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Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes.

Sellers K, Allen TD, Bousamra M 2nd, Tan J, Méndez-Lucas A, Lin W, Bah N, Chernyavskaya Y, MacRae JI, Higashi RM, Lane AN, Fan TW, Yuneva MO.

Br J Cancer. 2019 May 22. doi: 10.1038/s41416-019-0464-z. [Epub ahead of print]


Underwater endoscopic mucosal resection for a colonic polyp located at the scar after endoscopic band ligation.

Kono Y, Katayama T, Miyahara K, Moritou Y, Higashi R, Kunihiro M, Nakagawa M.

Endoscopy. 2019 Apr 12. doi: 10.1055/a-0875-3266. [Epub ahead of print] No abstract available.


Towards quality assurance and quality control in untargeted metabolomics studies.

Beger RD, Dunn WB, Bandukwala A, Bethan B, Broadhurst D, Clish CB, Dasari S, Derr L, Evans A, Fischer S, Flynn T, Hartung T, Herrington D, Higashi R, Hsu PC, Jones C, Kachman M, Karuso H, Kruppa G, Lippa K, Maruvada P, Mosley J, Ntai I, O'Donovan C, Playdon M, Raftery D, Shaughnessy D, Souza A, Spaeder T, Spalholz B, Tayyari F, Ubhi B, Verma M, Walk T, Wilson I, Witkin K, Bearden DW, Zanetti KA.

Metabolomics. 2019 Jan 3;15(1):4. doi: 10.1007/s11306-018-1460-7.


New methods to identify high peak density artifacts in Fourier transform mass spectra and to mitigate their effects on high-throughput metabolomic data analysis.

Mitchell JM, Flight RM, Wang QJ, Higashi RM, Fan TW, Lane AN, Moseley HNB.

Metabolomics. 2018 Sep 17;14(10):125. doi: 10.1007/s11306-018-1426-9.


Patient and Provider Perspectives on 30-Day Readmissions, Preventability, and Strategies for Improving Transitions of Care for Patients with HIV at a Safety Net Hospital.

Nijhawan AE, Higashi RT, Marks EG, Tiruneh YM, Lee SC.

J Int Assoc Provid AIDS Care. 2019 Jan-Dec;18:2325958219827615. doi: 10.1177/2325958219827615.


Long-term outcomes of patients with Crohn's disease who received infliximab or adalimumab as the first-line biologics.

Inokuchi T, Takahashi S, Hiraoka S, Toyokawa T, Takagi S, Takemoto K, Miyaike J, Fujimoto T, Higashi R, Morito Y, Nawa T, Suzuki S, Nishimura M, Inoue M, Kato J, Okada H.

J Gastroenterol Hepatol. 2019 Feb 6. doi: 10.1111/jgh.14624. [Epub ahead of print]


Neoadjuvant chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil (DCF-RT) for locally advanced esophageal squamous cell carcinoma.

Sasaki K, Uchikado Y, Omoto I, Arigami T, Osako Y, Noda M, Okumura H, Maemura K, Higashi R, Yoshiura T, Natsugoe S.

Cancer Chemother Pharmacol. 2019 Mar;83(3):581-587. doi: 10.1007/s00280-018-03764-4. Epub 2019 Jan 8.


Exosomal lipids for classifying early and late stage non-small cell lung cancer.

Fan TWM, Zhang X, Wang C, Yang Y, Kang WY, Arnold S, Higashi RM, Liu J, Lane AN.

Anal Chim Acta. 2018 Dec 11;1037:256-264. doi: 10.1016/j.aca.2018.02.051. Epub 2018 Mar 9.


Family and Social Context Contributes to the Interplay of Economic Insecurity, Food Insecurity, and Health.

Higashi RT, Craddock Lee SJ, Pezzia C, Quirk L, Leonard T, Pruitt SL.

Ann Anthropol Pract. 2017 Nov;41(2):67-77. doi: 10.1111/napa.12114. Epub 2017 Nov 21.


