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Items: 1 to 50 of 62

1.

An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread.

Tan JMJ, Mellouk N, Osborne SE, Ammendolia DA, Dyer DN, Li R, Brunen D, van Rijn JM, Huang J, Czuczman MA, Cemma MA, Won AM, Yip CM, Xavier RJ, MacDuff DA, Reggiori F, Debnath J, Yoshimori T, Kim PK, Fairn GD, Coyaud E, Raught B, Muise AM, Higgins DE, Brumell JH.

Nat Microbiol. 2018 Dec;3(12):1472-1485. doi: 10.1038/s41564-018-0293-5. Epub 2018 Nov 26.

PMID:
30478389
2.

The Vacuolar Pathway in Macrophages Plays a Major Role in Antigen Cross-Presentation Induced by the Pore-Forming Protein Sticholysin II Encapsulated Into Liposomes.

Cruz-Leal Y, Grubaugh D, Nogueira CV, Lopetegui-González I, Del Valle A, Escalona F, Laborde RJ, Alvarez C, Fernández LE, Starnbach MN, Higgins DE, Lanio ME.

Front Immunol. 2018 Nov 5;9:2473. doi: 10.3389/fimmu.2018.02473. eCollection 2018.

3.

Listeria monocytogenes Infection of the Brain.

Ghosh P, Higgins DE.

J Vis Exp. 2018 Oct 2;(140). doi: 10.3791/58723.

PMID:
30346400
4.

Invasion of the Brain by Listeria monocytogenes Is Mediated by InlF and Host Cell Vimentin.

Ghosh P, Halvorsen EM, Ammendolia DA, Mor-Vaknin N, O'Riordan MXD, Brumell JH, Markovitz DM, Higgins DE.

MBio. 2018 Feb 27;9(1). pii: e00160-18. doi: 10.1128/mBio.00160-18.

5.

The VirAB ABC Transporter Is Required for VirR Regulation of Listeria monocytogenes Virulence and Resistance to Nisin.

Grubaugh D, Regeimbal JM, Ghosh P, Zhou Y, Lauer P, Dubensky TW Jr.,, Higgins DE.

Infect Immun. 2018 Feb 20;86(3). pii: e00901-17. doi: 10.1128/IAI.00901-17. Print 2018 Mar.

6.

Deciphering the landscape of host barriers to Listeria monocytogenes infection.

Zhang T, Abel S, Abel Zur Wiesch P, Sasabe J, Davis BM, Higgins DE, Waldor MK.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6334-6339. doi: 10.1073/pnas.1702077114. Epub 2017 May 30.

7.

Novel Adjuvant Based on the Pore-Forming Protein Sticholysin II Encapsulated into Liposomes Effectively Enhances the Antigen-Specific CTL-Mediated Immune Response.

Laborde RJ, Sanchez-Ferras O, Luzardo MC, Cruz-Leal Y, Fernández A, Mesa C, Oliver L, Canet L, Abreu-Butin L, Nogueira CV, Tejuca M, Pazos F, Álvarez C, Alonso ME, Longo-Maugéri IM, Starnbach MN, Higgins DE, Fernández LE, Lanio ME.

J Immunol. 2017 Apr 1;198(7):2772-2784. doi: 10.4049/jimmunol.1600310. Epub 2017 Mar 3.

8.

Type I interferon promotes cell-to-cell spread of Listeria monocytogenes.

Osborne SE, Sit B, Shaker A, Currie E, Tan JM, van Rijn J, Higgins DE, Brumell JH.

Cell Microbiol. 2017 Mar;19(3). doi: 10.1111/cmi.12660. Epub 2016 Oct 10.

PMID:
27582004
9.

Resolution of Chlamydia trachomatis Infection Is Associated with a Distinct T Cell Response Profile.

Picard MD, Bodmer JL, Gierahn TM, Lee A, Price J, Cohane K, Clemens V, DeVault VL, Gurok G, Kohberger R, Higgins DE, Siber GR, Flechtner JB, Geisler WM.

Clin Vaccine Immunol. 2015 Nov;22(11):1206-18. doi: 10.1128/CVI.00247-15. Epub 2015 Oct 7.

10.

Strain-Specific Interactions of Listeria monocytogenes with the Autophagy System in Host Cells.

Cemma M, Lam GY, Stöckli M, Higgins DE, Brumell JH.

PLoS One. 2015 May 13;10(5):e0125856. doi: 10.1371/journal.pone.0125856. eCollection 2015.

11.

Identification of Listeria monocytogenes determinants required for biofilm formation.

Alonso AN, Perry KJ, Regeimbal JM, Regan PM, Higgins DE.

PLoS One. 2014 Dec 17;9(12):e113696. doi: 10.1371/journal.pone.0113696. eCollection 2014.

12.

The diaphanous-related formins promote protrusion formation and cell-to-cell spread of Listeria monocytogenes.

Fattouh R, Kwon H, Czuczman MA, Copeland JW, Pelletier L, Quinlan ME, Muise AM, Higgins DE, Brumell JH.

