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The neural ELAVL protein HuB enhances endogenous proto-oncogene activation.

Hatanaka T, Higashino F, Tei K, Yasuda M.

Biochem Biophys Res Commun. 2019 Sep 17;517(2):330-337. doi: 10.1016/j.bbrc.2019.07.089. Epub 2019 Jul 26.


Oncolytic potential of an E4-deficient adenovirus that can recognize the stabilization of AU-rich element containing mRNA in cancer cells.

Yanagawa-Matsuda A, Mikawa Y, Habiba U, Kitamura T, Yasuda M, Towfik-Alam M, Kitagawa Y, Minowa K, Shindoh M, Higashino F.

Oncol Rep. 2019 Feb;41(2):954-960. doi: 10.3892/or.2018.6865. Epub 2018 Nov 12.


HuR translocation to the cytoplasm of cancer cells in actin-independent manner.

Habiba U, Kuroshima T, Yanagawa-Matsuda A, Kitamura T, Chowdhury A, Jehung JP, Hossain E, Sano H, Kitagawa Y, Shindoh M, Higashino F.

Exp Cell Res. 2018 Aug 15;369(2):218-225. doi: 10.1016/j.yexcr.2018.05.021. Epub 2018 May 26.


Adenovirus infection induces HuR relocalization to facilitate virus replication.

Jehung JP, Kitamura T, Yanagawa-Matsuda A, Kuroshima T, Towfik A, Yasuda M, Sano H, Kitagawa Y, Minowa K, Shindoh M, Higashino F.

Biochem Biophys Res Commun. 2018 Jan 8;495(2):1795-1800. doi: 10.1016/j.bbrc.2017.12.036. Epub 2017 Dec 7.


ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia.

Habiba U, Hida K, Kitamura T, Matsuda AY, Higashino F, Ito YM, Ohiro Y, Totsuka Y, Shindoh M.

Oncol Lett. 2017 Jan;13(1):321-328. doi: 10.3892/ol.2016.5379. Epub 2016 Nov 10.


HuR and podoplanin expression is associated with a high risk of malignant transformation in patients with oral preneoplastic lesions.

Habiba U, Kitamura T, Yanagawa-Matsuda A, Higashino F, Hida K, Totsuka Y, Shindoh M.

Oncol Lett. 2016 Nov;12(5):3199-3207. Epub 2016 Aug 29.


Cytoplasmic expression of HuR may be a valuable diagnostic tool for determining the potential for malignant transformation of oral verrucous borderline lesions.

Habiba U, Kitamura T, Yanagawa-Matsuda A, Hida K, Higashino F, Ohiro Y, Totsuka Y, Shindoh M.

Oncol Rep. 2014 Apr;31(4):1547-54. doi: 10.3892/or.2014.3017. Epub 2014 Feb 10.


pp32r1 controls the decay of the RNA-binding protein HuR.

Imamachi K, Higashino F, Kitamura T, Kakuguchi W, Yanagawa-Matsuda A, Ishikawa M, Kitagawa Y, Totsuka Y, Shindoh M.

Oncol Rep. 2014 Mar;31(3):1103-8. doi: 10.3892/or.2013.2956. Epub 2013 Dec 31.


Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma.

Nagamine K, Kitamura T, Yanagawa-Matsuda A, Ohiro Y, Tei K, Hida K, Higashino F, Totsuka Y, Shindoh M.

Oncol Rep. 2013 Jun;29(6):2114-8. doi: 10.3892/or.2013.2393. Epub 2013 Apr 8.


E1A expression might be controlled by miR-214 in cells with low adenovirus productivity.

Yanagawa-Matsuda A, Kitamura T, Higashino F, Yamano S, Totsuka Y, Shindoh M.

Virus Res. 2012 Dec;170(1-2):85-90. doi: 10.1016/j.virusres.2012.09.001. Epub 2012 Sep 11.


Viral-mediated stabilization of AU-rich element containing mRNA contributes to cell transformation.

Kuroshima T, Aoyagi M, Yasuda M, Kitamura T, Jehung JP, Ishikawa M, Kitagawa Y, Totsuka Y, Shindoh M, Higashino F.

