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5-(Hydroxymethyl)furfural restores low-oxygen rheology of sickle trait blood in vitro.

Hansen S, Wood DK, Higgins JM.

Br J Haematol. 2019 Dec 30. doi: 10.1111/bjh.16251. [Epub ahead of print]


Data-driven physiologic thresholds for iron deficiency associated with hematologic decline.

Foy BH, Li A, McClung JP, Ranganath R, Higgins JM.

Am J Hematol. 2019 Dec 17. doi: 10.1002/ajh.25706. [Epub ahead of print]


Single-cell modeling of routine clinical blood tests reveals transient dynamics of human response to blood loss.

Chaudhury A, Miller GD, Eichner D, Higgins JM.

Elife. 2019 Dec 17;8. pii: e48590. doi: 10.7554/eLife.48590.


A microfluidic platform for simultaneous quantification of oxygen-dependent viscosity and shear thinning in sickle cell blood.

Valdez JM, Datta YH, Higgins JM, Wood DK.

APL Bioeng. 2019 Nov 15;3(4):046102. doi: 10.1063/1.5118212. eCollection 2019 Dec.


High-throughput assessment of hemoglobin polymer in single red blood cells from sickle cell patients under controlled oxygen tension.

Di Caprio G, Schonbrun E, Gonçalves BP, Valdez JM, Wood DK, Higgins JM.

Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):25236-25242. doi: 10.1073/pnas.1914056116. Epub 2019 Nov 25.


Rationale and Design for a GRADE Substudy of Continuous Glucose Monitoring.

Larkin ME, Nathan DM, Bebu I, Krause-Steinrauf H, Herman WH, Higgins JM, Tiktin M, Cohen RM, Lund C, Bergenstal RM, Johnson ML, Arends V; GRADE Research Group.

Diabetes Technol Ther. 2019 Dec;21(12):682-690. doi: 10.1089/dia.2019.0202. Epub 2019 Sep 4.


CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation.

Seibert M, Krüger M, Watson NA, Sen O, Daum JR, Slotman JA, Braun T, Houtsmuller AB, Gorbsky GJ, Jacob R, Kracht M, Higgins JMG, Schmitz ML.

J Cell Biol. 2019 Apr 1;218(4):1164-1181. doi: 10.1083/jcb.201806057. Epub 2019 Feb 14.


Aneuploidy in Oocytes Is Prevented by Sustained CDK1 Activity through Degron Masking in Cyclin B1.

Levasseur MD, Thomas C, Davies OR, Higgins JMG, Madgwick S.

Dev Cell. 2019 Mar 11;48(5):672-684.e5. doi: 10.1016/j.devcel.2019.01.008. Epub 2019 Feb 7.


Incidence and Management of Clozapine-Induced Myocarditis in a Large Tertiary Hospital.

Higgins JM, San C, Lagnado G, Chua D, Mihic T.

Can J Psychiatry. 2019 Aug;64(8):561-567. doi: 10.1177/0706743718816058. Epub 2019 Jan 1.


When HbA1c and Blood Glucose Do Not Match: How Much Is Determined by Race, by Genetics, by Differences in Mean Red Blood Cell Age?

Cohen RM, Franco RS, Smith EP, Higgins JM.

J Clin Endocrinol Metab. 2019 Mar 1;104(3):707-710. doi: 10.1210/jc.2018-02409. No abstract available.


Oxygen-dependent flow of sickle trait blood as an in vitro therapeutic benchmark for sickle cell disease treatments.

Lu X, Chaudhury A, Higgins JM, Wood DK.

Am J Hematol. 2018 Oct;93(10):1227-1235. doi: 10.1002/ajh.25227. Epub 2018 Aug 21.


The live cell DNA stain SiR-Hoechst induces DNA damage responses and impairs cell cycle progression.

Sen O, Saurin AT, Higgins JMG.

Sci Rep. 2018 May 21;8(1):7898. doi: 10.1038/s41598-018-26307-6.