Tumor bleeding requiring intervention and the correlation with anemia in uterine cervical cancer for definitive radiotherapy.

Yanazume S, Karakida N, Higashi R, Fukuda M, Togami S, Kamio M, Ota S, Kobayashi H.

Jpn J Clin Oncol. 2018 Oct 1;48(10):892-899. doi: 10.1093/jjco/hyy113.


The Progression of Esophageal Mucosa-associated Lymphoid Tissue Lymphoma after Helicobacter pylori Eradication Therapy: A Case Report and Discussion of Therapeutic Options.

Takeuchi Y, Miyahara K, Morito T, Okikawa Y, Kinugasa H, Moritou Y, Higashi R, Kunihiro M, Nakagawa M.

Intern Med. 2019 Jan 15;58(2):207-212. doi: 10.2169/internalmedicine.1112-18. Epub 2018 Aug 24.


Effects of program scale-up on time to resolution for patients with abnormal screening mammography results.

Lee SC, Higashi RT, Sanders JM, Zhu H, Inrig SJ, Mejias C, Argenbright KE, Tiro JA.

Cancer Causes Control. 2018 Oct;29(10):995-1005. doi: 10.1007/s10552-018-1074-4. Epub 2018 Aug 23.


Dexmedetomidine for conscious sedation with colorectal endoscopic submucosal dissection: a prospective double-blind randomized controlled study.

Kinugasa H, Higashi R, Miyahara K, Moritou Y, Hirao K, Ogawa T, Kunihiro M, Nakagawa M.

Clin Transl Gastroenterol. 2018 Jul 4;9(7):167. doi: 10.1038/s41424-018-0032-5.


Extracellular volume fraction determined by equilibrium contrast-enhanced multidetector computed tomography as a prognostic factor in unresectable pancreatic adenocarcinoma treated with chemotherapy.

Fukukura Y, Kumagae Y, Higashi R, Hakamada H, Takumi K, Maemura K, Higashi M, Kamimura K, Nakajo M, Yoshiura T.

Eur Radiol. 2019 Jan;29(1):353-361. doi: 10.1007/s00330-018-5570-4. Epub 2018 Jun 19.


Parent-Provider Communication of HPV Vaccine Hesitancy.

Shay LA, Baldwin AS, Betts AC, Marks EG, Higashi RT, Street RL Jr, Persaud D, Tiro JA.

Pediatrics. 2018 Jun;141(6). pii: e20172312. doi: 10.1542/peds.2017-2312. Epub 2018 May 15.


Isolation of High Carotenoid-producing Aurantiochytrium sp. Mutants and Improvement of Astaxanthin Productivity Using Metabolic Information.

Watanabe K, Arafiles KHV, Higashi R, Okamura Y, Tajima T, Matsumura Y, Nakashimada Y, Matsuyama K, Aki T.

J Oleo Sci. 2018 May 1;67(5):571-578. doi: 10.5650/jos.ess17230. Epub 2018 Apr 9.


Risk factors for radiation pneumonitis after stereotactic radiation therapy for lung tumours: clinical usefulness of the planning target volume to total lung volume ratio.

Ueyama T, Arimura T, Takumi K, Nakamura F, Higashi R, Ito S, Fukukura Y, Umanodan T, Nakajo M, Koriyama C, Yoshiura T.

Br J Radiol. 2018 Jun;91(1086):20170453. doi: 10.1259/bjr.20170453. Epub 2018 Apr 16.


Identifying quality improvement targets to facilitate colorectal cancer screening completion.

Lee SJC, Inrig SJ, Balasubramanian BA, Skinner CS, Higashi RT, McCallister K, Bishop WP, Santini NO, Tiro JA.

Prev Med Rep. 2018 Feb 2;9:138-143. doi: 10.1016/j.pmedr.2018.01.004. eCollection 2018 Mar.


[Gastric type adenoma with submucosal invasive carcinoma:a case study].

Hirata I, Kinugasa H, Miyahara K, Higashi R, Kunihiro M, Morito T, Ichimura K, Tanaka T, Nakagawa M.

