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A systemic treatment confronts a systemic disease.

Hightower LE.

Am J Physiol Regul Integr Comp Physiol. 2019 Jul 1;317(1):R147-R148. doi: 10.1152/ajpregu.00142.2019. Epub 2019 May 29. No abstract available.


Small heat shock proteins: multifaceted proteins with important implications for life.

Carra S, Alberti S, Benesch JLP, Boelens W, Buchner J, Carver JA, Cecconi C, Ecroyd H, Gusev N, Hightower LE, Klevit RE, Lee HO, Liberek K, Lockwood B, Poletti A, Timmerman V, Toth ME, Vierling E, Wu T, Tanguay RM.

Cell Stress Chaperones. 2019 Mar;24(2):295-308. doi: 10.1007/s12192-019-00979-z. Epub 2019 Feb 13.


Might hyperbaric oxygen therapy (HBOT) reduce renal injury in diabetic people with diabetes mellitus? From preclinical models to human metabolomics.

Harrison LE, Giardina C, Hightower LE, Anderson C, Perdrizet GA.

Cell Stress Chaperones. 2018 Nov;23(6):1143-1152. doi: 10.1007/s12192-018-0944-8. Epub 2018 Oct 30.


The VIII International Congress on Stress Proteins in Biology and Medicine: täynnä henkeä.

Bonorino C, Sistonen L, Eriksson J, Mezger V, Santoro G, Hightower LE.

Cell Stress Chaperones. 2018 Mar;23(2):171-177. doi: 10.1007/s12192-018-0878-1.


The growing world of small heat shock proteins: from structure to functions.

Carra S, Alberti S, Arrigo PA, Benesch JL, Benjamin IJ, Boelens W, Bartelt-Kirbach B, Brundel BJJM, Buchner J, Bukau B, Carver JA, Ecroyd H, Emanuelsson C, Finet S, Golenhofen N, Goloubinoff P, Gusev N, Haslbeck M, Hightower LE, Kampinga HH, Klevit RE, Liberek K, Mchaourab HS, McMenimen KA, Poletti A, Quinlan R, Strelkov SV, Toth ME, Vierling E, Tanguay RM.

Cell Stress Chaperones. 2017 Jul;22(4):601-611. doi: 10.1007/s12192-017-0787-8. Epub 2017 Mar 31. Review.


The remarkable multivalency of the Hsp70 chaperones.

Zuiderweg ER, Hightower LE, Gestwicki JE.

Cell Stress Chaperones. 2017 Mar;22(2):173-189. doi: 10.1007/s12192-017-0776-y. Epub 2017 Feb 20. Review.


Susan Lee Lindquist (1949-2016): It is personal.

Hightower LE.

Cell Stress Chaperones. 2017 Jan;22(1):1-4. doi: 10.1007/s12192-016-0759-4. No abstract available.


Stress and health Huangshan-style.

Qian L, Tanguay RM, Wu T, Hightower LE.

Cell Stress Chaperones. 2016 May;21(3):373-8. doi: 10.1007/s12192-016-0674-8. Review.


Hyperbaric oxygen therapy (HBOT) suppresses biomarkers of cell stress and kidney injury in diabetic mice.

Verma R, Chopra A, Giardina C, Sabbisetti V, Smyth JA, Hightower LE, Perdrizet GA.

Cell Stress Chaperones. 2015 May;20(3):495-505. doi: 10.1007/s12192-015-0574-3. Epub 2015 Feb 4.


Report on the VIIth International Symposium on Heat Shock Proteins in Biology & Medicine.

Calderwood SK, Hightower LE.

Cell Stress Chaperones. 2015 Mar;20(2):213-6. doi: 10.1007/s12192-014-0562-z. Epub 2014 Dec 27. Review.


Small heat shock proteins: big folding machines.

Morrow G, Hightower LE, Tanguay RM.

Cell Stress Chaperones. 2015 Mar;20(2):207-12. doi: 10.1007/s12192-014-0561-0. Epub 2014 Dec 24. Review.


A note in passing: Walter Gehring and desert ants.

Hightower LE.

Cell Stress Chaperones. 2014 Nov;19(6):749-51. doi: 10.1007/s12192-014-0541-4. No abstract available.


The life and times of Ferruccio Ritossa.

Capocci M, Santoro MG, Hightower LE.

Cell Stress Chaperones. 2014 Sep;19(5):599-604. doi: 10.1007/s12192-014-0525-4.


Hyperbaric oxygen preconditioning protects skin from UV-A damage.

Fuller AM, Giardina C, Hightower LE, Perdrizet GA, Tierney CA.

