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Prognostic factors for cancer patient admitted to a medical intensive care unit.

Baylot C, Francopoulo A, Gross-Goupil M, Quivy A, Guisset O, Hilbert G, Frison E, Ravaud A, Daste A.

Acta Oncol. 2020 Jan 16:1-4. doi: 10.1080/0284186X.2019.1711171. [Epub ahead of print] No abstract available.


Metabolite profiling during graft union formation reveals the reprogramming of primary metabolism and the induction of stilbene synthesis at the graft interface in grapevine.

Prodhomme D, Valls Fonayet J, Hévin C, Franc C, Hilbert G, de Revel G, Richard T, Ollat N, Cookson SJ.

BMC Plant Biol. 2019 Dec 30;19(1):599. doi: 10.1186/s12870-019-2055-9.


Aminoacids and Flavonoids Profiling in Tempranillo Berries Can Be Modulated by the Arbuscular Mycorrhizal Fungi.

Torres N, Hilbert G, Antolín MC, Goicoechea N.

Plants (Basel). 2019 Oct 8;8(10). pii: E400. doi: 10.3390/plants8100400.


Acute respiratory distress syndrome and cutaneous eruption in an immunocompetent adult.

Lannou A, Prevel R, Hilbert G, Bui HN.

Intensive Care Med. 2019 Oct 7. doi: 10.1007/s00134-019-05803-x. [Epub ahead of print] No abstract available.


The sustainable impact of an educational approach to improve the appropriateness of laboratory test orders in the ICU.

Clouzeau B, Caujolle M, San-Miguel A, Pillot J, Gazeau N, Tacaille C, Dousset V, Bazin F, Vargas F, Hilbert G, Molimard M, Gruson D, Boyer A.

PLoS One. 2019 May 1;14(5):e0214802. doi: 10.1371/journal.pone.0214802. eCollection 2019.


Tailoring Empirical Antimicrobial Therapy in Subjects With Ventilator-Associated Pneumonia With a 10-Hour E-Test Approach.

Boyer A, Goret J, Clouzeau B, Romen A, Prevel R, Lhomme E, Vargas F, Hilbert G, Bébéar C, Gruson D, M'Zali F.

Respir Care. 2019 Mar;64(3):307-312. doi: 10.4187/respcare.06255. Epub 2018 Dec 11.


Disagreement Between Clinicians and Score in Decision-Making Capacity of Critically Ill Patients.

Bertrand PM, Pereira B, Adda M, Timsit JF, Wolff M, Hilbert G, Gruson D, Garrouste-Orgeas M, Argaud L, Constantin JM, Chabanne R, Quenot JP, Bohe J, Guerin C, Papazian L, Jonquet O, Klouche K, Delahaye A, Riu B, Zieleskiewicz L, Darmon M, Azoulay E, Souweine B, Lautrette A.

Crit Care Med. 2019 Mar;47(3):337-344. doi: 10.1097/CCM.0000000000003550.


Constraint-Based Modeling Highlights Cell Energy, Redox Status and α-Ketoglutarate Availability as Metabolic Drivers for Anthocyanin Accumulation in Grape Cells Under Nitrogen Limitation.

Soubeyrand E, Colombié S, Beauvoit B, Dai Z, Cluzet S, Hilbert G, Renaud C, Maneta-Peyret L, Dieuaide-Noubhani M, Mérillon JM, Gibon Y, Delrot S, Gomès E.

Front Plant Sci. 2018 May 17;9:421. doi: 10.3389/fpls.2018.00421. eCollection 2018.


My paper 20 years later: NIV in immunocompromized patients.

Hilbert G, Vargas F.

Intensive Care Med. 2018 Dec;44(12):2225-2228. doi: 10.1007/s00134-018-5155-3. Epub 2018 Apr 5. No abstract available.


Tempranillo clones differ in the response of berry sugar and anthocyanin accumulation to elevated temperature.

Arrizabalaga M, Morales F, Oyarzun M, Delrot S, Gomès E, Irigoyen JJ, Hilbert G, Pascual I.

