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The combination of oral-recombinant methioninase and azacitidine arrests a chemotherapy-resistant osteosarcoma patient-derived orthotopic xenograft mouse model.

Higuchi T, Sugisawa N, Yamamoto J, Oshiro H, Han Q, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Tan Y, Kuchipudi S, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM.

Cancer Chemother Pharmacol. 2019 Nov 8. doi: 10.1007/s00280-019-03986-0. [Epub ahead of print]


Anti-tumor Effects of Cyclolinopeptide on Giant-cell Tumor of the Bone.

Taniguchi Y, Yamamoto N, Hayashi K, Takeuchi A, Miwa S, Igarashi K, Higuchi T, Abe K, Yonezawa H, Araki Y, Morinaga S, Kamei J, Nugroho AE, Kaneda T, Morita H, Tsuchiya H.

Anticancer Res. 2019 Nov;39(11):6145-6153. doi: 10.21873/anticanres.13822.


Prevalence of Carnitine Deficiency and Decreased Carnitine Levels in Patients on Peritoneal Dialysis.

Shimizu S, Takashima H, Tei R, Furukawa T, Okamura M, Kitai M, Nagura C, Maruyama T, Higuchi T, Abe M.

Nutrients. 2019 Nov 4;11(11). pii: E2645. doi: 10.3390/nu11112645.


Changes in muscle strength of the hip after rotational acetabular osteotomy: a retrospective study.

Enishi T, Yagi H, Higuchi T, Takeuchi M, Sato R, Yoshioka S, Nakamura M, Nakano S.

Bone Joint J. 2019 Nov;101-B(11):1459-1463. doi: 10.1302/0301-620X.101B11.BJJ-2019-0204.R1.


Immuno-PET imaging for non-invasive assessment of cetuximab accumulation in non-small cell lung cancer.

Yamaguchi A, Achmad A, Hanaoka H, Heryanto YD, Bhattarai A, Ratianto, Khongorzul E, Shintawati R, Kartamihardja AAP, Kanai A, Sugo Y, S Ishioka N, Higuchi T, Tsushima Y.

BMC Cancer. 2019 Oct 24;19(1):1000. doi: 10.1186/s12885-019-6238-4.


Laparoscopic technique for step-by-step nerve-sparing Okabayashi radical hysterectomy.

Sekiyama K, Ando Y, Taga A, Kozono Y, Higuchi T, Fujii S.

Int J Gynecol Cancer. 2019 Oct 23. pii: ijgc-2019-000726. doi: 10.1136/ijgc-2019-000726. [Epub ahead of print] No abstract available.


Patient-derived orthotopic xenograft models of sarcoma.

Igarashi K, Kawaguchi K, Murakami T, Miyake K, Kiyuna T, Miyake M, Hiroshima Y, Higuchi T, Oshiro H, Nelson SD, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Singh SR, Tsuchiya H, Hoffman RM.

Cancer Lett. 2019 Oct 19. pii: S0304-3835(19)30525-7. doi: 10.1016/j.canlet.2019.10.028. [Epub ahead of print]


Specific effects of antitumor active norspermidine on the structure and function of DNA.

Nishio T, Yoshikawa Y, Shew CY, Umezawa N, Higuchi T, Yoshikawa K.

Sci Rep. 2019 Oct 18;9(1):14971. doi: 10.1038/s41598-019-50943-1.


FDG-PET reflects tumor viability on SUV in colorectal cancer liver metastasis.

Watanabe A, Harimoto N, Yokobori T, Araki K, Kubo N, Igarashi T, Tsukagoshi M, Ishii N, Yamanaka T, Handa T, Oyama T, Higuchi T, Shirabe K.

Int J Clin Oncol. 2019 Oct 14. doi: 10.1007/s10147-019-01557-0. [Epub ahead of print]


Total serum protein reference value as a clinical diagnostic index of equine proliferative enteropathy.

Ueno Y, Uemura R, Niwa H, Higuchi T, Sekiguchi S, Sasaki Y, Sueyoshi M.

J Equine Sci. 2019 Sep;30(3):63-67. doi: 10.1294/jes.30.63. Epub 2019 Oct 2.


Value and limitation of conization as a diagnostic procedure for cervical neoplasm.

