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Items: 18

1.

MYBL2 supports DNA double strand break repair in haematopoietic stem cells.

Bayley R, Blakemore D, Cancian L, Dumon S, Volpe G, Ward C, Almaghrabi R, Gujar J, Reeve N, Raghavan M, Higgs MR, Stewart GS, Petermann E, Garcia P.

Cancer Res. 2018 Aug 6. pii: canres.0273.2018. doi: 10.1158/0008-5472.CAN-18-0273. [Epub ahead of print]

PMID:
30082276
2.

Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2.

Higgs MR, Sato K, Reynolds JJ, Begum S, Bayley R, Goula A, Vernet A, Paquin KL, Skalnik DG, Kobayashi W, Takata M, Howlett NG, Kurumizaka H, Kimura H, Stewart GS.

Mol Cell. 2018 Jul 5;71(1):25-41.e6. doi: 10.1016/j.molcel.2018.05.018. Epub 2018 Jun 21.

3.

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.

Ronson GE, Piberger AL, Higgs MR, Olsen AL, Stewart GS, McHugh PJ, Petermann E, Lakin ND.

Nat Commun. 2018 Feb 21;9(1):746. doi: 10.1038/s41467-018-03159-2.

4.

Hepatitis C virus induces a prediabetic state by directly impairing hepatic glucose metabolism in mice.

Lerat H, Imache MR, Polyte J, Gaudin A, Mercey M, Donati F, Baudesson C, Higgs MR, Picard A, Magnan C, Foufelle F, Pawlotsky JM.

J Biol Chem. 2017 Aug 4;292(31):12860-12873. doi: 10.1074/jbc.M117.785030. Epub 2017 May 30.

5.

Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism.

Reynolds JJ, Bicknell LS, Carroll P, Higgs MR, Shaheen R, Murray JE, Papadopoulos DK, Leitch A, Murina O, Tarnauskaitė Ž, Wessel SR, Zlatanou A, Vernet A, von Kriegsheim A, Mottram RM, Logan CV, Bye H, Li Y, Brean A, Maddirevula S, Challis RC, Skouloudaki K, Almoisheer A, Alsaif HS, Amar A, Prescott NJ, Bober MB, Duker A, Faqeih E, Seidahmed MZ, Al Tala S, Alswaid A, Ahmed S, Al-Aama JY, Altmüller J, Al Balwi M, Brady AF, Chessa L, Cox H, Fischetto R, Heller R, Henderson BD, Hobson E, Nürnberg P, Percin EF, Peron A, Spaccini L, Quigley AJ, Thakur S, Wise CA, Yoon G, Alnemer M, Tomancak P, Yigit G, Taylor AM, Reijns MA, Simpson MA, Cortez D, Alkuraya FS, Mathew CG, Jackson AP, Stewart GS.

Nat Genet. 2017 Apr;49(4):537-549. doi: 10.1038/ng.3790. Epub 2017 Feb 13.

6.

Mitotic control of human papillomavirus genome-containing cells is regulated by the function of the PDZ-binding motif of the E6 oncoprotein.

Marsh EK, Delury CP, Davies NJ, Weston CJ, Miah MAL, Banks L, Parish JL, Higgs MR, Roberts S.

Oncotarget. 2017 Mar 21;8(12):19491-19506. doi: 10.18632/oncotarget.14469.

7.

Protection or resection: BOD1L as a novel replication fork protection factor.

Higgs MR, Stewart GS.

Nucleus. 2016;7(1):34-40. doi: 10.1080/19491034.2016.1143183. Epub 2016 Feb 18. Review.

8.

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism.

Harley ME, Murina O, Leitch A, Higgs MR, Bicknell LS, Yigit G, Blackford AN, Zlatanou A, Mackenzie KJ, Reddy K, Halachev M, McGlasson S, Reijns MAM, Fluteau A, Martin CA, Sabbioneda S, Elcioglu NH, Altmüller J, Thiele H, Greenhalgh L, Chessa L, Maghnie M, Salim M, Bober MB, Nürnberg P, Jackson SP, Hurles ME, Wollnik B, Stewart GS, Jackson AP.