White blood cell population dynamics for risk stratification of acute coronary syndrome.

Chaudhury A, Noiret L, Higgins JM.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12344-12349. doi: 10.1073/pnas.1709228114. Epub 2017 Oct 27.


Determinants of red blood cell alloantibody detection duration: analysis of multiply alloimmunized patients supports peritransfusion factors.

Noiret L, Slater A, Higgins JM.

Transfusion. 2017 Aug;57(8):1930-1937. doi: 10.1111/trf.14157. Epub 2017 Jun 21.


A microfluidic platform to study the effects of vascular architecture and oxygen gradients on sickle blood flow.

Lu X, Galarneau MM, Higgins JM, Wood DK.

Microcirculation. 2017 Jul;24(5). doi: 10.1111/micc.12357. Review.


Cellular normoxic biophysical markers of hydroxyurea treatment in sickle cell disease.

Hosseini P, Abidi SZ, Du E, Papageorgiou DP, Choi Y, Park Y, Higgins JM, Kato GJ, Suresh S, Dao M, Yaqoob Z, So PT.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9527-32. doi: 10.1073/pnas.1610435113. Epub 2016 Aug 10.


Deoxygenation Reduces Sickle Cell Blood Flow at Arterial Oxygen Tension.

Lu X, Wood DK, Higgins JM.

Biophys J. 2016 Jun 21;110(12):2751-2758. doi: 10.1016/j.bpj.2016.04.050.


Mitotic Mysteries: The Case of HP1.

Higgins JM, Prendergast L.

Dev Cell. 2016 Mar 7;36(5):477-8. doi: 10.1016/j.devcel.2016.02.019.


Prior cytopenia predicts worse clinical outcome in acute myeloid leukemia.

Huck A, Pozdnyakova O, Brunner A, Higgins JM, Fathi AT, Hasserjian RP.

Leuk Res. 2015 Oct;39(10):1034-40. doi: 10.1016/j.leukres.2015.06.012. Epub 2015 Jun 28.


Single-cell measurement of red blood cell oxygen affinity.

Di Caprio G, Stokes C, Higgins JM, Schonbrun E.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9984-9. doi: 10.1073/pnas.1509252112. Epub 2015 Jul 27.


TD-60 links RalA GTPase function to the CPC in mitosis.

Papini D, Langemeyer L, Abad MA, Kerr A, Samejima I, Eyers PA, Jeyaprakash AA, Higgins JM, Barr FA, Earnshaw WC.

Nat Commun. 2015 Jul 9;6:7678. doi: 10.1038/ncomms8678.


Modulation of red blood cell population dynamics is a fundamental homeostatic response to disease.

Patel HH, Patel HR, Higgins JM.

Am J Hematol. 2015 May;90(5):422-8. doi: 10.1002/ajh.23982. Epub 2015 Apr 2.


Red blood cell population dynamics.

Higgins JM.

Clin Lab Med. 2015 Mar;35(1):43-57. doi: 10.1016/j.cll.2014.10.002. Epub 2014 Dec 18. Review.


Age-related clonal hematopoiesis associated with adverse outcomes.

Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kuo FC, Kluk MJ, Henderson B, Kinnunen L, Koistinen HA, Ladenvall C, Getz G, Correa A, Banahan BF, Gabriel S, Kathiresan S, Stringham HM, McCarthy MI, Boehnke M, Tuomilehto J, Haiman C, Groop L, Atzmon G, Wilson JG, Neuberg D, Altshuler D, Ebert BL.

N Engl J Med. 2014 Dec 25;371(26):2488-98. doi: 10.1056/NEJMoa1408617. Epub 2014 Nov 26.


In vivo volume and hemoglobin dynamics of human red blood cells.

Malka R, Delgado FF, Manalis SR, Higgins JM.

PLoS Comput Biol. 2014 Oct 9;10(10):e1003839. doi: 10.1371/journal.pcbi.1003839. eCollection 2014 Oct.


