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Items: 1 to 50 of 223

1.

mRNA escape from stress granule sequestration is dictated by localization to the endoplasmic reticulum.

Unsworth H, Raguz S, Edwards HJ, Higgins CF, Yagüe E.

FASEB J. 2010 Sep;24(9):3370-80. doi: 10.1096/fj.09-151142. Epub 2010 May 7.

2.

Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death.

Taylor SR, Gonzalez-Begne M, Dewhurst S, Chimini G, Higgins CF, Melvin JE, Elliott JI.

J Immunol. 2008 Jan 1;180(1):300-8.

3.

Production of P-glycoprotein from the MDR1 upstream promoter is insufficient to affect the response to first-line chemotherapy in advanced breast cancer.

Raguz S, Randle RA, Sharpe ER, Foekens JA, Sieuwerts AM, Meijer-van Gelder ME, Melo JV, Higgins CF, Yagüe E.

Int J Cancer. 2008 Mar 1;122(5):1058-67.

4.

Role of the highly structured 5'-end region of MDR1 mRNA in P-glycoprotein expression.

Randle RA, Raguz S, Higgins CF, Yagüe E.

Biochem J. 2007 Sep 15;406(3):445-55.

5.

Multiple molecular mechanisms for multidrug resistance transporters.

Higgins CF.

Nature. 2007 Apr 12;446(7137):749-57. Review.

PMID:
17429392
6.

ClC-3 expression enhances etoposide resistance by increasing acidification of the late endocytic compartment.

Weylandt KH, Nebrig M, Jansen-Rosseck N, Amey JS, Carmena D, Wiedenmann B, Higgins CF, Sardini A.

Mol Cancer Ther. 2007 Mar;6(3):979-86. Erratum in: Mol Cancer Ther. 2008 Jul;7(7):2261.

7.

Regulatory T cells are resistant to apoptosis via TCR but not P2X7.

Taylor SR, Alexander DR, Cooper JC, Higgins CF, Elliott JI.

J Immunol. 2007 Mar 15;178(6):3474-82.

8.

Ability to acquire drug resistance arises early during the tumorigenesis process.

Yagüe E, Arance A, Kubitza L, O'Hare M, Jat P, Ogilvie CM, Hart IR, Higgins CF, Raguz S.

Cancer Res. 2007 Feb 1;67(3):1130-7.

9.

Twenty years of ATP-binding cassette (ABC) transporters.

Stieger B, Higgins CF.

Pflugers Arch. 2007 Feb;453(5):543. No abstract available.

10.

The human ClC-4 protein, a member of the CLC chloride channel/transporter family, is localized to the endoplasmic reticulum by its N-terminus.

Okkenhaug H, Weylandt KH, Carmena D, Wells DJ, Higgins CF, Sardini A.

FASEB J. 2006 Nov;20(13):2390-2. Epub 2006 Oct 3.

PMID:
17023393
11.

Structure and function of ABC transporters: the ATP switch provides flexible control.

Linton KJ, Higgins CF.

Pflugers Arch. 2007 Feb;453(5):555-67. Epub 2006 Aug 26. Review.

PMID:
16937116
12.

Phosphatidylserine exposure in B lymphocytes: a role for lipid packing.

Elliott JI, Sardini A, Cooper JC, Alexander DR, Davanture S, Chimini G, Higgins CF.

Blood. 2006 Sep 1;108(5):1611-7. Epub 2006 May 9.

13.

Role for centromeric heterochromatin and PML nuclear bodies in the cellular response to foreign DNA.

Bishop CL, Ramalho M, Nadkarni N, May Kong W, Higgins CF, Krauzewicz N.

Mol Cell Biol. 2006 Apr;26(7):2583-94. Erratum in: Mol Cell Biol. 2006 May;26(10):3997.

14.

Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes.

Elliott JI, Surprenant A, Marelli-Berg FM, Cooper JC, Cassady-Cain RL, Wooding C, Linton K, Alexander DR, Higgins CF.

Nat Cell Biol. 2005 Aug;7(8):808-16. Epub 2005 Jul 17.

PMID:
16025105
15.

Expression of RPIP9 (Rap2 interacting protein 9) is activated in breast carcinoma and correlates with a poor prognosis.

