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Items: 50


Neuronal nitric oxide synthase regulation of calcium cycling in ventricular cardiomyocytes is independent of Cav1.2 channel modulation under basal conditions.

Ebner J, Cagalinec M, Kubista H, Todt H, Szabo PL, Kiss A, Podesser BK, Cserne Szappanos H, Hool LC, Hilber K, Koenig X.

Pflugers Arch. 2020 Jan;472(1):61-74. doi: 10.1007/s00424-019-02335-7. Epub 2019 Dec 10.


Pharmacological Profile of the Bradycardic Agent Ivabradine on Human Cardiac Ion Channels.

Haechl N, Ebner J, Hilber K, Todt H, Koenig X.

Cell Physiol Biochem. 2019;53(1):36-48. doi: 10.33594/000000119.


Mechanistic insights into store-operated Ca2+ entry during excitation-contraction coupling in skeletal muscle.

Koenig X, Choi RH, Schicker K, Singh DP, Hilber K, Launikonis BS.

Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1239-1248. doi: 10.1016/j.bbamcr.2019.02.014. Epub 2019 Feb 27.


Voltage-Dependent Sarcolemmal Ion Channel Abnormalities in the Dystrophin-Deficient Heart.

Koenig X, Ebner J, Hilber K.

Int J Mol Sci. 2018 Oct 23;19(11). pii: E3296. doi: 10.3390/ijms19113296. Review.


Calcium current properties in dystrophin-deficient ventricular cardiomyocytes from aged mdx mice.

Rubi L, Todt H, Kubista H, Koenig X, Hilber K.

Physiol Rep. 2018 Jan;6(1). doi: 10.14814/phy2.13567.


Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na+ channels: mechanistic insights from recent crystal structures.

Cervenka R, Lukacs P, Gawali VS, Ke S, Koenig X, Rubi L, Zarrabi T, Hilber K, Sandtner W, Stary-Weinzinger A, Todt H.

Sci Rep. 2018 Jan 12;8(1):631. doi: 10.1038/s41598-017-18919-1.


Modulation of the heart's electrical properties by the anticonvulsant drug retigabine.

Rubi L, Kovar M, Zebedin-Brandl E, Koenig X, Dominguez-Rodriguez M, Todt H, Kubista H, Boehm S, Hilber K.

Toxicol Appl Pharmacol. 2017 Aug 15;329:309-317. doi: 10.1016/j.taap.2017.06.018. Epub 2017 Jun 20.


Cav 1.3 channels play a crucial role in the formation of paroxysmal depolarization shifts in cultured hippocampal neurons.

Stiglbauer V, Hotka M, Ruiß M, Hilber K, Boehm S, Kubista H.

Epilepsia. 2017 May;58(5):858-871. doi: 10.1111/epi.13719. Epub 2017 Mar 11.


Decreased inward rectifier potassium current IK1 in dystrophin-deficient ventricular cardiomyocytes.

Rubi L, Koenig X, Kubista H, Todt H, Hilber K.

Channels (Austin). 2017 Mar 4;11(2):101-108. doi: 10.1080/19336950.2016.1228498. Epub 2016 Aug 25.


Anti-addiction Drug Ibogaine Prolongs the Action Potential in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Rubi L, Eckert D, Boehm S, Hilber K, Koenig X.

Cardiovasc Toxicol. 2017 Apr;17(2):215-218. doi: 10.1007/s12012-016-9366-y.


Mechanism of Modification, by Lidocaine, of Fast and Slow Recovery from Inactivation of Voltage-Gated Na⁺ Channels.

Gawali VS, Lukacs P, Cervenka R, Koenig X, Rubi L, Hilber K, Sandtner W, Todt H.

Mol Pharmacol. 2015 Nov;88(5):866-79. doi: 10.1124/mol.115.099580. Epub 2015 Sep 10.


Proper Voltage-Dependent Ion Channel Function in Dysferlin-Deficient Cardiomyocytes.

Rubi L, Gawali VS, Kubista H, Todt H, Hilber K, Koenig X.

Cell Physiol Biochem. 2015;36(3):1049-58. doi: 10.1159/000430278. Epub 2015 Jun 18.


The anticonvulsant retigabine is a subtype selective modulator of GABAA receptors.

Treven M, Koenig X, Assadpour E, Gantumur E, Meyer C, Hilber K, Boehm S, Kubista H.

Epilepsia. 2015 Apr;56(4):647-57. doi: 10.1111/epi.12950. Epub 2015 Mar 16.


The anti-addiction drug ibogaine and the heart: a delicate relation.

Koenig X, Hilber K.

