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Items: 1 to 50 of 842

1.

Chondroitin sulfate E blocks enzymatic action of heparanase and heparanase-induced cellular responses.

Higashi N, Maeda R, Sesoko N, Isono M, Ishikawa S, Tani Y, Takahashi K, Oku T, Higashi K, Onishi S, Nakajima M, Irimura T.

Biochem Biophys Res Commun. 2019 Oct 1. pii: S0006-291X(19)31864-9. doi: 10.1016/j.bbrc.2019.09.126. [Epub ahead of print]

PMID:
31582210
2.
3.

Detection of Selenocyanate in Biological Samples by HPLC with Fluorescence Detection Using König Reaction.

Mochizuki R, Higashi K, Okamoto Y, Abe H, Iwase H, Toida T.

Chem Pharm Bull (Tokyo). 2019;67(8):884-887. doi: 10.1248/cpb.c19-00277.

4.

Intravoxel incoherent motion imaging has the possibility to detect liver abnormalities in young Fontan patients with good hemodynamics.

Shiraga K, Ono K, Inuzuka R, Asakai H, Ookubo T, Shirayama A, Higashi K, Nakajima H.

Cardiol Young. 2019 Jul;29(7):898-903. doi: 10.1017/S1047951119001070. Epub 2019 Jun 28.

PMID:
31250776
5.

Congenital Primary Hypothyroidism with the Homozygous Nonsense Mutation P.K1374* in the Thyroglobulin Gene and a Normal-sized Thyroid Gland on Levothyroxine Replacement.

Mizokami T, Fukata S, Kogai T, Hishinuma A, Hamada K, Maruta T, Higashi K, Tajiri J.

Intern Med. 2019 Sep 15;58(18):2669-2673. doi: 10.2169/internalmedicine.1163-18. Epub 2019 Jun 7.

6.

Preparation of 99mTc-Labeled Mannan-S-Cysteine and Effect of Molecular Size of Mannan on Its Biodistribution.

Hagiwara Y, Higashi K, Hagita H, Uehara T, Ito D, Hanaoka H, Suzuki H, Arano Y, Toida T.

Biol Pharm Bull. 2019;42(5):819-826. doi: 10.1248/bpb.b19-00026.

7.

An Integrated Single-Electrode Method Reveals the Template Roles of Atomic Steps: Disturb Interfacial Water Networks and Thus Affect the Reactivity of Electrocatalysts.

Zhao X, Gunji T, Kaneko T, Yoshida Y, Takao S, Higashi K, Uruga T, He W, Liu J, Zou Z.

J Am Chem Soc. 2019 May 29;141(21):8516-8526. doi: 10.1021/jacs.9b02049. Epub 2019 May 10.

PMID:
31050410
8.

Effect of Drug-Polymer Interactions through Hypromellose Acetate Succinate Substituents on the Physical Stability on Solid Dispersions Studied by Fourier-Transform Infrared and Solid-State Nuclear Magnetic Resonance.

Ishizuka Y, Ueda K, Okada H, Takeda J, Karashima M, Yazawa K, Higashi K, Kawakami K, Ikeda Y, Moribe K.

Mol Pharm. 2019 Jun 3;16(6):2785-2794. doi: 10.1021/acs.molpharmaceut.9b00301. Epub 2019 May 14.

PMID:
31045376
9.

Effect of molecular weight of hypromellose on mucin diffusion and oral absorption behavior of fenofibrate nanocrystal.

Ueda K, Iwai T, Sunazuka Y, Chen Z, Kato N, Higashi K, Moribe K.

Int J Pharm. 2019 Jun 10;564:39-47. doi: 10.1016/j.ijpharm.2019.04.033. Epub 2019 Apr 11.

PMID:
30981872
10.

Cryo-TEM and AFM Observation of the Time-Dependent Evolution of Amorphous Probucol Nanoparticles Formed by the Aqueous Dispersion of Ternary Solid Dispersions.

Zhao Z, Katai H, Higashi K, Ueda K, Kawakami K, Moribe K.

Mol Pharm. 2019 May 6;16(5):2184-2198. doi: 10.1021/acs.molpharmaceut.9b00158. Epub 2019 Apr 9.

PMID:
30925218
11.

