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Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland.

Cacciottolo TM, Perikari A, van der Klaauw A, Henning E, Stadler LKJ, Keogh J, Farooqi IS, Tenin G, Keavney B, Ryan E, Budd R, Bewley M, Coelho P, Rumsey W, Sanchez Y, McCafferty J, Dockrell D, Walmsley S, Whyte M, Liu Y, Choy MK, Tenin G, Abraham S, Black G, Keavney B, Ford T, Stanley B, Good R, Rocchiccioli P, McEntegart M, Watkins S, Eteiba H, Shaukat A, Lindsay M, Robertson K, Hood S, McGeoch R, McDade R, Sidik N, McCartney P, Corcoran D, Collison D, Rush C, McConnachie A, Touyz R, Oldroyd K, Berry C, Gazdagh G, Diver L, Marshall J, McGowan R, Ahmed F; DDD Study, Tobias E, Curtis E, Parsons C, Maslin K, D'Angelo S, Moon R, Crozier S, Gossiel F, Bishop N, Kennedy S, Papageorghiou A, Fraser R, Gandhi S, Prentice A, Inskip H, Godfrey K, Schoenmakers I, Javaid MK, Eastell R, Cooper C, Harvey N, Watt ER, Howden A, Mirchandani A, Coelho P, Hukelmann JL, Sadiku P, Plant TM, Cantrell DA, Whyte MKB, Walmsley SR, Mordi I, Forteath C, Wong A, Mohan M, Palmer C, Doney A, Rena G, Lang C, Gray EH, Azarian S, Riva A, Edwards H, McPhail MJW, Williams R, Chokshi S, Patel VC, Edwards LA, Page D, Miossec M, Williams S, Monaghan R, Fotiou E; CHANGE Study Collaborators, CheartED Study Collaborators, Santibanez-Koref M, Keavney B, Badat M, Mettananda S, Hua P, Schwessinger R, Hughes J, Higgs D, Davies J.

QJM. 2019 Sep 1;112(9):724-729. doi: 10.1093/qjmed/hcz175. No abstract available.


Revision shoulder arthroplasty for failed humeral head resurfacing hemiarthroplasty.

Thangarajah T, Ajami S, Coathup M, Blunn GW, Higgs D, Falworth M, Lambert S.

Shoulder Elbow. 2019 Jul;11(2 Suppl):35-41. doi: 10.1177/1758573217715256. Epub 2017 Jun 13.


Synergistic silencing of α-globin and induction of γ-globin by histone deacetylase inhibitor, vorinostat as a potential therapy for β-thalassaemia.

Mettananda S, Yasara N, Fisher CA, Taylor S, Gibbons R, Higgs D.

Sci Rep. 2019 Aug 12;9(1):11649. doi: 10.1038/s41598-019-48204-2.


Robust CRISPR/Cas9 Genome Editing of the HUDEP-2 Erythroid Precursor Line Using Plasmids and Single-Stranded Oligonucleotide Donors.

Moir-Meyer G, Cheong PL, Olijnik AA, Brown J, Knight S, King A, Kurita R, Nakamura Y, Gibbons RJ, Higgs DR, Buckle VJ, Babbs C.

Methods Protoc. 2018 Jul 30;1(3). pii: E28. doi: 10.3390/mps1030028.


The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist.

van Bemmel JG, Galupa R, Gard C, Servant N, Picard C, Davies J, Szempruch AJ, Zhan Y, Żylicz JJ, Nora EP, Lameiras S, de Wit E, Gentien D, Baulande S, Giorgetti L, Guttman M, Hughes JR, Higgs DR, Gribnau J, Heard E.

Nat Genet. 2019 Jun;51(6):1024-1034. doi: 10.1038/s41588-019-0412-0. Epub 2019 May 27.


Integrative roles of nitric oxide and hydrogen sulfide in melatonin-induced tolerance of pepper (Capsicum annuum L.) plants to iron deficiency and salt stress alone or in combination.

Kaya C, Higgs D, Ashraf M, Alyemeni MN, Ahmad P.