J Infect Dis. 2015 Apr 1;211(7):1185-95. doi: 10.1093/infdis/jiu546. Epub 2014 Oct 3.

13.

Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread.

Czuczman MA, Fattouh R, van Rijn JM, Canadien V, Osborne S, Muise AM, Kuchroo VK, Higgins DE, Brumell JH.

Nature. 2014 May 8;509(7499):230-4. doi: 10.1038/nature13168. Epub 2014 Apr 13.

14.

Proteins as T cell antigens: methods for high-throughput identification.

Grubaugh D, Flechtner JB, Higgins DE.

Vaccine. 2013 Aug 20;31(37):3805-10. doi: 10.1016/j.vaccine.2013.06.046. Epub 2013 Jun 24. Review.

PMID:
23806245
15.

A differential fluorescence-based genetic screen identifies Listeria monocytogenes determinants required for intracellular replication.

Perry KJ, Higgins DE.

J Bacteriol. 2013 Aug;195(15):3331-40. doi: 10.1128/JB.00210-13. Epub 2013 May 17.

16.

Host and bacterial factors that regulate LC3 recruitment to Listeria monocytogenes during the early stages of macrophage infection.

Lam GY, Cemma M, Muise AM, Higgins DE, Brumell JH.

Autophagy. 2013 Jul;9(7):985-95. doi: 10.4161/auto.24406. Epub 2013 Apr 12.

17.

The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction.

Chen L, Chen Z, Baker K, Halvorsen EM, da Cunha AP, Flak MB, Gerber G, Huang YH, Hosomi S, Arthur JC, Dery KJ, Nagaishi T, Beauchemin N, Holmes KV, Ho JW, Shively JE, Jobin C, Onderdonk AB, Bry L, Weiner HL, Higgins DE, Blumberg RS.

Immunity. 2012 Nov 16;37(5):930-46. doi: 10.1016/j.immuni.2012.07.016. Epub 2012 Nov 1.

18.

High-throughput proteomic screening identifies Chlamydia trachomatis antigens that are capable of eliciting T cell and antibody responses that provide protection against vaginal challenge.

Picard MD, Cohane KP, Gierahn TM, Higgins DE, Flechtner JB.

Vaccine. 2012 Jun 19;30(29):4387-93. doi: 10.1016/j.vaccine.2012.01.017.

PMID:
22682294
19.

Interactions of Listeria monocytogenes with the autophagy system of host cells.

Lam GY, Czuczman MA, Higgins DE, Brumell JH.

Adv Immunol. 2012;113:7-18. doi: 10.1016/B978-0-12-394590-7.00008-7. Review.

PMID:
22244576
20.

Listeriolysin O suppresses phospholipase C-mediated activation of the microbicidal NADPH oxidase to promote Listeria monocytogenes infection.

Lam GY, Fattouh R, Muise AM, Grinstein S, Higgins DE, Brumell JH.

Cell Host Microbe. 2011 Dec 15;10(6):627-34. doi: 10.1016/j.chom.2011.11.005.

21.

A protein thermometer controls temperature-dependent transcription of flagellar motility genes in Listeria monocytogenes.

Kamp HD, Higgins DE.

PLoS Pathog. 2011 Aug;7(8):e1002153. doi: 10.1371/journal.ppat.1002153. Epub 2011 Aug 4.

22.

T(H)17-based vaccine design for prevention of Streptococcus pneumoniae colonization.

Moffitt KL, Gierahn TM, Lu YJ, Gouveia P, Alderson M, Flechtner JB, Higgins DE, Malley R.

Cell Host Microbe. 2011 Feb 17;9(2):158-65. doi: 10.1016/j.chom.2011.01.007.

23.

Inhibition of Listeria monocytogenes infection by neurological drugs.

Lieberman LA, Higgins DE.

Int J Antimicrob Agents. 2010 Mar;35(3):292-6. doi: 10.1016/j.ijantimicag.2009.10.011. Epub 2009 Dec 23.

24.
25.

Perturbation of vacuolar maturation promotes listeriolysin O-independent vacuolar escape during Listeria monocytogenes infection of human cells.

Burrack LS, Harper JW, Higgins DE.

Cell Microbiol. 2009 Sep;11(9):1382-98. doi: 10.1111/j.1462-5822.2009.01338.x. Epub 2009 Jun 2.

26.

Recognition of AT-rich DNA binding sites by the MogR repressor.

Shen A, Higgins DE, Panne D.

Structure. 2009 May 13;17(5):769-77. doi: 10.1016/j.str.2009.02.018.

27.

A small-molecule screen identifies the antipsychotic drug pimozide as an inhibitor of Listeria monocytogenes infection.

Lieberman LA, Higgins DE.

Antimicrob Agents Chemother. 2009 Feb;53(2):756-64. doi: 10.1128/AAC.00607-08. Epub 2008 Nov 17.

28.

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease.

Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EE, Higgins DE, Schreiber S, Glimcher LH, Blumberg RS.

Cell. 2008 Sep 5;134(5):743-56. doi: 10.1016/j.cell.2008.07.021.

29.

Inhibition of ROCK activity allows InlF-mediated invasion and increased virulence of Listeria monocytogenes.

