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Hydrogel-Coated Microneedle Arrays for Minimally Invasive Sampling and Sensing of Specific Circulating Nucleic Acids from Skin Interstitial Fluid.

Al Sulaiman D, Chang JYH, Bennett NR, Topouzi H, Higgins CA, Irvine DJ, Ladame S.

ACS Nano. 2019 Aug 27;13(8):9620-9628. doi: 10.1021/acsnano.9b04783. Epub 2019 Aug 16.


Predictors of Readmission Following Proctectomy for Rectal Cancer.

O'Connell EP, Healy V, Fitzpatrick F, Higgins CA, Burke JP, McNamara DA.

Dis Colon Rectum. 2019 Jun;62(6):703-710. doi: 10.1097/DCR.0000000000001355.


Demethylation of ITGAV accelerates osteogenic differentiation in a blast-induced heterotopic ossification in vitro cell culture model.

Logan NJ, Camman M, Williams G, Higgins CA.

Bone. 2018 Dec;117:149-160. doi: 10.1016/j.bone.2018.09.008. Epub 2018 Sep 13.


Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Haematopoiesis in Mouse Cultures.

Liu J, Higgins CA, Whitehouse JC, Harris SJ, Crawford H, Christiano AM, Lako M, Hole N, Jahoda CAB.

Stem Cells Int. 2018 Aug 2;2018:8631432. doi: 10.1155/2018/8631432. eCollection 2018.


A bald statement - Current approaches to manipulate miniaturisation focus only on promoting hair growth.

Pantelireis N, Higgins CA.

Exp Dermatol. 2018 Sep;27(9):959-965. doi: 10.1111/exd.13690. Epub 2018 Jun 28.


The Hair Follicle: An Underutilized Source of Cells and Materials for Regenerative Medicine.

Kiani MT, Higgins CA, Almquist BD.

ACS Biomater Sci Eng. 2018 Apr 9;4(4):1193-1207. doi: 10.1021/acsbiomaterials.7b00072. Epub 2017 Mar 21.


Subpopulations of dermal skin fibroblasts secrete distinct extracellular matrix: implications for using skin substitutes in the clinic.

Ghetti M, Topouzi H, Theocharidis G, Papa V, Williams G, Bondioli E, Cenacchi G, Connelly JT, Higgins CA.

Br J Dermatol. 2018 Aug;179(2):381-393. doi: 10.1111/bjd.16255. Epub 2018 May 16.


Evaluating Primary Blast Effects In Vitro.

Logan NJ, Arora H, Higgins CA.

J Vis Exp. 2017 Sep 18;(127). doi: 10.3791/55618.


Methods for the isolation and 3D culture of dermal papilla cells from human hair follicles.

Topouzi H, Logan NJ, Williams G, Higgins CA.

Exp Dermatol. 2017 Jun;26(6):491-496. doi: 10.1111/exd.13368. Review.


The onward march of PCSK9 inhibition.

Higgins CA, Rees A.

Curr Opin Lipidol. 2017 Apr;28(2):222-223. doi: 10.1097/MOL.0000000000000401. No abstract available.


Baseline Prevalence of Birth Defects Associated with Congenital Zika Virus Infection - Massachusetts, North Carolina, and Atlanta, Georgia, 2013-2014.

Cragan JD, Mai CT, Petersen EE, Liberman RF, Forestieri NE, Stevens AC, Delaney A, Dawson AL, Ellington SR, Shapiro-Mendoza CK, Dunn JE, Higgins CA, Meyer RE, Williams T, Polen KN, Newsome K, Reynolds M, Isenburg J, Gilboa SM, Meaney-Delman DM, Moore CA, Boyle CA, Honein MA.

MMWR Morb Mortal Wkly Rep. 2017 Mar 3;66(8):219-222. doi: 10.15585/mmwr.mm6608a4.


Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export.

Behrens RT, Aligeti M, Pocock GM, Higgins CA, Sherer NM.

