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Principal component and correlation Analysis of biochemical and endocrine markers in a healthy pediatric population (CALIPER).

Higgins V, Hooshmand S, Adeli K.

Clin Biochem. 2019 Feb 11. pii: S0009-9120(18)31003-8. doi: 10.1016/j.clinbiochem.2019.02.004. [Epub ahead of print]


High-Sensitivity Generation 5 Cardiac Troponin T Sex- and Age-Specific 99th Percentiles in the CALIPER Cohort of Healthy Children and Adolescents.

Bohn MK, Higgins V, Kavsak P, Hoffman B, Adeli K.

Clin Chem. 2019 Feb 8. pii: clinchem.2018.299156. doi: 10.1373/clinchem.2018.299156. [Epub ahead of print] No abstract available.


Pediatric reference intervals for clinical chemistry assays on Siemens ADVIA XPT/1800 and Dimension EXL in the CALIPER cohort of healthy children and adolescents.

Tahmasebi H, Higgins V, Woroch A, Asgari S, Adeli K.

Clin Chim Acta. 2019 Mar;490:88-97. doi: 10.1016/j.cca.2018.12.011. Epub 2018 Dec 12.


Ten simple rules for measuring the impact of workshops.

Sufi S, Nenadic A, Silva R, Duckles B, Simera I, de Beyer JA, Struthers C, Nurmikko-Fuller T, Bellis L, Miah W, Wilde A, Emsley I, Philippe O, Balzano M, Coelho S, Ford H, Jones C, Higgins V.

PLoS Comput Biol. 2018 Aug 30;14(8):e1006191. doi: 10.1371/journal.pcbi.1006191. eCollection 2018 Aug.


Pediatric reference intervals for calculated LDL cholesterol, non-HDL cholesterol, and remnant cholesterol in the healthy CALIPER cohort.

Higgins V, Asgari S, Chan MK, Adeli K.

Clin Chim Acta. 2018 Nov;486:129-134. doi: 10.1016/j.cca.2018.07.028. Epub 2018 Jul 17.


Influence of ethnicity on population reference values for biochemical markers.

Tahmasebi H, Trajcevski K, Higgins V, Adeli K.

Crit Rev Clin Lab Sci. 2018 Aug;55(5):359-375. doi: 10.1080/10408363.2018.1476455. Epub 2018 Jun 6.


Important considerations for interpreting biochemical tests in children.

Adeli K, Higgins V, Trajcevski K, Palmert MR.

BMJ. 2018 May 24;361:k1950. doi: 10.1136/bmj.k1950. No abstract available.


Pediatric decision limits for lipid parameters in the Brazilian population.

Higgins V, Adeli K.

J Pediatr (Rio J). 2018 May 17. pii: S0021-7557(18)30560-6. doi: 10.1016/j.jped.2018.05.002. [Epub ahead of print] No abstract available.


Verification of reference intervals in routine clinical laboratories: practical challenges and recommendations.

Ozarda Y, Higgins V, Adeli K.

Clin Chem Lab Med. 2018 Dec 19;57(1):30-37. doi: 10.1515/cclm-2018-0059.


Laboratory reference intervals in the assessment of iron status in young children.

Parkin PC, Hamid J, Borkhoff CM, Abdullah K, Atenafu EG, Birken CS, Maguire JL, Azad A, Higgins V, Adeli K.

BMJ Paediatr Open. 2017 Aug 31;1(1):e000074. doi: 10.1136/bmjpo-2017-000074. eCollection 2017.


Pediatric reference intervals for 1,25-dihydroxyvitamin D using the DiaSorin LIAISON XL assay in the healthy CALIPER cohort.

Higgins V, Truong D, White-Al Habeeb NMA, Fung AWS, Hoffman B, Adeli K.

Clin Chem Lab Med. 2018 May 24;56(6):964-972. doi: 10.1515/cclm-2017-0767.


CLSI-based transference and verification of CALIPER pediatric reference intervals for 29 Ortho VITROS 5600 chemistry assays.

Higgins V, Truong D, Woroch A, Chan MK, Tahmasebi H, Adeli K.

Clin Biochem. 2018 Mar;53:93-103. doi: 10.1016/j.clinbiochem.2017.12.011. Epub 2018 Jan 4.


Redefining Cut-Points for High Symptom Burden of the Global Initiative for Chronic Obstructive Lung Disease Classification in 18,577 Patients With Chronic Obstructive Pulmonary Disease.

