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Distinct Requirements for Tail-Anchored Membrane Protein Biogenesis in Escherichia coli.

Peschke M, Le Goff M, Koningstein GM, Vischer NO, Abdel-Rehim A, High S, van Ulsen P, Luirink J.

MBio. 2019 Oct 15;10(5). pii: e01580-19. doi: 10.1128/mBio.01580-19.


Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation.

Zong G, Hu Z, O'Keefe S, Tranter D, Iannotti MJ, Baron L, Hall B, Corfield K, Paatero AO, Henderson MJ, Roboti P, Zhou J, Sun X, Govindarajan M, Rohde JM, Blanchard N, Simmonds R, Inglese J, Du Y, Demangel C, High S, Paavilainen VO, Shi WQ.

J Am Chem Soc. 2019 May 29;141(21):8450-8461. doi: 10.1021/jacs.8b13506. Epub 2019 May 15.


Characterizing the selectivity of ER α-glucosidase inhibitors.

O'Keefe S, Roebuck QP, Nakagome I, Hirono S, Kato A, Nash R, High S.

Glycobiology. 2019 Jul 1;29(7):530-542. doi: 10.1093/glycob/cwz029.


Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca2+ Leakage from the Endoplasmic Reticulum.

Gamayun I, O'Keefe S, Pick T, Klein MC, Nguyen D, McKibbin C, Piacenti M, Williams HM, Flitsch SL, Whitehead RC, Swanton E, Helms V, High S, Zimmermann R, Cavalié A.

Cell Chem Biol. 2019 Apr 18;26(4):571-583.e6. doi: 10.1016/j.chembiol.2019.01.010. Epub 2019 Feb 21.


The use of tail-anchored protein chimeras to enhance liposomal cargo delivery.

Abdelrehim A, Shaltiel L, Zhang L, Barenholz Y, High S, Harris LK.

PLoS One. 2019 Feb 22;14(2):e0212701. doi: 10.1371/journal.pone.0212701. eCollection 2019.


Female Sex Development and Reproductive Duct Formation Depend on Wnt4a in Zebrafish.

Kossack ME, High SK, Hopton RE, Yan YL, Postlethwait JH, Draper BW.

Genetics. 2019 Jan;211(1):219-233. doi: 10.1534/genetics.118.301620. Epub 2018 Nov 16.


Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease.

Demangel C, High S.

Biol Cell. 2018 Nov;110(11):237-248. doi: 10.1111/boc.201800030. Epub 2018 Aug 14. Review.


Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control.

Martínez-Lumbreras S, Krysztofinska EM, Thapaliya A, Spilotros A, Matak-Vinkovic D, Salvadori E, Roboti P, Nyathi Y, Muench JH, Roessler MM, Svergun DI, High S, Isaacson RL.

BMC Biol. 2018 Jul 11;16(1):76. doi: 10.1186/s12915-018-0542-3.


Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.

Haßdenteufel S, Johnson N, Paton AW, Paton JC, High S, Zimmermann R.

Cell Rep. 2018 May 1;23(5):1373-1386. doi: 10.1016/j.celrep.2018.03.122.


Multiple pathways facilitate the biogenesis of mammalian tail-anchored proteins.

Casson J, McKenna M, Haßdenteufel S, Aviram N, Zimmerman R, High S.

J Cell Sci. 2017 Nov 15;130(22):3851-3861. doi: 10.1242/jcs.207829. Epub 2017 Oct 11.


Gonadal soma controls ovarian follicle proliferation through Gsdf in zebrafish.

Yan YL, Desvignes T, Bremiller R, Wilson C, Dillon D, High S, Draper B, Buck CL, Postlethwait J.

Dev Dyn. 2017 Nov;246(11):925-945. doi: 10.1002/dvdy.24579. Epub 2017 Sep 25.


Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis.

McKenna M, Simmonds RE, High S.

J Cell Sci. 2017 Apr 1;130(7):1307-1320. doi: 10.1242/jcs.198655. Epub 2017 Feb 20.


SGTA interacts with the proteasomal ubiquitin receptor Rpn13 via a carboxylate clamp mechanism.

Thapaliya A, Nyathi Y, Martínez-Lumbreras S, Krysztofinska EM, Evans NJ, Terry IL, High S, Isaacson RL.

Sci Rep. 2016 Nov 9;6:36622. doi: 10.1038/srep36622.


The Charcot Marie Tooth disease protein LITAF is a zinc-binding monotopic membrane protein.

Qin W, Wunderley L, Barrett AL, High S, Woodman PG.

Biochem J. 2016 Nov 1;473(21):3965-3978. Epub 2016 Aug 31.


On the road to nowhere: cross-talk between post-translational protein targeting and cytosolic quality control.

Casson J, McKenna M, High S.

Biochem Soc Trans. 2016 Jun 15;44(3):796-801. doi: 10.1042/BST20160045. Review.


Structural and functional insights into the E3 ligase, RNF126.

Krysztofinska EM, Martínez-Lumbreras S, Thapaliya A, Evans NJ, High S, Isaacson RL.

Sci Rep. 2016 May 19;6:26433. doi: 10.1038/srep26433.