J Virol. 2017 Jan 18;91(3). pii: e02107-16. doi: 10.1128/JVI.02107-16. Print 2017 Feb 1.


Multifaceted role of hair follicle dermal cells in bioengineered skins.

Higgins CA, Roger MF, Hill RP, Ali-Khan AS, Garlick JA, Christiano AM, Jahoda CAB.

Br J Dermatol. 2017 May;176(5):1259-1269. doi: 10.1111/bjd.15087. Epub 2017 Mar 14.


Changing faces: can a new identity stop balding?

Topouzi H, Higgins CA.

Exp Dermatol. 2016 Oct;25(10):765-6. doi: 10.1111/exd.13094. No abstract available.


Do the mechanisms by which LDL-c levels are reduced influence the extent of clinical benefit which subsequently accrues?

Higgins CA, Rees A.

Curr Opin Lipidol. 2016 Apr;27(2):207-8. doi: 10.1097/MOL.0000000000000284. No abstract available.


Pharmacologic inhibition of JAK-STAT signaling promotes hair growth.

Harel S, Higgins CA, Cerise JE, Dai Z, Chen JC, Clynes R, Christiano AM.

Sci Adv. 2015 Oct 23;1(9):e1500973. doi: 10.1126/sciadv.1500973. eCollection 2015 Oct.


Development of a potent and selective cell penetrant Legumain inhibitor.

Ness KA, Eddie SL, Higgins CA, Templeman A, D'Costa Z, Gaddale KK, Bouzzaoui S, Jordan L, Janssen D, Harrison T, Burkamp F, Young A, Burden R, Scott CJ, Mullan PB, Williams R.

Bioorg Med Chem Lett. 2015 Dec 1;25(23):5642-5. doi: 10.1016/j.bmcl.2015.10.001. Epub 2015 Oct 9.


Melanin Transfer in Human 3D Skin Equivalents Generated Exclusively from Induced Pluripotent Stem Cells.

Gledhill K, Guo Z, Umegaki-Arao N, Higgins CA, Itoh M, Christiano AM.

PLoS One. 2015 Aug 26;10(8):e0136713. doi: 10.1371/journal.pone.0136713. eCollection 2015.


Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.

Xing L, Dai Z, Jabbari A, Cerise JE, Higgins CA, Gong W, de Jong A, Harel S, DeStefano GM, Rothman L, Singh P, Petukhova L, Mackay-Wiggan J, Christiano AM, Clynes R.

Nat Med. 2014 Sep;20(9):1043-9. doi: 10.1038/nm.3645. Epub 2014 Aug 17.


Delayed diagnosis of critical congenital heart defects: trends and associated factors.

Liberman RF, Getz KD, Lin AE, Higgins CA, Sekhavat S, Markenson GR, Anderka M.

Pediatrics. 2014 Aug;134(2):e373-81. doi: 10.1542/peds.2013-3949.


FGF5 is a crucial regulator of hair length in humans.

Higgins CA, Petukhova L, Harel S, Ho YY, Drill E, Shapiro L, Wajid M, Christiano AM.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10648-53. doi: 10.1073/pnas.1402862111. Epub 2014 Jul 2.


Interrogating the integument: the role of the epidermis in hair induction.

Higgins CA.

Exp Dermatol. 2014 Oct;23(10):714-5. doi: 10.1111/exd.12465.


Differential affinity of FLIP and procaspase 8 for FADD's DED binding surfaces regulates DISC assembly.

Majkut J, Sgobba M, Holohan C, Crawford N, Logan AE, Kerr E, Higgins CA, Redmond KL, Riley JS, Stasik I, Fennell DA, Van Schaeybroeck S, Haider S, Johnston PG, Haigh D, Longley DB.

Nat Commun. 2014 Feb 28;5:3350. doi: 10.1038/ncomms4350.


Building a microphysiological skin model from induced pluripotent stem cells.