Cell Stress Chaperones. 2013 Jan;18(1):97-107. doi: 10.1007/s12192-012-0362-2. Epub 2012 Aug 3.


Loss of stress response as a consequence of viral infection: implications for disease and therapy.

Hooper PL, Hightower LE, Hooper PL.

Cell Stress Chaperones. 2012 Nov;17(6):647-55. doi: 10.1007/s12192-012-0352-4. Epub 2012 Jul 14.


Ferruccio Ritossa's scientific legacy 50 years after his discovery of the heat shock response: a new view of biology, a new society, and a new journal.

De Maio A, Santoro MG, Tanguay RM, Hightower LE.

Cell Stress Chaperones. 2012 Mar;17(2):139-43. doi: 10.1007/s12192-012-0320-z. Epub 2012 Jan 18.


Distinguishing integral and receptor-bound heat shock protein 70 (Hsp70) on the cell surface by Hsp70-specific antibodies.

Multhoff G, Hightower LE.

Cell Stress Chaperones. 2011 May;16(3):251-5. doi: 10.1007/s12192-010-0247-1. Epub 2010 Dec 17. Review.


Hyperbaric oxygen treatment induces antioxidant gene expression.

Godman CA, Joshi R, Giardina C, Perdrizet G, Hightower LE.

Ann N Y Acad Sci. 2010 Jun;1197:178-83. doi: 10.1111/j.1749-6632.2009.05393.x. Review.


HSPB1, actin filament dynamics, and aging cells.

Doshi BM, Hightower LE, Lee J.

Ann N Y Acad Sci. 2010 Jun;1197:76-84. doi: 10.1111/j.1749-6632.2010.05191.x. Review.


Hyperbaric oxygen induces a cytoprotective and angiogenic response in human microvascular endothelial cells.

Godman CA, Chheda KP, Hightower LE, Perdrizet G, Shin DG, Giardina C.

Cell Stress Chaperones. 2010 Jul;15(4):431-42. doi: 10.1007/s12192-009-0159-0. Epub 2009 Dec 1.


The role of Hsp27 and actin in the regulation of movement in human cancer cells responding to heat shock.

Doshi BM, Hightower LE, Lee J.

Cell Stress Chaperones. 2009 Sep;14(5):445-57. doi: 10.1007/s12192-008-0098-1. Epub 2009 Feb 18.


Guidelines for the nomenclature of the human heat shock proteins.

Kampinga HH, Hageman J, Vos MJ, Kubota H, Tanguay RM, Bruford EA, Cheetham ME, Chen B, Hightower LE.

Cell Stress Chaperones. 2009 Jan;14(1):105-11. doi: 10.1007/s12192-008-0068-7. Epub 2008 Jul 29.


Wound healing from a cellular stress response perspective.

Doshi BM, Perdrizet GA, Hightower LE.

Cell Stress Chaperones. 2008 Dec;13(4):393-9. doi: 10.1007/s12192-008-0059-8. Epub 2008 Jul 15.


Surface expression of Hsp70B' in response to proteasome inhibition in human colon cells.

Noonan EJ, Fournier G, Hightower LE.

Cell Stress Chaperones. 2008 Spring;13(1):105-10. doi: 10.1007/s12192-007-0003-3. Epub 2008 Feb 12.


Hsp70B' regulation and function.

Noonan EJ, Place RF, Giardina C, Hightower LE.

Cell Stress Chaperones. 2007 Winter;12(4):393-402.


Hsp70B' regulation and function.

Noonan EJ, Place RF, Giardina C, Hightower LE.

Cell Stress Chaperones. 2007 Autumn;12(3):219-29. Corrected and republished in: Cell Stress Chaperones. 2007 Winter;12(4):393-402.


Heavy metal ions in normal physiology, toxic stress, and cytoprotection.

Lynes MA, Kang YJ, Sensi SL, Perdrizet GA, Hightower LE.

Ann N Y Acad Sci. 2007 Oct;1113:159-72. Epub 2007 May 4. Review.


Cell number-dependent regulation of Hsp70B' expression: evidence of an extracellular regulator.

Noonan EJ, Place RF, Rasoulpour RJ, Giardina C, Hightower LE.

J Cell Physiol. 2007 Jan;210(1):201-11.


Use of fish liver PLHC-1 cells and zebrafish embryos in cytotoxicity assays.

Krone PH, Blechinger SR, Evans TG, Ryan JA, Noonan EJ, Hightower LE.

Methods. 2005 Feb;35(2):176-87. Epub 2004 Dec 19.


Introducing Professor Masataka Mori, Asia-Australian Regional Editor.