Smid DE, Franssen FME, Gonik M, Miravitlles M, Casanova C, Cosio BG, de Lucas-Ramos P, Marin JM, Martinez C, Mir I, Soriano JB, de Torres JP, Agusti A, Atalay NB, Billington J, Boutou AK, Brighenti-Zogg S, Chaplin E, Coster S, Dodd JW, Dürr S, Fernandez-Villar A, Groenen MTJ, Guimarães M, Hejduk K, Higgins V, Hopkinson NS, Horita N, Houben-Wilke S, Janssen DJA, Jehn M, Joerres R, Karch A, Kelly JL, Kim YI, Kimura H, Koblizek V, Kocks JH, Kon SSC, Kwon N, Ladeira I, Lee SD, Leuppi JD, Locantore N, Lopez-Campos JL, D-C Man W, Maricic L, Mendoza L, Miedinger D, Mihaltan F, Minami S, van der Molen T, Murrells TJ, Nakken N, Nishijima Y, Norman IJ, Novotna B, O'Donnell DE, Ogata Y, Pereira ED, Piercy J, Price D, Pothirat C, Raghavan N, Ringbaek T, Sajkov D, Sigari N, Singh S, Small M, da Silva GF, Tanner RJ, Tsiligianni IG, Tulek B, Tzanakis N, Vanfleteren LEGW, Watz H, Webb KA, Wouters EFM, Xie GG, Yoshikawa M, Spruit MA.

J Am Med Dir Assoc. 2017 Dec 1;18(12):1097.e11-1097.e24. doi: 10.1016/j.jamda.2017.09.003. Review.


Postprandial Dyslipidemia: Pathophysiology and Cardiovascular Disease Risk Assessment.

Higgins V, Adeli K.

EJIFCC. 2017 Oct 10;28(3):168-184. eCollection 2017 Oct.


Reasons for discontinuation of GLP1 receptor agonists: data from a real-world cross-sectional survey of physicians and their patients with type 2 diabetes.

Sikirica MV, Martin AA, Wood R, Leith A, Piercy J, Higgins V.

Diabetes Metab Syndr Obes. 2017 Sep 29;10:403-412. doi: 10.2147/DMSO.S141235. eCollection 2017.


The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper.

Adeli K, Higgins V, Trajcevski K, White-Al Habeeb N.

Crit Rev Clin Lab Sci. 2017 Sep;54(6):358-413. doi: 10.1080/10408363.2017.1379945. Epub 2017 Oct 11. Review.


Reference interval estimation: Methodological comparison using extensive simulations and empirical data.

Daly CH, Higgins V, Adeli K, Grey VL, Hamid JS.

Clin Biochem. 2017 Dec;50(18):1145-1158. doi: 10.1016/j.clinbiochem.2017.07.005. Epub 2017 Jul 19.


Pediatric reference intervals for 29 Ortho VITROS 5600 immunoassays using the CALIPER cohort of healthy children and adolescents.

Higgins V, Fung AWS, Chan MK, Macri J, Adeli K.

Clin Chem Lab Med. 2018 Jan 26;56(2):327-340. doi: 10.1515/cclm-2017-0349.


Role of resveratrol in the management of insulin resistance and related conditions: Mechanism of action.

Abbasi Oshaghi E, Goodarzi MT, Higgins V, Adeli K.

Crit Rev Clin Lab Sci. 2017 Jun;54(4):267-293. doi: 10.1080/10408363.2017.1343274. Epub 2017 Jul 13. Review.


National Survey of Adult and Pediatric Reference Intervals in Clinical Laboratories across Canada: A Report of the CSCC Working Group on Reference Interval Harmonization.

Adeli K, Higgins V, Seccombe D, Collier CP, Balion CM, Cembrowski G, Venner AA, Shaw J; CSCC Reference Interval Harmonization (hRI) Working Group.

Clin Biochem. 2017 Nov;50(16-17):925-935. doi: 10.1016/j.clinbiochem.2017.06.006. Epub 2017 Jun 21.


Pediatric Reference Intervals for Biochemical Markers: Gaps and Challenges, Recent National Initiatives and Future Perspectives.

Tahmasebi H, Higgins V, Fung AWS, Truong D, White-Al Habeeb NMA, Adeli K.

EJIFCC. 2017 Mar 8;28(1):43-63. eCollection 2017 Mar.


Pediatric Metabolic Syndrome: Pathophysiology and Laboratory Assessment.

Higgins V, Adeli K.

EJIFCC. 2017 Mar 8;28(1):25-42. eCollection 2017 Mar.