Guo Z, Higgins CA, Gillette BM, Itoh M, Umegaki N, Gledhill K, Sia SK, Christiano AM.

Stem Cell Res Ther. 2013;4 Suppl 1:S2. doi: 10.1186/scrt363. Epub 2013 Dec 20. Review.


Identification of distinct mutations in AAGAB in families with type 1 punctate palmoplantar keratoderma.

Furniss M, Higgins CA, Martinez-Mir A, Horev L, Petukhova L, Stanimirović A, Miljković J, Zlotogorski A, Christiano AM.

J Invest Dermatol. 2014 Jun;134(6):1749-1752. doi: 10.1038/jid.2014.4. Epub 2014 Jan 3. No abstract available.


Regenerative medicine and hair loss: how hair follicle culture has advanced our understanding of treatment options for androgenetic alopecia.

Higgins CA, Christiano AM.

Regen Med. 2014 Jan;9(1):101-11. doi: 10.2217/rme.13.87. Review.


Generation of 3D skin equivalents fully reconstituted from human induced pluripotent stem cells (iPSCs).

Itoh M, Umegaki-Arao N, Guo Z, Liu L, Higgins CA, Christiano AM.

PLoS One. 2013 Oct 11;8(10):e77673. doi: 10.1371/journal.pone.0077673. eCollection 2013.


Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth.

Higgins CA, Chen JC, Cerise JE, Jahoda CA, Christiano AM.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19679-88. doi: 10.1073/pnas.1309970110. Epub 2013 Oct 21.


Protease activity, localization and inhibition in the human hair follicle.

Bhogal RK, Mouser PE, Higgins CA, Turner GA.

Int J Cosmet Sci. 2014 Feb;36(1):46-53. doi: 10.1111/ics.12091. Epub 2013 Oct 15.


Generation and characterization of multipotent stem cells from established dermal cultures.

Hill RP, Gledhill K, Gardner A, Higgins CA, Crawford H, Lawrence C, Hutchison CJ, Owens WA, Kara B, James SE, Jahoda CA.

PLoS One. 2012;7(11):e50742. doi: 10.1371/journal.pone.0050742. Epub 2012 Nov 30.


Real-time monitoring of tyrosine hydroxylase activity using a plate reader assay.

Vermeer LM, Higgins CA, Roman DL, Doorn JA.

Anal Biochem. 2013 Jan 1;432(1):11-5. doi: 10.1016/j.ab.2012.09.005. Epub 2012 Sep 23.


Expression and purification of recombinant human tyrosine hydroxylase as a fusion protein in Escherichia coli.

Higgins CA, Vermeer LM, Doorn JA, Roman DL.

Protein Expr Purif. 2012 Aug;84(2):219-23. doi: 10.1016/j.pep.2012.05.007. Epub 2012 Jun 1.


A population-based case-control study of aetiological factors associated with vulval lichen sclerosus.

Higgins CA, Cruickshank ME.

J Obstet Gynaecol. 2012 Apr;32(3):271-5. doi: 10.3109/01443615.2011.649320.


Reprogramming of human hair follicle dermal papilla cells into induced pluripotent stem cells.

Higgins CA, Itoh M, Inoue K, Richardson GD, Jahoda CA, Christiano AM.

J Invest Dermatol. 2012 Jun;132(6):1725-7. doi: 10.1038/jid.2012.12. Epub 2012 Feb 16. No abstract available.


The chemokine receptor CCR2 is not required for successful initiation of labor in mice.

Menzies FM, Khan AH, Higgins CA, Nelson SM, Nibbs RJ.

Biol Reprod. 2012 Apr 19;86(4):118. doi: 10.1095/biolreprod.111.094631. Print 2012 Apr.


Specificity determinants of allosteric modulation in the neuronal nicotinic acetylcholine receptor: a fine line between inhibition and potentiation.