Sivelestat sodium hydrate treatment for refractory Kawasaki disease.

Ebata R, Yasukawa K, Nagai K, Saito Y, Higashi K, Homma J, Takada N, Takechi F, Saito N, Kobayashi H, Okunushi K, Hamada H, Kohno Y, Hanaoka H, Shimojo N.

Pediatr Int. 2019 May;61(5):438-443. doi: 10.1111/ped.13851. Epub 2019 May 17.

PMID:
30916859
12.

Mechanistic elucidation of formation of drug-rich amorphous nanodroplets by dissolution of the solid dispersion formulation.

Ueda K, Higashi K, Moribe K.

Int J Pharm. 2019 Apr 20;561:82-92. doi: 10.1016/j.ijpharm.2019.02.034. Epub 2019 Feb 26.

PMID:
30822504
13.

Supramolecular Polymeric Hydrogels for Ultrasound-Guided Protein Release.

Yamaguchi S, Higashi K, Azuma T, Okamoto A.

Biotechnol J. 2019 May;14(5):e1800530. doi: 10.1002/biot.201800530. Epub 2019 Apr 15.

PMID:
30810275
14.

A Novel Drug-Drug Cocrystal of Levofloxacin and Metacetamol: Reduced Hygroscopicity and Improved Photostability of Levofloxacin.

Shinozaki T, Ono M, Higashi K, Moribe K.

J Pharm Sci. 2019 Jul;108(7):2383-2390. doi: 10.1016/j.xphs.2019.02.014. Epub 2019 Feb 23.

PMID:
30807761
15.

Probucol Slows the Progression of Cataracts in Streptozotocin-Induced Hyperglycemic Rats.

Higashi K, Mori A, Sakamoto K, Ishii K, Nakahara T.

Pharmacology. 2019;103(3-4):212-219. doi: 10.1159/000496055. Epub 2019 Feb 5.

PMID:
30721902
16.

[Design Features in the Molecular-level Development of Solid Pharmaceutical Formulations Based on Supramolecular Structures].

Higashi K, Ueda K, Moribe K.

Yakugaku Zasshi. 2019;139(2):157-164. doi: 10.1248/yakushi.18-00168-2. Review. Japanese.

17.

Inhibition of post-transcriptional gene silencing of chalcone synthase genes in petunia picotee petals by fluacrypyrim.

Ban Y, Morita Y, Ogawa M, Higashi K, Nakatsuka T, Nishihara M, Nakayama M.

J Exp Bot. 2019 Mar 11;70(5):1513-1523. doi: 10.1093/jxb/erz009.

PMID:
30690559
18.

Hardness Perception Based on Dynamic Stiffness in Tapping.

Higashi K, Okamoto S, Yamada Y, Nagano H, Konyo M.

Front Psychol. 2019 Jan 4;9:2654. doi: 10.3389/fpsyg.2018.02654. eCollection 2018.

19.

Development of nobiletin-methyl hesperidin amorphous solid dispersion: Novel application of methyl hesperidin as an excipient for hot-melt extrusion.

Iwashita M, Hashizume K, Umehara M, Ishigami T, Onishi S, Yamamoto M, Higashi K, Moribe K.

Int J Pharm. 2019 Mar 10;558:215-224. doi: 10.1016/j.ijpharm.2018.12.092. Epub 2019 Jan 14.

PMID:
30654059
20.

Real-world safety and efficacy of sofosbuvir and ledipasvir for elderly patients.

Tamai H, Shingaki N, Ida Y, Shimizu R, Maeshima S, Okamura J, Kawashima A, Nakao T, Hara T, Matsutani H, Nishikawa I, Higashi K.

JGH Open. 2018 Sep 19;2(6):300-306. doi: 10.1002/jgh3.12088. eCollection 2018 Dec.

21.

The Relationship Between Microbial Community Structures and Environmental Parameters Revealed by Metagenomic Analysis of Hot Spring Water in the Kirishima Area, Japan.

Nishiyama E, Higashi K, Mori H, Suda K, Nakamura H, Omori S, Maruyama S, Hongoh Y, Kurokawa K.

Front Bioeng Biotechnol. 2018 Dec 20;6:202. doi: 10.3389/fbioe.2018.00202. eCollection 2018.

