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Items: 32


Production of a Functional Factor, p40, by Lactobacillus rhamnosus GG Is Promoted by Intestinal Epithelial Cell-Secreted Extracellular Vesicles.

Yang L, Higginbotham JN, Liu L, Zhao G, Acra SA, Peek RM Jr, Polk DB, Li H, Yan F.

Infect Immun. 2019 Jun 20;87(7). pii: e00113-19. doi: 10.1128/IAI.00113-19. Print 2019 Jul.


Transfer of Functional Cargo in Exomeres.

Zhang Q, Higginbotham JN, Jeppesen DK, Yang YP, Li W, McKinley ET, Graves-Deal R, Ping J, Britain CM, Dorsett KA, Hartman CL, Ford DA, Allen RM, Vickers KC, Liu Q, Franklin JL, Bellis SL, Coffey RJ.

Cell Rep. 2019 Apr 16;27(3):940-954.e6. doi: 10.1016/j.celrep.2019.01.009. Epub 2019 Apr 4.


Reassessment of Exosome Composition.

Jeppesen DK, Fenix AM, Franklin JL, Higginbotham JN, Zhang Q, Zimmerman LJ, Liebler DC, Ping J, Liu Q, Evans R, Fissell WH, Patton JG, Rome LH, Burnette DT, Coffey RJ.

Cell. 2019 Apr 4;177(2):428-445.e18. doi: 10.1016/j.cell.2019.02.029.


Broad-spectrum receptor tyrosine kinase inhibitors overcome de novo and acquired modes of resistance to EGFR-targeted therapies in colorectal cancer.

Graves-Deal R, Bogatcheva G, Rehman S, Lu Y, Higginbotham JN, Singh B.

Oncotarget. 2019 Feb 12;10(13):1320-1333. doi: 10.18632/oncotarget.26663. eCollection 2019 Feb 12.


Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells.

Hinger SA, Cha DJ, Franklin JL, Higginbotham JN, Dou Y, Ping J, Shu L, Prasad N, Levy S, Zhang B, Liu Q, Weaver AM, Coffey RJ, Patton JG.

Cell Rep. 2018 Oct 16;25(3):715-725.e4. doi: 10.1016/j.celrep.2018.09.054.


Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells.

Zhang Q, Jeppesen DK, Higginbotham JN, Demory Beckler M, Poulin EJ, Walsh AJ, Skala MC, McKinley ET, Manning HC, Hight MR, Schulte ML, Watt KR, Ayers GD, Wolf MM, Andrejeva G, Rathmell JC, Franklin JL, Coffey RJ.

Cell Mol Gastroenterol Hepatol. 2018 Jan 31;5(4):627-629.e6. doi: 10.1016/j.jcmgh.2018.01.013. eCollection 2018. No abstract available.


Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes.

Dou Y, Cha DJ, Franklin JL, Higginbotham JN, Jeppesen DK, Weaver AM, Prasad N, Levy S, Coffey RJ, Patton JG, Zhang B.

Sci Rep. 2016 Nov 28;6:37982. doi: 10.1038/srep37982.


Autofluorescence flow sorting of breast cancer cell metabolism.

Shah AT, Cannon TM, Higginbotham JN, Coffey RJ, Skala MC.

J Biophotonics. 2017 Aug;10(8):1026-1033. doi: 10.1002/jbio.201600128. Epub 2016 Oct 12.


Identification and characterization of EGF receptor in individual exosomes by fluorescence-activated vesicle sorting.

Higginbotham JN, Zhang Q, Jeppesen DK, Scott AM, Manning HC, Ochieng J, Franklin JL, Coffey RJ.

J Extracell Vesicles. 2016 Jun 24;5:29254. doi: 10.3402/jev.v5.29254. eCollection 2016.


KRAS-dependent sorting of miRNA to exosomes.

Cha DJ, Franklin JL, Dou Y, Liu Q, Higginbotham JN, Demory Beckler M, Weaver AM, Vickers K, Prasad N, Levy S, Zhang B, Coffey RJ, Patton JG.

Elife. 2015 Jul 1;4:e07197. doi: 10.7554/eLife.07197.


Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.

Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.

Mol Cell Proteomics. 2013 Feb;12(2):343-55. doi: 10.1074/mcp.M112.022806. Epub 2012 Nov 15.


The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor.

Powell AE, Wang Y, Li Y, Poulin EJ, Means AL, Washington MK, Higginbotham JN, Juchheim A, Prasad N, Levy SE, Guo Y, Shyr Y, Aronow BJ, Haigis KM, Franklin JL, Coffey RJ.

Cell. 2012 Mar 30;149(1):146-58. doi: 10.1016/j.cell.2012.02.042.


Enterocyte microvillus-derived vesicles detoxify bacterial products and regulate epithelial-microbial interactions.

Shifrin DA Jr, McConnell RE, Nambiar R, Higginbotham JN, Coffey RJ, Tyska MJ.

Curr Biol. 2012 Apr 10;22(7):627-31. doi: 10.1016/j.cub.2012.02.022. Epub 2012 Mar 1.