Computational pathology: an emerging definition.

Louis DN, Gerber GK, Baron JM, Bry L, Dighe AS, Getz G, Higgins JM, Kuo FC, Lane WJ, Michaelson JS, Le LP, Mermel CH, Gilbertson JR, Golden JA.

Arch Pathol Lab Med. 2014 Sep;138(9):1133-8. doi: 10.5858/arpa.2014-0034-ED. No abstract available.


Production and isolation of axons from sensory neurons for biochemical analysis using porous filters.

Unsain N, Heard KN, Higgins JM, Barker PA.

J Vis Exp. 2014 Jul 8;(89). doi: 10.3791/51795.


Hereditary xerocytosis revisited.

Archer NM, Shmukler BE, Andolfo I, Vandorpe DH, Gnanasambandam R, Higgins JM, Rivera A, Fleming MD, Sachs F, Gottlieb PA, Iolascon A, Brugnara C, Alper SL, Nathan DG.

Am J Hematol. 2014 Dec;89(12):1142-6. doi: 10.1002/ajh.23799. Epub 2014 Jul 21. No abstract available.


Integrin αEβ7: molecular features and functional significance in the immune system.

Hadley GA, Higgins JM.

Adv Exp Med Biol. 2014;819:97-110. doi: 10.1007/978-94-017-9153-3_7. Review.


Polyoma small T antigen triggers cell death via mitotic catastrophe.

Pores Fernando AT, Andrabi S, Cizmecioglu O, Zhu C, Livingston DM, Higgins JM, Schaffhausen BS, Roberts TM.

Oncogene. 2015 May 7;34(19):2483-92. doi: 10.1038/onc.2014.192. Epub 2014 Jul 7.


Plasma interleukin-27 (IL-27) levels are not modulated in patients with chronic HIV-1 infection.

Swaminathan S, Hu Z, Rupert AW, Higgins JM, Dewar RL, Stevens R, Chen Q, Rehm CA, Metcalf JA, Baseler MW, Lane HC, Imamichi T.

PLoS One. 2014 Jun 4;9(6):e98989. doi: 10.1371/journal.pone.0098989. eCollection 2014.


Quantitative absorption cytometry for measuring red blood cell hemoglobin mass and volume.

Schonbrun E, Malka R, Di Caprio G, Schaak D, Higgins JM.

Cytometry A. 2014 Apr;85(4):332-8. doi: 10.1002/cyto.a.22450. Epub 2014 Feb 12.


The 2013 symposium on pathology data integration and clinical decision support and the current state of field.

Baron JM, Dighe AS, Arnaout R, Balis UJ, Black-Schaffer WS, Carter AB, Henricks WH, Higgins JM, Jackson BR, Kim J, Klepeis VE, Le LP, Louis DN, Mandelker D, Mermel CH, Michaelson JS, Nagarajan R, Platt ME, Quinn AM, Rao L, Shirts BH, Gilbertson JR.

J Pathol Inform. 2014 Jan 31;5(1):2. doi: 10.4103/2153-3539.126145. eCollection 2014.


Developmental plasticity of red blood cell homeostasis.

Golub MS, Hogrefe CE, Malka R, Higgins JM.

Am J Hematol. 2014 May;89(5):459-66. doi: 10.1002/ajh.23666. Epub 2014 Mar 3.


Polo-like kinase-1 triggers histone phosphorylation by Haspin in mitosis.

Zhou L, Tian X, Zhu C, Wang F, Higgins JM.

EMBO Rep. 2014 Mar;15(3):273-81. doi: 10.1002/embr.201338080. Epub 2014 Jan 10.


Chromosome segregation: learning to let go.

Higgins JM.

Curr Biol. 2013 Oct 7;23(19):R883-5. doi: 10.1016/j.cub.2013.08.026.


Nucleosome assembly proteins get SET to defeat the guardian of chromosome cohesion.

Higgins JM, Herbert M.