22.

Combination of Roll Grinding and High-Pressure Homogenization Can Prepare Stable Bicelles for Drug Delivery.

Matsuo S, Higashi K, Moribe K, Kimura SI, Itai S, Kondo H, Iwao Y.

Nanomaterials (Basel). 2018 Dec 3;8(12). pii: E998. doi: 10.3390/nano8120998.

23.

Nodular gastritis in association with gastric cancer development before and after Helicobacter pylori eradication.

Nishikawa I, Kato J, Terasoma S, Matsutani H, Tamaki H, Tamaki T, Kuwashima F, Nakata H, Tomeki T, Matsunaka H, Ibata Y, Yamashita Y, Maekita T, Higashi K, Ichinose M.

JGH Open. 2018 Mar 25;2(3):80-86. doi: 10.1002/jgh3.12049. eCollection 2018 Jun.

24.

Microbes Culture System Using Cellulose Tubes and Photocatalyst-Coated Glass Balls.

Saito K, Fujimoto K, Higashi K, Miki N.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:5741-5744. doi: 10.1109/EMBC.2018.8513570.

PMID:
30441640
25.

Polyamines stimulate the CHSY1 synthesis through the unfolding of the RNA G-quadruplex at the 5'-untraslated region.

Yamaguchi K, Asakura K, Imamura M, Kawai G, Sakamoto T, Furihata T, Linhardt RJ, Igarashi K, Toida T, Higashi K.

Biochem J. 2018 Dec 6;475(23):3797-3812. doi: 10.1042/BCJ20180672.

PMID:
30401686
26.

Development of a Triple-Coaxial Flow Device for Fabricating a Hydrogel Microtube and Its Application to Bioremediation.

Fujimoto K, Higashi K, Onoe H, Miki N.

Micromachines (Basel). 2018 Feb 12;9(2). pii: E76. doi: 10.3390/mi9020076.

27.

Hydrogel Fiber Cultivation Method for Forming Bacterial Cellulose Microspheres.

Higashi K, Miki N.

Micromachines (Basel). 2018 Jan 17;9(1). pii: E36. doi: 10.3390/mi9010036.

28.

Identification of a Novel Bone Marrow Cell-Derived Accelerator of Fibrotic Liver Regeneration Through Mobilization of Hepatic Progenitor Cells in Mice.

Yanagawa T, Sumiyoshi H, Higashi K, Nakao S, Higashiyama R, Fukumitsu H, Minakawa K, Chiba Y, Suzuki Y, Sumida K, Saito K, Kamiya A, Inagaki Y.

Stem Cells. 2019 Jan;37(1):89-101. doi: 10.1002/stem.2916. Epub 2018 Oct 31.

PMID:
30270488
29.

Anti-cataract Effect of Resveratrol in High-Glucose-Treated Streptozotocin-Induced Diabetic Rats.

Higashi Y, Higashi K, Mori A, Sakamoto K, Ishii K, Nakahara T.

Biol Pharm Bull. 2018;41(10):1586-1592. doi: 10.1248/bpb.b18-00328.

30.

Long-Term Outcomes of Patients with Squamous Cell Carcinoma of the Temporal Bone after Concomitant Chemoradiotherapy.

Shiga K, Katagiri K, Saitoh D, Ogawa T, Higashi K, Ariga H.

J Neurol Surg B Skull Base. 2018 Oct;79(Suppl 4):S316-S321. doi: 10.1055/s-0038-1651522. Epub 2018 May 14.

31.

An Insight into Stabilization Mechanism of a Solid Dispersion of Indomethacin/Partially Hydrolyzed Polyvinyl Alcohol Prepared by Hot-Melt Extrusion.

Benjasirimongkol P, Ueda K, Higashi K, Sriamornsak P, Moribe K.

Chem Pharm Bull (Tokyo). 2018;66(9):859-865. doi: 10.1248/cpb.c18-00362.

32.

DNA-loaded nano-adjuvant formed with a vitamin E-scaffold intracellular environmentally-responsive lipid-like material for cancer immunotherapy.

Kawai M, Nakamura T, Miura N, Maeta M, Tanaka H, Ueda K, Higashi K, Moribe K, Tange K, Nakai Y, Yoshioka H, Harashima H, Akita H.

