Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2012 2
2014 4
2015 4
2016 3
2017 3
2018 2
2019 1
2020 2
2021 2
2022 3
2023 3
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

26 results

Results by year

Filters applied: . Clear all
Page 1
Did you mean hideshi (43 results)?
Nuclear import carrier Hikeshi cooperates with HSP70 to promote murine oligodendrocyte differentiation and CNS myelination.
Li L, Li D, Sun D, Zhang X, Lei W, Wu M, Huang Q, Nian X, Dai W, Lu X, Zhou Z, Zhu Y, Xiao Y, Zhang L, Mo W, Liu Z, Zhang L. Li L, et al. Dev Cell. 2023 Nov 6;58(21):2275-2291.e6. doi: 10.1016/j.devcel.2023.09.002. Epub 2023 Oct 20. Dev Cell. 2023. PMID: 37865085
Here, we showed that Hikeshi is essential for central nervous system (CNS) myelination. ...Hikeshi is required for nuclear translocation of HSP70s upon differentiation. ...
Here, we showed that Hikeshi is essential for central nervous system (CNS) myelination. ...Hikeshi is required for nuclear tra …
Heat stress-induced nuclear transport mediated by Hikeshi confers nuclear function of Hsp70s.
Imamoto N. Imamoto N. Curr Opin Cell Biol. 2018 Jun;52:82-87. doi: 10.1016/j.ceb.2018.02.010. Epub 2018 Feb 25. Curr Opin Cell Biol. 2018. PMID: 29490261 Free article. Review.
In this report, we focus on a nuclear transport receptor named Hikeshi, which mediates the heat stress-induced nuclear import of 70-kDa heat shock proteins (Hsp70s), and discuss how the same protein can function differently depending on the cellular compartment in which it …
In this report, we focus on a nuclear transport receptor named Hikeshi, which mediates the heat stress-induced nuclear import of 70-k …
Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response.
Kose S, Imai K, Watanabe A, Nakai A, Suzuki Y, Imamoto N. Kose S, et al. Life Sci Alliance. 2022 May 17;5(9):e202101241. doi: 10.26508/lsa.202101241. Print 2022 Sep. Life Sci Alliance. 2022. PMID: 35580988 Free PMC article.
Hikeshi mediates the nuclear import of the molecular chaperone HSP70 under heat-shock (acute heat stress) conditions, which is crucial for recovery from cellular damage. ...Furthermore, the cytotoxicity of nuclear pathologic polyglutamine proteins was increased by Hikes …
Hikeshi mediates the nuclear import of the molecular chaperone HSP70 under heat-shock (acute heat stress) conditions, which is crucia …
HIKESHI silencing can enhance mild hyperthermia sensitivity in human oral squamous cell carcinoma HSC-3 cells.
Tabuchi Y, Maekawa K, Torigoe M, Furusawa Y, Hirano T, Minagawa S, Yunoki T, Hayashi A. Tabuchi Y, et al. Int J Mol Med. 2020 Jul;46(1):58-66. doi: 10.3892/ijmm.2020.4591. Epub 2020 Apr 28. Int J Mol Med. 2020. PMID: 32377716 Free PMC article.
Recent findings have indicated that heat shock protein nuclear import factor hikeshi (HIKESHI), also referred to as C11orf73, acts as a nuclear import carrier of Hsp70 under heat stress conditions. ...The mRNA and protein expression of HIKESHI was found to be …
Recent findings have indicated that heat shock protein nuclear import factor hikeshi (HIKESHI), also referred to as C11orf73, …
Role of HIKESHI on Hyperthermia for Castration-Resistant Prostate Cancer and Application of a Novel Magnetic Nanoparticle with Carbon Nanohorn for Magnetic Hyperthermia.
Nagai T, Kawai N, Gonda M, Iida K, Etani T, Kobayashi D, Naiki T, Naiki-Ito A, Ando R, Yamaguchi S, Sugahara Y, Ueno S, Tsutsumiuchi K, Imae T, Yasui T. Nagai T, et al. Pharmaceutics. 2023 Feb 13;15(2):626. doi: 10.3390/pharmaceutics15020626. Pharmaceutics. 2023. PMID: 36839948 Free PMC article.
