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The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1.

Samarakoon R, Higgins SP, Higgins CE, Higgins PJ.

Biomolecules. 2019 Aug 3;9(8). pii: E341. doi: 10.3390/biom9080341. Review.


TGF-β1-p53 cooperativity regulates a profibrotic genomic program in the kidney: molecular mechanisms and clinical implications.

Higgins CE, Tang J, Mian BM, Higgins SP, Gifford CC, Conti DJ, Meldrum KK, Samarakoon R, Higgins PJ.

FASEB J. 2019 Oct;33(10):10596-10606. doi: 10.1096/fj.201900943R. Epub 2019 Jul 6.


Rac-GTPase promotes fibrotic TGF-β1 signaling and chronic kidney disease via EGFR, p53, and Hippo/YAP/TAZ pathways.

Patel S, Tang J, Overstreet JM, Anorga S, Lian F, Arnouk A, Goldschmeding R, Higgins PJ, Samarakoon R.

FASEB J. 2019 Sep;33(9):9797-9810. doi: 10.1096/fj.201802489RR. Epub 2019 May 16.


Multi-state study of Enterobacteriaceae harboring extended-spectrum beta-lactamase and carbapenemase genes in U.S. drinking water.

Tanner WD, VanDerslice JA, Goel RK, Leecaster MK, Fisher MA, Olstadt J, Gurley CM, Morris AG, Seely KA, Chapman L, Korando M, Shabazz KA, Stadsholt A, VanDeVelde J, Braun-Howland E, Minihane C, Higgins PJ, Deras M, Jaber O, Jette D, Gundlapalli AV.

Sci Rep. 2019 Mar 8;9(1):3938. doi: 10.1038/s41598-019-40420-0.


Molecular biomarkers of Graves' ophthalmopathy.

Longo CM, Higgins PJ.

Exp Mol Pathol. 2019 Feb;106:1-6. doi: 10.1016/j.yexmp.2018.11.004. Epub 2018 Nov 8. Review.


Deregulation of Negative Controls on TGF-β1 Signaling in Tumor Progression.

Tang J, Gifford CC, Samarakoon R, Higgins PJ.

Cancers (Basel). 2018 May 25;10(6). pii: E159. doi: 10.3390/cancers10060159. Review.


The Cytoskeletal Network Regulates Expression of the Profibrotic Genes PAI-1 and CTGF in Vascular Smooth Muscle Cells.

Samarakoon R, Higgins PJ.

Adv Pharmacol. 2018;81:79-94. doi: 10.1016/bs.apha.2017.08.006. Epub 2017 Oct 31. Review.


Deregulation of Hippo-TAZ pathway during renal injury confers a fibrotic maladaptive phenotype.

Anorga S, Overstreet JM, Falke LL, Tang J, Goldschmeding RG, Higgins PJ, Samarakoon R.

FASEB J. 2018 May;32(5):2644-2657. doi: 10.1096/fj.201700722R. Epub 2018 Jan 3.


TGF-β1/p53 signaling in renal fibrogenesis.

Higgins SP, Tang Y, Higgins CE, Mian B, Zhang W, Czekay RP, Samarakoon R, Conti DJ, Higgins PJ.

Cell Signal. 2018 Mar;43:1-10. doi: 10.1016/j.cellsig.2017.11.005. Epub 2017 Nov 28. Review.


Integration of Canonical and Noncanonical Pathways in TLR4 Signaling: Complex Regulation of the Wound Repair Program.

McKeown-Longo PJ, Higgins PJ.

Adv Wound Care (New Rochelle). 2017 Oct 1;6(10):320-329. doi: 10.1089/wound.2017.0736. Review.


Insights into cellular and molecular basis for urinary tract infection in autosomal-dominant polycystic kidney disease.

Gao C, Zhang L, Zhang Y, Wallace DP, Lopez-Soler RI, Higgins PJ, Zhang W.

Am J Physiol Renal Physiol. 2017 Nov 1;313(5):F1077-F1083. doi: 10.1152/ajprenal.00279.2017. Epub 2017 Aug 9. Review.


Disulfide bond disrupting agents activate the unfolded protein response in EGFR- and HER2-positive breast tumor cells.

Ferreira RB, Wang M, Law ME, Davis BJ, Bartley AN, Higgins PJ, Kilberg MS, Santostefano KE, Terada N, Heldermon CD, Castellano RK, Law BK.

Oncotarget. 2017 Apr 25;8(17):28971-28989. doi: 10.18632/oncotarget.15952.


Development and Diseases of the Collecting Duct System.

Chen L, Higgins PJ, Zhang W.

Results Probl Cell Differ. 2017;60:165-203. doi: 10.1007/978-3-319-51436-9_7. Review. Erratum in: Results Probl Cell Differ. 2017;60:E1.


Erratum to: Development and Diseases of the Collecting Duct System.

Chen L, Higgins PJ, Zhang W.

