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Items: 1 to 50 of 84

1.

Two distinct actin filament populations have effects on mitochondria, with differences in stimuli and assembly factors.

Fung TS, Ji WK, Higgs HN, Chakrabarti R.

J Cell Sci. 2019 Aug 14. pii: jcs.234435. doi: 10.1242/jcs.234435. [Epub ahead of print]

PMID:
31413070
2.

A complex containing lysine-acetylated actin inhibits the formin INF2.

A M, Fung TS, Kettenbach AN, Chakrabarti R, Higgs HN.

Nat Cell Biol. 2019 May;21(5):592-602. doi: 10.1038/s41556-019-0307-4. Epub 2019 Apr 8.

PMID:
30962575
3.

The Pollard lab at Salk: moving the leading edge forward.

Higgs HN.

Biophys Rev. 2018 Dec;10(6):1487-1490. doi: 10.1007/s12551-018-0480-x. Epub 2018 Nov 12. Review.

4.

Roles for Ena/VASP proteins in FMNL3-mediated filopodial assembly.

Young LE, Latario CJ, Higgs HN.

J Cell Sci. 2018 Oct 29;131(21). pii: jcs220814. doi: 10.1242/jcs.220814.

5.

Long-Term Potentiation Requires a Rapid Burst of Dendritic Mitochondrial Fission during Induction.

Divakaruni SS, Van Dyke AM, Chandra R, LeGates TA, Contreras M, Dharmasri PA, Higgs HN, Lobo MK, Thompson SM, Blanpied TA.

Neuron. 2018 Nov 21;100(4):860-875.e7. doi: 10.1016/j.neuron.2018.09.025. Epub 2018 Oct 11.

PMID:
30318410
6.

Focal Adhesions Undergo Longitudinal Splitting into Fixed-Width Units.

Young LE, Higgs HN.

Curr Biol. 2018 Jul 9;28(13):2033-2045.e5. doi: 10.1016/j.cub.2018.04.073. Epub 2018 Jun 14.

7.

Receptor-mediated Drp1 oligomerization on endoplasmic reticulum.

Ji WK, Chakrabarti R, Fan X, Schoenfeld L, Strack S, Higgs HN.

J Cell Biol. 2017 Dec 4;216(12):4123-4139. doi: 10.1083/jcb.201610057. Epub 2017 Nov 20.

8.

INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division.

Chakrabarti R, Ji WK, Stan RV, de Juan Sanz J, Ryan TA, Higgs HN.

J Cell Biol. 2018 Jan 2;217(1):251-268. doi: 10.1083/jcb.201709111. Epub 2017 Nov 15.

9.

Function-Oriented Studies Targeting Pectenotoxin 2: Synthesis of the GH-Ring System and a Structurally Simplified Macrolactone.

O'Rourke NF, A M, Higgs HN, Eastman A, Micalizio GC.

Org Lett. 2017 Oct 6;19(19):5154-5157. doi: 10.1021/acs.orglett.7b02435. Epub 2017 Sep 13.

10.

Calcium-mediated actin reset (CaAR) mediates acute cell adaptations.

Wales P, Schuberth CE, Aufschnaiter R, Fels J, García-Aguilar I, Janning A, Dlugos CP, Schäfer-Herte M, Klingner C, Wälte M, Kuhlmann J, Menis E, Hockaday Kang L, Maier KC, Hou W, Russo A, Higgs HN, Pavenstädt H, Vogl T, Roth J, Qualmann B, Kessels MM, Martin DE, Mulder B, Wedlich-Söldner R.

Elife. 2016 Dec 6;5. pii: e19850. doi: 10.7554/eLife.19850.

11.

Actin filaments as dynamic reservoirs for Drp1 recruitment.

Hatch AL, Ji WK, Merrill RA, Strack S, Higgs HN.

Mol Biol Cell. 2016 Oct 15;27(20):3109-3121. Epub 2016 Aug 24.

12.

Mice with mutant Inf2 show impaired podocyte and slit diaphragm integrity in response to protamine-induced kidney injury.

Subramanian B, Sun H, Yan P, Charoonratana VT, Higgs HN, Wang F, Lai KV, Valenzuela DM, Brown EJ, Schlöndorff JS, Pollak MR.