In this study, the analysis focused on the association between CRPC and heat shock protein nuclear import factor "hikeshi (HIKESHI)", a factor of heat tolerance. Silencing the HIKESHI expression of 22Rv1 cells (human CRPC cell line) treated with siRNAs inhibi …
In this study, the analysis focused on the association between CRPC and heat shock protein nuclear import factor "hikeshi (HIKESHI …
Hikeshi modulates the proteotoxic stress response in human cells: Implication for the importance of the nuclear function of HSP70s.
Rahman KMZ, Mamada H, Takagi M, Kose S, Imamoto N. Rahman KMZ, et al. Genes Cells. 2017 Nov;22(11):968-976. doi: 10.1111/gtc.12536. Epub 2017 Oct 5. Genes Cells. 2017. PMID: 28980748 Free article.
Hikeshi mediates the heat stress-induced nuclear import of heat-shock protein 70 (HSP70s: HSP70/HSC70). Dysfunction of Hikeshi causes some serious effects in humans; however, the cellular function of Hikeshi is largely unknown. ...
Hikeshi mediates the heat stress-induced nuclear import of heat-shock protein 70 (HSP70s: HSP70/HSC70). Dysfunction of Hikeshi …
Diosgenin revealed potential effect against cerebral ischemia reperfusion through HIKESHI/HSP70/NF-kappaB anti-inflammatory axis.
Zhang X, Xue Z, Zhu S, Guo Y, Zhang Y, Dou J, Zhang J, Ito Y, Guo Z. Zhang X, et al. Phytomedicine. 2022 May;99:153991. doi: 10.1016/j.phymed.2022.153991. Epub 2022 Feb 15. Phytomedicine. 2022. PMID: 35217435
Mechanistically, DIO stimulated the binding of HIKESHI to HSP70 and facilitated the translocation of HSP70 into nucleus. ...NF-kappaB activation also relieved the inhibitory inflammation and reversed DIO's effect against I/R, suggesting that NF-kappaB was the downstream ta …
Mechanistically, DIO stimulated the binding of HIKESHI to HSP70 and facilitated the translocation of HSP70 into nucleus. ...NF-kappaB …
Hikeshi, a nuclear import carrier for Hsp70s, protects cells from heat shock-induced nuclear damage.
Kose S, Furuta M, Imamoto N. Kose S, et al. Cell. 2012 Apr 27;149(3):578-89. doi: 10.1016/j.cell.2012.02.058. Cell. 2012. PMID: 22541429 Free article.
Here, we identify a nuclear import pathway that operates during heat shock stress and is mediated by an evolutionarily conserved protein named "Hikeshi," which does not belong to the importin beta family. Hikeshi binds to FG-Nups and translocates through nuclear por …
Here, we identify a nuclear import pathway that operates during heat shock stress and is mediated by an evolutionarily conserved protein nam …
Further Delineation of the Clinical and Pathologic Features of HIKESHI-Related Hypomyelinating Leukodystrophy.
Helman G, Zerem A, Almad A, Hacker JL, Woidill S, Sase S, LeFevre AN, Ekstein J, Johansson MM, Stutterd CA, Taft RJ, Simons C, Grinspan JB, Pizzino A, Schmidt JL, Harding B, Hirsch Y, Viaene AN, Fattal-Valevski A, Vanderver A. Helman G, et al. Pediatr Neurol. 2021 Aug;121:11-19. doi: 10.1016/j.pediatrneurol.2021.04.014. Epub 2021 May 14. Pediatr Neurol. 2021. PMID: 34111619 Free PMC article.
BACKGROUND: A recurrent homozygous missense variant, c.160G>C;p.(Val54Leu) in HIKESHI, was found to cause a hypomyelinating leukodystrophy with high frequency in the Ashkenazi Jewish population. ...Brain autopsy was performed for one case. RESULTS: Individuals with H …
BACKGROUND: A recurrent homozygous missense variant, c.160G>C;p.(Val54Leu) in HIKESHI, was found to cause a hypomyelinating leukod …
26 results