Reductase InhA.

Slepikas L, Chiriano G, Perozzo R, Tardy S, Kranjc A, Patthey-Vuadens O, Ouertatani-Sakouhi H, Kicka S, Harrison CF, Scrignari T, Perron K, Hilbi H, Soldati T, Cosson P, Tarasevicius E, Scapozza L.

J Med Chem. 2016 Dec 22;59(24):10917-10928. doi: 10.1021/acs.jmedchem.5b01620. Epub 2016 Dec 9.

PMID:
26730986
33.

Pathway analysis using (13) C-glycerol and other carbon tracers reveals a bipartite metabolism of Legionella pneumophila.

Häuslein I, Manske C, Goebel W, Eisenreich W, Hilbi H.

Mol Microbiol. 2016 Apr;100(2):229-46. doi: 10.1111/mmi.13313. Epub 2016 Feb 19.

34.

Inter-kingdom Signaling by the Legionella Quorum Sensing Molecule LAI-1 Modulates Cell Migration through an IQGAP1-Cdc42-ARHGEF9-Dependent Pathway.

Simon S, Schell U, Heuer N, Hager D, Albers MF, Matthias J, Fahrnbauer F, Trauner D, Eichinger L, Hedberg C, Hilbi H.

PLoS Pathog. 2015 Dec 3;11(12):e1005307. doi: 10.1371/journal.ppat.1005307. eCollection 2015 Dec.

35.

The α-hydroxyketone LAI-1 regulates motility, Lqs-dependent phosphorylation signalling and gene expression of Legionella pneumophila.

Schell U, Simon S, Sahr T, Hager D, Albers MF, Kessler A, Fahrnbauer F, Trauner D, Hedberg C, Buchrieser C, Hilbi H.

Mol Microbiol. 2016 Feb;99(4):778-93. doi: 10.1111/mmi.13265. Epub 2015 Nov 27.

36.

Subversion of Cell-Autonomous Immunity and Cell Migration by Legionella pneumophila Effectors.

Simon S, Hilbi H.

Front Immunol. 2015 Sep 14;6:447. doi: 10.3389/fimmu.2015.00447. eCollection 2015. Review.

37.

Amoebae-Based Screening Reveals a Novel Family of Compounds Restricting Intracellular Legionella pneumophila.

Harrison CF, Chiriano G, Finsel I, Manske C, Hoffmann C, Steiner B, Kranjc A, Patthey-Vuadens O, Kicka S, Trofimov V, Ouertatani-Sakouhi H, Soldati T, Scapozza L, Hilbi H.

ACS Infect Dis. 2015 Jul 10;1(7):327-38. doi: 10.1021/acsinfecdis.5b00002. Epub 2015 May 16.

PMID:
27622823
38.

Purification and proteomics of pathogen-modified vacuoles and membranes.

Herweg JA, Hansmeier N, Otto A, Geffken AC, Subbarayal P, Prusty BK, Becher D, Hensel M, Schaible UE, Rudel T, Hilbi H.

Front Cell Infect Microbiol. 2015 Jun 2;5:48. doi: 10.3389/fcimb.2015.00048. eCollection 2015. Review.

39.

Formation of a pathogen vacuole according to Legionella pneumophila: how to kill one bird with many stones.

Finsel I, Hilbi H.

Cell Microbiol. 2015 Jul;17(7):935-50. doi: 10.1111/cmi.12450. Epub 2015 May 13. Review.

PMID:
25903720
40.

Adrenergic antagonists restrict replication of Legionella.

Harrison CF, Kicka S, Kranjc A, Finsel I, Chiriano G, Ouertatani-Sakouhi H, Soldati T, Scapozza L, Hilbi H.

Microbiology. 2015 Jul;161(7):1392-406. doi: 10.1099/mic.0.000094. Epub 2015 Apr 14.

PMID:
25873585
41.

Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis.

Jeschke A, Zehethofer N, Lindner B, Krupp J, Schwudke D, Haneburger I, Jovic M, Backer JM, Balla T, Hilbi H, Haas A.

Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4636-41. doi: 10.1073/pnas.1423456112. Epub 2015 Mar 30.

42.

Beyond Rab GTPases Legionella activates the small GTPase Ran to promote microtubule polymerization, pathogen vacuole motility, and infection.

Hilbi H, Rothmeier E, Hoffmann C, Harrison CF.

Small GTPases. 2014;5(3):1-6. doi: 10.4161/21541248.2014.972859.

43.

A type IV translocated Legionella cysteine phytase counteracts intracellular growth restriction by phytate.

Weber S, Stirnimann CU, Wieser M, Frey D, Meier R, Engelhardt S, Li X, Capitani G, Kammerer RA, Hilbi H.

J Biol Chem. 2014 Dec 5;289(49):34175-88. doi: 10.1074/jbc.M114.592568. Epub 2014 Oct 22.

44.

Metabolism of the vacuolar pathogen Legionella and implications for virulence.

Manske C, Hilbi H.

Front Cell Infect Microbiol. 2014 Sep 9;4:125. doi: 10.3389/fcimb.2014.00125. eCollection 2014.

45.

Live cell imaging of phosphoinositide dynamics during Legionella infection.

Weber S, Hilbi H.

Methods Mol Biol. 2014;1197:153-67. doi: 10.1007/978-1-4939-1261-2_9.

PMID:
25172280
46.

The Legionella longbeachae Icm/Dot substrate SidC selectively binds phosphatidylinositol 4-phosphate with nanomolar affinity and promotes pathogen vacuole-endoplasmic reticulum interactions.

Dolinsky S, Haneburger I, Cichy A, Hannemann M, Itzen A, Hilbi H.

Infect Immun. 2014 Oct;82(10):4021-33. doi: 10.1128/IAI.01685-14. Epub 2014 Jul 14.

47.

Phosphorylation signalling through the Legionella quorum sensing histidine kinases LqsS and LqsT converges on the response regulator LqsR.

Schell U, Kessler A, Hilbi H.

Mol Microbiol. 2014 Jun;92(5):1039-55. doi: 10.1111/mmi.12612. Epub 2014 May 6.

48.

Establishment and validation of whole-cell based fluorescence assays to identify anti-mycobacterial compounds using the Acanthamoeba castellanii-Mycobacterium marinum host-pathogen system.

Kicka S, Trofimov V, Harrison C, Ouertatani-Sakouhi H, McKinney J, Scapozza L, Hilbi H, Cosson P, Soldati T.

PLoS One. 2014 Jan 31;9(1):e87834. doi: 10.1371/journal.pone.0087834. eCollection 2014.

49.

Live-cell imaging of phosphoinositide dynamics and membrane architecture during Legionella infection.

Weber S, Wagner M, Hilbi H.

MBio. 2014 Jan 28;5(1):e00839-13. doi: 10.1128/mBio.00839-13.

50.

Icm/Dot-dependent inhibition of phagocyte migration by Legionella is antagonized by a translocated Ran GTPase activator.

Simon S, Wagner MA, Rothmeier E, Müller-Taubenberger A, Hilbi H.

Cell Microbiol. 2014 Jul;16(7):977-92. doi: 10.1111/cmi.12258. Epub 2014 Jan 27.

PMID:
24397557

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