Nanomedicine. 2018 Nov;14(8):2587-2597. doi: 10.1016/j.nano.2018.08.006. Epub 2018 Aug 29.

PMID:
30170077
33.

GLI1 Inhibitors Identified by Target Protein Oriented Natural Products Isolation (TPO-NAPI) with Hedgehog Inhibition.

Arai MA, Ochi F, Makita Y, Chiba T, Higashi K, Suganami A, Tamura Y, Toida T, Iwama A, Sadhu SK, Ahmed F, Ishibashi M.

ACS Chem Biol. 2018 Sep 21;13(9):2551-2559. doi: 10.1021/acschembio.8b00492. Epub 2018 Sep 7.

PMID:
30160475
34.

Acute peri-myocarditis with an unusual initial manifestation of gallbladder edema and a profound eosinophilic surge during convalescence.

Zenda T, Araki I, Nakamiya O, Ogawa M, Higashi K, Ueno T.

Fukushima J Med Sci. 2018;64(2):95-102. doi: 10.5387/fms.2018-08.

35.

Correlation between clinical and radiologic features of patients with Gerstmann-Sträussler-Scheinker syndrome (Pro102Leu).

Yoshimura M, Yuan JH, Higashi K, Yoshimura A, Arata H, Okubo R, Nakabeppu Y, Yoshiura T, Takashima H.

J Neurol Sci. 2018 Aug 15;391:15-21. doi: 10.1016/j.jns.2018.05.012. Epub 2018 May 17.

36.

Mechanism of Enhanced Nifedipine Dissolution by Polymer-Blended Solid Dispersion through Molecular-Level Characterization.

Ueda K, Yamazoe C, Yasuda Y, Higashi K, Kawakami K, Moribe K.

Mol Pharm. 2018 Sep 4;15(9):4099-4109. doi: 10.1021/acs.molpharmaceut.8b00523. Epub 2018 Aug 13.

PMID:
30064220
37.

Observation of Degradation of Pt and Carbon Support in Polymer Electrolyte Fuel Cell Using Combined Nano-X-ray Absorption Fine Structure and Transmission Electron Microscopy Techniques.

Takao S, Sekizawa O, Samjeské G, Kaneko T, Higashi K, Yoshida Y, Zhao X, Sakata T, Yamamoto T, Gunji T, Uruga T, Iwasawa Y.

ACS Appl Mater Interfaces. 2018 Aug 22;10(33):27734-27744. doi: 10.1021/acsami.8b04407. Epub 2018 Aug 13.

PMID:
30044074
38.

Perceived Hardness through Actual and Virtual Damped Natural Vibrations.

Higashi K, Okamoto S, Yamada Y.

IEEE Trans Haptics. 2018 Oct-Dec;11(4):646-651. doi: 10.1109/TOH.2018.2841820. Epub 2018 May 29.

PMID:
29993586
39.

A Novel SDHB IVS2-2A>C Mutation Is Responsible for Hereditary Pheochromocytoma/Paraganglioma Syndrome.

Yamanaka M, Shiga K, Fujiwara S, Mizuguchi Y, Yasuda S, Ishizawa K, Saiki Y, Higashi K, Ogawa T, Kimura N, Horii A.

Tohoku J Exp Med. 2018 Jun;245(2):99-105. doi: 10.1620/tjem.245.99.

40.

Latent environment allocation of microbial community data.

Higashi K, Suzuki S, Kurosawa S, Mori H, Kurokawa K.

PLoS Comput Biol. 2018 Jun 6;14(6):e1006143. doi: 10.1371/journal.pcbi.1006143. eCollection 2018 Jun.

41.

Protective Effects of Brain Infarction by N-Acetylcysteine Derivatives.

Uemura T, Watanabe K, Ko K, Higashi K, Kogure N, Kitajima M, Takayama H, Takao K, Sugita Y, Sakamoto A, Terui Y, Toida T, Kashiwagi K, Igarashi K.

Stroke. 2018 Jul;49(7):1727-1733. doi: 10.1161/STROKEAHA.118.021755. Epub 2018 Jun 4.

PMID:
29866754
42.