Results Probl Cell Differ. 2017;60:E1. doi: 10.1007/978-3-319-51436-9_14. No abstract available.


CUB domain-containing protein 1 and the epidermal growth factor receptor cooperate to induce cell detachment.

Law ME, Ferreira RB, Davis BJ, Higgins PJ, Kim JS, Castellano RK, Chen S, Luesch H, Law BK.

Breast Cancer Res. 2016 Aug 5;18(1):80. doi: 10.1186/s13058-016-0741-1.


Loss of expression of protein phosphatase magnesium-dependent 1A during kidney injury promotes fibrotic maladaptive repair.

Samarakoon R, Rehfuss A, Khakoo NS, Falke LL, Dobberfuhl AD, Helo S, Overstreet JM, Goldschmeding R, Higgins PJ.

FASEB J. 2016 Oct;30(10):3308-3320. Epub 2016 Jun 21.


Chemical Antagonists of Plasminogen Activator Inhibitor-1: Mechanisms of Action and Therapeutic Potential in Vascular Disease.

Simone TM, Higgins SP, Higgins CE, Lennartz MR, Higgins PJ.

J Mol Genet Med. 2014 Oct;8(3). pii: 125. No abstract available.


Targeted Inhibition of PAI-1 Activity Impairs Epithelial Migration and Wound Closure Following Cutaneous Injury.

Simone TM, Longmate WM, Law BK, Higgins PJ.

Adv Wound Care (New Rochelle). 2015 Jun 1;4(6):321-328.


Loss of tumour suppressor PTEN expression in renal injury initiates SMAD3- and p53-dependent fibrotic responses.

Samarakoon R, Helo S, Dobberfuhl AD, Khakoo NS, Falke L, Overstreet JM, Goldschmeding R, Higgins PJ.

J Pathol. 2015 Aug;236(4):421-32. doi: 10.1002/path.4538. Epub 2015 Apr 27.


A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage.

Simone TM, Higgins SP, Archambeault J, Higgins CE, Ginnan RG, Singer H, Higgins PJ.

Cell Signal. 2015 May;27(5):923-33. doi: 10.1016/j.cellsig.2015.01.009. Epub 2015 Jan 22.


Tumor suppressor ataxia telangiectasia mutated functions downstream of TGF-β1 in orchestrating profibrotic responses.

Overstreet JM, Samarakoon R, Cardona-Grau D, Goldschmeding R, Higgins PJ.

FASEB J. 2015 Apr;29(4):1258-68. doi: 10.1096/fj.14-262527. Epub 2014 Dec 5.


The basic helix-loop-helix/leucine zipper transcription factor USF2 integrates serum-induced PAI-1 expression and keratinocyte growth.

Qi L, Higgins CE, Higgins SP, Law BK, Simone TM, Higgins PJ.

J Cell Biochem. 2014 Oct;115(10):1840-7. doi: 10.1002/jcb.24861.


SERPINE1: A Molecular Switch in the Proliferation-Migration Dichotomy in Wound-"Activated" Keratinocytes.

Simone TM, Higgins CE, Czekay RP, Law BK, Higgins SP, Archambeault J, Kutz SM, Higgins PJ.

Adv Wound Care (New Rochelle). 2014 Mar 1;3(3):281-290. Review.


Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity.

Overstreet JM, Samarakoon R, Meldrum KK, Higgins PJ.

Cell Signal. 2014 Jul;26(7):1427-36. doi: 10.1016/j.cellsig.2014.02.017. Epub 2014 Mar 5.


Small Molecule Targeting of PAI-1 Function: A New Therapeutic Approach for Treatment of Vascular Stenosis.

Simone TM, Archambeault J, Higgins PJ.

J Mol Genet Med. 2013 Jul 8;7(2). pii: 1000059. No abstract available.


Enhancing the function of CD34(+) cells by targeting plasminogen activator inhibitor-1.

Hazra S, Stepps V, Bhatwadekar AD, Caballero S, Boulton ME, Higgins PJ, Nikonova EV, Pepine CJ, Thut C, Finney EM, Stone DJ, Bartelmez SH, Grant MB.

PLoS One. 2013 Nov 1;8(11):e79067. doi: 10.1371/journal.pone.0079067. eCollection 2013.


Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species.

Samarakoon R, Dobberfuhl AD, Cooley C, Overstreet JM, Patel S, Goldschmeding R, Meldrum KK, Higgins PJ.

Cell Signal. 2013 Nov;25(11):2198-209. doi: 10.1016/j.cellsig.2013.07.007. Epub 2013 Jul 18.


Ureteral Obstruction-Induced Renal Fibrosis: An In Vivo Platform for Mechanistic Discovery and Therapeutic Intervention.

Dobberfuhl AD, Samarakoon R, Higgins CE, Mian BM, Overstreet JM, Higgins SP, Kogan BA, Higgins PJ.

Cell Dev Biol. 2012;1(3). pii: e107. Epub 2012 Jul 3. No abstract available.


Drugging the undruggable: transcription therapy for cancer.