Nat Genet. 2016 Jan;48(1):36-43. doi: 10.1038/ng.3451. Epub 2015 Nov 23.

9.

BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks.

Higgs MR, Reynolds JJ, Winczura A, Blackford AN, Borel V, Miller ES, Zlatanou A, Nieminuszczy J, Ryan EL, Davies NJ, Stankovic T, Boulton SJ, Niedzwiedz W, Stewart GS.

Mol Cell. 2015 Aug 6;59(3):462-77. doi: 10.1016/j.molcel.2015.06.007. Epub 2015 Jul 9.

10.

Cancer therapy and replication stress: forks on the road to perdition.

Kotsantis P, Jones RM, Higgs MR, Petermann E.

Adv Clin Chem. 2015;69:91-138. doi: 10.1016/bs.acc.2014.12.003. Epub 2015 Feb 7. Review.

PMID:
25934360
11.

'Liver let die': oxidative DNA damage and hepatotropic viruses.

Higgs MR, Chouteau P, Lerat H.

J Gen Virol. 2014 May;95(Pt 5):991-1004. doi: 10.1099/vir.0.059485-0. Epub 2014 Feb 4. Review.

PMID:
24496828
12.

Regulation of hepatitis C virus replication by nuclear translocation of nonstructural 5A protein and transcriptional activation of host genes.

Maqbool MA, Imache MR, Higgs MR, Carmouse S, Pawlotsky JM, Lerat H.

J Virol. 2013 May;87(10):5523-39. doi: 10.1128/JVI.00585-12. Epub 2013 Mar 6. Erratum in: J Virol. 2013 Sep;87(17):9963.

13.

Hepatitis C virus-induced activation of β-catenin promotes c-Myc expression and a cascade of pro-carcinogenetic events.

Higgs MR, Lerat H, Pawlotsky JM.

Oncogene. 2013 Sep 26;32(39):4683-93. doi: 10.1038/onc.2012.484. Epub 2012 Oct 29.

PMID:
23108410
14.

A summary of the 18th International Symposium on Hepatitis C Virus and Related Viruses.

Polyak SJ, Morishima C, Scott JD, Gastaminza P, Cox A, de Araújo ES, Higgs MR, Loo YM, Golden-Mason L, Lindenbach BD, Baumert TF, Randall G, Gale M Jr.

Gastroenterology. 2012 Jan;142(1):e1-5. doi: 10.1053/j.gastro.2011.11.002. No abstract available. Erratum in: Gastroenterology. 2012 Feb;142(2):411. Gastaminza, Pablo [added].

PMID:
22185796
15.

Downregulation of Gadd45beta expression by hepatitis C virus leads to defective cell cycle arrest.

Higgs MR, Lerat H, Pawlotsky JM.

Cancer Res. 2010 Jun 15;70(12):4901-11. doi: 10.1158/0008-5472.CAN-09-4554. Epub 2010 Jun 8.

16.

Hepatitis C virus proteins induce lipogenesis and defective triglyceride secretion in transgenic mice.

Lerat H, Kammoun HL, Hainault I, Mérour E, Higgs MR, Callens C, Lemon SM, Foufelle F, Pawlotsky JM.

J Biol Chem. 2009 Nov 27;284(48):33466-74. doi: 10.1074/jbc.M109.019810. Epub 2009 Oct 6.

17.

Mutational analysis of the herpes simplex virus type 1 DNA packaging protein UL33.

Beilstein F, Higgs MR, Stow ND.

J Virol. 2009 Sep;83(17):8938-45. doi: 10.1128/JVI.01048-09. Epub 2009 Jun 24.

18.

The UL15 protein of herpes simplex virus type 1 is necessary for the localization of the UL28 and UL33 proteins to viral DNA replication centres.

Higgs MR, Preston VG, Stow ND.

J Gen Virol. 2008 Jul;89(Pt 7):1709-15. doi: 10.1099/vir.0.2008/000448-0.

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