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Items: 1 to 50 of 294

1.

Publisher Correction: 3D Shape Modeling for Cell Nuclear Morphological Analysis and Classification.

Kalinin AA, Allyn-Feuer A, Ade A, Fon GV, Meixner W, Dilworth D, Husain SS, de Wet JR, Higgins GA, Zheng G, Creekmore A, Wiley JW, Verdone JE, Veltri RW, Pienta KJ, Coffey DS, Athey BD, Dinov ID.

Sci Rep. 2018 Oct 26;8(1):16142. doi: 10.1038/s41598-018-33574-w.

2.

Novel KV7 ion channel openers for the treatment of epilepsy and implications for detrusor tissue contraction.

Seefeld MA, Lin H, Holenz J, Downie D, Donovan B, Fu T, Pasikanti K, Zhen W, Cato M, Chaudhary KW, Brady P, Bakshi T, Morrow D, Rajagopal S, Samanta SK, Madhyastha N, Kuppusamy BM, Dougherty RW, Bhamidipati R, Mohd Z, Higgins GA, Chapman M, Rouget C, Lluel P, Matsuoka Y.

Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3793-3797. doi: 10.1016/j.bmcl.2018.09.036. Epub 2018 Sep 29.

PMID:
30327146
3.

3D Shape Modeling for Cell Nuclear Morphological Analysis and Classification.

Kalinin AA, Allyn-Feuer A, Ade A, Fon GV, Meixner W, Dilworth D, Husain SS, de Wet JR, Higgins GA, Zheng G, Creekmore A, Wiley JW, Verdone JE, Veltri RW, Pienta KJ, Coffey DS, Athey BD, Dinov ID.

Sci Rep. 2018 Sep 12;8(1):13658. doi: 10.1038/s41598-018-31924-2. Erratum in: Sci Rep. 2018 Oct 26;8(1):16142.

4.

A similarity-based approach to leverage multi-cohort medical data on the diagnosis and prognosis of Alzheimer's disease.

Zhang H, Zhu F, Dodge HH, Higgins GA, Omenn GS, Guan Y; Alzheimer's Disease Neuroimaging Initiative.

Gigascience. 2018 Jul 1;7(7). doi: 10.1093/gigascience/giy085.

5.

Rapid valproic acid-induced modulation of the traumatic proteome in a porcine model of traumatic brain injury and hemorrhagic shock.

Weykamp M, Nikolian VC, Dennahy IS, Higgins GA, Georgoff PE, Remmer H, Ghandour MH, Alam HB.

J Surg Res. 2018 Aug;228:84-92. doi: 10.1016/j.jss.2018.02.046. Epub 2018 Apr 25.

PMID:
29907235
6.

Deep learning in pharmacogenomics: from gene regulation to patient stratification.

Kalinin AA, Higgins GA, Reamaroon N, Soroushmehr S, Allyn-Feuer A, Dinov ID, Najarian K, Athey BD.

Pharmacogenomics. 2018 May;19(7):629-650. doi: 10.2217/pgs-2018-0008. Epub 2018 Apr 26. Review.

PMID:
29697304
7.

Effects of the NMDA receptor antagonists dizocilpine and Ro 63-1908 on delay-discounting and risky decision-making in a gambling task.

Higgins GA, Silenieks LB, MacMillan C, Zeeb FD, Thevarkunnel S.

Behav Brain Res. 2018 Aug 1;348:201-210. doi: 10.1016/j.bbr.2018.04.028. Epub 2018 Apr 22.

PMID:
29689373
8.

Preclinical evidence for combining the 5-HT2C receptor agonist lorcaserin and varenicline as a treatment for nicotine dependence.

Fletcher PJ, Li Z, Silenieks LB, MacMillan C, DeLannoy I, Higgins GA.

Addict Biol. 2018 Mar 2. doi: 10.1111/adb.12602. [Epub ahead of print]

PMID:
29498158
9.

The pharmacoepigenomics informatics pipeline defines a pathway of novel and known warfarin pharmacogenomics variants.

Allyn-Feuer A, Ade A, Luzum JA, Higgins GA, Athey BD.