Physiol Plant. 2019 Apr 13. doi: 10.1111/ppl.12976. [Epub ahead of print]


Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-Specific Transcription Factors Determine Cell Fate.

Palii CG, Cheng Q, Gillespie MA, Shannon P, Mazurczyk M, Napolitani G, Price ND, Ranish JA, Morrissey E, Higgs DR, Brand M.

Cell Stem Cell. 2019 May 2;24(5):812-820.e5. doi: 10.1016/j.stem.2019.02.006. Epub 2019 Mar 14.


Potential new approaches to the management of the Hb Bart's hydrops fetalis syndrome: the most severe form of α-thalassemia.

King AJ, Higgs DR.

Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):353-360. doi: 10.1182/asheducation-2018.1.353. Review.


The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male Mice.

Young CC, Baker RM, Howlett CJ, Hryciw T, Herman JE, Higgs D, Gibbons R, Crawford H, Brown A, Pin CL.

Cell Mol Gastroenterol Hepatol. 2018 Sep 14;7(1):93-113. doi: 10.1016/j.jcmgh.2018.09.004. eCollection 2019.


Anaemia among females in child-bearing age: Relative contributions, effects and interactions of α- and β-thalassaemia.

Mettananda S, Suranjan M, Fernando R, Dias T, Mettananda C, Rodrigo R, Perera L, Gibbons R, Premawardhena A, Higgs D.

PLoS One. 2018 Nov 2;13(11):e0206928. doi: 10.1371/journal.pone.0206928. eCollection 2018.


Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains.

Oudelaar AM, Davies JOJ, Hanssen LLP, Telenius JM, Schwessinger R, Liu Y, Brown JM, Downes DJ, Chiariello AM, Bianco S, Nicodemi M, Buckle VJ, Dekker J, Higgs DR, Hughes JR.

Nat Genet. 2018 Dec;50(12):1744-1751. doi: 10.1038/s41588-018-0253-2. Epub 2018 Oct 29.


A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions.

Brown JM, Roberts NA, Graham B, Waithe D, Lagerholm C, Telenius JM, De Ornellas S, Oudelaar AM, Scott C, Szczerbal I, Babbs C, Kassouf MT, Hughes JR, Higgs DR, Buckle VJ.

Nat Commun. 2018 Sep 21;9(1):3849. doi: 10.1038/s41467-018-06248-4.


How to Tackle Challenging ChIP-Seq, with Long-Range Cross-Linking, Using ATRX as an Example.

Truch J, Telenius J, Higgs DR, Gibbons RJ.

Methods Mol Biol. 2018;1832:105-130. doi: 10.1007/978-1-4939-8663-7_6.


Advance care planning documentation strategies; goals-of-care as an alternative to not-for-resuscitation in medical and oncology patients. A pre-post controlled study on quantifiable outcomes.

Morgan DJR, Eng D, Higgs D, Beilin M, Bulsara C, Wong M, Angus L, Waldron N.

Intern Med J. 2018 Dec;48(12):1472-1480. doi: 10.1111/imj.14048.


Comparative analysis of silage fermentation and in vitro digestibility of tropical grass prepared with Acremonium and Tricoderma species producing cellulases.

Khota W, Pholsen S, Higgs D, Cai Y.

Asian-Australas J Anim Sci. 2018 Dec;31(12):1913-1922. doi: 10.5713/ajas.18.0083. Epub 2018 May 31.


Knowledge, attitudes, and practice of oncologists and oncology health care providers in promoting physical activity to cancer survivors: an international survey.

Hardcastle SJ, Kane R, Chivers P, Hince D, Dean A, Higgs D, Cohen PA.

Support Care Cancer. 2018 Nov;26(11):3711-3719. doi: 10.1007/s00520-018-4230-1. Epub 2018 May 8.


The management of infected elbow arthroplasty by two-stage revision.

Rudge WBJ, Eseonu K, Brown M, Warren S, Majed A, Bayley IL, Lambert SM, Higgs D, Falworth M.

J Shoulder Elbow Surg. 2018 May;27(5):879-886. doi: 10.1016/j.jse.2017.12.033. Epub 2018 Mar 1.


