Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 55

1.

Alpha-blockers as colorectal cancer chemopreventatives: findings from a case-control study, human cell cultures, and in vivo preclinical testing.

Suzuki N, Niikura R, Ihara S, Hikiba Y, Kinoshita H, Higashishima N, Hayakawa Y, Yamada A, Hirata Y, Nakata R, Okamoto M, Sano M, Kushiyama A, Ichinose M, Woods SL, Worthley D, Iwamoto Y, Koike K.

Cancer Prev Res (Phila). 2019 Jan 30. pii: canprevres.0288.2018. doi: 10.1158/1940-6207.CAPR-18-0288. [Epub ahead of print]

PMID:
30700439
2.

BHLHA15-positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice.

Hayakawa Y, Tsuboi M, Asfaha S, Kinoshita H, Niikura R, Konishi M, Hata M, Oya Y, Kim W, Middelhoff M, Hikiba Y, Higashijima N, Ihara S, Ushiku T, Fukayama M, Tailor Y, Hirata Y, Guha C, Yan KS, Koike K, Wang TC.

Gastroenterology. 2018 Nov 15. pii: S0016-5085(18)35272-7. doi: 10.1053/j.gastro.2018.11.024. [Epub ahead of print]

PMID:
30448068
3.

Three types of metaplasia model through Kras activation, Pten deletion, or Cdh1 deletion in the gastric epithelium.

Kinoshita H, Hayakawa Y, Konishi M, Hata M, Tsuboi M, Hayata Y, Hikiba Y, Ihara S, Nakagawa H, Ikenoue T, Ushiku T, Fukayama M, Hirata Y, Koike K.

J Pathol. 2019 Jan;247(1):35-47. doi: 10.1002/path.5163. Epub 2018 Nov 27.

PMID:
30168144
4.

Adhesive Interactions between Mononuclear Phagocytes and Intestinal Epithelium Perturb Normal Epithelial Differentiation and Serve as a Therapeutic Target in Inflammatory Bowel Disease.

Ihara S, Hirata Y, Hikiba Y, Yamashita A, Tsuboi M, Hata M, Konishi M, Suzuki N, Sakitani K, Kinoshita H, Hayakawa Y, Nakagawa H, Ijichi H, Tateishi K, Koike K.

J Crohns Colitis. 2018 Nov 9;12(10):1219-1231. doi: 10.1093/ecco-jcc/jjy088.

PMID:
29917067
5.

Overexpression of HER2 in the pancreas promotes development of intraductal papillary mucinous neoplasms in mice.

Shibata W, Kinoshita H, Hikiba Y, Sato T, Ishii Y, Sue S, Sugimori M, Suzuki N, Sakitani K, Ijichi H, Mori R, Endo I, Maeda S.

Sci Rep. 2018 Apr 18;8(1):6150. doi: 10.1038/s41598-018-24375-2.

6.

CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity.

Fujiwara N, Nakagawa H, Enooku K, Kudo Y, Hayata Y, Nakatsuka T, Tanaka Y, Tateishi R, Hikiba Y, Misumi K, Tanaka M, Hayashi A, Shibahara J, Fukayama M, Arita J, Hasegawa K, Hirschfield H, Hoshida Y, Hirata Y, Otsuka M, Tateishi K, Koike K.

Gut. 2018 Aug;67(8):1493-1504. doi: 10.1136/gutjnl-2017-315193. Epub 2018 Feb 6.

PMID:
29437870
7.

Mature gastric chief cells are not required for the development of metaplasia.

Kinoshita H, Hayakawa Y, Niu Z, Konishi M, Hata M, Tsuboi M, Hayata Y, Hikiba Y, Ihara S, Nakagawa H, Hirata Y, Wang TC, Koike K.

Am J Physiol Gastrointest Liver Physiol. 2018 May 1;314(5):G583-G596. doi: 10.1152/ajpgi.00351.2017. Epub 2018 Jan 18.

PMID:
29345968
8.

c-Jun N-terminal kinase in pancreatic tumor stroma augments tumor development in mice.

Sato T, Shibata W, Hikiba Y, Kaneta Y, Suzuki N, Ihara S, Ishii Y, Sue S, Kameta E, Sugimori M, Yamada H, Kaneko H, Sasaki T, Ishii T, Tamura T, Kondo M, Maeda S.