Nihon Shokakibyo Gakkai Zasshi. 2018;115(3):283-289. doi: 10.11405/nisshoshi.115.283. Japanese.


Acute loss of iron-sulfur clusters results in metabolic reprogramming and generation of lipid droplets in mammalian cells.

Crooks DR, Maio N, Lane AN, Jarnik M, Higashi RM, Haller RG, Yang Y, Fan TW, Linehan WM, Rouault TA.

J Biol Chem. 2018 May 25;293(21):8297-8311. doi: 10.1074/jbc.RA118.001885. Epub 2018 Mar 9.


Correction: Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS.

Deng P, Higashi RM, Lane AN, Bruntz RC, Sun RC, Raju MVR, Nantz MH, Qi Z, Fan TW.

Analyst. 2018 Feb 12;143(4):999. doi: 10.1039/c8an90009d.


Impact of Computed Tomography Evaluation Before Colonoscopy for the Management of Colonic Diverticular Hemorrhage.

Ichiba T, Hara M, Miyahara K, Urashima M, Shintani A, Naitou H, Higashi R.

J Clin Gastroenterol. 2019 Feb;53(2):e75-e83. doi: 10.1097/MCG.0000000000000988.


The Influence of Financial Strain on Health Decision-Making.

Nguyen OK, Higashi RT, Makam AN, Mijares JC, Lee SC.

J Gen Intern Med. 2018 Apr;33(4):406-408. doi: 10.1007/s11606-017-4296-3. No abstract available.


Endoscopic band ligation for colonic diverticular bleeding.

Higashi R, Kinugasa H, Nakagawa M.

Dig Endosc. 2018 May;30(3):399. doi: 10.1111/den.13015. Epub 2018 Feb 4. No abstract available.


[Native Aortic Valve Endocarditis Caused by Nocardia asteroides;Report of a Case].

Ishitoya H, Sano E, Higashi R, Isshiki S, Sasaki H.

Kyobu Geka. 2017 Dec;70(13):1093-1096. Japanese.


Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS.

Deng P, Higashi RM, Lane AN, Bruntz RC, Sun RC, Ramakrishnam Raju MV, Nantz MH, Qi Z, Fan TW.

Analyst. 2017 Dec 18;143(1):311-322. doi: 10.1039/c7an01256j. Erratum in: Analyst. 2018 Feb 12;143(4):999.


Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing.

Sun RC, Fan TW, Deng P, Higashi RM, Lane AN, Le AT, Scott TL, Sun Q, Warmoes MO, Yang Y.

Nat Commun. 2017 Nov 21;8(1):1646. doi: 10.1038/s41467-017-01518-z.


Selenium toxicity to survival and reproduction of Collembola and Enchytraeids in a sandy loam soil.

Kuperman RG, Checkai RT, Simini M, Phillips CT, Higashi RM, Fan TW, Sappington K.

Environ Toxicol Chem. 2018 Mar;37(3):846-853. doi: 10.1002/etc.4017. Epub 2018 Jan 4.


Root aneurysm following aortic valve replacement 20 years after an arterial switch operation.

Ishii H, Aomi S, Tomioka H, Umeda E, Higashi R, Yamazaki K.

J Card Surg. 2017 Nov;32(11):721-723. doi: 10.1111/jocs.13226. Epub 2017 Oct 18.


Simultaneous Measurements of Faecal Calprotectin and the Faecal Immunochemical Test in Quiescent Ulcerative Colitis Patients Can Stratify Risk of Relapse.

Nakarai A, Hiraoka S, Takahashi S, Inaba T, Higashi R, Mizuno M, Takashima S, Inokuchi T, Sugihara Y, Takahara M, Harada K, Kato J, Okada H.

J Crohns Colitis. 2018 Jan 5;12(1):71-76. doi: 10.1093/ecco-jcc/jjx118.


Colonic lesion characterisation skills among UK endoscopists and the impact of a brief training intervention.