Plant Sci. 2018 Feb;267:74-83. doi: 10.1016/j.plantsci.2017.11.009. Epub 2017 Nov 24.


Cluster shading modifies amino acids in grape (Vitis vinifera L.) berries in a genotype- and tissue-dependent manner.

Guan L, Wu B, Hilbert G, Li S, Gomès E, Delrot S, Dai Z.

Food Res Int. 2017 Aug;98:2-9. doi: 10.1016/j.foodres.2017.01.008. Epub 2017 Jan 11.


Intermittent noninvasive ventilation after extubation in patients with chronic respiratory disorders: a multicenter randomized controlled trial (VHYPER).

Vargas F, Clavel M, Sanchez-Verlan P, Garnier S, Boyer A, Bui HN, Clouzeau B, Sazio C, Kerchache A, Guisset O, Benard A, Asselineau J, Gauche B, Gruson D, Silva S, Vignon P, Hilbert G.

Intensive Care Med. 2017 Nov;43(11):1626-1636. doi: 10.1007/s00134-017-4785-1. Epub 2017 Apr 9.


Dissecting the Biochemical and Transcriptomic Effects of a Locally Applied Heat Treatment on Developing Cabernet Sauvignon Grape Berries.

Lecourieux F, Kappel C, Pieri P, Charon J, Pillet J, Hilbert G, Renaud C, Gomès E, Delrot S, Lecourieux D.

Front Plant Sci. 2017 Jan 31;8:53. doi: 10.3389/fpls.2017.00053. eCollection 2017.


Ultrasonographic diaphragmatic excursion is inaccurate and not better than the MRC score for predicting weaning-failure in mechanically ventilated patients.

Carrie C, Gisbert-Mora C, Bonnardel E, Gauche B, Biais M, Vargas F, Hilbert G.

Anaesth Crit Care Pain Med. 2017 Feb;36(1):9-14. doi: 10.1016/j.accpm.2016.05.009. Epub 2016 Sep 16.


Roostocks/Scion/Nitrogen Interactions Affect Secondary Metabolism in the Grape Berry.

Habran A, Commisso M, Helwi P, Hilbert G, Negri S, Ollat N, Gomès E, van Leeuwen C, Guzzo F, Delrot S.

Front Plant Sci. 2016 Aug 9;7:1134. doi: 10.3389/fpls.2016.01134. eCollection 2016.


Vine nitrogen status and volatile thiols and their precursors from plot to transcriptome level.

Helwi P, Guillaumie S, Thibon C, Keime C, Habran A, Hilbert G, Gomes E, Darriet P, Delrot S, van Leeuwen C.

BMC Plant Biol. 2016 Aug 8;16(1):173. doi: 10.1186/s12870-016-0836-y.


Blood fibrocytes are recruited during acute exacerbations of chronic obstructive pulmonary disease through a CXCR4-dependent pathway.

Dupin I, Allard B, Ozier A, Maurat E, Ousova O, Delbrel E, Trian T, Bui HN, Dromer C, Guisset O, Blanchard E, Hilbert G, Vargas F, Thumerel M, Marthan R, Girodet PO, Berger P.

J Allergy Clin Immunol. 2016 Apr;137(4):1036-1042.e7. doi: 10.1016/j.jaci.2015.08.043. Epub 2015 Oct 23.


Water limitation and rootstock genotype interact to alter grape berry metabolism through transcriptome reprogramming.

Berdeja M, Nicolas P, Kappel C, Dai ZW, Hilbert G, Peccoux A, Lafontaine M, Ollat N, Gomès E, Delrot S.

Hortic Res. 2015 Apr 15;2:15012. doi: 10.1038/hortres.2015.12. eCollection 2015.


Vine Nitrogen Status Does Not Have a Direct Impact on 2-Methoxy-3-isobutylpyrazine in Grape Berries and Wines.

Helwi P, Habran A, Guillaumie S, Thibon C, Hilbert G, Gomes E, Delrot S, Darriet P, van Leeuwen C.

J Agric Food Chem. 2015 Nov 11;63(44):9789-802. doi: 10.1021/acs.jafc.5b03838. Epub 2015 Nov 3.