Telehealth for patients with Parkinson's disease: delivering efficient and sustainable long-term care.

Barbour PJ, Arroyo J, High S, Fichera LB, Staska-Pier MM, McMahon MK.

Hosp Pract (1995). 2016;44(2):92-7. doi: 10.1080/21548331.2016.1166922.


Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone.

McKenna M, Simmonds RE, High S.

J Cell Sci. 2016 Apr 1;129(7):1404-15. doi: 10.1242/jcs.182352. Epub 2016 Feb 11.


Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation.

Jadhav B, McKenna M, Johnson N, High S, Sinning I, Pool MR.

Nat Commun. 2015 Dec 4;6:10133. doi: 10.1038/ncomms10133.


Binding of SGTA to Rpn13 selectively modulates protein quality control.

Leznicki P, Korac-Prlic J, Kliza K, Husnjak K, Nyathi Y, Dikic I, High S.

J Cell Sci. 2015 Sep 1;128(17):3187-96. doi: 10.1242/jcs.165209. Epub 2015 Jul 13.


Editorial overview: elucidation of protein translocation pathways, part II.

Mokranjac D, High S.

J Mol Biol. 2015 Mar 27;427(6 Pt A):1133-4. doi: 10.1016/j.jmb.2015.02.020. No abstract available.


Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4A.

Darby JF, Krysztofinska EM, Simpson PJ, Simon AC, Leznicki P, Sriskandarajah N, Bishop DS, Hale LR, Alfano C, Conte MR, Martínez-Lumbreras S, Thapaliya A, High S, Isaacson RL.

PLoS One. 2014 Nov 21;9(11):e113281. doi: 10.1371/journal.pone.0113281. eCollection 2014.


Elevation of proteasomal substrate levels sensitizes cells to apoptosis induced by inhibition of proteasomal deubiquitinases.

Sun C, Roboti P, Puumalainen MR, Fryknäs M, Wang X, D'Arcy P, Hult M, High S, Linder S, Swanton E.

PLoS One. 2014 Oct 6;9(10):e108839. doi: 10.1371/journal.pone.0108839. eCollection 2014.


Wild sex in zebrafish: loss of the natural sex determinant in domesticated strains.

Wilson CA, High SK, McCluskey BM, Amores A, Yan YL, Titus TA, Anderson JL, Batzel P, Carvan MJ 3rd, Schartl M, Postlethwait JH.

Genetics. 2014 Nov;198(3):1291-308. doi: 10.1534/genetics.114.169284. Epub 2014 Sep 18.


SGTA regulates the cytosolic quality control of hydrophobic substrates.

Wunderley L, Leznicki P, Payapilly A, High S.

J Cell Sci. 2014 Nov 1;127(Pt 21):4728-39. doi: 10.1242/jcs.155648. Epub 2014 Sep 1.


BAG6 regulates the quality control of a polytopic ERAD substrate.

Payapilly A, High S.

J Cell Sci. 2014 Jul 1;127(Pt 13):2898-909. doi: 10.1242/jcs.145565. Epub 2014 May 7.


The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER.

Hall BS, Hill K, McKenna M, Ogbechi J, High S, Willis AE, Simmonds RE.

PLoS Pathog. 2014 Apr 3;10(4):e1004061. doi: 10.1371/journal.ppat.1004061. eCollection 2014 Apr.


The signal sequence influences post-translational ER translocation at distinct stages.

Johnson N, Haßdenteufel S, Theis M, Paton AW, Paton JC, Zimmermann R, High S.

PLoS One. 2013 Oct 9;8(10):e75394. doi: 10.1371/journal.pone.0075394. eCollection 2013.


Reorientation of the first signal-anchor sequence during potassium channel biogenesis at the Sec61 complex.

Watson HR, Wunderley L, Andreou T, Warwicker J, High S.

Biochem J. 2013 Dec 1;456(2):297-309. doi: 10.1042/BJ20130100.


OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation.

Dumax-Vorzet A, Roboti P, High S.

J Cell Sci. 2013 Jun 15;126(Pt 12):2595-606. doi: 10.1242/jcs.115410. Epub 2013 Apr 19.


The association of BAG6 with SGTA and tail-anchored proteins.

Leznicki P, Roebuck QP, Wunderley L, Clancy A, Krysztofinska EM, Isaacson RL, Warwicker J, Schwappach B, High S.

PLoS One. 2013;8(3):e59590. doi: 10.1371/journal.pone.0059590. Epub 2013 Mar 22.


A novel approach to improving emergency department consultant response times.

Soong C, High S, Morgan MW, Ovens H.

BMJ Qual Saf. 2013 Apr;22(4):299-305. doi: 10.1136/bmjqs-2012-001503. Epub 2013 Jan 15.


Structure of the Sgt2/Get5 complex provides insights into GET-mediated targeting of tail-anchored membrane proteins.

Simon AC, Simpson PJ, Goldstone RM, Krysztofinska EM, Murray JW, High S, Isaacson RL.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1327-32. doi: 10.1073/pnas.1207518110. Epub 2013 Jan 7.


Post-translational translocation into the endoplasmic reticulum.

