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Randomised, double-blind, multicentre, mixed-methods, dose-escalation feasibility trial of mirtazapine for better treatment of severe breathlessness in advanced lung disease (BETTER-B feasibility).

Higginson IJ, Wilcock A, Johnson MJ, Bajwah S, Lovell N, Yi D, Hart SP, Crosby V, Poad H, Currow D, Best E, Brown S; BETTER-B Feasibility Trial Group.

Thorax. 2020 Jan 8. pii: thoraxjnl-2019-213879. doi: 10.1136/thoraxjnl-2019-213879. [Epub ahead of print]


What is the evidence for mirtazapine in treating cancer-related symptomatology? A systematic review.

Economos G, Lovell N, Johnston A, Higginson IJ.

Support Care Cancer. 2019 Dec 19. doi: 10.1007/s00520-019-05229-7. [Epub ahead of print] Review.


The impact of population ageing on end-of-life care in Scotland: projections of place of death and recommendations for future service provision.

Finucane AM, Bone AE, Evans CJ, Gomes B, Meade R, Higginson IJ, Murray SA.

BMC Palliat Care. 2019 Dec 12;18(1):112. doi: 10.1186/s12904-019-0490-x.


How can we achieve person-centred care for people living with HIV/AIDS? A qualitative interview study with healthcare professionals and patients in Ghana.

Abboah-Offei M, Bristowe K, Koffman J, Vanderpuye-Donton NA, Ansa G, Abas M, Higginson I, Harding R.

AIDS Care. 2019 Dec 4:1-10. doi: 10.1080/09540121.2019.1698708. [Epub ahead of print]


Short-term integrated rehabilitation for people with newly diagnosed thoracic cancer: a multi-centre randomized controlled feasibility trial.

Bayly J, Fettes L, Douglas E, Teixiera MJ, Peat N, Tunnard I, Patel V, Gao W, Wilcock A, Higginson IJ, Maddocks M.

Clin Rehabil. 2019 Dec 2:269215519888794. doi: 10.1177/0269215519888794. [Epub ahead of print]


Intention-to-Treat Analyses for Randomized Controlled Trials in Hospice/Palliative Care: The Case for Analyses to be of People Exposed to the Intervention.

Kochovska S, Huang C, Johnson MJ, Agar MR, Fallon MT, Kaasa S, Hussain JA, Portenoy RK, Higginson IJ, Currow DC.

J Pain Symptom Manage. 2019 Nov 9. pii: S0885-3924(19)30643-8. doi: 10.1016/j.jpainsymman.2019.10.026. [Epub ahead of print]


End-of-life care and place of death in adults with serious mental illness: A systematic review and narrative synthesis.

Wilson R, Hepgul N, Higginson IJ, Gao W.

Palliat Med. 2020 Jan;34(1):49-68. doi: 10.1177/0269216319867847. Epub 2019 Oct 14.


The AMBER care bundle for hospital inpatients with uncertain recovery nearing the end of life: the ImproveCare feasibility cluster RCT.

Koffman J, Yorganci E, Murtagh F, Yi D, Gao W, Barclay S, Pickles A, Higginson I, Johnson H, Wilson R, Bailey S, Ewart C, Evans C.

Health Technol Assess. 2019 Oct;23(55):1-150. doi: 10.3310/hta23550.


Equal or not? Women hold less prestigious roles at respiratory medicine conferences than men.

Raviskanthan M, Rees M, Douglass J, Sleeman K, Higginson I, Smallwood N.

Eur Respir J. 2020 Jan 23;55(1). pii: 1900701. doi: 10.1183/13993003.00701-2019. Print 2020 Jan. No abstract available.


Exploratory analyses of the Danish Palliative Care Trial (DanPaCT): a randomized trial of early specialized palliative care plus standard care versus standard care in advanced cancer patients.

Johnsen AT, Petersen MA, Sjøgren P, Pedersen L, Neergaard MA, Damkier A, Gluud C, Fayers P, Lindschou J, Strömgren AS, Nielsen JB, Higginson IJ, Groenvold M.

Support Care Cancer. 2019 Aug 13. doi: 10.1007/s00520-019-05021-7. [Epub ahead of print]


Correction: Socioeconomic position and use of healthcare in the last year of life: A systematic review and meta-analysis.

Davies JM, Sleeman KE, Leniz J, Wilson R, Higginson IJ, Verne J, Maddocks M, Murtagh FEM.

PLoS Med. 2019 Jul 18;16(7):e1002878. doi: 10.1371/journal.pmed.1002878. eCollection 2019 Jul.


Establishing key criteria to define and compare models of specialist palliative care: A mixed-methods study using qualitative interviews and Delphi survey.

Firth AM, O'Brien SM, Guo P, Seymour J, Richardson H, Bridges C, Hocaoglu MB, Grande G, Dzingina M, Higginson IJ, Murtagh FE.