Oncogene. 2011 Jun 30;30(26):2912-20. doi: 10.1038/onc.2011.14. Epub 2011 Feb 14.


HuR keeps an angiogenic switch on by stabilising mRNA of VEGF and COX-2 in tumour endothelium.

Kurosu T, Ohga N, Hida Y, Maishi N, Akiyama K, Kakuguchi W, Kuroshima T, Kondo M, Akino T, Totsuka Y, Shindoh M, Higashino F, Hida K.

Br J Cancer. 2011 Mar 1;104(5):819-29. doi: 10.1038/bjc.2011.20. Epub 2011 Feb 1.


Phenotype of tumor lymphatic vessels is a prognostic factor in human tongue squamous cell carcinoma.

Nitta Y, Hida K, Kitamura T, Higashino F, Ohga N, Fukushima K, Shindoh M.

Oncol Lett. 2011 Jan;2(1):79-83. Epub 2010 Nov 8.


HuR knockdown changes the oncogenic potential of oral cancer cells.

Kakuguchi W, Kitamura T, Kuroshima T, Ishikawa M, Kitagawa Y, Totsuka Y, Shindoh M, Higashino F.

Mol Cancer Res. 2010 Apr;8(4):520-8. doi: 10.1158/1541-7786.MCR-09-0367. Epub 2010 Mar 23.


HuR is exported to the cytoplasm in oral cancer cells in a different manner from that of normal cells.

Hasegawa H, Kakuguchi W, Kuroshima T, Kitamura T, Tanaka S, Kitagawa Y, Totsuka Y, Shindoh M, Higashino F.

Br J Cancer. 2009 Jun 16;100(12):1943-8. doi: 10.1038/sj.bjc.6605084.


Pim-1 activation of cell motility induces the malignant phenotype of tongue carcinoma.

Tanaka S, Kitamura T, Higashino F, Hida K, Ohiro Y, Ono M, Kobayashi M, Totsuka Y, Shindoh M.

Mol Med Rep. 2009 Mar-Apr;2(2):313-8. doi: 10.3892/mmr_00000102.


Expression of E1AF, an ets-oncogene transcription factor, highly correlates with malignant phenotype of malignant melanoma through up-regulation of the membrane-type-1 matrix metalloproteinase gene.

Hata H, Kitamura T, Higashino F, Hida K, Yoshida K, Ohiro Y, Totsuka Y, Kitagawa Y, Shindoh M.

Oncol Rep. 2008 May;19(5):1093-8.


Synergistic up-regulation of Hexokinase-2, glucose transporters and angiogenic factors in pancreatic cancer cells by glucose deprivation and hypoxia.

Natsuizaka M, Ozasa M, Darmanin S, Miyamoto M, Kondo S, Kamada S, Shindoh M, Higashino F, Suhara W, Koide H, Aita K, Nakagawa K, Kondo T, Asaka M, Okada F, Kobayashi M.

Exp Cell Res. 2007 Sep 10;313(15):3337-48. Epub 2007 Jun 29.


Enhanced expression of asparagine synthetase under glucose-deprived conditions protects pancreatic cancer cells from apoptosis induced by glucose deprivation and cisplatin.

Cui H, Darmanin S, Natsuisaka M, Kondo T, Asaka M, Shindoh M, Higashino F, Hamuro J, Okada F, Kobayashi M, Nakagawa K, Koide H, Kobayashi M.

Cancer Res. 2007 Apr 1;67(7):3345-55.


Adenovirus E1A negatively regulates E1AF, an ets family of the protein.

Takahashi A, Higashino F, Aoyagi M, Nakayama M, Yanagawa A, Hasegawa H, Hatta M, Ishida S, Nakajima K, Totsuka Y, Shindoh M.

Biochem Biophys Res Commun. 2007 Apr 6;355(2):438-43. Epub 2007 Feb 7.


Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist.

Miseki T, Kawakami H, Natsuizaka M, Darmanin S, Cui HY, Chen J, Fu Q, Okada F, Shindo M, Higashino F, Asaka M, Hamuro J, Kobayashi M.