Identification of a novel mono-leucine basolateral sorting motif within the cytoplasmic domain of amphiregulin.

Gephart JD, Singh B, Higginbotham JN, Franklin JL, Gonzalez A, Fölsch H, Coffey RJ.

Traffic. 2011 Dec;12(12):1793-804. doi: 10.1111/j.1600-0854.2011.01282.x. Epub 2011 Oct 13.


Amphiregulin exosomes increase cancer cell invasion.

Higginbotham JN, Demory Beckler M, Gephart JD, Franklin JL, Bogatcheva G, Kremers GJ, Piston DW, Ayers GD, McConnell RE, Tyska MJ, Coffey RJ.

Curr Biol. 2011 May 10;21(9):779-86. doi: 10.1016/j.cub.2011.03.043. Epub 2011 Apr 21.


Transformation of rat intestinal epithelial cells by overexpression of Rab25 is microtubule dependent.

Lapierre LA, Caldwell CM, Higginbotham JN, Avant KM, Hall J, Beauchamp RD, Goldenring JR.

Cytoskeleton (Hoboken). 2011 Feb;68(2):97-111. doi: 10.1002/cm.20497. Epub 2011 Jan 3.


The enterocyte microvillus is a vesicle-generating organelle.

McConnell RE, Higginbotham JN, Shifrin DA Jr, Tabb DL, Coffey RJ, Tyska MJ.

J Cell Biol. 2009 Jun 29;185(7):1285-98. doi: 10.1083/jcb.200902147.


Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis.

Cao Z, Li C, Higginbotham JN, Franklin JL, Tabb DL, Graves-Deal R, Hill S, Cheek K, Jerome WG, Lapierre LA, Goldenring JR, Ham AJ, Coffey RJ.

Mol Cell Proteomics. 2008 Sep;7(9):1651-67. doi: 10.1074/mcp.M700155-MCP200. Epub 2008 May 25.


Kinetic analysis of nanoparticulate polyelectrolyte complex interactions with endothelial cells.

Hartig SM, Greene RR, Carlesso G, Higginbotham JN, Khan WN, Prokop A, Davidson JM.

Biomaterials. 2007 Sep;28(26):3843-55. Epub 2007 May 3.


Cutting Edge: Oseltamivir decreases T cell GM1 expression and inhibits clearance of respiratory syncytial virus: potential role of endogenous sialidase in antiviral immunity.

Moore ML, Chi MH, Zhou W, Goleniewska K, O'Neal JF, Higginbotham JN, Peebles RS Jr.

J Immunol. 2007 Mar 1;178(5):2651-4.


Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human naïve and memory B cells.

Tian C, Luskin GK, Dischert KM, Higginbotham JN, Shepherd BE, Crowe JE Jr.

Mol Immunol. 2007 Mar;44(9):2173-83. Epub 2006 Dec 29.


Low expression of the interleukin (IL)-4 receptor alpha chain and reduced signalling via the IL-4 receptor complex in human neonatal B cells.

Tian C, Kron GK, Dischert KM, Higginbotham JN, Crowe JE Jr.

Immunology. 2006 Sep;119(1):54-62. Epub 2006 Jun 8.


Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier.

Choo EF, Kurnik D, Muszkat M, Ohkubo T, Shay SD, Higginbotham JN, Glaeser H, Kim RB, Wood AJ, Wilkinson GR.

J Pharmacol Exp Ther. 2006 Jun;317(3):1012-8. Epub 2006 Mar 14.


A novel approach using transcomplementing adenoviral vectors for gene therapy of adrenocortical cancer.

Wolkersdörfer GW, Bornstein SR, Higginbotham JN, Hiroi N, Vaquero JJ, Green MV, Blaese RM, Aguilera G, Chrousos GP, Ramsey WJ.

Horm Metab Res. 2002 Jun;34(6):279-87. Erratum in: Horm Metab Res. 2002 Oct;34(10):604..


AV.TK-mediated killing of subcutaneous tumors in situ results in effective immunization against established secondary intracranial tumor deposits.

Okada T, Shah M, Higginbotham JN, Li Q, Wildner O, Walbridge S, Oldfield E, Blaese RM, Ramsey WJ.

Gene Ther. 2001 Sep;8(17):1315-22.


Adeno-retroviral chimeric viruses as in vivo transducing agents.

Caplen NJ, Higginbotham JN, Scheel JR, Vahanian N, Yoshida Y, Hamada H, Blaese RM, Ramsey WJ.

Gene Ther. 1999 Mar;6(3):454-9.


Adenovirus vectors as transcomplementing templates for the production of replication defective retroviral vectors.

Ramsey WJ, Caplen NJ, Li Q, Higginbotham JN, Shah M, Blaese RM.

Biochem Biophys Res Commun. 1998 May 29;246(3):912-9.


Quantitative aspects of the feeder cell phenomenon: direct assessment of enhanced cystine uptake by lymphocytes.

Pruett SB, Higginbotham JN, Kiel JL.

Immunobiology. 1989 Oct;179(4-5):308-13.


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