Kidney Int. 2016 Aug;90(2):363-372. doi: 10.1016/j.kint.2016.04.020. Epub 2016 Jun 24.

13.

Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites.

Ji WK, Hatch AL, Merrill RA, Strack S, Higgs HN.

Elife. 2015 Nov 26;4:e11553. doi: 10.7554/eLife.11553.

14.

Cell type-dependent mechanisms for formin-mediated assembly of filopodia.

Young LE, Heimsath EG, Higgs HN.

Mol Biol Cell. 2015 Dec 15;26(25):4646-59. doi: 10.1091/mbc.E15-09-0626. Epub 2015 Oct 7.

15.

Assembly and turnover of short actin filaments by the formin INF2 and profilin.

Gurel PS, A M, Guo B, Shu R, Mierke DF, Higgs HN.

J Biol Chem. 2015 Sep 11;290(37):22494-506. doi: 10.1074/jbc.M115.670166. Epub 2015 Jun 29.

16.

The formin FMNL3 assembles plasma membrane protrusions that participate in cell-cell adhesion.

Gauvin TJ, Young LE, Higgs HN.

Mol Biol Cell. 2015 Feb 1;26(3):467-77. doi: 10.1091/mbc.E14-07-1247. Epub 2014 Nov 26.

17.

Novel roles for actin in mitochondrial fission.

Hatch AL, Gurel PS, Higgs HN.

J Cell Sci. 2014 Nov 1;127(Pt 21):4549-60. doi: 10.1242/jcs.153791. Epub 2014 Sep 12.

18.

Monitoring ATP hydrolysis and ATPase inhibitor screening using (1)H NMR.

Guo B, Gurel PS, Shu R, Higgs HN, Pellegrini M, Mierke DF.

Chem Commun (Camb). 2014 Oct 18;50(81):12037-9. doi: 10.1039/c4cc04399e.

19.

Connecting the cytoskeleton to the endoplasmic reticulum and Golgi.

Gurel PS, Hatch AL, Higgs HN.

Curr Biol. 2014 Jul 21;24(14):R660-R672. doi: 10.1016/j.cub.2014.05.033. Review.

20.

Nanostructured self-assembly of inverted formin 2 (INF2) and F-actin-INF2 complexes revealed by atomic force microscopy.

Sharma S, Grintsevich EE, Woo J, Gurel PS, Higgs HN, Reisler E, Gimzewski JK.

Langmuir. 2014 Jul 1;30(25):7533-9. doi: 10.1021/la501748x. Epub 2014 Jun 20.

21.

A role for myosin II in mammalian mitochondrial fission.

Korobova F, Gauvin TJ, Higgs HN.

Curr Biol. 2014 Feb 17;24(4):409-14. doi: 10.1016/j.cub.2013.12.032. Epub 2014 Jan 30.

22.

Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse.

Kim J, Shapiro MJ, Bamidele AO, Gurel P, Thapa P, Higgs HN, Hedin KE, Shapiro VS, Billadeau DD.

PLoS One. 2014 Jan 13;9(1):e85090. doi: 10.1371/journal.pone.0085090. eCollection 2014.

23.

INF2-mediated severing through actin filament encirclement and disruption.

Gurel PS, Ge P, Grintsevich EE, Shu R, Blanchoin L, Zhou ZH, Reisler E, Higgs HN.

Curr Biol. 2014 Jan 20;24(2):156-64. doi: 10.1016/j.cub.2013.12.018. Epub 2014 Jan 9.

24.

Actin monomers activate inverted formin 2 by competing with its autoinhibitory interaction.

Ramabhadran V, Hatch AL, Higgs HN.

J Biol Chem. 2013 Sep 13;288(37):26847-55. doi: 10.1074/jbc.M113.472415. Epub 2013 Aug 6.

25.

Inverted formin 2 regulates actin dynamics by antagonizing Rho/diaphanous-related formin signaling.

Sun H, Schlondorff J, Higgs HN, Pollak MR.

J Am Soc Nephrol. 2013 May;24(6):917-29. doi: 10.1681/ASN.2012080834. Epub 2013 Apr 25.