Pharmacogenomics. 2018 Apr;19(5):413-434. doi: 10.2217/pgs-2017-0186. Epub 2018 Feb 5.

10.

Transcriptomic changes following valproic acid treatment promote neurogenesis and minimize secondary brain injury.

Nikolian VC, Dennahy IS, Higgins GA, Williams AM, Weykamp M, Georgoff PE, Eidy H, Ghandour MH, Chang P, Alam HB.

J Trauma Acute Care Surg. 2018 Mar;84(3):459-465. doi: 10.1097/TA.0000000000001765.

11.

Improvement of Blood-Brain Barrier Integrity in Traumatic Brain Injury and Hemorrhagic Shock Following Treatment With Valproic Acid and Fresh Frozen Plasma.

Nikolian VC, Dekker SE, Bambakidis T, Higgins GA, Dennahy IS, Georgoff PE, Williams AM, Andjelkovic AV, Alam HB.

Crit Care Med. 2018 Jan;46(1):e59-e66. doi: 10.1097/CCM.0000000000002800.

PMID:
29095204
12.

Role of impulsivity and reward in the anti-obesity actions of 5-HT2C receptor agonists.

Higgins GA, Zeeb FD, Fletcher PJ.

J Psychopharmacol. 2017 Nov;31(11):1403-1418. doi: 10.1177/0269881117735797. Epub 2017 Oct 26. Review.

PMID:
29072522
13.

The 'egg topping' technique for bone graft harvesting in hip arthroplasty.

Awad AS, Williams MG, Higgins GA.

Ann R Coll Surg Engl. 2018 Jan;100(1):80. doi: 10.1308/rcsann.2017.0125. Epub 2017 Sep 13. No abstract available.

14.

Rodent Test of Attention and Impulsivity: The 5-Choice Serial Reaction Time Task.

Higgins GA, Silenieks LB.

Curr Protoc Pharmacol. 2017 Sep 11;78:5.49.1-5.49.34. doi: 10.1002/cpph.27.

PMID:
28892143
15.

Pharmacological Modulation of 5-HT2C Receptor Activity Produces Bidirectional Changes in Locomotor Activity, Responding for a Conditioned Reinforcer, and Mesolimbic DA Release in C57BL/6 Mice.

Browne CJ, Ji X, Higgins GA, Fletcher PJ, Harvey-Lewis C.

Neuropsychopharmacology. 2017 Oct;42(11):2178-2187. doi: 10.1038/npp.2017.124. Epub 2017 Jun 13.

16.

18F-FPP: A PET Ligand for the 5-HT2C Receptor?

Higgins GA.

ACS Chem Neurosci. 2017 May 17;8(5):904-907. doi: 10.1021/acschemneuro.7b00133. Epub 2017 May 1.

PMID:
28459529
17.

Mining the topography and dynamics of the 4D Nucleome to identify novel CNS drug pathways.

Higgins GA, Allyn-Feuer A, Georgoff P, Nikolian V, Alam HB, Athey BD.

Methods. 2017 Jul 1;123:102-118. doi: 10.1016/j.ymeth.2017.03.012. Epub 2017 Apr 4. Review.

PMID:
28385536
18.

Studies To Examine Potential Tolerability Differences between the 5-HT2C Receptor Selective Agonists Lorcaserin and CP-809101.

Higgins GA, Silenieks LB, Patrick A, De Lannoy IAM, Fletcher PJ, Parker LA, MacLusky NJ, Sullivan LC, Chavera TA, Berg KA.

ACS Chem Neurosci. 2017 May 17;8(5):1074-1084. doi: 10.1021/acschemneuro.6b00444. Epub 2017 Mar 24.

PMID:
28338324
19.

Network Reconstruction Reveals that Valproic Acid Activates Neurogenic Transcriptional Programs in Adult Brain Following Traumatic Injury.

Higgins GA, Georgoff P, Nikolian V, Allyn-Feuer A, Pauls B, Higgins R, Athey BD, Alam HE.

Pharm Res. 2017 Aug;34(8):1658-1672. doi: 10.1007/s11095-017-2130-6. Epub 2017 Mar 7.

20.

Effects of 5-HT1A, 5-HT2A and 5-HT2C receptor agonists and antagonists on responding for a conditioned reinforcer and its enhancement by methylphenidate.

