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Items: 1 to 50 of 72

1.

Supercoil Levels in E. coli and Salmonella Chromosomes Are Regulated by the C-Terminal 35⁻38 Amino Acids of GyrA.

Rovinskiy NS, Agbleke AA, Chesnokova ON, Higgins NP.

Microorganisms. 2019 Mar 15;7(3). pii: E81. doi: 10.3390/microorganisms7030081.

2.

Efficient, ultra-high-affinity chromatography in a one-step purification of complex proteins.

Vassylyeva MN, Klyuyev S, Vassylyev AD, Wesson H, Zhang Z, Renfrow MB, Wang H, Higgins NP, Chow LT, Vassylyev DG.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5138-E5147. doi: 10.1073/pnas.1704872114. Epub 2017 Jun 12.

3.

Species-specific supercoil dynamics of the bacterial nucleoid.

Higgins NP.

Biophys Rev. 2016 Nov;8(Suppl 1):113-121. doi: 10.1007/s12551-016-0207-9. Epub 2016 Jul 20.

4.

Topological Behavior of Plasmid DNA.

Higgins NP, Vologodskii AV.

Microbiol Spectr. 2015 Apr;3(2). doi: 10.1128/microbiolspec.PLAS-0036-2014. Review.

5.

RNA polymerase: chromosome domain boundary maker and regulator of supercoil density.

Higgins NP.

Curr Opin Microbiol. 2014 Dec;22:138-43. doi: 10.1016/j.mib.2014.10.002. Review.

6.

A human TOP2A core DNA binding X-ray structure reveals topoisomerase subunit dynamics and a potential mechanism for SUMO modulation of decatenation.

Higgins NP.

J Mol Biol. 2012 Dec 7;424(3-4):105-8. doi: 10.1016/j.jmb.2012.10.002. Epub 2012 Oct 4. No abstract available.

7.

Rates of gyrase supercoiling and transcription elongation control supercoil density in a bacterial chromosome.

Rovinskiy N, Agbleke AA, Chesnokova O, Pang Z, Higgins NP.

PLoS Genet. 2012;8(8):e1002845. doi: 10.1371/journal.pgen.1002845. Epub 2012 Aug 16.

8.

DNA topology of highly transcribed operons in Salmonella enterica serovar Typhimurium.

Booker BM, Deng S, Higgins NP.

Mol Microbiol. 2010 Dec;78(6):1348-64. doi: 10.1111/j.1365-2958.2010.07394.x. Epub 2010 Sep 30.

9.

Comparison of epidermal morphologic response to commercial antiwrinkle agents in the hairless mouse.

Bhattacharyya TK, Higgins NP, Sebastian JS, Thomas JR.

Dermatol Surg. 2009 Jul;35(7):1109-18. doi: 10.1111/j.1524-4725.2009.01196.x. Epub 2009 Apr 28.

PMID:
19438686
10.

Microarray analysis of Mu transposition in Salmonella enterica, serovar Typhimurium: transposon exclusion by high-density DNA binding proteins.

Manna D, Porwollik S, McClelland M, Tan R, Higgins NP.

Mol Microbiol. 2007 Oct;66(2):315-28. Epub 2007 Sep 10.

11.

Under DNA stress, gyrase makes the sign of the cross.

Higgins NP.

Nat Struct Mol Biol. 2007 Apr;14(4):256-8. No abstract available.

PMID:
17410088
12.
14.

Biological markers of intellectual disability in tuberous sclerosis.

Raznahan A, Higgins NP, Griffiths PD, Humphrey A, Yates JR, Bolton PF.

Psychol Med. 2007 Sep;37(9):1293-304. Epub 2007 Mar 5.

PMID:
17335641
15.

Perfusion CT helps decision making for thrombolysis when there is no clear time of onset.

Hellier KD, Hampton JL, Guadagno JV, Higgins NP, Antoun NM, Day DJ, Gillard JH, Warburton EA, Baron JC.

J Neurol Neurosurg Psychiatry. 2006 Mar;77(3):417-9.

16.

A gyrase mutant with low activity disrupts supercoiling at the replication terminus.

Pang Z, Chen R, Manna D, Higgins NP.

J Bacteriol. 2005 Nov;187(22):7773-83.

17.

Organization of supercoil domains and their reorganization by transcription.

Deng S, Stein RA, Higgins NP.

Mol Microbiol. 2005 Sep;57(6):1511-21. Review.

18.

Bacteriophage Mu targets the trinucleotide sequence CGG.

Manna D, Deng S, Breier AM, Higgins NP.

J Bacteriol. 2005 May;187(10):3586-8.

19.
20.

Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts.

Zhou D, Ren JX, Ryan TM, Higgins NP, Townes TM.

Nucleic Acids Res. 2004 Sep 8;32(16):e128.

21.

Microarray analysis of transposition targets in Escherichia coli: the impact of transcription.