Basford P, Longcroft-Wheaton G, Higashi R, Uraoka T, Bhandari P.

Frontline Gastroenterol. 2017 Jan;8(1):2-7. doi: 10.1136/flgastro-2016-100689. Epub 2016 May 31.


Comparison of proton beam radiotherapy and hyper-fractionated accelerated chemoradiotherapy for locally advanced pancreatic cancer.

Maemura K, Mataki Y, Kurahara H, Kawasaki Y, Iino S, Sakoda M, Ueno S, Arimura T, Higashi R, Yoshiura T, Shinchi H, Natsugoe S.

Pancreatology. 2017 Sep - Oct;17(5):833-838. doi: 10.1016/j.pan.2017.07.191. Epub 2017 Jul 27.


Importance of Second-look Endoscopy on an Empty Stomach for Finding Gastric Bezoars in Patients with Gastric Ulcers.

Iwamuro M, Tanaka S, Moritou Y, Inaba T, Higashi R, Kusumoto C, Yunoki N, Ishikawa S, Okamoto Y, Kawai Y, Kitada KI, Takenaka R, Toyokawa T, Okada H.

Acta Med Okayama. 2017 Jun;71(3):241-247. doi: 10.18926/AMO/55207.


Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM).

Bruntz RC, Lane AN, Higashi RM, Fan TW.

J Biol Chem. 2017 Jul 14;292(28):11601-11609. doi: 10.1074/jbc.R117.776054. Epub 2017 Jun 7. Review.


Chloroformate derivatization for tracing the fate of Amino acids in cells and tissues by multiple stable isotope resolved metabolomics (mSIRM).

Yang Y, Fan TW, Lane AN, Higashi RM.

Anal Chim Acta. 2017 Jul 11;976:63-73. doi: 10.1016/j.aca.2017.04.014. Epub 2017 Apr 10.


Role of mucosa in generating spontaneous activity in the guinea pig seminal vesicle.

Takeya M, Hashitani H, Hayashi T, Higashi R, Nakamura KI, Takano M.

J Physiol. 2017 Jul 15;595(14):4803-4821. doi: 10.1113/JP273872. Epub 2017 May 25.


Probing the metabolic phenotype of breast cancer cells by multiple tracer stable isotope resolved metabolomics.

Lane AN, Tan J, Wang Y, Yan J, Higashi RM, Fan TW.

Metab Eng. 2017 Sep;43(Pt B):125-136. doi: 10.1016/j.ymben.2017.01.010. Epub 2017 Feb 2.


Interstitial cell modulation of pyeloureteric peristalsis in the mouse renal pelvis examined using FIBSEM tomography and calcium indicators.

Hashitani H, Nguyen MJ, Noda H, Mitsui R, Higashi R, Ohta K, Nakamura KI, Lang RJ.

Pflugers Arch. 2017 Jun;469(5-6):797-813. doi: 10.1007/s00424-016-1930-6. Epub 2017 Jan 4.


Assessing local capacity to expand rural breast cancer screening and patient navigation: An iterative mixed-method tool.

Inrig SJ, Higashi RT, Tiro JA, Argenbright KE, Lee SJ.

Eval Program Plann. 2017 Apr;61:113-124. doi: 10.1016/j.evalprogplan.2016.11.006. Epub 2016 Nov 23.


Who Is Food Insecure? Implications for Targeted Recruitment and Outreach, National Health and Nutrition Examination Survey, 2005-2010.

Pruitt SL, Leonard T, Xuan L, Amory R, Higashi RT, Nguyen OK, Pezzia C, Swales S.

Prev Chronic Dis. 2016 Oct 13;13:E143. doi: 10.5888/pcd13.160103.


Treatment Result in the Initial Stage of Kanazawa Mobile Embolectomy Team for Acute Ischemic Stroke.

Uchiyama N, Misaki K, Mohri M, Kamide T, Hirota Y, Higashi R, Minamide H, Kohda Y, Asahi T, Shoin K, Iwato M, Kita D, Hamada Y, Yoshida Y, Nakada M.