Yamamoto R, Sekiyama K, Higuchi T, Ikeda M, Mikami M, Kobayashi Y, Nagase S, Yokoyama M, Enomoto T, Katabuchi H.

J Obstet Gynaecol Res. 2019 Oct 1. doi: 10.1111/jog.14118. [Epub ahead of print]


Atopic Dermatitis-like Eruption Induced by Two Different Biologics in a Patient with Psoriatic Arthritis.

Abe F, Mitsuyama S, Nagao E, Kimura M, Higuchi T.

Acta Derm Venereol. 2019 Sep 25. doi: 10.2340/00015555-3321. [Epub ahead of print] No abstract available.


A Single-centre, Retrospective, Observational Analysis of Fulvestrant for Recurrent/metastatic Breast Cancer According to Metastatic Site.

Ozawa H, Sata A, Fukui R, Bun A, Higuchi T, Fujimoto Y, Miyagawa Y, Imamura M, Miyoshi Y.

Anticancer Res. 2019 Oct;39(10):5653-5662. doi: 10.21873/anticanres.13762.


Induction of Metastasis by Low-dose Gemcitabine in a Pancreatic Cancer Orthotopic Mouse Model: An Opposite Effect of Chemotherapy.

Sugisawa N, Miyake K, Higuchi T, Oshiro H, Zhang Z, Park JH, Kawaguchi K, Chawla SP, Bouvet M, Singh SR, Unno M, Hoffman RM.

Anticancer Res. 2019 Oct;39(10):5339-5344. doi: 10.21873/anticanres.13726.


Left Ventricular Diastolic Function During the Normal Peripartum Period.

Kimura Y, Kato T, Miyata H, Sasaki I, Minamino-Muta E, Nagasawa Y, Numao S, Nagano T, Higuchi T, Inoko M.

Circ J. 2019 Oct 25;83(11):2265-2270. doi: 10.1253/circj.CJ-19-0501. Epub 2019 Sep 22.


Pioglitazone, an agonist of PPARγ, reverses doxorubicin-resistance in an osteosarcoma patient-derived orthotopic xenograft model by downregulating P-glycoprotein expression.

Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Kline Z, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM.

Biomed Pharmacother. 2019 Oct;118:109356. doi: 10.1016/j.biopha.2019.109356. Epub 2019 Aug 22.


Combination Treatment With Sorafenib and Everolimus Regresses a Doxorubicin-resistant Osteosarcoma in a PDOX Mouse Model.

Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Kline Z, Belt P, Chawla SP, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM.

Anticancer Res. 2019 Sep;39(9):4781-4786. doi: 10.21873/anticanres.13662.


Oral Recombinant Methioninase Overcomes Colorectal-cancer Liver Metastasis Resistance to the Combination of 5-Fluorouracil and Oxaliplatinum in a Patient-derived Orthotopic Xenograft Mouse Model.

Oshiro H, Tome Y, Kiyuna T, Yoon SN, Lwin TM, Han Q, Tan Y, Miyake K, Higuchi T, Sugisawa N, Katsuya Y, Park JH, Zang Z, Razmjooei S, Bouvet M, Clary B, Singh SR, Kanaya F, Nishida K, Hoffman RM.

Anticancer Res. 2019 Sep;39(9):4667-4671. doi: 10.21873/anticanres.13648.


Oral Recombinant Methioninase, Combined With Oral Caffeine and Injected Cisplatinum, Overcome Cisplatinum-Resistance and Regresses Patient-derived Orthotopic Xenograft Model of Osteosarcoma.

Higuchi T, Oshiro H, Miyake K, Sugisawa N, Han Q, Tan Y, Park J, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Chawla SP, Singh SR, Tsuchiya H, Hoffman RM.

Anticancer Res. 2019 Sep;39(9):4653-4657. doi: 10.21873/anticanres.13646.


Generation of 1.5 cycle pulses at 780 nm at oscillator repetition rates with stable carrier-envelope phase.

Dienstbier P, Tani F, Higuchi T, Travers J, Russell PSJ, Hommelhoff P.

Opt Express. 2019 Aug 19;27(17):24105-24113. doi: 10.1364/OE.27.024105.


Comparison of radiological features of high tibial osteotomy and tibial condylar valgus osteotomy.

Higuchi T, Koseki H, Yonekura A, Chiba K, Nakazoe Y, Sunagawa S, Noguchi C, Osaki M.