Palliat Med. 2019 Sep;33(8):1114-1124. doi: 10.1177/0269216319858237. Epub 2019 Jun 28.


Holistic services for people with advanced disease and chronic or refractory breathlessness: a mixed-methods evidence synthesis.

Maddocks M, Brighton LJ, Farquhar M, Booth S, Miller S, Klass L, Tunnard I, Yi D, Gao W, Bajwah S, Man WDC, Higginson IJ.

Southampton (UK): NIHR Journals Library; 2019 Jun.


To What Extent Do the NRS and CRQ Capture Change in Patients' Experience of Breathlessness in Advanced Disease? Findings From a Mixed-Methods Double-Blind Randomized Feasibility Trial.

Lovell N, Etkind SN, Bajwah S, Maddocks M, Higginson IJ.

J Pain Symptom Manage. 2019 Sep;58(3):369-381.e7. doi: 10.1016/j.jpainsymman.2019.06.004. Epub 2019 Jun 13.


Which outcome domains are important in palliative care and when? An international expert consensus workshop, using the nominal group technique.

de Wolf-Linder S, Dawkins M, Wicks F, Pask S, Eagar K, Evans CJ, Higginson IJ, Murtagh FEM.

Palliat Med. 2019 Sep;33(8):1058-1068. doi: 10.1177/0269216319854154. Epub 2019 Jun 12.


A brief, patient- and proxy-reported outcome measure in advanced illness: Validity, reliability and responsiveness of the Integrated Palliative care Outcome Scale (IPOS).

Murtagh FE, Ramsenthaler C, Firth A, Groeneveld EI, Lovell N, Simon ST, Denzel J, Guo P, Bernhardt F, Schildmann E, van Oorschot B, Hodiamont F, Streitwieser S, Higginson IJ, Bausewein C.

Palliat Med. 2019 Sep;33(8):1045-1057. doi: 10.1177/0269216319854264. Epub 2019 Jun 12.


Understanding which people with dementia are at risk of inappropriate care and avoidable transitions to hospital near the end-of-life: a retrospective cohort study.

Leniz J, Higginson IJ, Stewart R, Sleeman KE.

Age Ageing. 2019 Sep 1;48(5):672-679. doi: 10.1093/ageing/afz052.


The escalating global burden of serious health-related suffering: projections to 2060 by world regions, age groups, and health conditions.

Sleeman KE, de Brito M, Etkind S, Nkhoma K, Guo P, Higginson IJ, Gomes B, Harding R.

Lancet Glob Health. 2019 Jul;7(7):e883-e892. doi: 10.1016/S2214-109X(19)30172-X. Epub 2019 May 22.


Patterns of emergency department attendance among older people in the last three months of life and factors associated with frequent attendance: a mortality follow-back survey.

Bone AE, Evans CJ, Henson LA, Gao W, Higginson IJ; BUILDCARE study.

Age Ageing. 2019 Sep 1;48(5):680-687. doi: 10.1093/ageing/afz043.


Electronic palliative care coordination systems (EPaCCS): a systematic review.

Leniz J, Weil A, Higginson IJ, Sleeman KE.

BMJ Support Palliat Care. 2019 May 8. pii: bmjspcare-2018-001689. doi: 10.1136/bmjspcare-2018-001689. [Epub ahead of print] Review.


Place of death and other factors associated with unnatural mortality in patients with serious mental disorders: population-based retrospective cohort study.

Wilson R, Gaughran F, Whitburn T, Higginson IJ, Gao W.

BJPsych Open. 2019 Mar;5(2):e23. doi: 10.1192/bjo.2019.5.


Symptoms and anxiety predict declining health-related quality of life in multiple myeloma: A prospective, multi-centre longitudinal study.

Ramsenthaler C, Gao W, Siegert RJ, Edmonds PM, Schey SA, Higginson IJ.

Palliat Med. 2019 May;33(5):541-551. doi: 10.1177/0269216319833588.


Socioeconomic position and use of healthcare in the last year of life: A systematic review and meta-analysis.

Davies JM, Sleeman KE, Leniz J, Wilson R, Higginson IJ, Verne J, Maddocks M, Murtagh FEM.

PLoS Med. 2019 Apr 23;16(4):e1002782. doi: 10.1371/journal.pmed.1002782. eCollection 2019 Apr. Erratum in: PLoS Med. 2019 Jul 18;16(7):e1002878.


The King's Brief Interstitial Lung Disease (KBILD) questionnaire: an updated minimal clinically important difference.

Sinha A, Patel AS, Siegert RJ, Bajwah S, Maher TM, Renzoni EA, Wells AU, Higginson IJ, Birring SS.

BMJ Open Respir Res. 2019 Feb 18;6(1):e000363. doi: 10.1136/bmjresp-2018-000363. eCollection 2019.