26.

An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2.

Korobova F, Ramabhadran V, Higgs HN.

Science. 2013 Jan 25;339(6118):464-7. doi: 10.1126/science.1228360.

27.

FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation.

Thompson ME, Heimsath EG, Gauvin TJ, Higgs HN, Kull FJ.

Nat Struct Mol Biol. 2013 Jan;20(1):111-8. doi: 10.1038/nsmb.2462. Epub 2012 Dec 9.

28.

Mutations to the formin homology 2 domain of INF2 protein have unexpected effects on actin polymerization and severing.

Ramabhadran V, Gurel PS, Higgs HN.

J Biol Chem. 2012 Oct 5;287(41):34234-45. doi: 10.1074/jbc.M112.365122. Epub 2012 Aug 9.

29.

DIAPH3 governs the cellular transition to the amoeboid tumour phenotype.

Hager MH, Morley S, Bielenberg DR, Gao S, Morello M, Holcomb IN, Liu W, Mouneimne G, Demichelis F, Kim J, Solomon KR, Adam RM, Isaacs WB, Higgs HN, Vessella RL, Di Vizio D, Freeman MR.

EMBO Mol Med. 2012 Aug;4(8):743-60. doi: 10.1002/emmm.201200242. Epub 2012 May 16.

30.

The formin FMNL3 is a cytoskeletal regulator of angiogenesis.

Hetheridge C, Scott AN, Swain RK, Copeland JW, Higgs HN, Bicknell R, Mellor H.

J Cell Sci. 2012 Mar 15;125(Pt 6):1420-8. doi: 10.1242/jcs.091066. Epub 2012 Jan 24.

31.

The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends.

Heimsath EG Jr, Higgs HN.

J Biol Chem. 2012 Jan 27;287(5):3087-98. doi: 10.1074/jbc.M111.312207. Epub 2011 Nov 17.

32.

Differential interactions of the formins INF2, mDia1, and mDia2 with microtubules.

Gaillard J, Ramabhadran V, Neumanne E, Gurel P, Blanchoin L, Vantard M, Higgs HN.

Mol Biol Cell. 2011 Dec;22(23):4575-87. doi: 10.1091/mbc.E11-07-0616. Epub 2011 Oct 12.

33.

Splice variant-specific cellular function of the formin INF2 in maintenance of Golgi architecture.

Ramabhadran V, Korobova F, Rahme GJ, Higgs HN.

Mol Biol Cell. 2011 Dec;22(24):4822-33. doi: 10.1091/mbc.E11-05-0457. Epub 2011 Oct 12.

34.

Rho activation of mDia formins is modulated by an interaction with inverted formin 2 (INF2).

Sun H, Schlondorff JS, Brown EJ, Higgs HN, Pollak MR.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2933-8. doi: 10.1073/pnas.1017010108. Epub 2011 Jan 28.

35.

Bi-modal regulation of a formin by srGAP2.

Mason FM, Heimsath EG, Higgs HN, Soderling SH.

J Biol Chem. 2011 Feb 25;286(8):6577-86. doi: 10.1074/jbc.M110.190397. Epub 2010 Dec 9.

36.

Discussing the morphology of actin filaments in lamellipodia.

Higgs HN.

Trends Cell Biol. 2011 Jan;21(1):2-4; author reply 4-5. doi: 10.1016/j.tcb.2010.09.010. No abstract available.

37.

Purification of recombinant acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) from H293 cells and binding studies between the enzyme and substrates using difference intrinsic fluorescence spectroscopy.

Chang CC, Miyazaki A, Dong R, Kheirollah A, Yu C, Geng Y, Higgs HN, Chang TY.

Biochemistry. 2010 Nov 23;49(46):9957-63. doi: 10.1021/bi1013936. Epub 2010 Oct 29.

38.

Assembly of filopodia by the formin FRL2 (FMNL3).

Harris ES, Gauvin TJ, Heimsath EG, Higgs HN.

Cytoskeleton (Hoboken). 2010 Dec;67(12):755-72. doi: 10.1002/cm.20485. Epub 2010 Nov 2.

39.