Fletcher PJ, Zeeb FD, Browne CJ, Higgins GA, Soko AD.

Psychopharmacology (Berl). 2017 Mar;234(5):889-902. doi: 10.1007/s00213-017-4529-5. Epub 2017 Jan 18.

PMID:
28097374
21.

Profile of Antiemetic Activity of Netupitant Alone or in Combination with Palonosetron and Dexamethasone in Ferrets and Suncus murinus (House Musk Shrew).

Rudd JA, Ngan MP, Lu Z, Higgins GA, Giuliano C, Lovati E, Pietra C.

Front Pharmacol. 2016 Aug 31;7:263. doi: 10.3389/fphar.2016.00263. eCollection 2016.

22.

Alterations in the human proteome following administration of valproic acid.

Georgoff PE, Halaweish I, Nikolian VC, Higgins GA, Bonham T, Tafatia C, Remmer H, Menon R, Liu B, Li Y, Alam HB.

J Trauma Acute Care Surg. 2016 Dec;81(6):1020-1027.

PMID:
27602906
23.

Lorcaserin and CP-809101 reduce motor impulsivity and reinstatement of food seeking behavior in male rats: Implications for understanding the anti-obesity property of 5-HT2C receptor agonists.

Higgins GA, Silenieks LB, Altherr EB, MacMillan C, Fletcher PJ, Pratt WE.

Psychopharmacology (Berl). 2016 Jul;233(14):2841-56. doi: 10.1007/s00213-016-4329-3. Epub 2016 May 30.

PMID:
27241709
24.

Enhanced attention and impulsive action following NMDA receptor GluN2B-selective antagonist pretreatment.

Higgins GA, Silenieks LB, MacMillan C, Sevo J, Zeeb FD, Thevarkunnel S.

Behav Brain Res. 2016 Sep 15;311:1-14. doi: 10.1016/j.bbr.2016.05.025. Epub 2016 May 11.

PMID:
27180168
25.

Stress and glucocorticoid receptor transcriptional programming in time and space: Implications for the brain-gut axis.

Wiley JW, Higgins GA, Athey BD.

Neurogastroenterol Motil. 2016 Jan;28(1):12-25. doi: 10.1111/nmo.12706. Review.

26.

The 5-HT(2C) receptor agonist lorcaserin reduces cocaine self-administration, reinstatement of cocaine-seeking and cocaine induced locomotor activity.

Harvey-Lewis C, Li Z, Higgins GA, Fletcher PJ.

Neuropharmacology. 2016 Feb;101:237-45. doi: 10.1016/j.neuropharm.2015.09.028. Epub 2015 Sep 30.

PMID:
26427596
27.

A glutamatergic network mediates lithium response in bipolar disorder as defined by epigenome pathway analysis.

Higgins GA, Allyn-Feuer A, Barbour E, Athey BD.

Pharmacogenomics. 2015;16(14):1547-63. doi: 10.2217/pgs.15.106. Epub 2015 Sep 7.

28.

Epigenomic mapping and effect sizes of noncoding variants associated with psychotropic drug response.

Higgins GA, Allyn-Feuer A, Athey BD.

Pharmacogenomics. 2015;16(14):1565-83. doi: 10.2217/pgs.15.105. Epub 2015 Sep 4.

29.

The epigenome, 4D nucleome and next-generation neuropsychiatric pharmacogenomics.

Higgins GA, Allyn-Feuer A, Handelman S, Sadee W, Athey BD.

Pharmacogenomics. 2015;16(14):1649-69. doi: 10.2217/pgs.15.111. Epub 2015 Sep 4. Review.

30.

Therapeutic Potential of 5-HT2C Receptor Agonists for Addictive Disorders.

Higgins GA, Fletcher PJ.

ACS Chem Neurosci. 2015 Jul 15;6(7):1071-88. doi: 10.1021/acschemneuro.5b00025. Epub 2015 Apr 14. Review.

PMID:
25870913
31.

The Serotonin 2C Receptor Agonist Lorcaserin Attenuates Intracranial Self-Stimulation and Blocks the Reward-Enhancing Effects of Nicotine.