Molecules. 2015 Jan 29;20(2):2208-28. doi: 10.3390/molecules20022208. Review.


VUT-MK142 : a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes.

Koley M, Mike AK, Heher P, Koenig X, Schön M, Schnürch M, Hilber K, Weitzer G, Mihovilovic MD.

Medchemcomm. 2013 Aug 1;4(8):1189-1195. doi: 10.1039/C3MD00101F.


Exploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics.

Lukacs P, Gawali VS, Cervenka R, Ke S, Koenig X, Rubi L, Zarrabi T, Hilber K, Stary-Weinzinger A, Todt H.

J Biol Chem. 2014 Aug 1;289(31):21770-81. doi: 10.1074/jbc.M113.541763. Epub 2014 Jun 19.


Small molecule cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells.

Mike AK, Koenig X, Koley M, Heher P, Wahl G, Rubi L, Schnürch M, Mihovilovic MD, Weitzer G, Hilber K.

Cell Physiol Biochem. 2014;33(1):205-21. doi: 10.1159/000356663. Epub 2014 Jan 24.


Enhanced currents through L-type calcium channels in cardiomyocytes disturb the electrophysiology of the dystrophic heart.

Koenig X, Rubi L, Obermair GJ, Cervenka R, Dang XB, Lukacs P, Kummer S, Bittner RE, Kubista H, Todt H, Hilber K.

Am J Physiol Heart Circ Physiol. 2014 Feb 15;306(4):H564-H573. doi: 10.1152/ajpheart.00441.2013. Epub 2013 Dec 13.


Mechanism of hERG channel block by the psychoactive indole alkaloid ibogaine.

Thurner P, Stary-Weinzinger A, Gafar H, Gawali VS, Kudlacek O, Zezula J, Hilber K, Boehm S, Sandtner W, Koenig X.

J Pharmacol Exp Ther. 2014 Feb;348(2):346-58. doi: 10.1124/jpet.113.209643. Epub 2013 Dec 4.


Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: a study to assess the drug's cardiac ion channel profile.

Koenig X, Kovar M, Rubi L, Mike AK, Lukacs P, Gawali VS, Todt H, Hilber K, Sandtner W.

Toxicol Appl Pharmacol. 2013 Dec 1;273(2):259-68. doi: 10.1016/j.taap.2013.05.012. Epub 2013 May 22.


Anti-addiction drug ibogaine inhibits hERG channels: a cardiac arrhythmia risk.

Koenig X, Kovar M, Boehm S, Sandtner W, Hilber K.

Addict Biol. 2014 Mar;19(2):237-239. doi: 10.1111/j.1369-1600.2012.00447.x. Epub 2012 Mar 28.


Voltage-gated ion channel dysfunction precedes cardiomyopathy development in the dystrophic heart.

Koenig X, Dysek S, Kimbacher S, Mike AK, Cervenka R, Lukacs P, Nagl K, Dang XB, Todt H, Bittner RE, Hilber K.

PLoS One. 2011;6(5):e20300. doi: 10.1371/journal.pone.0020300. Epub 2011 May 23.


Synthesis of 5-arylated N-arylthiazole-2-amines as potential skeletal muscle cell differentiation promoters.

Schnürch M, Waldner B, Hilber K, Mihovilovic MD.

Bioorg Med Chem Lett. 2011 Apr 1;21(7):2149-54. doi: 10.1016/j.bmcl.2011.01.123. Epub 2011 Feb 2.


A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel.

Zarrabi T, Cervenka R, Sandtner W, Lukacs P, Koenig X, Hilber K, Mille M, Lipkind GM, Fozzard HA, Todt H.

J Biol Chem. 2010 Dec 10;285(50):39458-70. doi: 10.1074/jbc.M110.132886. Epub 2010 Oct 6.


Sodium current properties of primary skeletal myocytes and cardiomyocytes derived from different mouse strains.

Mille M, Koenig X, Zebedin E, Uhrin P, Cervenka R, Todt H, Hilber K.

Pflugers Arch. 2009 Mar;457(5):1023-33. doi: 10.1007/s00424-008-0570-x. Epub 2008 Aug 13.


Skeletal myocyte plasticity: basis for improved therapeutic potential?

Hilber K.

Curr Opin Pharmacol. 2008 Jun;8(3):327-32. doi: 10.1016/j.coph.2008.01.007. Epub 2008 Mar 7. Review.


Effects of duramycin on cardiac voltage-gated ion channels.

Zebedin E, Koenig X, Radenkovic M, Pankevych H, Todt H, Freissmuth M, Hilber K.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Mar;377(1):87-100. doi: 10.1007/s00210-007-0248-5. Epub 2008 Jan 5.


Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door?

Szendroedi J, Sandtner W, Zarrabi T, Zebedin E, Hilber K, Dudley SC Jr, Fozzard HA, Todt H.

Biophys J. 2007 Dec 15;93(12):4209-24. Epub 2007 Aug 24.


C2C12 skeletal muscle cells adopt cardiac-like sodium current properties in a cardiac cell environment.

Zebedin E, Mille M, Speiser M, Zarrabi T, Sandtner W, Latzenhofer B, Todt H, Hilber K.

Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H439-50. Epub 2006 Sep 15.


Selectivity filter residues contribute unequally to pore stabilization in voltage-gated sodium channels.

Hilber K, Sandtner W, Zarrabi T, Zebedin E, Kudlacek O, Fozzard HA, Todt H.

Biochemistry. 2005 Oct 25;44(42):13874-82.


Lidocaine: a foot in the door of the inner vestibule prevents ultra-slow inactivation of a voltage-gated sodium channel.

Sandtner W, Szendroedi J, Zarrabi T, Zebedin E, Hilber K, Glaaser I, Fozzard HA, Dudley SC, Todt H.

Mol Pharmacol. 2004 Sep;66(3):648-57.


Fiber type conversion alters inactivation of voltage-dependent sodium currents in murine C2C12 skeletal muscle cells.

Zebedin E, Sandtner W, Galler S, Szendroedi J, Just H, Todt H, Hilber K.

Am J Physiol Cell Physiol. 2004 Aug;287(2):C270-80. Epub 2004 Mar 24.


Interaction between fast and ultra-slow inactivation in the voltage-gated sodium channel. Does the inactivation gate stabilize the channel structure?

Hilber K, Sandtner W, Kudlacek O, Schreiner B, Glaaser I, Schütz W, Fozzard HA, Dudley SC, Todt H.

J Biol Chem. 2002 Oct 4;277(40):37105-15. Epub 2002 Jul 23.


The selectivity filter of the voltage-gated sodium channel is involved in channel activation.

Hilber K, Sandtner W, Kudlacek O, Glaaser IW, Weisz E, Kyle JW, French RJ, Fozzard HA, Dudley SC, Todt H.

J Biol Chem. 2001 Jul 27;276(30):27831-9. Epub 2001 May 29.


Effect of active shortening on the rate of ATP utilisation by rabbit psoas muscle fibres.

Sun YB, Hilber K, Irving M.

J Physiol. 2001 Mar 15;531(Pt 3):781-91.


Shortening properties of two biochemically defined muscle fibre types of the Norway lobster Nephrops norvegicus L.

Holmes JM, Hilber K, Galler S, Neil DM.

J Muscle Res Cell Motil. 1999 Apr;20(3):265-78.


Kinetic properties of myosin heavy chain isoforms in single fibers from human skeletal muscle.

Hilber K, Galler S, Gohlsch B, Pette D.

FEBS Lett. 1999 Jul 23;455(3):267-70.


Activation of skinned muscle fibres from the Norway lobster Nephrops norvegicus L. by manganese ions.

Holmes JM, Hilber K, Galler S, Neil DM.

J Muscle Res Cell Motil. 1998 Jun;19(5):537-48.


Tension/stiffness ratio of skinned rat skeletal muscle fibre types at various temperatures.

Galler S, Hilber K.

Acta Physiol Scand. 1998 Feb;162(2):119-26.


Stretch activation and isoforms of myosin heavy chain and troponin-T of rat skeletal muscle fibres.

Galler S, Schmitt TL, Hilber K, Pette D.

J Muscle Res Cell Motil. 1997 Oct;18(5):555-61.


Stretch activation and myosin heavy chain isoforms of rat, rabbit and human skeletal muscle fibres.

Galler S, Hilber K, Pette D.

J Muscle Res Cell Motil. 1997 Aug;18(4):441-8.


Effects of nitric oxide on force-generating proteins of skeletal muscle.

Galler S, Hilber K, Göbesberger A.

Pflugers Arch. 1997 Jul;434(3):242-5.


Two functionally distinct myosin heavy chain isoforms in slow skeletal muscle fibres.

Galler S, Hilber K, Gohlsch B, Pette D.

FEBS Lett. 1997 Jun 30;410(2-3):150-2.


Functional differences of myosin heavy-chain isoforms in skeletal muscle.

Hilber K, Galler S, Pette D.

Naturwissenschaften. 1997 May;84(5):201-4. Review. No abstract available.


Force responses following stepwise length changes of rat skeletal muscle fibre types.

Galler S, Hilber K, Pette D.

J Physiol. 1996 May 15;493 ( Pt 1):219-27.


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