PLoS Genet. 2013;9(9):e1003829. doi: 10.1371/journal.pgen.1003829. Epub 2013 Sep 26. No abstract available.


XIAP regulates caspase activity in degenerating axons.

Unsain N, Higgins JM, Parker KN, Johnstone AD, Barker PA.

Cell Rep. 2013 Aug 29;4(4):751-63. doi: 10.1016/j.celrep.2013.07.015. Epub 2013 Aug 15.


Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells.

Feijó Delgado F, Cermak N, Hecht VC, Son S, Li Y, Knudsen SM, Olcum S, Higgins JM, Chen J, Grover WH, Manalis SR.

PLoS One. 2013 Jul 2;8(7):e67590. doi: 10.1371/journal.pone.0067590. Print 2013. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/c3a3219b-935b-42ed-b3a7-bbbc36dc1dfe.


Histone modifications and mitosis: countermarks, landmarks, and bookmarks.

Wang F, Higgins JM.

Trends Cell Biol. 2013 Apr;23(4):175-84. doi: 10.1016/j.tcb.2012.11.005. Epub 2012 Dec 13. Review.


Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation.

Wang F, Ulyanova NP, Daum JR, Patnaik D, Kateneva AV, Gorbsky GJ, Higgins JM.

J Cell Biol. 2012 Oct 15;199(2):251-68. doi: 10.1083/jcb.201205106.


Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient.

Byun H, Hillman TR, Higgins JM, Diez-Silva M, Peng Z, Dao M, Dasari RR, Suresh S, Park Y.

Acta Biomater. 2012 Nov;8(11):4130-8. doi: 10.1016/j.actbio.2012.07.011. Epub 2012 Jul 20.


Anisotropic light scattering of individual sickle red blood cells.

Kim Y, Higgins JM, Dasari RR, Suresh S, Park Y.

J Biomed Opt. 2012 Apr;17(4):040501. doi: 10.1117/1.JBO.17.4.040501.


A biophysical indicator of vaso-occlusive risk in sickle cell disease.

Wood DK, Soriano A, Mahadevan L, Higgins JM, Bhatia SN.

Sci Transl Med. 2012 Feb 29;4(123):123ra26. doi: 10.1126/scitranslmed.3002738.


Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres.

Niedzialkowska E, Wang F, Porebski PJ, Minor W, Higgins JM, Stukenberg PT.

Mol Biol Cell. 2012 Apr;23(8):1457-66. doi: 10.1091/mbc.E11-11-0904. Epub 2012 Feb 22.


Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors.

Cuny GD, Ulyanova NP, Patnaik D, Liu JF, Lin X, Auerbach K, Ray SS, Xian J, Glicksman MA, Stein RL, Higgins JM.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):2015-9. doi: 10.1016/j.bmcl.2012.01.028. Epub 2012 Jan 28.


Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis.

Leuschner F, Rauch PJ, Ueno T, Gorbatov R, Marinelli B, Lee WW, Dutta P, Wei Y, Robbins C, Iwamoto Y, Sena B, Chudnovskiy A, Panizzi P, Keliher E, Higgins JM, Libby P, Moskowitz MA, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M.

J Exp Med. 2012 Jan 16;209(1):123-37. doi: 10.1084/jem.20111009. Epub 2012 Jan 2.


A revised timeline for the origin of Plasmodium falciparum as a human pathogen.

Baron JM, Higgins JM, Dzik WH.

J Mol Evol. 2011 Dec;73(5-6):297-304. doi: 10.1007/s00239-011-9476-x. Epub 2011 Dec 20.


Spin polarization measurement of homogeneously doped Fe(1-x)Co(x)Si nanowires by Andreev reflection spectroscopy.

Degrave JP, Schmitt AL, Selinsky RS, Higgins JM, Keavney DJ, Jin S.

Nano Lett. 2011 Oct 12;11(10):4431-7. doi: 10.1021/nl2026426. Epub 2011 Sep 21.


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