Anthocyanin biosynthesis is differentially regulated by light in the skin and flesh of white-fleshed and teinturier grape berries.

Guan L, Dai Z, Wu BH, Wu J, Merlin I, Hilbert G, Renaud C, Gomès E, Edwards E, Li SH, Delrot S.

Planta. 2016 Jan;243(1):23-41. doi: 10.1007/s00425-015-2391-4. Epub 2015 Sep 3.


Is sedation safe and beneficial in patients receiving NIV? Yes.

Hilbert G, Navalesi P, Girault C.

Intensive Care Med. 2015 Sep;41(9):1688-91. doi: 10.1007/s00134-015-3935-6. Epub 2015 Jul 7. No abstract available.


Differential responses of sugar, organic acids and anthocyanins to source-sink modulation in Cabernet Sauvignon and Sangiovese grapevines.

Bobeica N, Poni S, Hilbert G, Renaud C, Gomès E, Delrot S, Dai Z.

Front Plant Sci. 2015 May 29;6:382. doi: 10.3389/fpls.2015.00382. eCollection 2015.


Transcriptional and metabolic alternations rebalance wheat grain storage protein accumulation under variable nitrogen and sulfur supply.

Dai Z, Plessis A, Vincent J, Duchateau N, Besson A, Dardevet M, Prodhomme D, Gibon Y, Hilbert G, Pailloux M, Ravel C, Martre P.

Plant J. 2015 Jul;83(2):326-43. doi: 10.1111/tpj.12881. Epub 2015 Jun 8.


Physiologic Effects of High-Flow Nasal Cannula Oxygen in Critical Care Subjects.

Vargas F, Saint-Leger M, Boyer A, Bui NH, Hilbert G.

Respir Care. 2015 Oct;60(10):1369-76. doi: 10.4187/respcare.03814. Epub 2015 May 5.


Propensity-based study of aminoglycoside nephrotoxicity in patients with severe sepsis or septic shock.

Picard W, Bazin F, Clouzeau B, Bui HN, Soulat M, Guilhon E, Vargas F, Hilbert G, Bouchet S, Gruson D, Moore N, Boyer A.

Antimicrob Agents Chemother. 2014 Dec;58(12):7468-74. doi: 10.1128/AAC.03750-14. Epub 2014 Oct 6.


Flavonol profiles in berries of wild Vitis accessions using liquid chromatography coupled to mass spectrometry and nuclear magnetic resonance spectrometry.

Hilbert G, Temsamani H, Bordenave L, Pedrot E, Chaher N, Cluzet S, Delaunay JC, Ollat N, Delrot S, Mérillon JM, Gomès E, Richard T.

Food Chem. 2015 Feb 15;169:49-58. doi: 10.1016/j.foodchem.2014.07.079. Epub 2014 Jul 23.


Optimizing both noninvasive ventilation and antimicrobial approach in hematological patients with acute respiratory failure.

Hilbert G, Boyer A, Vargas F.

Rev Clin Esp. 2014 Oct;214(7):385-6. doi: 10.1016/j.rce.2014.05.026. Epub 2014 Jul 4. English, Spanish. No abstract available.


Nitrogen supply affects anthocyanin biosynthetic and regulatory genes in grapevine cv. Cabernet-Sauvignon berries.

Soubeyrand E, Basteau C, Hilbert G, van Leeuwen C, Delrot S, Gomès E.

Phytochemistry. 2014 Jul;103:38-49. doi: 10.1016/j.phytochem.2014.03.024. Epub 2014 Apr 12.


Ultraviolet-B radiation modifies the quantitative and qualitative profile of flavonoids and amino acids in grape berries.

Martínez-Lüscher J, Torres N, Hilbert G, Richard T, Sánchez-Díaz M, Delrot S, Aguirreolea J, Pascual I, Gomès E.

Phytochemistry. 2014 Jun;102:106-14. doi: 10.1016/j.phytochem.2014.03.014. Epub 2014 Apr 5.


Long-term in vitro culture of grape berries and its application to assess the effects of sugar supply on anthocyanin accumulation.