Johnson N, Powis K, High S.

Biochim Biophys Acta. 2013 Nov;1833(11):2403-9. doi: 10.1016/j.bbamcr.2012.12.008. Epub 2012 Dec 20. Review.


Positional editing of transmembrane domains during ion channel assembly.

Öjemalm K, Watson HR, Roboti P, Cross BC, Warwicker J, von Heijne G, High S.

J Cell Sci. 2013 Jan 15;126(Pt 2):464-72. doi: 10.1242/jcs.111773. Epub 2012 Dec 10.


Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome.

Lopez-Castejon G, Luheshi NM, Compan V, High S, Whitehead RC, Flitsch S, Kirov A, Prudovsky I, Swanton E, Brough D.

J Biol Chem. 2013 Jan 25;288(4):2721-33. doi: 10.1074/jbc.M112.422238. Epub 2012 Dec 3.


Get3 is a holdase chaperone and moves to deposition sites for aggregated proteins when membrane targeting is blocked.

Powis K, Schrul B, Tienson H, Gostimskaya I, Breker M, High S, Schuldiner M, Jakob U, Schwappach B.

J Cell Sci. 2013 Jan 15;126(Pt 2):473-83. doi: 10.1242/jcs.112151. Epub 2012 Nov 30.


SGTA antagonizes BAG6-mediated protein triage.

Leznicki P, High S.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19214-9. doi: 10.1073/pnas.1209997109. Epub 2012 Nov 5.


TRC40 can deliver short secretory proteins to the Sec61 translocon.

Johnson N, Vilardi F, Lang S, Leznicki P, Zimmermann R, High S.

J Cell Sci. 2012 Aug 1;125(Pt 15):3612-20. Epub 2012 Apr 14. Erratum in: J Cell Sci. 2012 Sep 15;125(Pt 18):4414.


The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylation.

Roboti P, High S.

J Cell Sci. 2012 Jul 15;125(Pt 14):3474-84. doi: 10.1242/jcs.103952. Epub 2012 Mar 30.


Keratinocyte-associated protein 2 is a bona fide subunit of the mammalian oligosaccharyltransferase.

Roboti P, High S.

J Cell Sci. 2012 Jan 1;125(Pt 1):220-32. doi: 10.1242/jcs.094599. Epub 2012 Jan 20.


Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response.

McKibbin C, Mares A, Piacenti M, Williams H, Roboti P, Puumalainen M, Callan AC, Lesiak-Mieczkowska K, Linder S, Harant H, High S, Flitsch SL, Whitehead RC, Swanton E.

Biochem J. 2012 Mar 15;442(3):639-48. doi: 10.1042/BJ20111220.


Ca2+-calmodulin inhibits tail-anchored protein insertion into the mammalian endoplasmic reticulum membrane.

Hassdenteufel S, Schäuble N, Cassella P, Leznicki P, Müller A, High S, Jung M, Zimmermann R.

FEBS Lett. 2011 Nov 4;585(21):3485-90. doi: 10.1016/j.febslet.2011.10.008. Epub 2011 Oct 12.


Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways.

Aletrari MO, McKibbin C, Williams H, Pawar V, Pietroni P, Lord JM, Flitsch SL, Whitehead R, Swanton E, High S, Spooner RA.

PLoS One. 2011;6(7):e22713. doi: 10.1371/journal.pone.0022713. Epub 2011 Jul 25.


A biochemical analysis of the constraints of tail-anchored protein biogenesis.

Leznicki P, Warwicker J, High S.

Biochem J. 2011 Jun 15;436(3):719-27. doi: 10.1042/BJ20101737.


Anti-NMDA-receptor encephalitis: case report and literature review of an under-recognized condition.

Day GS, High SM, Cot B, Tang-Wai DF.

J Gen Intern Med. 2011 Jul;26(7):811-6. doi: 10.1007/s11606-011-1641-9. Epub 2011 Feb 12. Review.


EBV protein BNLF2a exploits host tail-anchored protein integration machinery to inhibit TAP.

Horst D, Favaloro V, Vilardi F, van Leeuwen HC, Garstka MA, Hislop AD, Rabu C, Kremmer E, Rickinson AB, High S, Dobberstein B, Ressing ME, Wiertz EJ.

J Immunol. 2011 Mar 15;186(6):3594-605. doi: 10.4049/jimmunol.1002656. Epub 2011 Feb 4.


Pandemic H1N1 influenza infection and vascular thrombosis.

Bunce PE, High SM, Nadjafi M, Stanley K, Liles WC, Christian MD.

Clin Infect Dis. 2011 Jan 15;52(2):e14-7. doi: 10.1093/cid/ciq125.


Bat3 promotes the membrane integration of tail-anchored proteins.

Leznicki P, Clancy A, Schwappach B, High S.

J Cell Sci. 2010 Jul 1;123(Pt 13):2170-8. doi: 10.1242/jcs.066738. Epub 2010 Jun 1.


Studying endoplasmic reticulum function in vitro using siRNA.

Wilson CM, High S.

Methods Mol Biol. 2010;619:389-402. doi: 10.1007/978-1-60327-412-8_23.


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