Kirchner M, Higgins DE.

Mol Microbiol. 2008 May;68(3):749-67. doi: 10.1111/j.1365-2958.2008.06188.x. Epub 2008 Mar 4.

30.

Stimulation of enhanced CD8 T cell responses following immunization with a hyper-antigen secreting intracytosolic bacterial pathogen.

Smithey MJ, Brandt S, Freitag NE, Higgins DE, Bouwer HG.

J Immunol. 2008 Mar 1;180(5):3406-16.

31.

Avoiding death by autophagy: interactions of Listeria monocytogenes with the macrophage autophagy system.

Birmingham CL, Higgins DE, Brumell JH.

Autophagy. 2008 Apr;4(3):368-71. Epub 2008 Jan 17.

PMID:
18216493
32.

Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles.

Birmingham CL, Canadien V, Kaniuk NA, Steinberg BE, Higgins DE, Brumell JH.

Nature. 2008 Jan 17;451(7176):350-4. doi: 10.1038/nature06479.

PMID:
18202661
33.

Listeria monocytogenes evades killing by autophagy during colonization of host cells.

Birmingham CL, Canadien V, Gouin E, Troy EB, Yoshimori T, Cossart P, Higgins DE, Brumell JH.

Autophagy. 2007 Sep-Oct;3(5):442-51. Epub 2007 May 18.

PMID:
17568179
34.

Flagellar motility is critical for Listeria monocytogenes biofilm formation.

Lemon KP, Higgins DE, Kolter R.

J Bacteriol. 2007 Jun;189(12):4418-24. Epub 2007 Apr 6.

35.
36.

Genomic approaches to understanding bacterial virulence.

Burrack LS, Higgins DE.

Curr Opin Microbiol. 2007 Feb;10(1):4-9. Epub 2006 Dec 11. Review.

PMID:
17161645
37.

A bifunctional O-GlcNAc transferase governs flagellar motility through anti-repression.

Shen A, Kamp HD, Gründling A, Higgins DE.

Genes Dev. 2006 Dec 1;20(23):3283-95.

38.

Monitoring the T cell response to genital tract infection.

Roan NR, Gierahn TM, Higgins DE, Starnbach MN.

Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12069-74. Epub 2006 Jul 31.

39.

Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria.

Yoshida M, Kobayashi K, Kuo TT, Bry L, Glickman JN, Claypool SM, Kaser A, Nagaishi T, Higgins DE, Mizoguchi E, Wakatsuki Y, Roopenian DC, Mizoguchi A, Lencer WI, Blumberg RS.

J Clin Invest. 2006 Aug;116(8):2142-2151.

41.

Directed antigen delivery as a vaccine strategy for an intracellular bacterial pathogen.

Bouwer HG, Alberti-Segui C, Montfort MJ, Berkowitz ND, Higgins DE.

Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5102-7. Epub 2006 Mar 20.

42.

Cytolysin-dependent delay of vacuole maturation in macrophages infected with Listeria monocytogenes.

Henry R, Shaughnessy L, Loessner MJ, Alberti-Segui C, Higgins DE, Swanson JA.

Cell Microbiol. 2006 Jan;8(1):107-19.

44.
45.

Genome-wide RNAi screen for host factors required for intracellular bacterial infection.

Agaisse H, Burrack LS, Philips JA, Rubin EJ, Perrimon N, Higgins DE.

Science. 2005 Aug 19;309(5738):1248-51. Epub 2005 Jul 14.

46.

Ipr1 gene mediates innate immunity to tuberculosis.

Pan H, Yan BS, Rojas M, Shebzukhov YV, Zhou H, Kobzik L, Higgins DE, Daly MJ, Bloom BR, Kramnik I.

Nature. 2005 Apr 7;434(7034):767-72.

47.

The host resistance locus sst1 controls innate immunity to Listeria monocytogenes infection in immunodeficient mice.

Boyartchuk V, Rojas M, Yan BS, Jobe O, Hurt N, Dorfman DM, Higgins DE, Dietrich WF, Kramnik I.

J Immunol. 2004 Oct 15;173(8):5112-20.

48.

Listeria monocytogenes regulates flagellar motility gene expression through MogR, a transcriptional repressor required for virulence.

Gründling A, Burrack LS, Bouwer HG, Higgins DE.

Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12318-23. Epub 2004 Aug 9.

49.

Listeria monocytogenes as a vaccine vector: virulence attenuation or existing antivector immunity does not diminish therapeutic efficacy.

Starks H, Bruhn KW, Shen H, Barry RA, Dubensky TW, Brockstedt D, Hinrichs DJ, Higgins DE, Miller JF, Giedlin M, Bouwer HG.

J Immunol. 2004 Jul 1;173(1):420-7.

50.

Escherichia coli expressing recombinant antigen and listeriolysin O stimulate class I-restricted CD8+ T cells following uptake by human APC.

Hu PQ, Tuma-Warrino RJ, Bryan MA, Mitchell KG, Higgins DE, Watkins SC, Salter RD.

J Immunol. 2004 Feb 1;172(3):1595-601.

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