Dai ZW, Meddar M, Renaud C, Merlin I, Hilbert G, Delrot S, Gomès E.

J Exp Bot. 2014 Aug;65(16):4665-77. doi: 10.1093/jxb/ert489. Epub 2014 Jan 29.


Anthocyanin phytochemical profiles and anti-oxidant activities of Vitis candicans and Vitis doaniana.

De la Cruz AA, Hilbert G, Mengin V, Rivière C, Ollat N, Vitrac C, Bordenave L, Decroocq S, Delaunay JC, Mérillon JM, Monti JP, Gomès E, Richard T.

Phytochem Anal. 2013 Sep-Oct;24(5):446-52. doi: 10.1002/pca.2447. Epub 2013 Jul 9.


Methadone-induced toxic brain damage.

Corré J, Pillot J, Hilbert G.

Case Rep Radiol. 2013;2013:602981. doi: 10.1155/2013/602981. Epub 2013 May 22.


Prone positioning in severe acute respiratory distress syndrome.

Guérin C, Reignier J, Richard JC, Beuret P, Gacouin A, Boulain T, Mercier E, Badet M, Mercat A, Baudin O, Clavel M, Chatellier D, Jaber S, Rosselli S, Mancebo J, Sirodot M, Hilbert G, Bengler C, Richecoeur J, Gainnier M, Bayle F, Bourdin G, Leray V, Girard R, Baboi L, Ayzac L; PROSEVA Study Group.

N Engl J Med. 2013 Jun 6;368(23):2159-68. doi: 10.1056/NEJMoa1214103. Epub 2013 May 20.


Tracheal amylase dosage as a marker for microaspiration: a pilot study.

Filloux B, Bedel A, Nseir S, Mathiaux J, Amadéo B, Clouzeau B, Pillot J, Saghi T, Vargas F, Hilbert G, Gruson D, Boyer A.

Minerva Anestesiol. 2013 Sep;79(9):1003-10.


Anthocyanin identification and composition of wild Vitis spp. accessions by using LC-MS and LC-NMR.

Acevedo De la Cruz A, Hilbert G, Rivière C, Mengin V, Ollat N, Bordenave L, Decroocq S, Delaunay JC, Delrot S, Mérillon JM, Monti JP, Gomès E, Richard T.

Anal Chim Acta. 2012 Jun 30;732:145-52. doi: 10.1016/j.aca.2011.11.060. Epub 2011 Dec 7.


Sedation during non-invasive ventilation.

Hilbert G, Clouzeau B, Nam Bui H, Vargas F.

Minerva Anestesiol. 2012 Jul;78(7):842-6. Epub 2012 May 11. Review.


Fractional excretion of urea as a diagnostic index in acute kidney injury in intensive care patients.

Dewitte A, Biais M, Petit L, Cochard JF, Hilbert G, Combe C, Sztark F.

J Crit Care. 2012 Oct;27(5):505-10. doi: 10.1016/j.jcrc.2012.02.018. Epub 2012 Apr 18.


Direct testing of bronchoalveolar lavages from ventilator-associated pneumonia patients.

Boyer A, Medrano J, Mzali F, Balick-Weber CC, Bessède E, Picard W, Clouzeau B, Bébéar CM, Vargas F, Hilbert G, Rogues AM, Gruson D.

Diagn Microbiol Infect Dis. 2012 Jun;73(2):107-10. doi: 10.1016/j.diagmicrobio.2012.02.017. Epub 2012 Apr 5.


Immunoadsorption in patients with haemolytic uraemic syndrome.

Combe C, Bui HN, de Précigout V, Hilbert G, Delmas Y.

Lancet. 2012 Feb 11;379(9815):517-8; author reply 518-9. doi: 10.1016/S0140-6736(12)60228-1. No abstract available.


Echocardiographic evaluation and N-terminal pro-brain natriuretic peptide measurement of patients hospitalized for heart failure during weaning from mechanical ventilation.

Gerbaud E, Erickson M, Grenouillet-Delacre M, Beauvieux MC, Coste P, Durrieu-Jaïs C, Hilbert G, Castaing Y, Vargas F.