Cancer Sci. 2017 Nov;108(11):2156-2165. doi: 10.1111/cas.13382. Epub 2017 Sep 18.

9.

Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands.

Nakagawa H, Suzuki N, Hirata Y, Hikiba Y, Hayakawa Y, Kinoshita H, Ihara S, Uchino K, Nishikawa Y, Ijichi H, Otsuka M, Arita J, Sakamoto Y, Hasegawa K, Kokudo N, Tateishi K, Koike K.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):E3806-E3815. doi: 10.1073/pnas.1619416114. Epub 2017 Apr 24.

10.

Corrigendum: A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion.

Ikenoue T, Terakado Y, Nakagawa H, Hikiba Y, Fujii T, Matsubara D, Noguchi R, Zhu C, Yamamoto K, Kudo Y, Asaoka Y, Yamaguchi K, Ijichi H, Tateishi K, Fukushima N, Maeda S, Koike K, Furukawa Y.

Sci Rep. 2017 Jan 3;7:39567. doi: 10.1038/srep39567. No abstract available.

11.

A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion.

Ikenoue T, Terakado Y, Nakagawa H, Hikiba Y, Fujii T, Matsubara D, Noguchi R, Zhu C, Yamamoto K, Kudo Y, Asaoka Y, Yamaguchi K, Ijichi H, Tateishi K, Fukushima N, Maeda S, Koike K, Furukawa Y.

Sci Rep. 2016 Apr 1;6:23899. doi: 10.1038/srep23899. Erratum in: Sci Rep. 2017 Jan 03;7:39567.

12.

Gastric Metaplasia Induced by Helicobacter pylori Is Associated with Enhanced SOX9 Expression via Interleukin-1 Signaling.

Serizawa T, Hirata Y, Hayakawa Y, Suzuki N, Sakitani K, Hikiba Y, Ihara S, Kinoshita H, Nakagawa H, Tateishi K, Koike K.

Infect Immun. 2015 Dec 7;84(2):562-72. doi: 10.1128/IAI.01437-15. Print 2016 Feb.

13.

Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress.

Sakitani K, Hirata Y, Hikiba Y, Hayakawa Y, Ihara S, Suzuki H, Suzuki N, Serizawa T, Kinoshita H, Sakamoto K, Nakagawa H, Tateishi K, Maeda S, Ikenoue T, Kawazu S, Koike K.

BMC Cancer. 2015 Oct 24;15:795. doi: 10.1186/s12885-015-1789-5.

14.

Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis.

Nakagawa H, Hikiba Y, Hirata Y, Font-Burgada J, Sakamoto K, Hayakawa Y, Taniguchi K, Umemura A, Kinoshita H, Sakitani K, Nishikawa Y, Hirano K, Ikenoue T, Ijichi H, Dhar D, Shibata W, Akanuma M, Koike K, Karin M, Maeda S.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1090-5. doi: 10.1073/pnas.1322731111. Epub 2014 Jan 6.

15.

Heat shock factor 1 accelerates hepatocellular carcinoma development by activating nuclear factor-κB/mitogen-activated protein kinase.

Chuma M, Sakamoto N, Nakai A, Hige S, Nakanishi M, Natsuizaka M, Suda G, Sho T, Hatanaka K, Matsuno Y, Yokoo H, Kamiyama T, Taketomi A, Fujii G, Tashiro K, Hikiba Y, Fujimoto M, Asaka M, Maeda S.

Carcinogenesis. 2014 Feb;35(2):272-81. doi: 10.1093/carcin/bgt343. Epub 2013 Oct 15.

PMID:
24130164
16.

Interleukin-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesis.

Kinoshita H, Hirata Y, Nakagawa H, Sakamoto K, Hayakawa Y, Takahashi R, Nakata W, Sakitani K, Serizawa T, Hikiba Y, Akanuma M, Shibata W, Maeda S, Koike K.

PLoS One. 2013 Apr 12;8(4):e60914. doi: 10.1371/journal.pone.0060914. Print 2013.

17.

Therapeutic effect of c-Jun N-terminal kinase inhibition on pancreatic cancer.

Takahashi R, Hirata Y, Sakitani K, Nakata W, Kinoshita H, Hayakawa Y, Nakagawa H, Sakamoto K, Hikiba Y, Ijichi H, Moses HL, Maeda S, Koike K.