Combined effects of the drug distribution and mucus diffusion properties of self-microemulsifying drug delivery systems on the oral absorption of fenofibrate.

Sunazuka Y, Ueda K, Higashi K, Tanaka Y, Moribe K.

Int J Pharm. 2018 Jul 30;546(1-2):263-271. doi: 10.1016/j.ijpharm.2018.05.031. Epub 2018 May 26.

PMID:
29763688
43.

Annealing induced atomic rearrangements on (Ga,In) (N,As) probed by hard X-ray photoelectron spectroscopy and X-ray absorption fine structure.

Ishikawa F, Higashi K, Fuyuno S, Morifuji M, Kondow M, Trampert A.

Sci Rep. 2018 Apr 13;8(1):5962. doi: 10.1038/s41598-018-23941-y.

44.

Morphological and Physicochemical Evaluation of Two Distinct Glibenclamide/Hypromellose Amorphous Nanoparticles Prepared by the Antisolvent Method.

Yonashiro H, Higashi K, Morikawa C, Ueda K, Itoh T, Ito M, Masu H, Noguchi S, Moribe K.

Mol Pharm. 2018 Apr 2;15(4):1587-1597. doi: 10.1021/acs.molpharmaceut.7b01122. Epub 2018 Mar 12.

PMID:
29502422
45.

Cancer-Type OATP1B3 mRNA in Extracellular Vesicles as a Promising Candidate for a Serum-Based Colorectal Cancer Biomarker.

Morio H, Sun Y, Harada M, Ide H, Shimozato O, Zhou X, Higashi K, Yuki R, Yamaguchi N, Hofbauer JP, Guttmann-Gruber C, Anzai N, Akita H, Chiba K, Furihata T.

Biol Pharm Bull. 2018;41(3):445-449. doi: 10.1248/bpb.b17-00743.

46.

S1P-S1PR2 Axis Mediates Homing of Muse Cells Into Damaged Heart for Long-Lasting Tissue Repair and Functional Recovery After Acute Myocardial Infarction.

Yamada Y, Wakao S, Kushida Y, Minatoguchi S, Mikami A, Higashi K, Baba S, Shigemoto T, Kuroda Y, Kanamori H, Amin M, Kawasaki M, Nishigaki K, Taoka M, Isobe T, Muramatsu C, Dezawa M, Minatoguchi S.

Circ Res. 2018 Apr 13;122(8):1069-1083. doi: 10.1161/CIRCRESAHA.117.311648. Epub 2018 Feb 23.

PMID:
29475983
47.

Reduction of Spermidine Content Resulting from Inactivation of Two Arginine Decarboxylases Increases Biofilm Formation in Synechocystis sp. Strain PCC 6803.

Kera K, Nagayama T, Nanatani K, Saeki-Yamoto C, Tominaga A, Souma S, Miura N, Takeda K, Kayamori S, Ando E, Higashi K, Igarashi K, Uozumi N.

J Bacteriol. 2018 Apr 9;200(9). pii: e00664-17. doi: 10.1128/JB.00664-17. Print 2018 May 1.

48.

Simple laryngeal suspension procedure by suturing the digastric muscle to the periosteum of the mandible in neck dissection for tongue cancer.

Ohkoshi A, Ogawa T, Sagai S, Nakanome A, Higashi K, Ishii R, Kato K, Katori Y.

Am J Otolaryngol. 2018 Mar - Apr;39(2):77-81. doi: 10.1016/j.amjoto.2018.01.008. Epub 2018 Jan 31.

PMID:
29395281
49.

Comprehensive analysis of glycosaminoglycans from the edible shellfish.

Okamoto Y, Higashi K, Linhardt RJ, Toida T.

Carbohydr Polym. 2018 Mar 15;184:269-276. doi: 10.1016/j.carbpol.2017.12.076. Epub 2017 Dec 29.

PMID:
29352919
50.

Molecular-level elucidation of saccharin-assisted rapid dissolution and high supersaturation level of drug from Eudragit® E solid dispersion.

Ueda K, Kanaya H, Higashi K, Yamamoto K, Moribe K.

Int J Pharm. 2018 Mar 1;538(1-2):57-64. doi: 10.1016/j.ijpharm.2017.12.050. Epub 2018 Jan 16.

PMID:
29341907

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