Cancer Gene Ther. 2007 Jan;14(1):39-44. Epub 2006 Jul 14.


Genomic structure and promoter activity of the E1AF gene, a member of the ETS oncogene family.

Ishida S, Higashino F, Aoyagi M, Takahashi A, Suzuki T, Shindoh M, Fujinaga K, Yoshida K.

Biochem Biophys Res Commun. 2006 Jan 6;339(1):325-30. Epub 2005 Nov 15.


Adenovirus E4orf6 targets pp32/LANP to control the fate of ARE-containing mRNAs by perturbing the CRM1-dependent mechanism.

Higashino F, Aoyagi M, Takahashi A, Ishino M, Taoka M, Isobe T, Kobayashi M, Totsuka Y, Kohgo T, Shindoh M.

J Cell Biol. 2005 Jul 4;170(1):15-20. Epub 2005 Jun 27.


E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters.

Izumiyama Y, Ohiro Y, Higashino F, Yoshida K, Taguchi K, Todo S, Kohgo T, Totsuka Y, Shindoh M.

Oncol Rep. 2005 Apr;13(4):715-20.


E1AF degradation by a ubiquitin-proteasome pathway.

Takahashi A, Higashino F, Aoyagi M, Yoshida K, Itoh M, Kobayashi M, Totsuka Y, Kohgo T, Shindoh M.

Biochem Biophys Res Commun. 2005 Feb 11;327(2):575-80.


E1AF, an ets-oncogene family transcription factor.

Shindoh M, Higashino F, Kohgo T.

Cancer Lett. 2004 Dec 8;216(1):1-8. Review.


Bisphenol A from dental polycarbonate crown upregulates the expression of hTERT.

Takahashi A, Higashino F, Aoyagi M, Kyo S, Nakata T, Noda M, Shindoh M, Kohgo T, Sano H.

J Biomed Mater Res B Appl Biomater. 2004 Oct 15;71(1):214-21.


EWS/ETS fusions activate telomerase in Ewing's tumors.

Takahashi A, Higashino F, Aoyagi M, Yoshida K, Itoh M, Kyo S, Ohno T, Taira T, Ariga H, Nakajima K, Hatta M, Kobayashi M, Sano H, Kohgo T, Shindoh M.

Cancer Res. 2003 Dec 1;63(23):8338-44.


Nuclear export of adenovirus E4orf6 protein is necessary for its ability to antagonize apoptotic activity of BH3-only proteins.

Aoyagi M, Higashino F, Yasuda M, Takahashi A, Sawada Y, Totsuka Y, Kohgo T, Sano H, Kobayashi M, Shindoh M.

Oncogene. 2003 Oct 9;22(44):6919-27.


Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism.

Chen J, Zhao S, Nakada K, Kuge Y, Tamaki N, Okada F, Wang J, Shindo M, Higashino F, Takeda K, Asaka M, Katoh H, Sugiyama T, Hosokawa M, Kobayashi M.

Am J Pathol. 2003 Apr;162(4):1283-91.


Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis.

Ishikawa T, Chen J, Wang J, Okada F, Sugiyama T, Kobayashi T, Shindo M, Higashino F, Katoh H, Asaka M, Kondo T, Hosokawa M, Kobayashi M.

Oncogene. 2003 Feb 27;22(8):1238-42.


Increased pre-therapeutic serum vascular endothelial growth factor in patients with early clinical relapse of osteosarcoma.

Kaya M, Wada T, Kawaguchi S, Nagoya S, Yamashita T, Abe Y, Hiraga H, Isu K, Shindoh M, Higashino F, Okada F, Tada M, Yamawaki S, Ishii S.

Br J Cancer. 2002 Mar 18;86(6):864-9.


BAG-1 expression correlates highly with the malignant potential in early lesions (T1 and T2) of oral squamous cell carcinoma.

Shindoh M, Adachi M, Higashino F, Yasuda M, Hida K, Nishioka T, Ono M, Takayama S, Reed JC, Imai K, Totsuka Y, Kohgo T.

