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Items: 26


Solid-state MAS NMR resonance assignment methods for proteins.

Higman VA.

Prog Nucl Magn Reson Spectrosc. 2018 Jun - Aug;106-107:37-65. doi: 10.1016/j.pnmrs.2018.04.002. Epub 2018 Apr 25. Review.


The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere.

Fisher GL, Pastrana CL, Higman VA, Koh A, Taylor JA, Butterer A, Craggs T, Sobott F, Murray H, Crump MP, Moreno-Herrero F, Dillingham MS.

Elife. 2017 Dec 15;6. pii: e28086. doi: 10.7554/eLife.28086.


Structure of outer membrane protein G in lipid bilayers.

Retel JS, Nieuwkoop AJ, Hiller M, Higman VA, Barbet-Massin E, Stanek J, Andreas LB, Franks WT, van Rossum BJ, Vinothkumar KR, Handel L, de Palma GG, Bardiaux B, Pintacuda G, Emsley L, Kühlbrandt W, Oschkinat H.

Nat Commun. 2017 Dec 12;8(1):2073. doi: 10.1038/s41467-017-02228-2.


¹³C- and ¹H-detection under fast MAS for the study of poorly available proteins: application to sub-milligram quantities of a 7 trans-membrane protein.

Dannatt HR, Taylor GF, Varga K, Higman VA, Pfeil MP, Asilmovska L, Judge PJ, Watts A.

J Biomol NMR. 2015 May;62(1):17-23. doi: 10.1007/s10858-015-9911-1. Epub 2015 Feb 21.


The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation.

Butt A, Higman VA, Williams C, Crump MP, Hemsley CM, Harmer N, Titball RW.

Biochem J. 2014 Apr 15;459(2):333-44. doi: 10.1042/BJ20140073.


A refined model for the TSG-6 link module in complex with hyaluronan: use of defined oligosaccharides to probe structure and function.

Higman VA, Briggs DC, Mahoney DJ, Blundell CD, Sattelle BM, Dyer DP, Green DE, DeAngelis PL, Almond A, Milner CM, Day AJ.

J Biol Chem. 2014 Feb 28;289(9):5619-34. doi: 10.1074/jbc.M113.542357. Epub 2014 Jan 8.


Structural and biochemical characterization of Rv2140c, a phosphatidylethanolamine-binding protein from Mycobacterium tuberculosis.

Eulenburg G, Higman VA, Diehl A, Wilmanns M, Holton SJ.

FEBS Lett. 2013 Sep 17;587(18):2936-42. doi: 10.1016/j.febslet.2013.07.038. Epub 2013 Jul 29.


Three-dimensional deuterium-carbon correlation experiments for high-resolution solid-state MAS NMR spectroscopy of large proteins.

Lalli D, Schanda P, Chowdhury A, Retel J, Hiller M, Higman VA, Handel L, Agarwal V, Reif B, van Rossum B, Akbey U, Oschkinat H.

J Biomol NMR. 2011 Dec;51(4):477-85. doi: 10.1007/s10858-011-9578-1. Epub 2011 Oct 25.


A software framework for analysing solid-state MAS NMR data.

Stevens TJ, Fogh RH, Boucher W, Higman VA, Eisenmenger F, Bardiaux B, van Rossum BJ, Oschkinat H, Laue ED.

J Biomol NMR. 2011 Dec;51(4):437-47. doi: 10.1007/s10858-011-9569-2. Epub 2011 Sep 28.


The conformation of bacteriorhodopsin loops in purple membranes resolved by solid-state MAS NMR spectroscopy.

Higman VA, Varga K, Aslimovska L, Judge PJ, Sperling LJ, Rienstra CM, Watts A.

Angew Chem Int Ed Engl. 2011 Aug 29;50(36):8432-5. doi: 10.1002/anie.201100730. Epub 2011 Jul 18. No abstract available.


Residual dipolar couplings: are multiple independent alignments always possible?

Higman VA, Boyd J, Smith LJ, Redfield C.

J Biomol NMR. 2011 Jan;49(1):53-60. doi: 10.1007/s10858-010-9457-1. Epub 2010 Dec 24.