Cesa LC, Higgins CA, Sando SR, Kuo DW, Levandoski MM.

Mol Pharmacol. 2012 Feb;81(2):239-49. doi: 10.1124/mol.111.076059. Epub 2011 Nov 7.


Modulation in proteolytic activity is identified as a hallmark of exogen by transcriptional profiling of hair follicles.

Higgins CA, Westgate GE, Jahoda CA.

J Invest Dermatol. 2011 Dec;131(12):2349-57. doi: 10.1038/jid.2011.227. Epub 2011 Aug 11.


Mast cells reside in myometrium and cervix, but are dispensable in mice for successful pregnancy and labor.

Menzies FM, Higgins CA, Shepherd MC, Nibbs RJ, Nelson SM.

Immunol Cell Biol. 2012 Mar;90(3):321-9. doi: 10.1038/icb.2011.40. Epub 2011 May 17.


Growth inhibitory activity of extracted material and isolated compounds from the fruits of Kigelia pinnata.

Higgins CA, Bell T, Delbederi Z, Feutren-Burton S, McClean B, O'Dowd C, Watters W, Armstrong P, Waugh D, van den Berg H.

Planta Med. 2010 Nov;76(16):1840-6. doi: 10.1055/s-0030-1250046. Epub 2010 Jun 17.


Modelling the hair follicle dermal papilla using spheroid cell cultures.

Higgins CA, Richardson GD, Ferdinando D, Westgate GE, Jahoda CA.

Exp Dermatol. 2010 Jun;19(6):546-8. doi: 10.1111/j.1600-0625.2009.01007.x. Epub 2010 Apr 20.


Maternal obesity and its relationship with spontaneous and oxytocin-induced contractility of human myometrium in vitro.

Higgins CA, Martin W, Anderson L, Blanks AM, Norman JE, McConnachie A, Nelson SM.

Reprod Sci. 2010 Feb;17(2):177-85. doi: 10.1177/1933719109349780. Epub 2009 Oct 13.


Synthesis and in vitro and in vivo evaluation of a series of dihydroisocoumarin derivatives conjugated with fatty acids, alcohols, and amines as potential anticancer agents.

Higgins CA, Delbederi Z, McGarel K, Mills T, McGrath O, Feutren-Burton S, Watters W, Armstrong P, Johnston PG, Waugh D, van den Berg H.

Bioconjug Chem. 2009 Sep;20(9):1737-51. doi: 10.1021/bc900122g.


Exogen involves gradual release of the hair club fibre in the vibrissa follicle model.

Higgins CA, Richardson GD, Westgate GE, Jahoda CA.

Exp Dermatol. 2009 Sep;18(9):793-5. doi: 10.1111/j.1600-0625.2008.00833.x.


From telogen to exogen: mechanisms underlying formation and subsequent loss of the hair club fiber.

Higgins CA, Westgate GE, Jahoda CA.

J Invest Dermatol. 2009 Sep;129(9):2100-8. doi: 10.1038/jid.2009.66. Epub 2009 Apr 2. Review.


Clinician reviewers in birth defects surveillance programs: survey of the National Birth Defects Prevention Network.

Lin AE, Forrester MB, Cunniff C, Higgins CA, Anderka M.

Birth Defects Res A Clin Mol Teratol. 2006 Nov;76(11):781-6.


Revision cochlear implant surgery in adult patients with suspected device malfunction.

Buchman CA, Higgins CA, Cullen R, Pillsbury HC.

Otol Neurotol. 2004 Jul;25(4):504-10; discussion 510.


T cell activation: in vivo veritas.

Fazekas de St Groth B, Smith AL, Higgins CA.

Immunol Cell Biol. 2004 Jun;82(3):260-8.


A community-wide infant mortality review: findings and implications.

McCloskey L, Plough AL, Power KL, Higgins CA, Cruz AN, Brown ER.

Public Health Rep. 1999 Mar-Apr;114(2):165-77.

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