Manna D, Breier AM, Higgins NP.

Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9780-5. Epub 2004 Jun 21.

22.

Transcription-induced barriers to supercoil diffusion in the Salmonella typhimurium chromosome.

Deng S, Stein RA, Higgins NP.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3398-403. Epub 2004 Mar 1.

23.
24.

Transcription induces a supercoil domain barrier in bacteriophage Mu.

Scheirer KE, Higgins NP.

Biochimie. 2001 Feb;83(2):155-9.

PMID:
11278064
25.
26.

Gyrase and Topo IV modulate chromosome domain size in vivo.

Staczek P, Higgins NP.

Mol Microbiol. 1998 Sep;29(6):1435-48.

27.
28.

Surveying a supercoil domain by using the gamma delta resolution system in Salmonella typhimurium.

Higgins NP, Yang X, Fu Q, Roth JR.

J Bacteriol. 1996 May;178(10):2825-35.

29.

C-terminal deletions can suppress temperature-sensitive mutations and change dominance in the phage Mu repressor.

Vogel JL, Geuskens V, Desmet L, Higgins NP, Toussaint A.

Genetics. 1996 Mar;142(3):661-72.

30.

End joining of genomic DNA and transgene DNA in fertilized mouse eggs.

Pawlik KM, Sun CW, Higgins NP, Townes TM.

Gene. 1995 Nov 20;165(2):173-81.

PMID:
8522172
31.
32.
33.

H-NS over-expression induces an artificial stationary phase by silencing global transcription.

McGovern V, Higgins NP, Chiz RS, Jaworski A.

Biochimie. 1994;76(10-11):1019-29.

PMID:
7748923
34.

Expression of the gene encoding the major bacterial nucleoid protein H-NS is subject to transcriptional auto-repression.

Falconi M, Higgins NP, Spurio R, Pon CL, Gualerzi CO.

Mol Microbiol. 1993 Oct;10(2):273-282. doi: 10.1111/j.1365-2958.1993.tb01953.x.

PMID:
28776853
35.

Expression of the gene encoding the major bacterial nucleotide protein H-NS is subject to transcriptional auto-repression.

Falconi M, Higgins NP, Spurio R, Pon CL, Gualerzi CO.

Mol Microbiol. 1993 Oct;10(2):273-82.

PMID:
7934818
36.
37.

Death and transfiguration among bacteria.

Higgins NP.

Trends Biochem Sci. 1992 Jun;17(6):207-11. Review.

PMID:
1323887
38.

Frameshift mutations in the bacteriophage Mu repressor gene can confer a trans-dominant virulent phenotype to the phage.

Geuskens V, Vogel JL, Grimaud R, Desmet L, Higgins NP, Toussaint A.

J Bacteriol. 1991 Oct;173(20):6578-85.

39.

Temperature-sensitive mutations in the bacteriophage Mu c repressor locate a 63-amino-acid DNA-binding domain.

Vogel JL, Li ZJ, Howe MM, Toussaint A, Higgins NP.

J Bacteriol. 1991 Oct;173(20):6568-77.

40.

Mutations altering chromosomal protein H-NS induce mini-Mu transposition.

Falconi M, McGovern V, Gualerzi C, Hillyard D, Higgins NP.

New Biol. 1991 Jun;3(6):615-25.

PMID:
1655013
41.

Topoisomerase mutants and physiological conditions control supercoiling and Z-DNA formation in vivo.

Jaworski A, Higgins NP, Wells RD, Zacharias W.

J Biol Chem. 1991 Feb 5;266(4):2576-81.

42.
43.

Subunit-specific phenotypes of Salmonella typhimurium HU mutants.

Hillyard DR, Edlund M, Hughes KT, Marsh M, Higgins NP.

J Bacteriol. 1990 Sep;172(9):5402-7.

44.

Differential activity of a transposable element in Escherichia coli colonies.

Shapiro JA, Higgins NP.

J Bacteriol. 1989 Nov;171(11):5975-86.

45.

Supercoiling and integration host factor change the DNA conformation and alter the flow of convergent transcription in phage Mu.

Higgins NP, Collier DA, Kilpatrick MW, Krause HM.

J Biol Chem. 1989 Feb 15;264(5):3035-42.

46.

Primary structure and mapping of the hupA gene of Salmonella typhimurium.

Higgins NP, Hillyard D.

J Bacteriol. 1988 Dec;170(12):5751-8.

47.

Packaging specific segments of the Salmonella chromosome with locked-in Mud-P22 prophages.

Youderian P, Sugiono P, Brewer KL, Higgins NP, Elliott T.

Genetics. 1988 Apr;118(4):581-92.

48.

Variation of beta-galactosidase expression from Mudlac elements during the development of Escherichia coli colonies.

Shapiro JA, Higgins NP.

Ann Inst Pasteur Microbiol. 1988 Jan-Feb;139(1):79-103.

PMID:
2838063
49.
50.

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