Solid-state NMR and SAXS studies provide a structural basis for the activation of alphaB-crystallin oligomers.

Jehle S, Rajagopal P, Bardiaux B, Markovic S, Kühne R, Stout JR, Higman VA, Klevit RE, van Rossum BJ, Oschkinat H.

Nat Struct Mol Biol. 2010 Sep;17(9):1037-42. doi: 10.1038/nsmb.1891. Epub 2010 Aug 29.


A novel subtype of AP-1-binding motif within the palmitoylated trans-Golgi network/endosomal accessory protein Gadkin/gamma-BAR.

Maritzen T, Schmidt MR, Kukhtina V, Higman VA, Strauss H, Volkmer R, Oschkinat H, Dotti CG, Haucke V.

J Biol Chem. 2010 Feb 5;285(6):4074-86. doi: 10.1074/jbc.M109.049197. Epub 2009 Dec 3.


Regulation of endosomal membrane traffic by a Gadkin/AP-1/kinesin KIF5 complex.

Schmidt MR, Maritzen T, Kukhtina V, Higman VA, Doglio L, Barak NN, Strauss H, Oschkinat H, Dotti CG, Haucke V.

Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15344-9. doi: 10.1073/pnas.0904268106. Epub 2009 Aug 21.


Probing the urea dependence of residual structure in denatured human alpha-lactalbumin.

Higman VA, Rösner HI, Ugolini R, Greene LH, Redfield C, Smith LJ.

J Biomol NMR. 2009 Sep;45(1-2):121-31. doi: 10.1007/s10858-009-9342-y. Epub 2009 Jul 19.


Assigning large proteins in the solid state: a MAS NMR resonance assignment strategy using selectively and extensively 13C-labelled proteins.

Higman VA, Flinders J, Hiller M, Jehle S, Markovic S, Fiedler S, van Rossum BJ, Oschkinat H.

J Biomol NMR. 2009 Aug;44(4):245-60. doi: 10.1007/s10858-009-9338-7. Epub 2009 Jul 17.


Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.

Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundström M, Doyle DA, Siderovski DP.

Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6457-62. doi: 10.1073/pnas.0801508105. Epub 2008 Apr 23.


[2,3-(13)C]-labeling of aromatic residues--getting a head start in the magic-angle-spinning NMR assignment of membrane proteins.

Hiller M, Higman VA, Jehle S, van Rossum BJ, Kühlbrandt W, Oschkinat H.

J Am Chem Soc. 2008 Jan 16;130(2):408-9. Epub 2007 Dec 20. No abstract available.


Plasticity of the TSG-6 HA-binding loop and mobility in the TSG-6-HA complex revealed by NMR and X-ray crystallography.

Higman VA, Blundell CD, Mahoney DJ, Redfield C, Noble ME, Day AJ.

J Mol Biol. 2007 Aug 17;371(3):669-84. Epub 2007 Jun 2.


Resonance assignment of the RGS domain of human RGS10.

Fedorov OY, Higman VA, Schmieder P, Leidert M, Diehl A, Elkins J, Soundararajan M, Oschkinat H, Ball LJ.

J Biomol NMR. 2007 Jun;38(2):191. Epub 2006 Dec 19. No abstract available.


NMR assignment of human RGS18.

Higman VA, Leidert M, Diehl A, Elkins J, Soundararajan M, Oschkinat H, Ball LJ.

J Biomol NMR. 2006;36 Suppl 1:72. Epub 2006 Sep 9. No abstract available.


His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form.

Clark SJ, Higman VA, Mulloy B, Perkins SJ, Lea SM, Sim RB, Day AJ.

J Biol Chem. 2006 Aug 25;281(34):24713-20. Epub 2006 Jun 20.


TSG-6: a pluripotent inflammatory mediator?

Milner CM, Higman VA, Day AJ.

Biochem Soc Trans. 2006 Jun;34(Pt 3):446-50. Review.


Uncovering network systems within protein structures.

Greene LH, Higman VA.

J Mol Biol. 2003 Dec 5;334(4):781-91.


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