Symptom dimensions in people affected by long-term neurological conditions: a factor analysis of a patient-centred palliative care outcome symptom scale.

Wilson R, Hepgul N, Saha RA, Higginson IJ, Gao W.

Sci Rep. 2019 Mar 21;9(1):4972. doi: 10.1038/s41598-019-41370-3.


Service Delivery Models to Maximize Quality of Life for Older People at the End of Life: A Rapid Review.

Evans CJ, Ison L, Ellis-Smith C, Nicholson C, Costa A, Oluyase AO, Namisango E, Bone AE, Brighton LJ, Yi D, Combes S, Bajwah S, Gao W, Harding R, Ong P, Higginson IJ, Maddocks M.

Milbank Q. 2019 Mar;97(1):113-175. doi: 10.1111/1468-0009.12373. Review.


Change in multidimensional problems and quality of life over three months after HIV diagnosis: a multicentre longitudinal study in Kenya and Uganda.

Simms V, Downing J, Namisango E, Powell RA, Mwangi-Powell F, Higginson IJ, Harding R.

BMC Infect Dis. 2019 Mar 12;19(1):248. doi: 10.1186/s12879-019-3855-0.


The role of service factors on variations in place of death: an observational study.

Gao W, Chukwusa E, Verne J, Yu P, Polato G, Higginson IJ.

Southampton (UK): NIHR Journals Library; 2019 Feb.


Recommendations for services for people living with chronic breathlessness in advanced disease: Results of a transparent expert consultation.

Brighton LJ, Tunnard I, Farquhar M, Booth S, Miller S, Yi D, Gao W, Bajwah S, Man WD, Reilly CC, Ogden M, Bailey S, Ewart C, Higginson IJ, Maddocks M.

Chron Respir Dis. 2019 Jan-Dec;16:1479973118816448. doi: 10.1177/1479973118816448.


Predicting outcomes following holistic breathlessness services: A pooled analysis of individual patient data.

Brighton LJ, Gao W, Farquhar M, Booth S, Bajwah S, Man WD, Reilly CC, Yi D, Higginson IJ, Maddocks M.

Palliat Med. 2019 Apr;33(4):462-466. doi: 10.1177/0269216319830299. Epub 2019 Feb 15.


The views and experiences of older people with conservatively managed renal failure: a qualitative study of communication, information and decision-making.

Selman LE, Bristowe K, Higginson IJ, Murtagh FEM.

BMC Nephrol. 2019 Feb 4;20(1):38. doi: 10.1186/s12882-019-1230-4.


Invisible and intangible illness: a qualitative interview study of patients' experiences and understandings of conservatively managed end-stage kidney disease.

Bristowe K, Selman LE, Higginson IJ, Murtagh FEM.

Ann Palliat Med. 2019 Apr;8(2):121-129. doi: 10.21037/apm.2018.12.06. Epub 2019 Jan 3.


In response to Ballantyne and Schaefer's 'Consent and the ethical duty to participate in health data research'.

Hepgul N, Sleeman KE, Firth AM, Johnston A, Teo JTH, Bernal W, Dobson RJB, Higginson IJ.

J Med Ethics. 2019 May;45(5):351-352. doi: 10.1136/medethics-2018-105271. Epub 2019 Jan 7.


Translation and cognitive testing of the Italian Integrated Palliative Outcome Scale (IPOS) among patients and healthcare professionals.

Veronese S, Rabitti E, Costantini M, Valle A, Higginson I.

PLoS One. 2019 Jan 2;14(1):e0208536. doi: 10.1371/journal.pone.0208536. eCollection 2019.


Mirtazapine for chronic breathlessness? A review of mechanistic insights and therapeutic potential.

Lovell N, Wilcock A, Bajwah S, Etkind SN, Jolley CJ, Maddocks M, Higginson IJ.

Expert Rev Respir Med. 2019 Feb;13(2):173-180. doi: 10.1080/17476348.2019.1563486. Epub 2018 Dec 30. Review.


Finding a 'new normal' following acute illness: A qualitative study of influences on frail older people's care preferences.

Etkind SN, Lovell N, Nicholson CJ, Higginson IJ, Murtagh FE.

Palliat Med. 2019 Mar;33(3):301-311. doi: 10.1177/0269216318817706. Epub 2018 Dec 7. No abstract available.


Holistic services for people with advanced disease and chronic breathlessness: a systematic review and meta-analysis.

Brighton LJ, Miller S, Farquhar M, Booth S, Yi D, Gao W, Bajwah S, Man WD, Higginson IJ, Maddocks M.

Thorax. 2019 Mar;74(3):270-281. doi: 10.1136/thoraxjnl-2018-211589. Epub 2018 Nov 29.


A Rasch Analysis of the Integrated Palliative Care Outcome Scale.