Zeeb FD, Higgins GA, Fletcher PJ.

ACS Chem Neurosci. 2015 Jul 15;6(7):1231-40. doi: 10.1021/acschemneuro.5b00017. Epub 2015 Mar 17.

PMID:
25781911
32.

Enduring attentional deficits in rats treated with a peripheral nerve injury.

Higgins GA, Silenieks LB, Van Niekerk A, Desnoyer J, Patrick A, Lau W, Thevarkunnel S.

Behav Brain Res. 2015 Jun 1;286:347-55. doi: 10.1016/j.bbr.2015.02.050. Epub 2015 Mar 5.

PMID:
25746510
33.

Characterization of the 5-HT2C receptor agonist lorcaserin on efficacy and safety measures in a rat model of diet-induced obesity.

Higgins GA, Desnoyer J, Van Niekerk A, Silenieks LB, Lau W, Thevarkunnel S, Izhakova J, DeLannoy IA, Fletcher PJ, DeLay J, Dobson H.

Pharmacol Res Perspect. 2015 Feb;3(1):e00084. doi: 10.1002/prp2.84. Epub 2014 Nov 7.

34.

Examination of the effects of varenicline, bupropion, lorcaserin, or naltrexone on responding for conditioned reinforcement in nicotine-exposed rats.

Guy EG, Fisher DC, Higgins GA, Fletcher PJ.

Behav Pharmacol. 2014 Dec;25(8):775-83. doi: 10.1097/FBP.0000000000000092.

PMID:
25230208
35.

The effect of obesity and increasing age on operative time and length of stay in primary hip and knee arthroplasty.

Bradley BM, Griffiths SN, Stewart KJ, Higgins GA, Hockings M, Isaac DL.

J Arthroplasty. 2014 Oct;29(10):1906-10. doi: 10.1016/j.arth.2014.06.002. Epub 2014 Jun 7.

PMID:
25081514
36.

From obesity to substance abuse: therapeutic opportunities for 5-HT2C receptor agonists.

Higgins GA, Sellers EM, Fletcher PJ.

Trends Pharmacol Sci. 2013 Oct;34(10):560-70. doi: 10.1016/j.tips.2013.08.001. Epub 2013 Sep 13. Review.

PMID:
24041919
37.

A back translation of pregabalin and carbamazepine against evoked and non-evoked endpoints in the rat spared nerve injury model of neuropathic pain.

Lau W, Dykstra C, Thevarkunnel S, Silenieks LB, de Lannoy IA, Lee DK, Higgins GA.

Neuropharmacology. 2013 Oct;73:204-15. doi: 10.1016/j.neuropharm.2013.05.023. Epub 2013 Jun 5.

PMID:
23747575
38.

In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects.

Hyde LA, Zhang Q, Del Vecchio RA, Leach PT, Cohen-Williams ME, Chen L, Wong GT, McHugh NA, Chen J, Higgins GA, Asberom T, Li W, Pissarnitski D, Levitan D, Nomeir AA, Clader JW, Zhang L, Parker EM.

Int J Alzheimers Dis. 2013;2013:823528. doi: 10.1155/2013/823528. Epub 2013 Mar 14.

39.

The biomechanical effect of notch size, notch location, and femur orientation on hip resurfacing failure.

Morison Z, Olsen M, Higgins GA, Zdero R, Schemitsch EH.

IEEE Trans Biomed Eng. 2013 Aug;60(8):2214-21. doi: 10.1109/TBME.2013.2251745. Epub 2013 Mar 7.

PMID:
23481682
40.

Silexan, an essential oil from flowers of Lavandula angustifolia, is not recognized as benzodiazepine-like in rats trained to discriminate a diazepam cue.

Silenieks LB, Koch E, Higgins GA.

Phytomedicine. 2013 Jan 15;20(2):172-7. doi: 10.1016/j.phymed.2012.10.004. Epub 2012 Nov 30.

PMID:
23207249
41.

Impulsive action in the 5-choice serial reaction time test in 5-HT₂c receptor null mutant mice.

Fletcher PJ, Soko AD, Higgins GA.