More on clinical renal genetics.

Grünfeld JP, Hwu W, Chien Y, Lee N, Chiang S, Dobrovolny R, Huang A, Yeh H, Chao M, Lin S, Kitagawa T, Desnick R, Hsu L, Van Keimpema L, Nevens F, Vanslembrouck R, Van Oijen G, Hoffmann A, Dekker H, De Man R, Drenth J, Alamovitch S, Plaisier E, Favrole P, Prost C, Chen Z, Van Agrmael T, Marro B, Ronco P, Zivna M, Hulkova H, Matignon M, Hodanova K, Vylet'al P, Kalbacova M, Baresova V, Sikora J, Blazkova H, Zivny J, Ivanek R, Stranecky V, Sovova J, Claes K, Lerut E, Fryns J, Hart P, Hart T, Adams J, Pawtowski A, Clemessy M, Gasc J, Gubler M, Antignac C, Elleder M, Kapp K, Grimbert P, Bleyer A, Kmoch S, Brown E, Schlöndorff J, Becker Dj, Tsukaguchi H, Uschinski A, Higgs H, Henderson J, Pollak M.

Clin J Am Soc Nephrol. 2010 Apr;5(4):563-7. doi: 10.2215/CJN.01720210. Epub 2010 Mar 25. No abstract available.

40.

Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis.

Brown EJ, Schlöndorff JS, Becker DJ, Tsukaguchi H, Tonna SJ, Uscinski AL, Higgs HN, Henderson JM, Pollak MR.

Nat Genet. 2010 Jan;42(1):72-6. doi: 10.1038/ng.505. Epub 2009 Dec 20. Erratum in: Nat Genet. 2010 Apr;42(4):361. Tonna, Stephen J [added].

41.

Isoform-selective chemical inhibition of mDia-mediated actin assembly.

Gauvin TJ, Fukui J, Peterson JR, Higgs HN.

Biochemistry. 2009 Oct 13;48(40):9327-9. doi: 10.1021/bi901354z.

42.

INF2 is an endoplasmic reticulum-associated formin protein.

Chhabra ES, Ramabhadran V, Gerber SA, Higgs HN.

J Cell Sci. 2009 May 1;122(Pt 9):1430-40. doi: 10.1242/jcs.040691. Epub 2009 Apr 14.

43.

The filamentous actin cross-linking/bundling activity of mammalian formins.

Esue O, Harris ES, Higgs HN, Wirtz D.

J Mol Biol. 2008 Dec 12;384(2):324-34. doi: 10.1016/j.jmb.2008.09.043. Epub 2008 Sep 26.

PMID:
18835565
44.

Arp2 depletion inhibits sheet-like protrusions but not linear protrusions of fibroblasts and lymphocytes.

Nicholson-Dykstra SM, Higgs HN.

Cell Motil Cytoskeleton. 2008 Nov;65(11):904-22. doi: 10.1002/cm.20312.

45.

The many faces of actin: matching assembly factors with cellular structures.

Chhabra ES, Higgs HN.

Nat Cell Biol. 2007 Oct;9(10):1110-21. Review.

PMID:
17909522
46.

Tropomyosin regulates elongation by formin at the fast-growing end of the actin filament.

Wawro B, Greenfield NJ, Wear MA, Cooper JA, Higgs HN, Hitchcock-DeGregori SE.

Biochemistry. 2007 Jul 10;46(27):8146-55. Epub 2007 Jun 15.

47.

Dia-interacting protein modulates formin-mediated actin assembly at the cell cortex.

Eisenmann KM, Harris ES, Kitchen SM, Holman HA, Higgs HN, Alberts AS.

Curr Biol. 2007 Apr 3;17(7):579-91.

48.
49.

Mechanistic differences in actin bundling activity of two mammalian formins, FRL1 and mDia2.

Harris ES, Rouiller I, Hanein D, Higgs HN.

J Biol Chem. 2006 May 19;281(20):14383-92. Epub 2006 Mar 23.

50.

Biochemical analysis of mammalian formin effects on actin dynamics.

Harris ES, Higgs HN.

Methods Enzymol. 2006;406:190-214.

PMID:
16472659

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