BMC Musculoskelet Disord. 2019 Sep 4;20(1):409. doi: 10.1186/s12891-019-2764-0.


CXCR4-Directed Imaging in Solid Tumors.

Werner RA, Kircher S, Higuchi T, Kircher M, Schirbel A, Wester HJ, Buck AK, Pomper MG, Rowe SP, Lapa C.

Front Oncol. 2019 Aug 14;9:770. doi: 10.3389/fonc.2019.00770. eCollection 2019.


Efficacy and safety of blonanserin transdermal patch in patients with schizophrenia: A 6-week randomized, double-blind, placebo-controlled, multicenter study.

Iwata N, Ishigooka J, Kim WH, Yoon BH, Lin SK, Sulaiman AH, Cosca R, Wang L, Suchkov Y, Agarkov A, Watabe K, Matsui T, Sato T, Inoue Y, Higuchi T, Correll CU, Kane JM.

Schizophr Res. 2019 Aug 27. pii: S0920-9964(19)30335-4. doi: 10.1016/j.schres.2019.07.055. [Epub ahead of print]


Influence of phosphorus and trace metals in biofilters treating gaseous VOCs using a novel irrigation system.

Mansoori AM, Ando N, Higuchi T.

J Air Waste Manag Assoc. 2019 Nov;69(11):1348-1360. doi: 10.1080/10962247.2019.1658659. Epub 2019 Oct 15.


Dual Therapy with Vonoprazan and Amoxicillin Is as Effective as Triple Therapy with Vonoprazan, Amoxicillin and Clarithromycin for Eradication of Helicobacter pylori.

Furuta T, Yamade M, Kagami T, Uotani T, Suzuki T, Higuchi T, Tani S, Hamaya Y, Iwaizumi M, Miyajima H, Umemura K, Osawa S, Sugimoto K.

Digestion. 2019 Aug 21:1-9. doi: 10.1159/000502287. [Epub ahead of print]


Efficacy of oral recombinant methioninase combined with oxaliplatinum and 5-fluorouracil on primary colon cancer in a patient-derived orthotopic xenograft mouse model.

Park JH, Zhao M, Han Q, Sun Y, Higuchi T, Sugisawa N, Yamamoto J, Singh SR, Clary B, Bouvet M, Hoffman RM.

Biochem Biophys Res Commun. 2019 Oct 15;518(2):306-310. doi: 10.1016/j.bbrc.2019.08.051. Epub 2019 Aug 14.


Sorafenib and Palbociclib Combination Regresses a Cisplatinum-resistant Osteosarcoma in a PDOX Mouse Model.

Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Chawla SP, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM.

Anticancer Res. 2019 Aug;39(8):4079-4084. doi: 10.21873/anticanres.13565.


Impact of aging on semiquantitative uptake parameters in normal rated clinical baseline [123I]Ioflupane single photon emission computed tomography/computed tomography.

Werner RA, Lapa C, Sheikhbahaei S, Marcus C, Solnes LB, Du Y, Leal JP, Buck AK, Higuchi T, Rowe SP, Javadi MS.

Nucl Med Commun. 2019 Oct;40(10):1001-1004. doi: 10.1097/MNM.0000000000001061.


Possible association of arrestin domain-containing protein 3 and progression of non-alcoholic fatty liver disease.

Ogawa M, Kanda T, Higuchi T, Takahashi H, Kaneko T, Matsumoto N, Nirei K, Yamagami H, Matsuoka S, Kuroda K, Moriyama M.

Int J Med Sci. 2019 Jun 2;16(7):909-921. doi: 10.7150/ijms.34245. eCollection 2019.


Initial Evaluation of AF78: a Rationally Designed Fluorine-18-Labelled PET Radiotracer Targeting Norepinephrine Transporter.

Chen X, Fritz A, Werner RA, Nose N, Yagi Y, Kimura H, Rowe SP, Koshino K, Decker M, Higuchi T.

Mol Imaging Biol. 2019 Jul 22. doi: 10.1007/s11307-019-01407-5. [Epub ahead of print]


Stability of Distribution of F18 Flurpiridaz After Transient Coronary Occlusion in Pigs.

Werner RA, Koshino K, Arimitsu K, Lapa C, Javadi MS, Rowe SP, Nose N, Kimura H, Fukushima K, Higuchi T.