Neurol Med Chir (Tokyo). 2016 Dec 15;56(12):737-744. Epub 2016 Oct 11.


An Energy Dispersive X-ray Spectroscopy Analysis of Elemental Changes of a Persimmon Phytobezoar Dissolved in Coca-Cola.

Iwamuro M, Urata H, Higashi R, Nakagawa M, Ishikawa S, Shiraha H, Okada H.

Intern Med. 2016;55(18):2611-5. doi: 10.2169/internalmedicine.55.6985. Epub 2016 Sep 15.


Texture analysis of 18F-FDG PET/CT to predict tumour response and prognosis of patients with esophageal cancer treated by chemoradiotherapy.

Nakajo M, Jinguji M, Nakabeppu Y, Nakajo M, Higashi R, Fukukura Y, Sasaki K, Uchikado Y, Natsugoe S, Yoshiura T.

Eur J Nucl Med Mol Imaging. 2017 Feb;44(2):206-214. doi: 10.1007/s00259-016-3506-2. Epub 2016 Sep 10.


Pacemaker malfunction associated with proton beam therapy: a report of two cases and review of literature-does field-to-generator distance matter?

Ueyama T, Arimura T, Ogino T, Kondo N, Higashi R, Nakamura F, Ito S, Yoshiura T, Hishikawa Y.

Oxf Med Case Reports. 2016 Aug 29;2016(8):omw049. doi: 10.1093/omcr/omw049. eCollection 2016 Aug.


Distinctly perturbed metabolic networks underlie differential tumor tissue damages induced by immune modulator β-glucan in a two-case ex vivo non-small-cell lung cancer study.

Fan TW, Warmoes MO, Sun Q, Song H, Turchan-Cholewo J, Martin JT, Mahan A, Higashi RM, Lane AN.

Cold Spring Harb Mol Case Stud. 2016 Jul;2(4):a000893. doi: 10.1101/mcs.a000893.


Physical, Emotional, and Social Impacts of Restricting Back Pain in Older Adults: A Qualitative Study.

Makris UE, Higashi RT, Marks EG, Fraenkel L, Gill TM, Friedly JL, Reid MC.

Pain Med. 2017 Jul 1;18(7):1225-1235. doi: 10.1093/pm/pnw196.


Preclinical models for interrogating drug action in human cancers using Stable Isotope Resolved Metabolomics (SIRM).

Lane AN, Higashi RM, Fan TW.

Metabolomics. 2016 Jul;12(7). pii: 118. Epub 2016 Jun 29.


County-level outcomes of a rural breast cancer screening outreach strategy: a decentralized hub-and-spoke model (BSPAN2).

Lee SJC, Higashi RT, Inrig SJ, Sanders JM, Zhu H, Argenbright KE, Tiro JA.

Transl Behav Med. 2017 Jun;7(2):349-357. doi: 10.1007/s13142-016-0427-3.


Characterizing safety-net providers' HPV vaccine recommendations to undecided parents: A pilot study.

Shay LA, Street RL Jr, Baldwin AS, Marks EG, Lee SC, Higashi RT, Skinner CS, Fuller S, Persaud D, Tiro JA.

Patient Educ Couns. 2016 Sep;99(9):1452-60. doi: 10.1016/j.pec.2016.06.027. Epub 2016 Jun 25.


An obligatory role for neurotensin in high-fat-diet-induced obesity.

Li J, Song J, Zaytseva YY, Liu Y, Rychahou P, Jiang K, Starr ME, Kim JT, Harris JW, Yiannikouris FB, Katz WS, Nilsson PM, Orho-Melander M, Chen J, Zhu H, Fahrenholz T, Higashi RM, Gao T, Morris AJ, Cassis LA, Fan TW, Weiss HL, Dobner PR, Melander O, Jia J, Evers BM.

Nature. 2016 May 19;533(7603):411-5. doi: 10.1038/nature17662. Epub 2016 May 11.

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