Molecular Basis and Genetic Modifiers of Thalassemia.

Mettananda S, Higgs DR.

Hematol Oncol Clin North Am. 2018 Apr;32(2):177-191. doi: 10.1016/j.hoc.2017.11.003. Review.


Phenotypic and molecular characterization of a serum-free miniature erythroid differentiation system suitable for high-throughput screening and single-cell assays.

Mettananda S, Clark K, Fisher CA, Sloane-Stanley JA, Gibbons RJ, Higgs DR.

Exp Hematol. 2018 Apr;60:10-20. doi: 10.1016/j.exphem.2018.01.001. Epub 2018 Jan 9.


Neutral genetic variation in adult Chinook salmon (Oncorhynchus tshawytscha) affects brain-to-body trade-off and brain laterality.

Wiper ML, Lehnert SJ, Heath DD, Higgs DM.

R Soc Open Sci. 2017 Dec 6;4(12):170989. doi: 10.1098/rsos.170989. eCollection 2017 Dec.


Robust detection of chromosomal interactions from small numbers of cells using low-input Capture-C.

Oudelaar AM, Davies JOJ, Downes DJ, Higgs DR, Hughes JR.

Nucleic Acids Res. 2017 Dec 15;45(22):e184. doi: 10.1093/nar/gkx1194.


Between form and function: the complexity of genome folding.

Oudelaar AM, Hanssen LLP, Hardison RC, Kassouf MT, Hughes JR, Higgs DR.

Hum Mol Genet. 2017 Oct 1;26(R2):R208-R215. doi: 10.1093/hmg/ddx306. Review.


Sasquatch: predicting the impact of regulatory SNPs on transcription factor binding from cell- and tissue-specific DNase footprints.

Schwessinger R, Suciu MC, McGowan SJ, Telenius J, Taylor S, Higgs DR, Hughes JR.

Genome Res. 2017 Oct;27(10):1730-1742. doi: 10.1101/gr.220202.117. Epub 2017 Sep 13.


Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia.

Mettananda S, Fisher CA, Hay D, Badat M, Quek L, Clark K, Hublitz P, Downes D, Kerry J, Gosden M, Telenius J, Sloane-Stanley JA, Faustino P, Coelho A, Doondeea J, Usukhbayar B, Sopp P, Sharpe JA, Hughes JR, Vyas P, Gibbons RJ, Higgs DR.

Nat Commun. 2017 Sep 4;8(1):424. doi: 10.1038/s41467-017-00479-7.


The effects of stimulus parameters on auditory evoked potentials of Carassius auratus.

Garabon JR, Higgs DM.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2017 Nov;203(11):945-951. doi: 10.1007/s00359-017-1207-3. Epub 2017 Aug 23.


DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease.

Jeziorska DM, Murray RJS, De Gobbi M, Gaentzsch R, Garrick D, Ayyub H, Chen T, Li E, Telenius J, Lynch M, Graham B, Smith AJH, Lund JN, Hughes JR, Higgs DR, Tufarelli C.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7526-E7535. doi: 10.1073/pnas.1703087114. Epub 2017 Aug 21.


Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.

Hanssen LLP, Kassouf MT, Oudelaar AM, Biggs D, Preece C, Downes DJ, Gosden M, Sharpe JA, Sloane-Stanley JA, Hughes JR, Davies B, Higgs DR.

Nat Cell Biol. 2017 Aug;19(8):952-961. doi: 10.1038/ncb3573. Epub 2017 Jul 24.


Fermentation quality and in vitro methane production of sorghum silage prepared with cellulase and lactic acid bacteria.

Khota W, Pholsen S, Higgs D, Cai Y.

Asian-Australas J Anim Sci. 2017 Nov;30(11):1568-1574. doi: 10.5713/ajas.16.0502. Epub 2017 May 14.


The chromatin remodelling factor ATRX suppresses R-loops in transcribed telomeric repeats.

Nguyen DT, Voon HPJ, Xella B, Scott C, Clynes D, Babbs C, Ayyub H, Kerry J, Sharpe JA, Sloane-Stanley JA, Butler S, Fisher CA, Gray NE, Jenuwein T, Higgs DR, Gibbons RJ.