JACC Cardiovasc Imaging. 2019 Nov;12(11 Pt 1):2269-2271. doi: 10.1016/j.jcmg.2019.05.018. Epub 2019 Jul 17. No abstract available.


Neurite orientation dispersion and density imaging for evaluating the severity of neonatal hypoxic-ischemic encephalopathy in rats.

Ohki A, Saito S, Hata J, Okano HJ, Higuchi T, Fukuchi K.

Magn Reson Imaging. 2019 Oct;62:214-219. doi: 10.1016/j.mri.2019.07.013. Epub 2019 Jul 17.


Fluorodeoxyglucose uptake is associated with low tumor-infiltrating lymphocyte levels in patients with small cell lung cancer.

Kasahara N, Kaira K, Yamaguchi K, Masubuchi H, Tsurumaki H, Hara K, Koga Y, Sakurai R, Higuchi T, Handa T, Oyama T, Yokobori T, Shimizu K, Asao T, Hisada T.

Lung Cancer. 2019 Aug;134:180-186. doi: 10.1016/j.lungcan.2019.06.009. Epub 2019 Jun 11.


C-arm cone-beam computed tomography-guided minimally invasive open excision of an osteoid osteoma undetectable on fluoroscopy: A case report.

Higuchi T, Yamamoto N, Hayashi K, Takeuchi A, Abe K, Taniguchi Y, Araki Y, Tsuchiya H.

Int J Surg Case Rep. 2019;61:14-19. doi: 10.1016/j.ijscr.2019.06.062. Epub 2019 Jul 8.


The Combination of Olaratumab with Doxorubicin and Cisplatinum Regresses a Chemotherapy-Resistant Osteosarcoma in a Patient-Derived Orthotopic Xenograft Mouse Model.

Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM.

Transl Oncol. 2019 Sep;12(9):1257-1263. doi: 10.1016/j.tranon.2019.06.002. Epub 2019 Jul 9.


Idiopathic Multicentric Castleman Disease with Autoimmune Hemolytic Anemia and Production of Anti-drug Antibody Against Tocilizumab: A Case Report.

Tabata S, Higuchi T, Tatsukawa S, Narimatsu K, Takeo H, Matsukuma S, Ito T.

Intern Med. 2019 Jul 10. doi: 10.2169/internalmedicine.2989-19. [Epub ahead of print]


Correction to "Display Selection of Exotic Macrocyclic Peptides Expressed Under a Radically Reprogrammed 23 Amino Acid Genetic Code".

Passioura T, Liu W, Dunkelmann D, Higuchi T, Suga H.

J Am Chem Soc. 2019 Jul 24;141(29):11727-11728. doi: 10.1021/jacs.9b06806. Epub 2019 Jul 9. No abstract available.


FF-10832 enables long survival via effective gemcitabine accumulation in a lethal murine peritoneal dissemination model.

Higuchi T, Yokobori T, Takahashi R, Naito T, Kitahara H, Matsumoto T, Kakinuma C, Hagiwara S, Kuwano H, Shirabe K, Asao T.

Cancer Sci. 2019 Sep;110(9):2933-2940. doi: 10.1111/cas.14123. Epub 2019 Aug 1.


Superior outcomes (but at higher costs) of non-operative management with interval appendectomy over immediate surgery in appendicitis with abscess: Results from a large adult population cohort.

Watanabe R, Otsuji A, Nakamura Y, Higuchi T, Takahashi A, Saito T, Enomoto T, Quero G, Diana M, Dallemagne B, Marescaux J, Saida Y, Kusachi S.

Asian J Endosc Surg. 2019 Jul 2. doi: 10.1111/ases.12726. [Epub ahead of print]


Peritoneal Metastases in a Patient-derived Orthotopic Xenograft (PDOX) Model of Colon Cancer Imaged Non-invasively via Red Fluorescent Protein Labeled Stromal Cells.

Park JH, Zhao M, Oshiro H, Miyake K, Higuchi T, Reynoso J, Razmjooei S, Bouvet M, Clary B, Zhang Z, Sugisawa N, Yamamoto J, Singh SR, Hoffman RM.

Anticancer Res. 2019 Jul;39(7):3463-3467. doi: 10.21873/anticanres.13492.