Social Behavior and Impairments in Social Cognition Following Traumatic Brain Injury.

May M, Milders M, Downey B, Whyte M, Higgins V, Wojcik Z, Amin S, O'Rourke S.

J Int Neuropsychol Soc. 2017 May;23(5):400-411. doi: 10.1017/S1355617717000182. Epub 2017 Apr 12.


Trends in medication use in patients with type 2 diabetes mellitus: a long-term view of real-world treatment between 2000 and 2015.

Higgins V, Piercy J, Roughley A, Milligan G, Leith A, Siddall J, Benford M.

Diabetes Metab Syndr Obes. 2016 Nov 1;9:371-380. eCollection 2016.


Biosecurity and the management of emergency animal disease among commercial beef producers in New South Wales and Queensland (Australia).

Hernández-Jover M, Higgins V, Bryant M, Rast L, McShane C.

Prev Vet Med. 2016 Nov 1;134:92-102. doi: 10.1016/j.prevetmed.2016.10.005. Epub 2016 Oct 6.


Body mass index relates weight to height differently in women and older adults: serial cross-sectional surveys in England (1992-2011).

Sperrin M, Marshall AD, Higgins V, Renehan AG, Buchan IE.

J Public Health (Oxf). 2016 Sep;38(3):607-613. Epub 2015 Jun 1.


Health Status of Patients With Chronic Obstructive Pulmonary Disease by Symptom Level.

Marvel J, Yu TC, Wood R, Higgins VS, Make BJ.

Chronic Obstr Pulm Dis. 2016 May 5;3(3):643-652. doi: 10.15326/jcopdf.3.3.2015.0177.


Establishing the relationship of inhaler satisfaction, treatment adherence, and patient outcomes: a prospective, real-world, cross-sectional survey of US adult asthma patients and physicians.

Price D, Harrow B, Small M, Pike J, Higgins V.

World Allergy Organ J. 2015 Sep 10;8(1):26. doi: 10.1186/s40413-015-0075-y. eCollection 2015.


Transference of CALIPER pediatric reference intervals to biochemical assays on the Roche cobas 6000 and the Roche Modular P.

Higgins V, Chan MK, Nieuwesteeg M, Hoffman BR, Bromberg IL, Gornall D, Randell E, Adeli K.

Clin Biochem. 2016 Jan;49(1-2):139-49. doi: 10.1016/j.clinbiochem.2015.08.018. Epub 2015 Aug 19.


Physician-Patient Concordance in Pharmacological Management of Patients with COPD.

Small M, Higgins V, Lees A, Johns N, Mastrangelo A, Nazareth T, Turner SJ.

COPD. 2015;12(5):473-83.


Complex biological profile of hematologic markers across pediatric, adult, and geriatric ages: establishment of robust pediatric and adult reference intervals on the basis of the Canadian Health Measures Survey.

Adeli K, Raizman JE, Chen Y, Higgins V, Nieuwesteeg M, Abdelhaleem M, Wong SL, Blais D.

Clin Chem. 2015 Aug;61(8):1075-86. doi: 10.1373/clinchem.2015.240531. Epub 2015 Jun 4.


Biochemical marker reference values across pediatric, adult, and geriatric ages: establishment of robust pediatric and adult reference intervals on the basis of the Canadian Health Measures Survey.

Adeli K, Higgins V, Nieuwesteeg M, Raizman JE, Chen Y, Wong SL, Blais D.

Clin Chem. 2015 Aug;61(8):1049-62. doi: 10.1373/clinchem.2015.240515. Epub 2015 Jun 4.


A Systems Biology Approach to Understanding the Mechanisms of Action of an Alternative Anticancer Compound in Comparison to Cisplatin.

Wright EP, Padula MP, Higgins VJ, Aldrich-Wright JR, Coorssen JR.

Proteomes. 2014 Nov 10;2(4):501-526. doi: 10.3390/proteomes2040501.


Establishing the Relationship of Inhaler Satisfaction, Adherence, Smoking History and Allergic Rhinitis With Patient Outcomes: Real World Observations in US Adult Asthma Patients.

Harrow B, Price D, Pike J, Higgins V, Small M, Piercy J.

Value Health. 2014 Nov;17(7):A599. doi: 10.1016/j.jval.2014.08.2074. Epub 2014 Oct 26. No abstract available.


Real-world characterization and differentiation of the Global Initiative for Chronic Obstructive Lung Disease strategy classification.

Price DB, Baker CL, Zou KH, Higgins VS, Bailey JT, Pike JS.