EMBO Rep. 2017 Jun;18(6):914-928. doi: 10.15252/embr.201643078. Epub 2017 May 9.


Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo.

Simon CS, Downes DJ, Gosden ME, Telenius J, Higgs DR, Hughes JR, Costello I, Bikoff EK, Robertson EJ.

Development. 2017 Apr 1;144(7):1249-1260. doi: 10.1242/dev.147322. Epub 2017 Feb 7.


How best to identify chromosomal interactions: a comparison of approaches.

Davies JO, Oudelaar AM, Higgs DR, Hughes JR.

Nat Methods. 2017 Jan 31;14(2):125-134. doi: 10.1038/nmeth.4146. Review.


An international registry of survivors with Hb Bart's hydrops fetalis syndrome.

Songdej D, Babbs C, Higgs DR; BHFS International Consortium.

Blood. 2017 Mar 9;129(10):1251-1259. doi: 10.1182/blood-2016-08-697110. Epub 2017 Jan 5. Review.


Glenohumeral arthrodesis for recurrent types II and III shoulder instability.

Thangarajah T, Higgs D, Bayley JI, Lambert SM.

J Shoulder Elbow Surg. 2017 Apr;26(4):687-691. doi: 10.1016/j.jse.2016.09.012. Epub 2016 Nov 15.


Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia.

Mettananda S, Fisher CA, Sloane-Stanley JA, Taylor S, Oppermann U, Gibbons RJ, Higgs DR.

Haematologica. 2017 Mar;102(3):e80-e84. doi: 10.3324/haematol.2016.155655. Epub 2016 Nov 3. No abstract available.


Natural lactic acid bacteria population of tropical grasses and their fermentation factor analysis of silage prepared with cellulase and inoculant.

Khota W, Pholsen S, Higgs D, Cai Y.

J Dairy Sci. 2016 Dec;99(12):9768-9781. doi: 10.3168/jds.2016-11180. Epub 2016 Oct 13.


Beta thalassaemia intermedia due to co-inheritance of three unique alpha globin cluster duplications characterised by next generation sequencing analysis.

Clark B, Shooter C, Smith F, Brawand D, Steedman L, Oakley M, Rushton P, Rooks H, Wang X, Drousiotou A, Kyrri A, Hadjigavriel M, Will A, Fisher C, Higgs DR, Phylipsen M, Harteveld C, Kleanthous M, Thein SL.

Br J Haematol. 2018 Jan;180(1):160-164. doi: 10.1111/bjh.14294. Epub 2016 Jul 29. No abstract available.


Constrained fixed-fulcrum reverse shoulder arthroplasty improves functional outcome in epileptic patients with recurrent shoulder instability.

Thangarajah T, Higgs D, Bayley JI, Lambert SM.

World J Orthop. 2016 Jul 18;7(7):434-41. doi: 10.5312/wjo.v7.i7.434. eCollection 2016 Jul 18.


A novel 33-Gene targeted resequencing panel provides accurate, clinical-grade diagnosis and improves patient management for rare inherited anaemias.

Roy NB, Wilson EA, Henderson S, Wray K, Babbs C, Okoli S, Atoyebi W, Mixon A, Cahill MR, Carey P, Cullis J, Curtin J, Dreau H, Ferguson DJ, Gibson B, Hall G, Mason J, Morgan M, Proven M, Qureshi A, Sanchez Garcia J, Sirachainan N, Teo J, Tedgård U, Higgs D, Roberts D, Roberts I, Schuh A.

Br J Haematol. 2016 Oct;175(2):318-330. doi: 10.1111/bjh.14221. Epub 2016 Jul 19.


Genetic dissection of the α-globin super-enhancer in vivo.

Hay D, Hughes JR, Babbs C, Davies JOJ, Graham BJ, Hanssen L, Kassouf MT, Marieke Oudelaar AM, Sharpe JA, Suciu MC, Telenius J, Williams R, Rode C, Li PS, Pennacchio LA, Sloane-Stanley JA, Ayyub H, Butler S, Sauka-Spengler T, Gibbons RJ, Smith AJH, Wood WG, Higgs DR.