Cancer Sci. 2013 Mar;104(3):337-44. doi: 10.1111/cas.12080. Epub 2013 Jan 24.

18.

MicroRNA-140 acts as a liver tumor suppressor by controlling NF-κB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression.

Takata A, Otsuka M, Yoshikawa T, Kishikawa T, Hikiba Y, Obi S, Goto T, Kang YJ, Maeda S, Yoshida H, Omata M, Asahara H, Koike K.

Hepatology. 2013 Jan;57(1):162-70. doi: 10.1002/hep.26011.

19.

Promotion of DNA repair by nuclear IKKβ phosphorylation of ATM in response to genotoxic stimuli.

Sakamoto K, Hikiba Y, Nakagawa H, Hirata Y, Hayakawa Y, Kinoshita H, Nakata W, Sakitani K, Takahashi R, Akanuma M, Kamata H, Maeda S.

Oncogene. 2013 Apr 4;32(14):1854-62. doi: 10.1038/onc.2012.192. Epub 2012 May 21.

PMID:
22614018
20.

Colon cancer-derived factors activate NF-κB in myeloid cells via TLR2 to link inflammation and tumorigenesis.

Maeda S, Hikiba Y, Sakamoto K, Nakagawa H, Hirata Y, Hayakawa Y, Akanuma M.

Mol Med Rep. 2011 Nov-Dec;4(6):1083-8. doi: 10.3892/mmr.2011.545. Epub 2011 Aug 4.

PMID:
21822539
21.

Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase.

Nakagawa H, Hirata Y, Takeda K, Hayakawa Y, Sato T, Kinoshita H, Sakamoto K, Nakata W, Hikiba Y, Omata M, Yoshida H, Koike K, Ichijo H, Maeda S.

Hepatology. 2011 Jul;54(1):185-95. doi: 10.1002/hep.24357.

PMID:
21488081
22.

Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer.

Hayakawa Y, Hirata Y, Nakagawa H, Sakamoto K, Hikiba Y, Kinoshita H, Nakata W, Takahashi R, Tateishi K, Tada M, Akanuma M, Yoshida H, Takeda K, Ichijo H, Omata M, Maeda S, Koike K.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):780-5. doi: 10.1073/pnas.1011418108. Epub 2010 Dec 27.

23.

Inhibitor of kappaB kinase beta regulates gastric carcinogenesis via interleukin-1alpha expression.

Sakamoto K, Hikiba Y, Nakagawa H, Hayakawa Y, Yanai A, Akanuma M, Ogura K, Hirata Y, Kaestner KH, Omata M, Maeda S.

Gastroenterology. 2010 Jul;139(1):226-38.e6. doi: 10.1053/j.gastro.2010.03.047. Epub 2010 Mar 25.

24.

Apoptosis signal-regulating kinase 1 regulates colitis and colitis-associated tumorigenesis by the innate immune responses.

Hayakawa Y, Hirata Y, Nakagawa H, Sakamoto K, Hikiba Y, Otsuka M, Ijichi H, Ikenoue T, Tateishi K, Akanuma M, Ogura K, Yoshida H, Ichijo H, Omata M, Maeda S.

Gastroenterology. 2010 Mar;138(3):1055-67.e1-4. doi: 10.1053/j.gastro.2009.11.015. Epub 2009 Nov 18.

PMID:
19931259
25.

Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression.

Maeda S, Hikiba Y, Sakamoto K, Nakagawa H, Hirata Y, Hayakawa Y, Yanai A, Ogura K, Karin M, Omata M.

Hepatology. 2009 Dec;50(6):1851-60. doi: 10.1002/hep.23199.

PMID:
19821485
26.

Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis.

Hayakawa Y, Maeda S, Nakagawa H, Hikiba Y, Shibata W, Sakamoto K, Yanai A, Hirata Y, Ogura K, Muto S, Itai A, Omata M.

J Gastroenterol. 2009;44(9):935-43. doi: 10.1007/s00535-009-0098-7. Epub 2009 Jun 26.

PMID:
19557302
27.

Constitutive NF-kappaB activation in colorectal carcinoma plays a key role in angiogenesis, promoting tumor growth.

Sakamoto K, Maeda S, Hikiba Y, Nakagawa H, Hayakawa Y, Shibata W, Yanai A, Ogura K, Omata M.