Raguz S, De Bella MT, Slade MJ, Higgins CF, Coombes RC, Yagüe E.

Int J Cancer. 2005 Dec 20;117(6):934-41.

16.
17.

Accelerated exposure of phosphatidylserine on lymphocyte populations from patients with systemic lupus erythematosus or rheumatoid arthritis.

Albrecht C, Soumian S, Playford R, Higgins CF, Vyse T, Elliott J.

Thromb Haemost. 2005 May;93(5):989-92. No abstract available.

PMID:
15886819
18.

A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome.

Albrecht C, McVey JH, Elliott JI, Sardini A, Kasza I, Mumford AD, Naoumova RP, Tuddenham EG, Szabo K, Higgins CF.

Blood. 2005 Jul 15;106(2):542-9. Epub 2005 Mar 24.

19.

ABCA1 expression in carotid atherosclerotic plaques.

Albrecht C, Soumian S, Amey JS, Sardini A, Higgins CF, Davies AH, Gibbs RG.

Stroke. 2004 Dec;35(12):2801-6. Epub 2004 Nov 4.

PMID:
15528463
20.

Multidrug transporter activity in lymphocytes.

Elliott JI, Raguz S, Higgins CF.

Br J Pharmacol. 2004 Dec;143(7):899-907. Epub 2004 Oct 18.

21.
22.

Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state.

Rosenberg MF, Callaghan R, Modok S, Higgins CF, Ford RC.

J Biol Chem. 2005 Jan 28;280(4):2857-62. Epub 2004 Oct 13.

23.

The ATP switch model for ABC transporters.

Higgins CF, Linton KJ.

Nat Struct Mol Biol. 2004 Oct;11(10):918-26. Review.

PMID:
15452563
24.

Extracellular acidification elicits a chloride current that shares characteristics with ICl(swell).

Nobles M, Higgins CF, Sardini A.

Am J Physiol Cell Physiol. 2004 Nov;287(5):C1426-35. Epub 2004 Aug 11.

26.

Complete reversal of multidrug resistance by stable expression of small interfering RNAs targeting MDR1.

Yagüe E, Higgins CF, Raguz S.

Gene Ther. 2004 Jul;11(14):1170-4.

PMID:
15164094
27.

Two novel missense mutations in ABCA1 result in altered trafficking and cause severe autosomal recessive HDL deficiency.

Albrecht C, Baynes K, Sardini A, Schepelmann S, Eden ER, Davies SW, Higgins CF, Feher MD, Owen JS, Soutar AK.

Biochim Biophys Acta. 2004 May 24;1689(1):47-57.

28.

Activation of the MDR1 upstream promoter in breast carcinoma as a surrogate for metastatic invasion.

Raguz S, Tamburo De Bella M, Tripuraneni G, Slade MJ, Higgins CF, Coombes RC, Yagüe E.

Clin Cancer Res. 2004 Apr 15;10(8):2776-83.

29.

Characterisation of lymphocyte responses to Ca2+ in Scott syndrome.

Elliott JI, Mumford AD, Albrecht C, Collins PW, Giddings JC, Higgins CF, Tuddenham EG, McVey JH.

Thromb Haemost. 2004 Feb;91(2):412-5. Review. No abstract available.

PMID:
14961172
30.

Cell volume regulation and swelling-activated chloride channels.

Sardini A, Amey JS, Weylandt KH, Nobles M, Valverde MA, Higgins CF.

Biochim Biophys Acta. 2003 Dec 30;1618(2):153-62. Review.

31.

Leukocyte ABCA1 gene expression is associated with fasting glucose concentration in normoglycemic men.

Albrecht C, Simon-Vermot I, Elliott JI, Higgins CF, Johnston DG, Valabhji J.

Metabolism. 2004 Jan;53(1):17-21.

PMID:
14681836
32.

P-glycoprotein in blood-brain barrier endothelial cells: interaction and oligomerization with caveolins.

Jodoin J, Demeule M, Fenart L, Cecchelli R, Farmer S, Linton KJ, Higgins CF, Béliveau R.

J Neurochem. 2003 Nov;87(4):1010-23.

33.

An atomic detail model for the human ATP binding cassette transporter P-glycoprotein derived from disulfide cross-linking and homology modeling.