Int J Chron Obstruct Pulmon Dis. 2014 May 28;9:551-61. doi: 10.2147/COPD.S62104. eCollection 2014.


Understanding the GOLD 2011 Strategy as applied to a real-world COPD population.

Vestbo J, Vogelmeier C, Small M, Higgins V.

Respir Med. 2014 May;108(5):729-36. doi: 10.1016/j.rmed.2014.03.002. Epub 2014 Mar 14.


Impact of physician specialty on classification of physician-perceived patient severity for patients with osteoarthritis.

Bailey J, Hawker GA, Wood R, Cappelleri JC, Higgins V, Joyce N, Hsu MA.

Osteoarthritis Cartilage. 2014 May;22(5):647-51. doi: 10.1016/j.joca.2014.03.001. Epub 2014 Mar 12.


Impact of night-time symptoms in COPD: a real-world study in five European countries.

Price D, Small M, Milligan G, Higgins V, Gil EG, Estruch J.

Int J Chron Obstruct Pulmon Dis. 2013;8:595-603. doi: 10.2147/COPD.S48570. Epub 2013 Nov 27.


Impact of patients' satisfaction with their inhalers on treatment compliance and health status in COPD.

Chrystyn H, Small M, Milligan G, Higgins V, Gil EG, Estruch J.

Respir Med. 2014 Feb;108(2):358-65. doi: 10.1016/j.rmed.2013.09.021. Epub 2013 Oct 2.


Real world COPD: association of morning symptoms with clinical and patient reported outcomes.

Roche N, Small M, Broomfield S, Higgins V, Pollard R.

COPD. 2013 Dec;10(6):679-86. doi: 10.3109/15412555.2013.844784. Epub 2013 Oct 15.


Transcriptomic insights into the molecular response of Saccharomyces cerevisiae to linoleic acid hydroperoxide.

O'Doherty PJ, Lyons V, Higgins VJ, Rogers PJ, Bailey TD, Wu MJ.

Free Radic Res. 2013 Dec;47(12):1054-65. doi: 10.3109/10715762.2013.849344. Epub 2013 Oct 21.


Slowing down of adult body mass index trend increases in England: a latent class analysis of cross-sectional surveys (1992-2010).

Sperrin M, Marshall AD, Higgins V, Buchan IE, Renehan AG.

Int J Obes (Lond). 2014 Jun;38(6):818-24. doi: 10.1038/ijo.2013.161. Epub 2013 Sep 2.


Superoxide radicals have a protective role during H2O2 stress.

Thorpe GW, Reodica M, Davies MJ, Heeren G, Jarolim S, Pillay B, Breitenbach M, Higgins VJ, Dawes IW.

Mol Biol Cell. 2013 Sep;24(18):2876-84. doi: 10.1091/mbc.E13-01-0052. Epub 2013 Jul 17.


The Saccharomyces cerevisiae transcriptome as a mirror of phytochemical variation in complex extracts of Equisetum arvense from America, China, Europe and India.

Cook R, Hennell JR, Lee S, Khoo CS, Carles MC, Higgins VJ, Govindaraghavan S, Sucher NJ.

BMC Genomics. 2013 Jul 4;14:445. doi: 10.1186/1471-2164-14-445.


Identification of the molecular mechanisms underlying the cytotoxic action of a potent platinum metallointercalator.

Wang S, Higgins VJ, Aldrich-Wright JR, Wu MJ.

J Chem Biol. 2012 Apr;5(2):51-61. doi: 10.1007/s12154-011-0070-x. Epub 2011 Dec 6.


Comparative analyses of cytotoxicity and molecular mechanisms between platinum metallointercalators and cisplatin.

Wang S, Wu MJ, Higgins VJ, Aldrich-Wright JR.

Metallomics. 2012 Aug;4(9):950-9. doi: 10.1039/c2mt20102j.


Ethnicity and childhood overweight/obesity in England.

Higgins V, Dale A.

Pediatr Obes. 2012 Jun;7(3):e22-6. doi: 10.1111/j.2047-6310.2012.00051.x. Epub 2012 Apr 11.


Delineation of the molecular mechanism for disulfide stress-induced aluminium toxicity.

Wu MJ, Murphy PA, O'Doherty PJ, Mieruszynski S, Jones M, Kersaitis C, Rogers PJ, Bailey TD, Higgins VJ.

Biometals. 2012 Jun;25(3):553-61. doi: 10.1007/s10534-012-9534-x. Epub 2012 Mar 9.


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