Oral Oncol. 2000 Sep;36(5):444-9.


Membrane type 1-matrix metalloproteinase expression is regulated by E-cadherin through the suppression of mitogen-activated protein kinase cascade.

Ara T, Deyama Y, Yoshimura Y, Higashino F, Shindoh M, Matsumoto A, Fukuda H.

Cancer Lett. 2000 Sep 1;157(2):115-21.


[The cellular target proteins of adenovirus gene products].

Higashino F, Yasuda M, Shindoh M.

Tanpakushitsu Kakusan Koso. 2000 Jun;45(8):1350-7. Review. Japanese. No abstract available.


Hepatocyte growth factor upregulates E1AF that induces oral squamous cell carcinoma cell invasion by activating matrix metalloproteinase genes.

Hanzawa M, Shindoh M, Higashino F, Yasuda M, Inoue N, Hida K, Ono M, Kohgo T, Nakamura M, Notani K, Fukuda H, Totsuka Y, Yoshida K, Fujinaga K.

Carcinogenesis. 2000 Jun;21(6):1079-85.


Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis.

Kaya M, Wada T, Akatsuka T, Kawaguchi S, Nagoya S, Shindoh M, Higashino F, Mezawa F, Okada F, Ishii S.

Clin Cancer Res. 2000 Feb;6(2):572-7.


Selective secretion of chemoattractants for haemopoietic progenitor cells by bone marrow endothelial cells: a possible role in homing of haemopoietic progenitor cells to bone marrow.

Imai K, Kobayashi M, Wang J, Shinobu N, Yoshida H, Hamada J, Shindo M, Higashino F, Tanaka J, Asaka M, Hosokawa M.

Br J Haematol. 1999 Sep;106(4):905-11.


Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73.

Higashino F, Pipas JM, Shenk T.

Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15683-7.


Correlated expression of matrix metalloproteinases and ets family transcription factor E1A-F in invasive oral squamous-cell-carcinoma-derived cell lines.

Shindoh M, Higashino F, Kaya M, Yasuda M, Funaoka K, Hanzawa M, Hida K, Kohgo T, Amemiya A, Yoshida K, Fujinaga K.

Am J Pathol. 1996 Mar;148(3):693-700.


Fusion of an ETS-family gene, EIAF, to EWS by t(17;22)(q12;q12) chromosome translocation in an undifferentiated sarcoma of infancy.

Kaneko Y, Yoshida K, Handa M, Toyoda Y, Nishihira H, Tanaka Y, Sasaki Y, Ishida S, Higashino F, Fujinaga K.

Genes Chromosomes Cancer. 1996 Feb;15(2):115-21.


A single ets-related transcription factor, E1AF, confers invasive phenotype on human cancer cells.

Kaya M, Yoshida K, Higashino F, Mitaka T, Ishii S, Fujinaga K.

Oncogene. 1996 Jan 18;12(2):221-7.


Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21.

Isobe M, Yamagishi F, Yoshida K, Higashino F, Fujinaga K.

Genomics. 1995 Jul 20;28(2):357-9. No abstract available.


Ets-related protein E1A-F can activate three different matrix metalloproteinase gene promoters.

Higashino F, Yoshida K, Noumi T, Seiki M, Fujinaga K.

Oncogene. 1995 Apr 6;10(7):1461-3.


Transcriptional regulation of the adenovirus E1A gene.

Yoshida K, Higashino F, Fujinaga K.

Curr Top Microbiol Immunol. 1995;199 ( Pt 3):113-30. Review. No abstract available.


Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family.

Higashino F, Yoshida K, Fujinaga Y, Kamio K, Fujinaga K.

Nucleic Acids Res. 1993 Feb 11;21(3):547-53.


Hydrodynamics of arterial branching--the effect of arterial branching on distal blood supply.

Matsuo T, Okeda R, Higashino F.

Biorheology. 1989;26(4):799-811.


A study of experimental cyanide encephalopathy in the acute phase--physiological and neuropathological correlation.

Funata N, Song SY, Okeda R, Funata M, Higashino F.

Acta Neuropathol. 1984;64(2):99-107.


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