Psychopharmacology (Berl). 2013 Apr;226(3):561-70. doi: 10.1007/s00213-012-2929-0. Epub 2012 Nov 29.

PMID:
23192316
42.

Evaluation of chemically diverse 5-HT₂c receptor agonists on behaviours motivated by food and nicotine and on side effect profiles.

Higgins GA, Silenieks LB, Lau W, de Lannoy IA, Lee DK, Izhakova J, Coen K, Le AD, Fletcher PJ.

Psychopharmacology (Berl). 2013 Apr;226(3):475-90. doi: 10.1007/s00213-012-2919-2. Epub 2012 Nov 25.

PMID:
23184281
43.

Rolapitant (SCH 619734): a potent, selective and orally active neurokinin NK1 receptor antagonist with centrally-mediated antiemetic effects in ferrets.

Duffy RA, Morgan C, Naylor R, Higgins GA, Varty GB, Lachowicz JE, Parker EM.

Pharmacol Biochem Behav. 2012 Jul;102(1):95-100. doi: 10.1016/j.pbb.2012.03.021. Epub 2012 Mar 31.

PMID:
22497992
44.

Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5-HT2A receptor antagonist M100907 on nicotine self-administration and reinstatement.

Fletcher PJ, Rizos Z, Noble K, Soko AD, Silenieks LB, Lê AD, Higgins GA.

Neuropharmacology. 2012 Jun;62(7):2288-98. doi: 10.1016/j.neuropharm.2012.01.023. Epub 2012 Feb 8.

PMID:
22342986
45.

The 5-HT2C receptor agonist lorcaserin reduces nicotine self-administration, discrimination, and reinstatement: relationship to feeding behavior and impulse control.

Higgins GA, Silenieks LB, Rossmann A, Rizos Z, Noble K, Soko AD, Fletcher PJ.

Neuropsychopharmacology. 2012 Apr;37(5):1177-91. doi: 10.1038/npp.2011.303. Epub 2011 Dec 21.

46.

Computer navigation vs extramedullary guide for sagittal alignment of tibial components: radiographic study and meta-analysis.

Kuzyk PR, Higgins GA, Tunggal JA, Sellan ME, Waddell JP, Schemitsch EH.

J Arthroplasty. 2012 Apr;27(4):630-7. doi: 10.1016/j.arth.2011.07.001. Epub 2011 Sep 13. Review.

PMID:
21917415
47.

The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide (SCH 655842): comparison of efficacy and side effects across rodent species.

Lu SX, Higgins GA, Hodgson RA, Hyde LA, Del Vecchio RA, Guthrie DH, Kazdoba T, McCool MF, Morgan CA, Bercovici A, Ho GD, Tulshian D, Parker EM, Hunter JC, Varty GB.

Eur J Pharmacol. 2011 Jul 1;661(1-3):63-71. doi: 10.1016/j.ejphar.2011.04.034. Epub 2011 Apr 28.

PMID:
21545797
48.

Impulsive action induced by amphetamine, cocaine and MK801 is reduced by 5-HT(2C) receptor stimulation and 5-HT(2A) receptor blockade.

Fletcher PJ, Rizos Z, Noble K, Higgins GA.

Neuropharmacology. 2011 Sep;61(3):468-77. doi: 10.1016/j.neuropharm.2011.02.025. Epub 2011 Mar 21.

PMID:
21402085
49.

Genetic and pharmacological evidence that 5-HT2C receptor activation, but not inhibition, affects motivation to feed under a progressive ratio schedule of reinforcement.

Fletcher PJ, Sinyard J, Higgins GA.

Pharmacol Biochem Behav. 2010 Nov;97(1):170-8. doi: 10.1016/j.pbb.2010.07.002. Epub 2010 Jul 16.

PMID:
20624416
50.

Comparative study of five antiepileptic drugs on a translational cognitive measure in the rat: relationship to antiepileptic property.

Higgins GA, Breysse N, Undzys E, Derksen DR, Jeffrey M, Scott BW, Xin T, Roucard C, Bressand K, Depaulis A, Burnham WM.

Psychopharmacology (Berl). 2010 Jan;207(4):513-27. doi: 10.1007/s00213-009-1682-5. Epub 2009 Oct 16.

PMID:
19841906

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