Sandham MH, Medvedev ON, Hedgecock E, Higginson IJ, Siegert RJ.

J Pain Symptom Manage. 2019 Feb;57(2):290-296. doi: 10.1016/j.jpainsymman.2018.11.019. Epub 2018 Nov 26.


Factors associated with older people's emergency department attendance towards the end of life: a systematic review.

Bone AE, Evans CJ, Etkind SN, Sleeman KE, Gomes B, Aldridge M, Keep J, Verne J, Higginson IJ.

Eur J Public Health. 2019 Feb 1;29(1):67-74. doi: 10.1093/eurpub/cky241.


Place of death and factors associated with hospital death in patients who have died from liver disease in England: a national population-based study.

Peng JK, Higginson IJ, Gao W.

Lancet Gastroenterol Hepatol. 2019 Jan;4(1):52-62. doi: 10.1016/S2468-1253(18)30379-0. Epub 2018 Nov 22.


Validation of the short form of the International Crowding Measure in Emergency Departments: an international study.

Boyle A, Atkinson P, Basaure Verdejo C, Chan E, Clouston R, Gilligan P, Grewal K, Higginson I, Liston P, Newcombe V, Norton V, Richter S, Stoica G, Wakai A.

Eur J Emerg Med. 2019 Dec;26(6):405-411. doi: 10.1097/MEJ.0000000000000579.


Symptoms and Concerns Among Children and Young People with Life-Limiting and Life-Threatening Conditions: A Systematic Review Highlighting Meaningful Health Outcomes.

Namisango E, Bristowe K, Allsop MJ, Murtagh FEM, Abas M, Higginson IJ, Downing J, Harding R.

Patient. 2019 Feb;12(1):15-55. doi: 10.1007/s40271-018-0333-5.


Developing an integrated rehabilitation model for thoracic cancer services: views of patients, informal carers and clinicians.

Bayly J, Edwards BM, Peat N, Warwick G, Hennig IM, Arora A, Wilcock A, Higginson IJ, Maddocks M.

Pilot Feasibility Stud. 2018 Oct 18;4:160. doi: 10.1186/s40814-018-0350-0. eCollection 2018.


Symptom prevalence and quality of life of patients with end-stage liver disease: A systematic review and meta-analysis.

Peng JK, Hepgul N, Higginson IJ, Gao W.

Palliat Med. 2019 Jan;33(1):24-36. doi: 10.1177/0269216318807051. Epub 2018 Oct 22. No abstract available.


Integration of oncology and palliative care: a Lancet Oncology Commission.

Kaasa S, Loge JH, Aapro M, Albreht T, Anderson R, Bruera E, Brunelli C, Caraceni A, Cervantes A, Currow DC, Deliens L, Fallon M, Gómez-Batiste X, Grotmol KS, Hannon B, Haugen DF, Higginson IJ, Hjermstad MJ, Hui D, Jordan K, Kurita GP, Larkin PJ, Miccinesi G, Nauck F, Pribakovic R, Rodin G, Sjøgren P, Stone P, Zimmermann C, Lundeby T.

Lancet Oncol. 2018 Nov;19(11):e588-e653. doi: 10.1016/S1470-2045(18)30415-7. Epub 2018 Oct 18. Review.


Perspectives of patients, family caregivers and health professionals on the use of outcome measures in palliative care and lessons for implementation: a multi-method qualitative study.

Pinto C, Bristowe K, Witt J, Davies JM, de Wolf-Linder S, Dawkins M, Guo P, Higginson IJ, Daveson B, Murtagh FEM.

Ann Palliat Med. 2018 Oct;7(Suppl 3):S137-S150. doi: 10.21037/apm.2018.09.02.


Control and Context Are Central for People With Advanced Illness Experiencing Breathlessness: A Systematic Review and Thematic Synthesis.

Lovell N, Etkind SN, Bajwah S, Maddocks M, Higginson IJ.

J Pain Symptom Manage. 2019 Jan;57(1):140-155.e2. doi: 10.1016/j.jpainsymman.2018.09.021. Epub 2018 Oct 4.


The future of end-of-life care.

Bone AE, Evans CJ, Higginson IJ.

Lancet. 2018 Sep 15;392(10151):915-916. doi: 10.1016/S0140-6736(18)31823-3. No abstract available.


A Population-Based Conceptual Framework for Evaluating the Role of Healthcare Services in Place of Death.

Gao W, Huque S, Morgan M, Higginson IJ.

Healthcare (Basel). 2018 Aug 30;6(3). pii: E107. doi: 10.3390/healthcare6030107.


What should we do about crowding in emergency departments?

Higginson I, Boyle A.

Br J Hosp Med (Lond). 2018 Sep 2;79(9):500-503. doi: 10.12968/hmed.2018.79.9.500.


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