Hightower LE.

Cell Stress Chaperones. 2003 Winter;8(4):295-6. No abstract available.


Basal and inducible levels of Hsp70 in patients with acute heat illness induced during training.

Xiao C, Wu T, Ren A, Pan Q, Chen S, Wu F, Li X, Wang R, Hightower LE, Tanguay RM.

Cell Stress Chaperones. 2003 Spring;8(1):86-92.


Discovery of two distinct small heat shock protein (HSP) families in the desert fish Poeciliopsis.

Norris CE, Hightower LE.

Prog Mol Subcell Biol. 2002;28:19-35. No abstract available.


Effects of heat shock, stannous chloride, and gallium nitrate on the rat inflammatory response.

House SD, Guidon PT Jr, Perdrizet GA, Rewinski M, Kyriakos R, Bockman RS, Mistry T, Gallagher RA, Hightower LE.

Cell Stress Chaperones. 2001 Apr;6(2):164-71.


Tissue-level cytoprotection.

Hightower LE, Brown, Renfro JL, Perdrizet GA, Rewinski M, Guidon PT Jr, Mistry T, House SD.

Cell Stress Chaperones. 2000 Nov;5(5):412-4.


Introducing Professor John H. Crowe, Anhydrobiosis and Biostabilization Section Editor.

Hightower LE.

Cell Stress Chaperones. 2000 Jul;5(3):161-2. No abstract available.


Highlights of the 1998 Cold Spring Harbor Meeting: Molecular chaperones and the heat shock response.

Bensaude O, Hightower LE.

Cell Stress Chaperones. 1999 Mar;4(1):60-5. No abstract available.


The promise of molecular biomarkers for environmental monitoring.

Hightower LE.

Biol Chem. 1998 Oct;379(10):1213-5. No abstract available.


Molecular chaperones in biology and medicine at Obernai.

Bergeron JJ, Craig EA, Horwich AL, Langer T, Multhoff G, Smith DF, Hightower LE.

Cell Stress Chaperones. 1997 Dec;2(4):220-8. Review. No abstract available.


Low-molecular-weight heat shock proteins in a desert fish (Poeciliopsis lucida): homologs of human Hsp27 and Xenopus Hsp30.

Norris CE, Brown MA, Hickey E, Weber LA, Hightower LE.

Mol Biol Evol. 1997 Oct;14(10):1050-61.


Variation in hsp gene expression and Hsp polymorphism: do they contribute to differential disease susceptibility and stress tolerance?

Favatier F, Bornman L, Hightower LE, Günther E, Polla BS.

Cell Stress Chaperones. 1997 Sep;2(3):141-55. Review. No abstract available.


Are stress proteins part of a cell's solution to toxicity or are they part of the problem?

Hightower LE, Ryan JA.

Hepatology. 1997 May;25(5):1279-81. No abstract available.


Molecular chaperones and the heat shock response at Cold Spring Harbor.

Hightower LE, Hendershot LM.

Cell Stress Chaperones. 1997 Mar;2(1):1-11. Review. No abstract available.


A 16-kDa protein functions as a new regulatory protein for Hsc70 molecular chaperone and is identified as a member of the Nm23/nucleoside diphosphate kinase family.

Leung SM, Hightower LE.

J Biol Chem. 1997 Jan 31;272(5):2607-14. Erratum in: J Biol Chem 1997 May 2;272(18):12248.


Cell surface expression of heat shock proteins and the immune response.

Multhoff G, Hightower LE.

Cell Stress Chaperones. 1996 Sep;1(3):167-76. Review. No abstract available.


Quantitative evidence that both Hsc70 and Hsp70 contribute to thermal adaptation in hybrids of the livebearing fishes Poeciliopsis.

diIorio PJ, Holsinger K, Schultz RJ, Hightower LE.

Cell Stress Chaperones. 1996 Jun;1(2):139-47. Erratum in: Cell Stress Chaperones 1996 Sep;1(3):207.


Thermal activation of the bovine Hsc70 molecular chaperone at physiological temperatures: physical evidence of a molecular thermometer.

Leung SM, Senisterra G, Ritchie KP, Sadis SE, Lepock JR, Hightower LE.

Cell Stress Chaperones. 1996 Apr;1(1):78-89.


Stress proteins as molecular biomarkers for environmental toxicology.

Ryan JA, Hightower LE.

EXS. 1996;77:411-24. Review.


Variation in heat shock proteins within tropical and desert species of poeciliid fishes.

Norris CE, diIorio PJ, Schultz RJ, Hightower LE.

Mol Biol Evol. 1995 Nov;12(6):1048-62.


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