Stenham DR, Campbell JD, Sansom MS, Higgins CF, Kerr ID, Linton KJ.

FASEB J. 2003 Dec;17(15):2287-9. Epub 2003 Oct 16.

PMID:
14563687
34.

Definition of the domain boundaries is critical to the expression of the nucleotide-binding domains of P-glycoprotein.

Kerr ID, Berridge G, Linton KJ, Higgins CF, Callaghan R.

Eur Biophys J. 2003 Nov;32(7):644-54. Epub 2003 Jun 26.

PMID:
12830334
35.

ABCB4 gene sequence variation in women with intrahepatic cholestasis of pregnancy.

Müllenbach R, Linton KJ, Wiltshire S, Weerasekera N, Chambers J, Elias E, Higgins CF, Johnston DG, McCarthy MI, Williamson C.

J Med Genet. 2003 May;40(5):e70. No abstract available.

37.

P-glycoprotein (MDR1) expression in leukemic cells is regulated at two distinct steps, mRNA stabilization and translational initiation.

Yague E, Armesilla AL, Harrison G, Elliott J, Sardini A, Higgins CF, Raguz S.

J Biol Chem. 2003 Mar 21;278(12):10344-52. Epub 2003 Jan 13.

38.
39.

Functional analysis of candidate ABC transporter proteins for sitosterol transport.

Albrecht C, Elliott JI, Sardini A, Litman T, Stieger B, Meier PJ, Higgins CF.

Biochim Biophys Acta. 2002 Dec 23;1567(1-2):133-42.

40.

Scanning surface confocal microscopy for simultaneous topographical and fluorescence imaging: application to single virus-like particle entry into a cell.

Gorelik J, Shevchuk A, Ramalho M, Elliott M, Lei C, Higgins CF, Lab MJ, Klenerman D, Krauzewicz N, Korchev Y.

Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16018-23. Epub 2002 Dec 4.

41.

H-NS oligomerization domain structure reveals the mechanism for high order self-association of the intact protein.

Esposito D, Petrovic A, Harris R, Ono S, Eccleston JF, Mbabaali A, Haq I, Higgins CF, Hinton JC, Driscoll PC, Ladbury JE.

J Mol Biol. 2002 Dec 6;324(4):841-50.

PMID:
12460581
42.

The human bile salt export pump: characterization of substrate specificity and identification of inhibitors.

Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ.

Gastroenterology. 2002 Nov;123(5):1649-58.

PMID:
12404239
43.
44.

The vinblastine binding site adopts high- and low-affinity conformations during a transport cycle of P-glycoprotein.

Martin C, Higgins CF, Callaghan R.

Biochemistry. 2001 Dec 25;40(51):15733-42.

PMID:
11747450
45.

Detailed characterization of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild-type protein.

Taylor AM, Storm J, Soceneantu L, Linton KJ, Gabriel M, Martin C, Woodhouse J, Blott E, Higgins CF, Callaghan R.

Br J Pharmacol. 2001 Dec;134(8):1609-18.

46.

The importance of cholesterol in maintenance of P-glycoprotein activity and its membrane perturbing influence.

Rothnie A, Theron D, Soceneantu L, Martin C, Traikia M, Berridge G, Higgins CF, Devaux PF, Callaghan R.

Eur Biophys J. 2001 Oct;30(6):430-42.

PMID:
11718296
47.

Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1alpha promoter.

Gill DR, Smyth SE, Goddard CA, Pringle IA, Higgins CF, Colledge WH, Hyde SC.

Gene Ther. 2001 Oct;8(20):1539-46.

48.

Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle.

Rosenberg MF, Velarde G, Ford RC, Martin C, Berridge G, Kerr ID, Callaghan R, Schmidlin A, Wooding C, Linton KJ, Higgins CF.

EMBO J. 2001 Oct 15;20(20):5615-25.

49.

Structural biology. The xyz of ABC transporters.

Higgins CF, Linton KJ.

Science. 2001 Sep 7;293(5536):1782-4. No abstract available.

PMID:
11546861
50.

The multidrug resistance P-glycoprotein. Oligomeric state and intramolecular interactions.

Taylor JC, Horvath AR, Higgins CF, Begley GS.

J Biol Chem. 2001 Sep 28;276(39):36075-8. Epub 2001 Aug 8.

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