Novel 18F-Labeled α-Methyl-Phenylalanine Derivative with High Tumor Accumulation and Ideal Pharmacokinetics for Tumor-Specific Imaging.

Hanaoka H, Ohshima Y, Yamaguchi A, Suzuki H, Ishioka NS, Higuchi T, Arano Y, Tsushima Y.

Mol Pharm. 2019 Aug 5;16(8):3609-3616. doi: 10.1021/acs.molpharmaceut.9b00446. Epub 2019 Jul 10.


Moxifloxacin resistance and genotyping of Mycobacterium avium and Mycobacterium intracellulare isolates in Japan.

Yamaba Y, Ito Y, Suzuki K, Kikuchi T, Ogawa K, Fujiuchi S, Hasegawa N, Kurashima A, Higuchi T, Uchiya KI, Watanabe A, Niimi A.

J Infect Chemother. 2019 Dec;25(12):995-1000. doi: 10.1016/j.jiac.2019.05.028. Epub 2019 Jun 22.


Methylene chain ruler for evaluating the regioselectivity of a substrate-recognising oxidation catalyst.

Teramae S, Kito A, Shingaki T, Hamaguchi Y, Yano Y, Nakayama T, Kobayashi Y, Kato N, Umezawa N, Hisamatsu Y, Nagano T, Higuchi T.

Chem Commun (Camb). 2019 Jul 25;55(58):8378-8381. doi: 10.1039/c9cc03041g. Epub 2019 Jun 24.


Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction.

Hara A, Kobayashi H, Asai N, Saito S, Higuchi T, Kato K, Okumura T, Bando YK, Takefuji M, Mizutani Y, Miyai Y, Saito S, Maruyama S, Maeda K, Ouchi N, Nagasaka A, Miyata T, Mii S, Kioka N, Worthley DL, Murohara T, Takahashi M, Enomoto A.

Circ Res. 2019 Aug 2;125(4):414-430. doi: 10.1161/CIRCRESAHA.119.314806. Epub 2019 Jun 21.


Abnormal menstruation after radical trachelectomy and its effects on fertility.

Matsuoka M, Taga A, Hata S, Yamamoto R, Ando Y, Kozono Y, Tsuji N, Sekiyama K, Higuchi T, Nagano T.

J Obstet Gynaecol Res. 2019 Sep;45(9):1906-1912. doi: 10.1111/jog.14032. Epub 2019 Jun 19.


Herpes zoster and meningitis in an immunocompetent child: a case report.

Yasuda R, Minami K, Ogawa A, Okada H, Terakawa R, Koike Y, Ogura S, Takeuchi K, Higuchi T.

J Med Case Rep. 2019 Jun 15;13(1):182. doi: 10.1186/s13256-019-2082-z.


The combination of gemcitabine and docetaxel arrests a doxorubicin-resistant dedifferentiated liposarcoma in a patient-derived orthotopic xenograft model.

Miyake K, Higuchi T, Oshiro H, Zhang Z, Sugisawa N, Park JH, Razmjooei S, Katsuya Y, Barangi M, Li Y, Nelson SD, Murakami T, Homma Y, Hiroshima Y, Matsuyama R, Bouvet M, Chawla SP, Singh SR, Endo I, Hoffman RM.

Biomed Pharmacother. 2019 Sep;117:109093. doi: 10.1016/j.biopha.2019.109093. Epub 2019 Jun 11.


Triple nitrogen-vacancy centre fabrication by C5N4Hn ion implantation.

Haruyama M, Onoda S, Higuchi T, Kada W, Chiba A, Hirano Y, Teraji T, Igarashi R, Kawai S, Kawarada H, Ishii Y, Fukuda R, Tanii T, Isoya J, Ohshima T, Hanaizumi O.

Nat Commun. 2019 Jun 13;10(1):2664. doi: 10.1038/s41467-019-10529-x.


Clinical and Biological Significance of PD-L1 Expression Within the Tumor Microenvironment of Oral Squamous Cell Carcinoma.

Takahashi H, Sakakura K, Arisaka Y, Tokue A, Kaira K, Tada H, Higuchi T, Okamoto A, Tsushima Y, Chikamatsu K.

Anticancer Res. 2019 Jun;39(6):3039-3046. doi: 10.21873/anticanres.13437.


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