Minerva Anestesiol. 2012 Apr;78(4):415-25. Epub 2012 Feb 6.


Starting point to embark on a widespread use of noninvasive positive pressure ventilation in acute lung injury or early acute respiratory distress syndrome?.

Hilbert G, Vargas F, Boyer A, Bui HN.

Crit Care Med. 2012 Feb;40(2):669-71. doi: 10.1097/CCM.0b013e318236ec4f. No abstract available.


Fiberoptic bronchoscopy under noninvasive ventilation and propofol target-controlled infusion in hypoxemic patients.

Clouzeau B, Bui HN, Guilhon E, Grenouillet-Delacre M, Leger MS, Saghi T, Pillot J, Filloux B, Coz S, Boyer A, Vargas F, Gruson D, Hilbert G.

Intensive Care Med. 2011 Dec;37(12):1969-75. doi: 10.1007/s00134-011-2375-1. Epub 2011 Oct 8.


Noninvasive ventilation and weaning in patients with chronic hypercapnic respiratory failure: a randomized multicenter trial.

Girault C, Bubenheim M, Abroug F, Diehl JL, Elatrous S, Beuret P, Richecoeur J, L'Her E, Hilbert G, Capellier G, Rabbat A, Besbes M, Guérin C, Guiot P, Bénichou J, Bonmarchand G; VENISE Trial Group.

Am J Respir Crit Care Med. 2011 Sep 15;184(6):672-9. doi: 10.1164/rccm.201101-0035OC.


[Where to manage community acquired pneumonia? The assessment of severity].

Bui HN, Vargas F, Gruson D, Hilbert G.

Rev Mal Respir. 2011 Feb;28(2):240-53. doi: 10.1016/j.rmr.2010.08.010. French.


Myocardial ischaemia and weaning failure: is angioplasty the heart of the problem?

Carrié C, Bui HN, Gerbaud E, Vargas F, Hilbert G.

Intensive Care Med. 2011 Jul;37(7):1223-4. doi: 10.1007/s00134-011-2186-4. Epub 2011 Mar 11. No abstract available.


Pseudomonas aeruginosa acquisition on an intensive care unit: relationship between antibiotic selective pressure and patients' environment.

Boyer A, Doussau A, Thiébault R, Venier AG, Tran V, Boulestreau H, Bébéar C, Vargas F, Hilbert G, Gruson D, Rogues AM.

Crit Care. 2011;15(1):R55. doi: 10.1186/cc10026. Epub 2011 Feb 9.


Prognostic impact of high-flow nasal cannula oxygen supply in an ICU patient with pulmonary fibrosis complicated by acute respiratory failure.

Boyer A, Vargas F, Delacre M, Saint-Léger M, Clouzeau B, Hilbert G, Gruson D.

Intensive Care Med. 2011 Mar;37(3):558-9. doi: 10.1007/s00134-010-2036-9. Epub 2010 Sep 18. No abstract available.


Target-controlled infusion of propofol for sedation in patients with non-invasive ventilation failure due to low tolerance: a preliminary study.

Clouzeau B, Bui HN, Vargas F, Grenouillet-Delacre M, Guilhon E, Gruson D, Hilbert G.

Intensive Care Med. 2010 Oct;36(10):1675-80. doi: 10.1007/s00134-010-1904-7. Epub 2010 May 11.


Small dead space heat and moisture exchangers do not impede gas exchange during noninvasive ventilation: a comparison with a heated humidifier.

Boyer A, Vargas F, Hilbert G, Gruson D, Mousset-Hovaere M, Castaing Y, Dreyfuss D, Ricard JD.

Intensive Care Med. 2010 Aug;36(8):1348-54. doi: 10.1007/s00134-010-1894-5. Epub 2010 Apr 27.


Effect of intrapulmonary percussive ventilation on expiratory flow limitation in chronic obstructive pulmonary disease patients.

Vargas F, Boyer A, Bui HN, Guenard H, Gruson D, Hilbert G.

J Crit Care. 2009 Jun;24(2):212-9. doi: 10.1016/j.jcrc.2008.02.006. Epub 2008 May 14.


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