Yan C, Higgins PJ.

Biochim Biophys Acta. 2013 Jan;1835(1):76-85. doi: 10.1016/j.bbcan.2012.11.002. Epub 2012 Nov 9. Review.


TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities.

Samarakoon R, Overstreet JM, Higgins PJ.

Cell Signal. 2013 Jan;25(1):264-8. doi: 10.1016/j.cellsig.2012.10.003. Epub 2012 Oct 11. Review.


Caring for children of parents with frontotemporal degeneration: a report of the AFTD Task Force on Families With Children.

Denny SS, Morhardt D, Gaul JE, Lester P, Andersen G, Higgins PJ, Nee L.

Am J Alzheimers Dis Other Demen. 2012 Dec;27(8):568-78. doi: 10.1177/1533317512459791. Epub 2012 Oct 3. Review.


SERPINE1 expression discriminates site-specific metastasis in human melanoma.

Klein RM, Bernstein D, Higgins SP, Higgins CE, Higgins PJ.

Exp Dermatol. 2012 Jul;21(7):551-4. doi: 10.1111/j.1600-0625.2012.01523.x.


Complex Regulation of the Pericellular Proteolytic Microenvironment during Tumor Progression and Wound Repair: Functional Interactions between the Serine Protease and Matrix Metalloproteinase Cascades.

Wilkins-Port CE, Higgins SP, Higgins CE, Kobori-Hotchkiss I, Higgins PJ.

Biochem Res Int. 2012;2012:454368. doi: 10.1155/2012/454368. Epub 2012 Feb 20.


Editorial: focus on cardiovascular disease, diabetes and vessel fibrosis.

Higgins PJ.

Recent Pat Cardiovasc Drug Discov. 2012 Apr;7(1):1. No abstract available.


A switch in RND3-RHOA signaling is critical for melanoma cell invasion following mutant-BRAF inhibition.

Klein RM, Higgins PJ.

Mol Cancer. 2011 Sep 14;10:114. doi: 10.1186/1476-4598-10-114.


PAI-1 Expression Is Required for HDACi-Induced Proliferative Arrest in ras-Transformed Renal Epithelial Cells.

Higgins SP, Higgins CE, Higgins PJ.

Int J Cell Biol. 2011;2011:710974. doi: 10.1155/2011/710974. Epub 2011 Sep 6.


PAI-1: An Integrator of Cell Signaling and Migration.

Czekay RP, Wilkins-Port CE, Higgins SP, Freytag J, Overstreet JM, Klein RM, Higgins CE, Samarakoon R, Higgins PJ.

Int J Cell Biol. 2011;2011:562481. doi: 10.1155/2011/562481. Epub 2011 Aug 3.


Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression.

Samarakoon R, Chitnis SS, Higgins SP, Higgins CE, Krepinsky JC, Higgins PJ.

PLoS One. 2011;6(7):e22896. doi: 10.1371/journal.pone.0022896. Epub 2011 Jul 28.


TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis.

Samarakoon R, Overstreet JM, Higgins SP, Higgins PJ.

Cell Tissue Res. 2012 Jan;347(1):117-28. doi: 10.1007/s00441-011-1181-y. Epub 2011 Jun 4. Review.


Anti-inflammatory activity of tetracyclines: applications to human disease.

Higgins PJ, Draper M, Nelson M.

Antiinflamm Antiallergy Agents Med Chem. 2011;10(2):132-52.


Upstream stimulatory factor-2 mediates quercetin-induced suppression of PAI-1 gene expression in human endothelial cells.

Olave NC, Grenett MH, Cadeiras M, Grenett HE, Higgins PJ.

J Cell Biochem. 2010 Oct 15;111(3):720-6. doi: 10.1002/jcb.22760.


Transient inhibition of transforming growth factor-beta1 in human diabetic CD34+ cells enhances vascular reparative functions.

Bhatwadekar AD, Guerin EP, Jarajapu YP, Caballero S, Sheridan C, Kent D, Kennedy L, Lansang MC, Ruscetti FW, Pepine CJ, Higgins PJ, Bartelmez SH, Grant MB.

Diabetes. 2010 Aug;59(8):2010-9. doi: 10.2337/db10-0287. Epub 2010 May 11.


PAI-1 mediates the TGF-beta1+EGF-induced "scatter" response in transformed human keratinocytes.

Freytag J, Wilkins-Port CE, Higgins CE, Higgins SP, Samarakoon R, Higgins PJ.

J Invest Dermatol. 2010 Sep;130(9):2179-90. doi: 10.1038/jid.2010.106. Epub 2010 Apr 29.


Linking cell structure to gene regulation: signaling events and expression controls on the model genes PAI-1 and CTGF.

Samarakoon R, Goppelt-Struebe M, Higgins PJ.

Cell Signal. 2010 Oct;22(10):1413-9. doi: 10.1016/j.cellsig.2010.03.020. Epub 2010 Apr 2. Review.

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