Nat Genet. 2016 Aug;48(8):895-903. doi: 10.1038/ng.3605. Epub 2016 Jul 4.


MicroRNAs of the miR-290-295 Family Maintain Bivalency in Mouse Embryonic Stem Cells.

Graham B, Marcais A, Dharmalingam G, Carroll T, Kanellopoulou C, Graumann J, Nesterova TB, Bermange A, Brazauskas P, Xella B, Kriaucionis S, Higgs DR, Brockdorff N, Mann M, Fisher AG, Merkenschlager M.

Stem Cell Reports. 2016 May 10;6(5):635-642. doi: 10.1016/j.stemcr.2016.03.005. Epub 2016 Apr 14.


Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants.

Perkins A, Xu X, Higgs DR, Patrinos GP, Arnaud L, Bieker JJ, Philipsen S; KLF1 Consensus Workgroup.

Blood. 2016 Apr 14;127(15):1856-62. doi: 10.1182/blood-2016-01-694331. Epub 2016 Feb 22. Review.


Newborn Screening for Sickle Cell Disease: Jamaican Experience.

Mason K, Gibson F, Gardner R, Warren L, Fisher C, Higgs D, Happich M, Kulozik A, Hambleton I, Serjeant BE, Serjeant GR.

West Indian Med J. 2015 Sep 22;65(1):18-26. doi: 10.7727/wimj.2015.492.


Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.

Masuda T, Wang X, Maeda M, Canver MC, Sher F, Funnell AP, Fisher C, Suciu M, Martyn GE, Norton LJ, Zhu C, Kurita R, Nakamura Y, Xu J, Higgs DR, Crossley M, Bauer DE, Orkin SH, Kharchenko PV, Maeda T.

Science. 2016 Jan 15;351(6270):285-9. doi: 10.1126/science.aad3312.


Characterization and application of lactic acid bacteria for tropical silage preparation.

Pholsen S, Khota W, Pang H, Higgs D, Cai Y.

Anim Sci J. 2016 Oct;87(10):1202-1211. doi: 10.1111/asj.12534. Epub 2016 Jan 21.


Understanding α-globin gene regulation and implications for the treatment of β-thalassemia.

Mettananda S, Gibbons RJ, Higgs DR.

Ann N Y Acad Sci. 2016 Mar;1368(1):16-24. doi: 10.1111/nyas.12988. Epub 2015 Dec 22. Review.


Studying epigenomics in single cells: what is feasible and what can we learn?

Wills QF, Higgs DR, Mead AJ.

Epigenomics. 2015;7(8):1231-4. doi: 10.2217/epi.15.93. Epub 2015 Dec 8. No abstract available.


Multiplexed analysis of chromosome conformation at vastly improved sensitivity.

Davies JO, Telenius JM, McGowan SJ, Roberts NA, Taylor S, Higgs DR, Hughes JR.

Nat Methods. 2016 Jan;13(1):74-80. doi: 10.1038/nmeth.3664. Epub 2015 Nov 23.


The Potential Overlapping Roles of the Ear and Lateral Line in Driving "Acoustic" Responses.

Higgs DM, Radford CA.

Adv Exp Med Biol. 2016;877:255-70. doi: 10.1007/978-3-319-21059-9_12. Review.


Hearing in Cavefishes.

Soares D, Niemiller ML, Higgs DM.

Adv Exp Med Biol. 2016;877:187-95. doi: 10.1007/978-3-319-21059-9_9. Review.


Food Shortage Causes Differential Effects on Body Composition and Tissue-Specific Gene Expression in Salmon Modified for Increased Growth Hormone Production.

Abernathy J, Panserat S, Welker T, Plagne-Juan E, Sakhrani D, Higgs DA, Audouin F, Devlin RH, Overturf K.

Mar Biotechnol (NY). 2015 Dec;17(6):753-67. doi: 10.1007/s10126-015-9654-8. Epub 2015 Aug 12.


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