Clin Cancer Res. 2009 Apr 1;15(7):2248-58. doi: 10.1158/1078-0432.CCR-08-1383. Epub 2009 Mar 10.

28.

Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.

Nakagawa H, Maeda S, Hikiba Y, Ohmae T, Shibata W, Yanai A, Sakamoto K, Ogura K, Noguchi T, Karin M, Ichijo H, Omata M.

Gastroenterology. 2008 Oct;135(4):1311-21. doi: 10.1053/j.gastro.2008.07.006. Epub 2008 Jul 9.

PMID:
18700144
29.

c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice.

Shibata W, Maeda S, Hikiba Y, Yanai A, Sakamoto K, Nakagawa H, Ogura K, Karin M, Omata M.

Cancer Res. 2008 Jul 1;68(13):5031-9. doi: 10.1158/0008-5472.CAN-07-6332.

30.

Mortality from gastric cancer in patients followed with upper gastrointestinal endoscopy.

Ogura M, Hikiba Y, Maeda S, Matsumura M, Okano K, Sassa R, Yoshida H, Kawabe T, Omata M.

Scand J Gastroenterol. 2008;43(5):574-80. doi: 10.1080/00365520701813954.

PMID:
18415750
31.

Activation of IkappaB kinase and NF-kappaB is essential for Helicobacter pylori-induced chronic gastritis in Mongolian gerbils.

Yanai A, Maeda S, Shibata W, Hikiba Y, Sakamoto K, Nakagawa H, Ohmae T, Hirata Y, Ogura K, Muto S, Itai A, Omata M.

Infect Immun. 2008 Feb;76(2):781-7. Epub 2007 Dec 10.

32.

Clinical relevance of Helicobacter pylori sabA genotype in Japanese clinical isolates.

Yanai A, Maeda S, Hikiba Y, Shibata W, Ohmae T, Hirata Y, Ogura K, Yoshida H, Omata M.

J Gastroenterol Hepatol. 2007 Dec;22(12):2228-32.

PMID:
18031386
33.

Cutting edge: The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks inflammatory injury in murine colitis.

Shibata W, Maeda S, Hikiba Y, Yanai A, Ohmae T, Sakamoto K, Nakagawa H, Ogura K, Omata M.

J Immunol. 2007 Sep 1;179(5):2681-5.

34.

Essential roles of high-mobility group box 1 in the development of murine colitis and colitis-associated cancer.

Maeda S, Hikiba Y, Shibata W, Ohmae T, Yanai A, Ogura K, Yamada S, Omata M.

Biochem Biophys Res Commun. 2007 Aug 24;360(2):394-400. Epub 2007 Jun 19.

PMID:
17599806
35.

Gastric cancer among peptic ulcer patients: retrospective, long-term follow-up.

Ogura M, Yamaji Y, Hikiba Y, Maeda S, Matsumura M, Okano K, Sassa R, Yoshida H, Kawabe T, Omata M.

Dig Liver Dis. 2006 Nov;38(11):811-4. Epub 2006 Aug 17.

PMID:
16920046
36.

Functional analysis of PIK3CA gene mutations in human colorectal cancer.

Ikenoue T, Kanai F, Hikiba Y, Obata T, Tanaka Y, Imamura J, Ohta M, Jazag A, Guleng B, Tateishi K, Asaoka Y, Matsumura M, Kawabe T, Omata M.

Cancer Res. 2005 Jun 1;65(11):4562-7.

37.

Functional consequences of mutations in a putative Akt phosphorylation motif of B-raf in human cancers.

Ikenoue T, Kanai F, Hikiba Y, Tanaka Y, Imamura J, Ohta M, Jazag A, Guleng B, Asaoka Y, Tateishi K, Kawakami T, Matsumura M, Kawabe T, Omata M.

Mol Carcinog. 2005 May;43(1):59-63.

PMID:
15791648
38.

Different effects of point mutations within the B-Raf glycine-rich loop in colorectal tumors on mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase and nuclear factor kappaB pathway and cellular transformation.

Ikenoue T, Hikiba Y, Kanai F, Aragaki J, Tanaka Y, Imamura J, Imamura T, Ohta M, Ijichi H, Tateishi K, Kawakami T, Matsumura M, Kawabe T, Omata M.

Cancer Res. 2004 May 15;64(10):3428-35.

39.

Rapid detection of mutations in the BRAF gene using real-time polymerase chain reaction and melting curve analysis.

Ikenoue T, Hikiba Y, Kanai F, Ijichi H, Togo G, Ohta M, Watabe H, Yamaji Y, Okamoto M, Aragaki J, Matsumura M, Kawabe T, Omata M.

Cancer Genet Cytogenet. 2004 Feb;149(1):68-71.

PMID:
15104286
40.

Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors.

Ikenoue T, Hikiba Y, Kanai F, Tanaka Y, Imamura J, Imamura T, Ohta M, Ijichi H, Tateishi K, Kawakami T, Aragaki J, Matsumura M, Kawabe T, Omata M.

Cancer Res. 2003 Dec 1;63(23):8132-7.

41.

Simple quantitative assay of alpha-fetoprotein mRNA in liver tissue using the real-time detection polymerase chain reaction assay - its application for clinical use.

Matsumura M, Ijichi M, Shiratori Y, Togo G, Hikiba Y, Inoued K, Kohara M, Omata M.

Hepatol Res. 2001 May 1;20(1):84-96.

PMID:
11282488
42.

Rapid detection of mutations in the 23S rRNA gene of Helicobacter pylori that confers resistance to clarithromycin treatment to the bacterium.

Matsumura M, Hikiba Y, Ogura K, Togo G, Tsukuda I, Ushikawa K, Shiratori Y, Omata M.

J Clin Microbiol. 2001 Feb;39(2):691-5.

43.

Hepatocyte nitric oxide production is induced by Kupffer cells.

Shiratori Y, Ohmura K, Hikiba Y, Matsumura M, Nagura T, Okano K, Kamii K, Omata M.

Dig Dis Sci. 1998 Aug;43(8):1737-45.

PMID:
9724162
44.

Gene therapy for hepatic micrometastasis of murine colon carcinoma.

Shiratori Y, Kanai F, Hikiba Y, Moriyama H, Hamada H, Matsumura M, Tanaka T, Lan KH, Ohashi M, Okano K, Naito M, Omata M.

J Hepatol. 1998 May;28(5):886-95.

PMID:
9625325
45.

Role of macrophages in regeneration of liver.

Shiratori Y, Hongo S, Hikiba Y, Ohmura K, Nagura T, Okano K, Kamii K, Tanaka T, Komatsu Y, Ochiai T, Tsubouchi H, Omata M.

Dig Dis Sci. 1996 Oct;41(10):1939-46.

PMID:
8888704
46.

Role of platelet-activating factor in pathogenesis of galactosamine-lipopolysaccharide-induced liver injury.

Komatsu Y, Shiratori Y, Hikiba Y, Hashimoto N, Han K, Kawase T, Yoshida H, Okano K, Omata M.

Dig Dis Sci. 1996 May;41(5):1030-7.

PMID:
8625746
47.

Cytokine-induced neutrophil chemoattractant release from hepatocytes is modulated by Kupffer cells.

Mawet E, Shiratori Y, Hikiba Y, Takada H, Yoshida H, Okano K, Komatsu Y, Matsumura M, Niwa Y, Omata M.

Hepatology. 1996 Feb;23(2):353-8.

PMID:
8591863
48.

Ethanol decreases the levels of GLUT2 glucose transporter mRNA in hepatocytes.

Nagamatsu S, Yamamoto H, Hikiba Y, Nakamichi Y, Inoue M, Nishino H, Okano K.

Biochem Mol Biol Int. 1995 Nov;37(4):675-80.

PMID:
8589640
49.

Effect of splenectomy on hepatic metastasis of colon carcinoma and natural killer activity in the liver.

Shiratori Y, Kawase T, Nakata R, Tanaka M, Hikiba Y, Okano K, Matsumura M, Niwa Y, Komatsu Y, Shiina S, et al.

Dig Dis Sci. 1995 Nov;40(11):2398-406.

PMID:
7587821
50.

Chemotactic factors released from hepatocytes exposed to acetaminophen.

Takada H, Mawet E, Shiratori Y, Hikiba Y, Nakata R, Yoshida H, Okano K, Kamii K, Omata M.

Dig Dis Sci. 1995 Aug;40(8):1831-6.

PMID:
7648987

Supplemental Content

Loading ...
Support Center